Daniel Nowak

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3
    Daniel Nowak
    Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Germany
    Genes Chromosomes Cancer 51:756-67. 2012
  2. pmc SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations
    Daniel Nowak
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, CA 90048, USA
    Blood 115:1049-53. 2010
  3. doi request reprint High expression of the Ets-related gene (ERG) is an independent prognostic marker for relapse-free survival in patients with acute promyelocytic leukemia
    Anna Hecht
    Department of Hematology and Oncology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Ann Hematol 92:443-9. 2013
  4. pmc Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia
    Ryoko Okamoto
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700, Beverly Blvd, Los Angeles, CA90048, USA
    Haematologica 95:1481-8. 2010
  5. pmc In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 5:e15419. 2010
  6. doi request reprint In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany
    Leuk Res 37:378-82. 2013
  7. doi request reprint Identification of defects in the transcriptional program during lineage-specific in vitro differentiation of CD34(+) cells selected from patients with both low- and high-risk myelodysplastic syndrome
    Saskia Gueller
    Department of Hematology and Oncology, University Hospital, Frankfurt Main, Germany
    Exp Hematol 38:718-32, 732.e1-6. 2010
  8. doi request reprint Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis
    Olaf Hopfer
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Haematol 88:144-53. 2012
  9. doi request reprint Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay
    Maximilian Mossner
    Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany
    J Med Genet 50:108-17. 2013
  10. pmc Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms
    Nils H Thoennissen
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    Blood 115:2882-90. 2010

Detail Information

Publications15

  1. doi request reprint SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3
    Daniel Nowak
    Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Germany
    Genes Chromosomes Cancer 51:756-67. 2012
    ..9, P=0.0031). This study presents a comprehensive assessment of new CNAs as pathomechanistically relevant targets and possible prognostic factors which could refine risk stratification of APL...
  2. pmc SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations
    Daniel Nowak
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, CA 90048, USA
    Blood 115:1049-53. 2010
    ..This may support a hypothesis of TKI-induced selection of subclones differentiating into immature B-cell progenitors as a mechanism of disease progression and evasion of TKI sensitivity...
  3. doi request reprint High expression of the Ets-related gene (ERG) is an independent prognostic marker for relapse-free survival in patients with acute promyelocytic leukemia
    Anna Hecht
    Department of Hematology and Oncology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Ann Hematol 92:443-9. 2013
    ..Therefore, ERG expression might serve as a molecular marker for risk stratification in APL and might identify patients who could benefit from intensified treatment regimens...
  4. pmc Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia
    Ryoko Okamoto
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700, Beverly Blvd, Los Angeles, CA90048, USA
    Haematologica 95:1481-8. 2010
    ..The inferior prognosis in adult acute lymphoblastic leukemia is not fully understood but could be attributed, in part, to differences in genomic alterations found in adult as compared to in pediatric acute lymphoblastic leukemia...
  5. pmc In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 5:e15419. 2010
    ....
  6. doi request reprint In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany
    Leuk Res 37:378-82. 2013
    ..70%; p=0.035). In multivariate analyses low BAALC expression retained its prognostic relevance. In conclusion, BAALC expression analysis might be useful in further risk stratification in APL patients...
  7. doi request reprint Identification of defects in the transcriptional program during lineage-specific in vitro differentiation of CD34(+) cells selected from patients with both low- and high-risk myelodysplastic syndrome
    Saskia Gueller
    Department of Hematology and Oncology, University Hospital, Frankfurt Main, Germany
    Exp Hematol 38:718-32, 732.e1-6. 2010
    ....
  8. doi request reprint Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis
    Olaf Hopfer
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Haematol 88:144-53. 2012
    ..Its dysregulation may contribute to the ineffective erythropoiesis observed in MDS...
  9. doi request reprint Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay
    Maximilian Mossner
    Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany
    J Med Genet 50:108-17. 2013
    ..Recently, transcriptional XCIP ratio analysis challenged these results and questioned the suitability of methylation based clonality assays...
  10. pmc Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms
    Nils H Thoennissen
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    Blood 115:2882-90. 2010
    ..01 and P = .016, respectively). Our high-density SNP-array analysis of MPN genomes in the chronic compared with leukemic stage identified novel target genes and provided prognostic insights associated with the evolution to leukemia...
  11. doi request reprint Genome-wide DNA-mapping of CD34+ cells from patients with myelodysplastic syndrome using 500K SNP arrays identifies significant regions of deletion and uniparental disomy
    Daniel Nowak
    Department of Hematology and Oncology, Charite University Hospital, Campus Benjamin Franklin, Berlin, Germany
    Exp Hematol 37:215-224. 2009
    ..Identification of genomic lesions in progenitor cells of patients with myelodysplastic syndrome (MDS) could lead to the discovery of new disease-specific genes and may be of prognostic value...
  12. doi request reprint Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical results and open questions
    Eva Lengfelder
    Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany
    Expert Rev Anticancer Ther 13:1035-43. 2013
    ..The results of these newer studies indicate that the backbone of chemotherapy can be dramatically reduced or completely replaced by ATO and ATRA with similar or even better outcome. ..
  13. pmc Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy
    Daniel Nowak
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Haematologica 94:518-27. 2009
    ....
  14. pmc The effect of the CCR5-delta32 deletion on global gene expression considering immune response and inflammation
    Gero Hütter
    Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University German Red Cross Blood Service Baden Württemberg Hessen, Germany
    J Inflamm (Lond) 8:29. 2011
    ..abstract:..
  15. pmc Differentiation therapy of leukemia: 3 decades of development
    Daniel Nowak
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles UCLA School of Medicine, CA 90048, USA
    Blood 113:3655-65. 2009
    ....