Genomes and Genes
Affiliation: University of Heidelberg
- SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3Daniel Nowak
Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Germany
Genes Chromosomes Cancer 51:756-67. 2012..9, P=0.0031). This study presents a comprehensive assessment of new CNAs as pathomechanistically relevant targets and possible prognostic factors which could refine risk stratification of APL...
- SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterationsDaniel Nowak
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, CA 90048, USA
Blood 115:1049-53. 2010..This may support a hypothesis of TKI-induced selection of subclones differentiating into immature B-cell progenitors as a mechanism of disease progression and evasion of TKI sensitivity...
- High expression of the Ets-related gene (ERG) is an independent prognostic marker for relapse-free survival in patients with acute promyelocytic leukemiaAnna Hecht
Department of Hematology and Oncology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
Ann Hematol 92:443-9. 2013..Therefore, ERG expression might serve as a molecular marker for risk stratification in APL and might identify patients who could benefit from intensified treatment regimens...
- Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemiaRyoko Okamoto
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700, Beverly Blvd, Los Angeles, CA90048, USA
Haematologica 95:1481-8. 2010..The inferior prognosis in adult acute lymphoblastic leukemia is not fully understood but could be attributed, in part, to differences in genomic alterations found in adult as compared to in pediatric acute lymphoblastic leukemia...
- In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine responseTadayuki Akagi
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
PLoS ONE 5:e15419. 2010....
- In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survivalFlorian Nolte
Department of Hematology and Oncology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany
Leuk Res 37:378-82. 2013..70%; p=0.035). In multivariate analyses low BAALC expression retained its prognostic relevance. In conclusion, BAALC expression analysis might be useful in further risk stratification in APL patients...
- Identification of defects in the transcriptional program during lineage-specific in vitro differentiation of CD34(+) cells selected from patients with both low- and high-risk myelodysplastic syndromeSaskia Gueller
Department of Hematology and Oncology, University Hospital, Frankfurt Main, Germany
Exp Hematol 38:718-32, 732.e1-6. 2010....
- Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesisOlaf Hopfer
Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
Eur J Haematol 88:144-53. 2012..Its dysregulation may contribute to the ineffective erythropoiesis observed in MDS...
- Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasmsNils H Thoennissen
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
Blood 115:2882-90. 2010..01 and P = .016, respectively). Our high-density SNP-array analysis of MPN genomes in the chronic compared with leukemic stage identified novel target genes and provided prognostic insights associated with the evolution to leukemia...
- Genome-wide DNA-mapping of CD34+ cells from patients with myelodysplastic syndrome using 500K SNP arrays identifies significant regions of deletion and uniparental disomyDaniel Nowak
Department of Hematology and Oncology, Charite University Hospital, Campus Benjamin Franklin, Berlin, Germany
Exp Hematol 37:215-224. 2009..Identification of genomic lesions in progenitor cells of patients with myelodysplastic syndrome (MDS) could lead to the discovery of new disease-specific genes and may be of prognostic value...
- Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assayMaximilian Mossner
Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany
J Med Genet 50:108-17. 2013..Recently, transcriptional XCIP ratio analysis challenged these results and questioned the suitability of methylation based clonality assays...
- Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomyDaniel Nowak
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Haematologica 94:518-27. 2009....
- The effect of the CCR5-delta32 deletion on global gene expression considering immune response and inflammationGero Hütter
Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University German Red Cross Blood Service Baden Württemberg Hessen, Germany
J Inflamm (Lond) 8:29. 2011..abstract:..
- Differentiation therapy of leukemia: 3 decades of developmentDaniel Nowak
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles UCLA School of Medicine, CA 90048, USA
Blood 113:3655-65. 2009....