Florian Nolte

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany
    Leuk Res 37:378-82. 2013
  2. doi request reprint Results from a 1-year, open-label, single arm, multi-center trial evaluating the efficacy and safety of oral Deferasirox in patients diagnosed with low and int-1 risk myelodysplastic syndrome (MDS) and transfusion-dependent iron overload
    F Nolte
    III Medizinische Klinik, Hämatologie und Onkologie, Universitatsmedizin Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Ann Hematol 92:191-8. 2013
  3. doi request reprint Characteristics of MDS patients seen at private practices differ significantly from those treated at university hospitals in Germany
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Cancer Res Clin Oncol 138:953-7. 2012
  4. doi request reprint Molecular mechanisms involved in the progression of myelodysplastic syndrome
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, Germany
    Future Oncol 6:445-55. 2010
  5. doi request reprint Clinical management of gastrointestinal disturbances in patients with myelodysplastic syndromes receiving iron chelation treatment with deferasirox
    Florian Nolte
    Department of Hematology and Oncology, University Hospital, Mannheim, Germany
    Leuk Res 35:1131-5. 2011
  6. doi request reprint High expression of the Ets-related gene (ERG) is an independent prognostic marker for relapse-free survival in patients with acute promyelocytic leukemia
    Anna Hecht
    Department of Hematology and Oncology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Ann Hematol 92:443-9. 2013
  7. doi request reprint SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3
    Daniel Nowak
    Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Germany
    Genes Chromosomes Cancer 51:756-67. 2012
  8. doi request reprint Genome-wide DNA-mapping of CD34+ cells from patients with myelodysplastic syndrome using 500K SNP arrays identifies significant regions of deletion and uniparental disomy
    Daniel Nowak
    Department of Hematology and Oncology, Charite University Hospital, Campus Benjamin Franklin, Berlin, Germany
    Exp Hematol 37:215-224. 2009
  9. doi request reprint Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability
    Florian Nolte
    III Medizinische Klinik, Hämatologie und Onkologie, Medizinische Fakultät Mannheim der Universität Heidelberg, Universitatsmedizin Mannheim, Pettenkoferstrasse 22, 68169, Mannheim, Germany
    Ann Hematol 92:1325-33. 2013
  10. doi request reprint Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis
    Olaf Hopfer
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Haematol 88:144-53. 2012

Collaborators

Detail Information

Publications14

  1. doi request reprint In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany
    Leuk Res 37:378-82. 2013
    ..70%; p=0.035). In multivariate analyses low BAALC expression retained its prognostic relevance. In conclusion, BAALC expression analysis might be useful in further risk stratification in APL patients...
  2. doi request reprint Results from a 1-year, open-label, single arm, multi-center trial evaluating the efficacy and safety of oral Deferasirox in patients diagnosed with low and int-1 risk myelodysplastic syndrome (MDS) and transfusion-dependent iron overload
    F Nolte
    III Medizinische Klinik, Hämatologie und Onkologie, Universitatsmedizin Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Ann Hematol 92:191-8. 2013
    ..The safety profile of DFX was comparable to previous observations...
  3. doi request reprint Characteristics of MDS patients seen at private practices differ significantly from those treated at university hospitals in Germany
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Cancer Res Clin Oncol 138:953-7. 2012
    ..Commonly, MDS patients are treated in an outpatient setting making hematological/oncological private practices (PP) an important backbone in the management of MDS patients...
  4. doi request reprint Molecular mechanisms involved in the progression of myelodysplastic syndrome
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Mannheim, Germany
    Future Oncol 6:445-55. 2010
    ..Accumulation of such defects may finally cause the leukemic transformation of MDS...
  5. doi request reprint Clinical management of gastrointestinal disturbances in patients with myelodysplastic syndromes receiving iron chelation treatment with deferasirox
    Florian Nolte
    Department of Hematology and Oncology, University Hospital, Mannheim, Germany
    Leuk Res 35:1131-5. 2011
    ..An expert panel met in Lisbon in July 2010 to develop recommendations on prevention and management of GI disturbances based on existing data and personal experiences...
  6. doi request reprint High expression of the Ets-related gene (ERG) is an independent prognostic marker for relapse-free survival in patients with acute promyelocytic leukemia
    Anna Hecht
    Department of Hematology and Oncology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Ann Hematol 92:443-9. 2013
    ..Therefore, ERG expression might serve as a molecular marker for risk stratification in APL and might identify patients who could benefit from intensified treatment regimens...
  7. doi request reprint SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3
    Daniel Nowak
    Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Germany
    Genes Chromosomes Cancer 51:756-67. 2012
    ..9, P=0.0031). This study presents a comprehensive assessment of new CNAs as pathomechanistically relevant targets and possible prognostic factors which could refine risk stratification of APL...
  8. doi request reprint Genome-wide DNA-mapping of CD34+ cells from patients with myelodysplastic syndrome using 500K SNP arrays identifies significant regions of deletion and uniparental disomy
    Daniel Nowak
    Department of Hematology and Oncology, Charite University Hospital, Campus Benjamin Franklin, Berlin, Germany
    Exp Hematol 37:215-224. 2009
    ..Identification of genomic lesions in progenitor cells of patients with myelodysplastic syndrome (MDS) could lead to the discovery of new disease-specific genes and may be of prognostic value...
  9. doi request reprint Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability
    Florian Nolte
    III Medizinische Klinik, Hämatologie und Onkologie, Medizinische Fakultät Mannheim der Universität Heidelberg, Universitatsmedizin Mannheim, Pettenkoferstrasse 22, 68169, Mannheim, Germany
    Ann Hematol 92:1325-33. 2013
    ..We assume that centrosome defects could be involved in disease progression and may serve as a future prognostic marker. ..
  10. doi request reprint Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis
    Olaf Hopfer
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Eur J Haematol 88:144-53. 2012
    ..Its dysregulation may contribute to the ineffective erythropoiesis observed in MDS...
  11. pmc Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts
    Olga Blau
    Department of Hematology and Oncology, Charite University School of Medicine, Hindenburgdamm 30, Berlin, Germany
    Blood 118:5583-92. 2011
    ..We also analyzed the main characteristics of patients with MSCs carrying chromosomal aberrations. In view of these data, the genetic alterations in MSCs may constitute a particular mechanism of leukemogenesis...
  12. doi request reprint Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay
    Maximilian Mossner
    Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany
    J Med Genet 50:108-17. 2013
    ..Recently, transcriptional XCIP ratio analysis challenged these results and questioned the suitability of methylation based clonality assays...
  13. pmc Management of elderly patients with acute promyelocytic leukemia: progress and problems
    Eva Lengfelder
    Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany
    Ann Hematol 92:1181-8. 2013
    ..Considering the high curative potential and the excellent tolerance of ATO in newly diagnosed and relapsed APL, older patients are probably a particular target group for a chemotherapy-free approach with ATO. ..
  14. doi request reprint Myelodysplastic syndromes: molecular pathogenesis and genomic changes
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Benjamin Franklin, Charite, Hindenburgdamm 30, 12203, Berlin, Germany
    Ann Hematol 87:777-95. 2008
    ..Secondary signal proteins and transcription factors, which gives the cell a growth advantage over its normal counterpart, may be affected as well. The accumulation of such defects may finally cause the leukemic transformation of MDS...