Natalija Novak

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi Targeting dendritic cells in allergen immunotherapy
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Immunol Allergy Clin North Am 26:307-19, viii. 2006
  2. ncbi Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis?
    Caroline Bussmann
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 118:1292-8. 2006
  3. ncbi Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 130:1153-1158.e2. 2012
  4. ncbi Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 130:925-31.e4. 2012
  5. ncbi The immunoglobulin E-Toll-like receptor network
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    Int Arch Allergy Immunol 151:1-7. 2010
  6. ncbi 2. Dendritic cells as regulators of immunity and tolerance
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 121:S370-4; quiz S413. 2008
  7. ncbi Atopic dermatitis - from new pathophysiologic insights to individualized therapy
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 66:830-9. 2011
  8. ncbi Subcutaneous immunotherapy with a depigmented polymerized birch pollen extract--a new therapeutic option for patients with atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Int Arch Allergy Immunol 155:252-6. 2011
  9. ncbi Immunological mechanisms of sublingual allergen-specific immunotherapy
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 66:733-9. 2011
  10. ncbi Characterization of FcepsilonRI-bearing CD123 blood dendritic cell antigen-2 plasmacytoid dendritic cells in atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Germany
    J Allergy Clin Immunol 114:364-70. 2004

Detail Information

Publications115 found, 100 shown here

  1. ncbi Targeting dendritic cells in allergen immunotherapy
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Immunol Allergy Clin North Am 26:307-19, viii. 2006
    ..These experimental data should help confirm the hypothesis of DCs as efficient silencers and potential target cells and take advantage of the bivalent character and tolerogenic properties of DCs...
  2. ncbi Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis?
    Caroline Bussmann
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 118:1292-8. 2006
    ..In addition, we discuss prophylactic and therapeutic options for the treatment of HDM allergy in patients with AD, including a summary of the current data available on SIT as a potential therapeutic option for patients with AD...
  3. ncbi Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 130:1153-1158.e2. 2012
    ..However, its mechanisms have not been elucidated in detail. Histamine is one of the main mediators released on FcεRI triggering of basophils and mast cells, and it exerts its functions through histamine receptors (HRs)...
  4. ncbi Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 130:925-31.e4. 2012
    ..Exposure to house dust mites (HDMs) aggravates the course of atopic dermatitis (AD) in patients sensitized to HDMs...
  5. ncbi The immunoglobulin E-Toll-like receptor network
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    Int Arch Allergy Immunol 151:1-7. 2010
    ..Current knowledge about the cross talk of TLRs with FcepsilonRI- and IgE-related immune responses is discussed herein...
  6. ncbi 2. Dendritic cells as regulators of immunity and tolerance
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 121:S370-4; quiz S413. 2008
    ....
  7. ncbi Atopic dermatitis - from new pathophysiologic insights to individualized therapy
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 66:830-9. 2011
    ..In this review, we provide an overview about a selection of pathophysiologic pathways, which hold promise to represent targets of such therapeutic approaches in the near future...
  8. ncbi Subcutaneous immunotherapy with a depigmented polymerized birch pollen extract--a new therapeutic option for patients with atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Int Arch Allergy Immunol 155:252-6. 2011
    ..The aim of this study was to evaluate for the first time the safety and efficacy of SIT with a depigmented polymerized birch pollen extract in AD patients...
  9. ncbi Immunological mechanisms of sublingual allergen-specific immunotherapy
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 66:733-9. 2011
    ..However, recent research efforts as well as clinical approaches paved the way for another exciting 100 years of SLIT...
  10. ncbi Characterization of FcepsilonRI-bearing CD123 blood dendritic cell antigen-2 plasmacytoid dendritic cells in atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Germany
    J Allergy Clin Immunol 114:364-70. 2004
    ..Plasmacytoid dendritic cells (pDCs), which are instrumental in the defense of viral infections, are present in reduced amounts in the skin of patients with AD, which is characterized by a high susceptibility to viral infections...
  11. ncbi [Pathogenesis of atopic eczema]
    Natalija Novak

    J Dtsch Dermatol Ges 3:994-1004; quiz 1005-6. 2005
  12. ncbi Toll-like receptor 7 agonists and skin
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Drug News Perspect 21:158-65. 2008
    ..This review summarizes the current knowledge about the immunological mechanisms induced by the TLR7 agonist imiquimod as well as established clinical therapies and putative applications of TLR7 agonists in the near future...
  13. ncbi Human skin and oral mucosal dendritic cells as 'good guys' and 'bad guys' in allergic immune responses
    N Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Clin Exp Immunol 161:28-33. 2010
    ....
  14. ncbi Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Allergy Clin Immunol 115:828-33. 2005
    ..Human IL-18 is an inflammatory cytokine that plays a role in atopic diseases, such as atopic eczema (AE), by enhancing IL-4 and IL-13 production and stimulating the synthesis of IgE...
  15. ncbi Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells
    N Novak
    Department of Dermatology, University of Bonn, Germany
    Clin Exp Immunol 142:405-10. 2005
    ..Here, we provide a research update about the interaction of HSV with DC and summarize the latest proceedings in this field...
  16. ncbi The immune privilege of the oral mucosa
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Trends Mol Med 14:191-8. 2008
    ....
  17. ncbi FcεRI-Toll-like receptor interaction in atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Curr Probl Dermatol 41:47-53. 2011
    ....
  18. ncbi [Specific immunotherapy and atopic dermatitis. What is new?]
    N Novak
    Klinik und Poliklinik fur Dermatologie und Allergologie, Universitat Bonn, Bonn, Deutschland
    Hautarzt 62:650-6. 2011
    ..In this overview, we summarize the current data and provide a state-of-the-art view on the value of SIT in AD...
  19. ncbi Allergen specific immunotherapy for atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    Curr Opin Allergy Clin Immunol 7:542-46. 2007
    ..To describe recent developments as well as the pros and cons of allergen specific immunotherapy as a putative therapeutic option for a subgroup of patients with atopic dermatitis...
  20. ncbi Network of myeloid and plasmacytoid dendritic cells in atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    Adv Exp Med Biol 601:97-104. 2007
    ..In light of recent developments, the picture emerges that different IgE-receptor bearing DC subtypes in the blood and skin of AD patients play a pivotal role in the complex network of DCs, which is highlighted in this review...
  21. ncbi The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Am Acad Dermatol 53:S171-6. 2005
    ..Compelling evidence presented here suggests that two types of dendritic cells (DC), myeloid DC (mDC) and plasmacytoid DC (pDC), are important in the pathogenesis of AD...
  22. ncbi Mucosal dendritic cells in allergy and immunotherapy
    N Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 66:22-4. 2011
    ..Thus, oLCs are important targets for allergens and adjuvants during sublingual immunotherapy, and characterizing them is crucial for improving allergen-specific immunotherapy...
  23. ncbi Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:1430-5. 2008
    ..From these data, we conclude that a genetically determined FLG deficiency manifests as dry skin and features of ichthyosis vulgaris. In addition, FLG deficiency may also represent a risk factor for contact sensitization to allergens...
  24. ncbi Tacrolimus and TGF-beta act synergistically on the generation of Langerhans cells
    Bartlomiej Kwiek
    Department of Dermatology and Allergology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 122:126-32, 132.e1. 2008
    ....
  25. ncbi FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
    J Allergy Clin Immunol 113:949-57. 2004
    ..CONCLUSION: The present study provides evidence that FcepsilonRI-activated LC-DCs and IDEC-DCs contribute distinctly to the outcome of T-cell responses in vitro and might have implications for the biphasic nature of AD in vivo...
  26. ncbi Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 121:368-374.e1. 2008
    ..Bacterial antigens like LPSs are recognized by innate immunity receptors such as Toll-like receptor 4 (TLR4), associated with LPS receptor (CD14)...
  27. ncbi Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 126:638-45.e1. 2010
    ..Oral mucosal Langerhans cells (oLCs) play a central role. However, little is known about allergen binding by oLCs during mucosal allergen resorption and its impact on oLC functions...
  28. ncbi Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
    ..Our data furthermore confirm association of STAT6 variation with serum IgE levels...
  29. ncbi Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation
    Chun Feng Yu
    Department of Dermatology and Allergy, University Hospital, University of Bonn, Bonn, Germany
    J Immunol 184:1159-67. 2010
    ....
  30. ncbi Risk estimation for a malignant transformation of oral lesions by S100A7 and Doc-1 gene expression
    Jochen Winter
    Department of Oral and Maxillofacial Plastic Surgery, University of Bonn, Germany
    Cancer Invest 29:478-84. 2011
    ....
  31. ncbi Characterization of dendritic cells from human oral mucosa: a new Langerhans' cell type with high constitutive FcepsilonRI expression
    Jean-Pierre Allam
    Department of Dermatology, Friedrich-Wilhelms-University, Bonn, Germany
    J Allergy Clin Immunol 112:141-8. 2003
    ..The constitutive high expression of FcepsilonRI on oLC could point to particular skills of these cells within the regional immune system of the oral mucosa...
  32. ncbi Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis
    Natalija Novak
    Department of Dermatology, Friedrich-Wilhelms University, D-53105 Bonn, Germany
    J Invest Dermatol 119:870-5. 2002
    ..Altogether our findings indicate that intrinsic atopic dermatitis patients exhibit phenotypic and immunologic features, which differ from those of patients with extrinsic atopic dermatitis or other atopic disorders...
  33. ncbi Molecular pathogenesis and clinical implications of eczema herpeticum
    Caroline Bussmann
    Department of Dermatology and Allergology, University of Bonn, Bonn, Germany
    Expert Rev Mol Med 10:e21. 2008
    ..In this review, we summarise the current knowledge of the molecular pathogenesis of eczema herpeticum...
  34. ncbi Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis
    Eva Gros
    Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    J Allergy Clin Immunol 124:753-60.e1. 2009
    ..Trafficking of dendritic cell (DC) subtypes to and from the skin plays a pivotal role in atopic dermatitis (AD)...
  35. ncbi A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC)
    Natalija Novak
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Invest Dermatol 119:842-9. 2002
    ....
  36. ncbi Inhibitory oligodeoxynucleotides downregulate herpes simplex virus-induced plasmacytoid dendritic cell type I interferon production and modulate cell function
    Wen Ming Peng
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Hum Immunol 68:879-87. 2007
    ....
  37. ncbi Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation
    Jochen Winter
    Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
    Cancer Invest 29:196-201. 2011
    ..HBD-3 stimulation enhanced hBD-1 expression. HBDs profoundly impact on OSCC proliferation and hBD expression in vitro. Therefore, hBD-1 might function as a tumor suppressor gene in OSCCs, while hBD-2 and -3 might be protooncogenes...
  38. ncbi Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors
    Natalija Novak
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Clin Invest 111:1047-56. 2003
    ..We propose that enhanced Fc epsilon RI on DCs from atopic donors is driven by enhanced expression of otherwise limiting amounts of Fc epsilon RI gamma and is preserved by increased IgE levels...
  39. ncbi Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours
    Jochen Winter
    Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Welschnonnenstr, 1753111, Bonn, Germany
    BMC Cancer 12:465. 2012
    ..In order to define new proliferation associated genes, purpose of this study was to investigate the expression of human α-defensins (DEFA) 1/3 and 4 in different tumour entities of the salivary glands with respect to malignancy...
  40. ncbi Genetics of atopic dermatitis
    Caroline Bussmann
    Department of Dermatology and Allergy, University of Bonn, Germany
    J Dtsch Dermatol Ges 9:670-6. 2011
    ..Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease...
  41. ncbi Positive lymphocyte transformation test in a patient with allergic contact dermatitis of the scalp after short-term use of topical minoxidil solution
    Tobias Hagemann
    Department of Dermatology, University of Bonn, Bonn, Germany
    Contact Dermatitis 53:53-5. 2005
    ..In contrast, patients with allergies to the active ingredient itself are no longer candidates for treatment with minoxidil and should undergo alternative therapeutic options...
  42. ncbi Local immunological mechanisms of sublingual immunotherapy
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Curr Opin Allergy Clin Immunol 11:571-8. 2011
    ....
  43. ncbi Dendritic cells as potential targets for mucosal immunotherapy
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Curr Opin Allergy Clin Immunol 9:554-7. 2009
    ..Without doubt, oral mucosal antigen-presenting cells such as dendritic cells play a central role as they process antigens to initialize and modulate T-cell activation...
  44. ncbi Immune mechanisms leading to atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 112:S128-39. 2003
    ..The current review will examine recent advances that have been made in our understanding of the genetic and pathophysiologic prerequisites that form the basis of this common recalcitrant skin disorder...
  45. ncbi Pathogenesis of atopic dermatitis: new developments
    Thomas Bieber
    Department of Dermatology and Allergy, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
    Curr Allergy Asthma Rep 9:291-4. 2009
    ..This review aims to summarize the most recent findings in this field...
  46. ncbi Superimposed linear lichen planopilaris: another polygenic disorder exemplifying a new genetic concept
    Caroline Bussmann
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Eur J Dermatol 20:269-70. 2010
    ..This is to our knowledge the first described case of a superimposed lichen planopilaris...
  47. ncbi Transforming growth factor-beta1 regulates the expression of the high-affinity receptor for IgE on CD34 stem cell-derived CD1a dendritic cells in vitro
    Jean Pierre Allam
    Department of Dermatology, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    J Invest Dermatol 123:676-82. 2004
    ..In view of these data, a picture emerges that FcepsilonRI+ on DC is finely modified by the TGF-beta1 concentration in the microenvironment and could be of primary relevance in the context of atopic diseases...
  48. ncbi Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis
    Eva Gros
    Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    J Allergy Clin Immunol 128:1015-21. 2011
    ..Atopic dermatitis (AD) is characterized by a predominance of T(H)2 immune reactions but weaker T(H)1 immune responses in acute skin lesions...
  49. ncbi IL-23-producing CD68(+) macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Germany
    J Clin Periodontol 38:879-86. 2011
    ..To analyse antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages (Mo) or B cells depending on the regional site of chronic periodontitis (CP), and to investigate their relation to Th17 cells...
  50. ncbi Facing psoriasis and atopic dermatitis: are there more similarities or more differences?
    Dagmar Wilsmann-Theis
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Dermatol 18:172-80. 2008
    ..Beyond that, in view of these findings, the question arises, which similarities and differences between AD and Pso exist. In order to address this point, we provide an overview about the current knowledge in the field of AD and Pso...
  51. ncbi Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema
    Laura Maintz
    Department of Dermatology, University of Bonn, Germany
    J Allergy Clin Immunol 117:1106-12. 2006
    ....
  52. ncbi Dendritic cells: bridging innate and adaptive immunity in atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, D 53105 Bonn, Germany
    J Allergy Clin Immunol 125:50-9. 2010
    ..Therefore TLR-bearing DCs represent promising targets, which might help to improve tolerance induction during immunotherapeutic approaches in the future...
  53. ncbi Aggregation of the high-affinity IgE receptor Fc(epsilon)RI on human monocytes and dendritic cells induces NF-kappaB activation
    Stefan Kraft
    Department of Dermatology, Friedrich-Wilhelms-University, Bonn, Germany
    J Invest Dermatol 118:830-7. 2002
    ..Thus NF-kappaB activation represents a novel mechanism by which Fc(epsilon)RI on monocytes and DC potentially controls inflammatory reactions...
  54. ncbi Allergic and nonallergic forms of atopic diseases
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 112:252-62. 2003
    ....
  55. ncbi Genome-wide association studies on IgE regulation: are genetics of IgE also genetics of atopic disease?
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munich, Germany
    Curr Opin Allergy Clin Immunol 10:408-17. 2010
    ..Total IgE levels are considered a useful endophenotype for studying the genetics of atopic diseases. However, the role and significance of genetic factors influencing IgE regulation for atopic diseases as endpoints is unclear...
  56. ncbi Keratitis-ichthyosis-deafness syndrome in association with follicular occlusion triad
    Laura Maintz
    Department of Dermatology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany
    Eur J Dermatol 15:347-52. 2005
    ..To our knowledge, only one case of KID syndrome occurring in association with follicular occlusion triad has been reported before...
  57. ncbi High α-defensin and S100A7 expression and missing DOC-1 down-regulation characterize irritation fibromas of the oral cavity and may counteract malignant transformation
    Jochen Winter
    Department of Periodontology, University of Bonn, Germany
    J Craniofac Surg 22:100-4. 2011
    ....
  58. ncbi Biologicals dramatic advances in the treatment of psoriasis
    Dagmar Wilsmann-Theis
    Department of Dermatology, University of Bonn, Germany
    Curr Pharm Des 12:989-99. 2006
    ..Four of these agents, alefacept, efalizumab, etanercept and infliximab have already impacted on routine clinical practice. Current developments in the treatment of psoriasis with biologicals are reviewed...
  59. ncbi Getting more and more complex: the pathophysiology of atopic eczema
    Laura Maintz
    Department of Dermatology, Sigmund Freud Str 25, 53105 Bonn, University of Bonn
    Eur J Dermatol 17:267-83. 2007
    ..In this review, we provide an overview of the complex pathophysiology of AE with a focus on recent advances published in this field...
  60. ncbi The good, the bad and the ugly--APCs of the eye
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Trends Immunol 24:570-4. 2003
    ..Thus, the corneal DC, as well as the DC and the macrophages in the iris and ciliary body, have the potential of determining the outcome of immunity or tolerance within this organ...
  61. ncbi Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy?
    J P Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 63:720-7. 2008
    ..As little is known about LCs and MCs within the oral cavity, we investigated their distribution in search for mucosal sites with highest LCs and lowest MCs density...
  62. ncbi The pathophysiology of atopic eczema
    J-P Allam
    Department of Dermatology, Friedrich-Wilhelms-University, Bonn, Germany
    Clin Exp Dermatol 31:89-93. 2006
    ..In this review, we highlight the recent progress made in the pathophysiology of AE focusing on the latest research results published in this field...
  63. ncbi Comparative analysis of nasal and oral mucosa dendritic cells
    J-P Allam
    Department of Dermatology, University of Bonn, Bonn, Germany
    Allergy 61:166-72. 2006
    ..Moreover these data provide a basis for further studies investigating immunological mechanisms underlying mucosal immunotherapy...
  64. ncbi Unraveling the mission of FcepsilonRI on antigen-presenting cells
    Natalija Novak
    Department of Dermatology, Rheinische-Friedrich-Wilhelms-University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 111:38-44. 2003
    ..This review is dedicated to the 10th anniversary of the discovery of FcepsilonRI on APCs and describes the numerous areas of research in this field...
  65. ncbi Effects of histamine and diamine oxidase activities on pregnancy: a critical review
    Laura Maintz
    Department of Dermatology and Allergology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Hum Reprod Update 14:485-95. 2008
    ....
  66. ncbi Systemic therapeutic options for severe atopic dermatitis
    Caroline BuBmann
    Clinic and Polyclinic for Dermatology and Allergology, University of Bonn, Germany
    J Dtsch Dermatol Ges 7:205-19. 2009
    ..We review the modes of action, as well as advantages and disadvantages of current and new systemic therapeutic options for severe AD...
  67. ncbi Histamine and histamine intolerance
    Laura Maintz
    Department of Dermatology, University of Bonn, Bonn, Germany
    Am J Clin Nutr 85:1185-96. 2007
    ..In patients in whom the abovementioned symptoms are triggered by the corresponding substances and who have a negative diagnosis of allergy or internal disorders, histamine intolerance should be considered as an underlying pathomechanism...
  68. ncbi Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities
    L Maintz
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 66:893-902. 2011
    ..Histamine intolerance (HIT) is associated with an excess of histamine because of an impaired function of the histamine-degrading enzyme diamine oxidase (DAO). The genetic background of HIT is unknown yet...
  69. ncbi The mode of topical immunomodulators in the immunological network of atopic dermatitis
    N Novak
    Department of Dermatology, University of Bonn, Germany
    Clin Exp Dermatol 30:160-4. 2005
    ..In this overview, we provide a research update about the anti-inflammatory and anti-allergic properties of TIMs on effector cells of AD that may be involved in the complex pathophysiology of AD...
  70. ncbi Mast cells in the seminal plasma of infertile men as detected by flow cytometry
    J P Allam
    Andrology Unit, Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany
    Andrologia 41:1-6. 2009
    ..A potential role of MCs in seminal plasma as well as the association between MCs and IgA on spermatozoa remains to be elucidated...
  71. ncbi Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1% ointment
    D Wilsmann-Theis
    Department of Dermatology, University of Bonn, 53105, Germany
    Br J Dermatol 150:1194-7. 2004
    ..1% ointment. Our observations raise hopes that this new treatment strategy for ACS may constitute a novel effective therapeutic option for this recalcitrant condition...
  72. ncbi High percentage of apoptotic spermatozoa in ejaculates from men with chronic genital tract inflammation
    J P Allam
    Andrology Unit, Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany
    Andrologia 40:329-34. 2008
    ..In conclusion, patients with signs of CIGT display high numbers of apoptotic spermatozoa with progressive motility, which might have an impact on reproductive techniques such as intrauterine insemination or in-vitro fertilisation...
  73. ncbi IgE receptors
    N Novak
    Department of Dermatology, Friedrich-Wilhelms-University of Bonn, D-53105, Bonn, Germany
    Curr Opin Immunol 13:721-6. 2001
    ..Studies of the mechanisms involved might provide opportunities for therapeutic intervention strategies in the treatment of allergic and hypersensitivity reactions...
  74. ncbi The central role of FcepsilonRI in allergy
    D von Bubnoff
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    Clin Exp Dermatol 28:184-7. 2003
    ..Recently, we and others have gained new insight into the regulation and function of FcepsilonRI on APCs, which has shed new light on the modulating effects of the immune system in atopic inflammation...
  75. ncbi Flushing and increase of serum tryptase after mechanical irritation of a solitary mastocytoma
    Caroline Bussmann
    Department of Dermatology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Dermatol 17:332-4. 2007
    ....
  76. ncbi Photodynamic therapy as an alternative treatment for cutaneous sarcoidosis
    Dagmar Wilsmann-Theis
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Dermatology 217:343-6. 2008
    ..We report two cases of cutaneous sarcoidosis successfully treated with photodynamic therapy, which represents an effective alternative therapy with fewer side effects...
  77. ncbi New insights into the mechanism and management of allergic diseases: atopic dermatitis
    N Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 64:265-75. 2009
    ..In contrast, therapeutic approaches selectively regulating aberrant pathophysiological mechanisms in AD itself would be much more effective and promising...
  78. ncbi Role of dendritic cells in atopic dermatitis: an update
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn Medical Center, Germany
    Clin Rev Allergy Immunol 41:254-8. 2011
    ..This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD...
  79. ncbi The role of antigen presenting cells at distinct anatomic sites: they accelerate and they slow down allergies
    N Novak
    Department of Dermatology, University of Bonn, Germany
    Allergy 59:5-14. 2004
    ....
  80. ncbi Unexpected functions of FcepsilonRI on antigen-presenting cells
    S Kraft
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    Int Arch Allergy Immunol 124:35-7. 2001
    ....
  81. ncbi Enhanced expression and activity of protein-tyrosine kinases establishes a functional signaling pathway only in FcepsilonRIhigh Langerhans cells from atopic individuals
    Stefan Kraft
    Department of Dermatology, Friedrich-Wilhelms-University, Bonn, Germany
    J Invest Dermatol 119:804-11. 2002
    ..Key words:..
  82. ncbi Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: a pilot study
    C Bussmann
    Department of Dermatology, University of Bonn, Bonn, Germany
    Clin Exp Allergy 37:1277-85. 2007
    ..However, only a few studies have been conducted on the effectiveness of HDM SCIT in AD, resulting in controversial clinical results. Data on immunological changes induced by SCIT in AD patients are rare...
  83. ncbi Standardized extracts from Chinese herbs induce IL-10 production in human monocyte-derived dendritic cells and alter their differentiation in vitro
    N Novak
    Department of Dermatology, Friedrich-Wilhelms-University of Bonn, Germany
    J Allergy Clin Immunol 108:588-93. 2001
    ..CONCLUSION: TCM induces immunopharmacologic alterations on DCs from atopic donors in vitro. These alterations might account, at least in part, for the therapeutic effect of this treatment in AD in vivo...
  84. ncbi New treatment modalities for granuloma faciale
    E Ludwig
    Department of Dermatology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany
    Br J Dermatol 149:634-7. 2003
    ..1%. Our observations suggest that these new treatment modalities for GF, which we report here for the first time, can provide effective and non-invasive treatment for this disease...
  85. ncbi Engagement of Fc epsilon RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells
    N Novak
    Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany
    J Immunol 167:797-804. 2001
    ..These results suggest that FcepsilonRI aggregation prevents the generation of CD1a(+) MoDCs and imply a novel pivotal function of this receptor in modulating the differentiation of monocytes...
  86. ncbi Monocyte-derived dendritic cells from highly atopic individuals are not impaired in their pro-inflammatory response to toll-like receptor ligands
    D Terhorst
    Department of Dermatology and Allergy, Biederstein, Technical University Munich, Munich, Germany
    Clin Exp Allergy 37:381-90. 2007
    ..Toll-like receptor (TLR) agonists are widely used as adjuvants in specific immune therapy protocols for patients with atopic disposition. Monocyte-derived dendritic cells (mDCs) are thought to be important target cells for these compounds...
  87. ncbi [Associated diseases and differential diagnostic considerations in childhood atopic eczema]
    C Jenneck
    Klinik und Poliklinik fur Dermatologie, Universitat Bonn, Sigmund Freud Strasse 25, 53105 Bonn
    Hautarzt 58:163-74; quiz 175-6. 2007
    ..Additionally, it is important to consider diseases which can occur in association with AE, such as keratosis pilaris, alopecia areata or sweat disturbances...
  88. ncbi Putative association of a TLR9 promoter polymorphism with atopic eczema
    N Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    Allergy 62:766-72. 2007
    ....
  89. ncbi The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, Department of Neurology, University of Bonn, Bonn 53105, Germany
    J Exp Med 206:2079-89. 2009
    ..We therefore propose that PPAR gamma represents a promising molecular target for specific immunointervention in Th17-mediated autoimmune diseases such as MS...
  90. ncbi Pulsed-field gel electrophoresis of Staphylococcus aureus isolates from atopic patients revealing presence of similar strains in isolates from children and their parents
    Sonja Bonness
    Institut fur Medizinische Mikrobiologie, Immunologie und Parasitologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Clin Microbiol 46:456-61. 2008
    ..aureus or methicillin-resistant S. aureus strains were not detected. In conclusion, this study indicates that the colonization rate of parents of atopic children is rather high and may increase the risk of recolonization of the child...
  91. ncbi Pathogenesis, diagnosis, and treatment of aspirin intolerance
    Claudia Jenneck
    Department of Dermatology, University of Bonn, Bonn, Germany
    Ann Allergy Asthma Immunol 99:13-21. 2007
    ..To provide an overview of aspirin intolerance (AI), to summarize the latest genetic and pathophysiologic findings, and to discuss the current therapeutic recommendations, including aspirin desensitization...
  92. ncbi Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity
    M Wenghoefer
    University of Bonn, Uni Klinikum Bonn Klinik and Poliklinik for MKG Chirurgie, Bonn, Germany
    Int J Oral Maxillofac Surg 37:660-3. 2008
    ..5-fold in leukoplakia), but most significantly (50-fold) in OSCC. hBD-1 appears to play a role in the development of OSCC. The loss of its function might contribute to the malignant progression of these tumours...
  93. ncbi Nuclear hBD-1 accumulation in malignant salivary gland tumours
    M Wenghoefer
    Department of Oral and Maxillofacial Plastic Surgery, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    BMC Cancer 8:290. 2008
    ..Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue...
  94. ncbi Recent highlights in the pathophysiology of atopic eczema
    J-P Allam
    Department of Dermatology, Friedrich Wilhelm University, Bonn, Germany
    Int Arch Allergy Immunol 136:191-7. 2005
    ..This review provides an update on the scientific progress that has been achieved in clarifying the pathophysiological mechanisms of AE...
  95. ncbi Different expression of adhesion molecules and tetraspanins of monocytes of patients with atopic eczema
    J J Jockers
    Department of Dermatology, University of Bonn, Bonn, Germany
    Allergy 61:1419-22. 2006
    ....
  96. ncbi In search for predictive factors for atopy in human cord blood
    J P Allam
    Department of Dermatology, University of Bonn, Bonn, Germany
    Allergy 60:743-50. 2005
    ..In order to provide an up-date about the current developments in this field, recent research findings on predictive factors for atopy in cord blood are summarized in the following synopsis...
  97. ncbi Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data
    Hansjörg Baurecht
    Institute for Medical Statistics and Epidemiology IMSE, Technical University Munich TUM, Munich, Germany
    J Allergy Clin Immunol 120:1406-12. 2007
    ..However, studies published to date demonstrate differences concerning study design and strength of associations...
  98. ncbi To bend or not to bend
    Natalija Novak
    Nat Immunol 3:607-8. 2002
  99. ncbi Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
    J Allergy Clin Immunol 118:214-9. 2006
    ..One of the characteristic features of AD and causative factor for the disease is an impaired epidermal skin barrier based on a primary defect of epidermal differentiation...
  100. ncbi Allergic hyperreactivity to microbial components: a trigger factor of "intrinsic" atopic dermatitis?
    Natalija Novak
    J Allergy Clin Immunol 112:215-6. 2003
  101. ncbi Risk factors of atopic dermatitis patients for eczema herpeticum
    Wenming M Peng
    J Invest Dermatol 127:1261-3. 2007