Angelika A Noegel


Affiliation: University of Cologne
Country: Germany


  1. Deckstein J, van Appeldorn J, Tsangarides M, Yiannakou K, Müller R, Stumpf M, et al. The Dictyostelium discoideum GPHR ortholog is an endoplasmic reticulum and Golgi protein with roles during development. Eukaryot Cell. 2015;14:41-54 pubmed publisher
    ..Also, changes in the external pH were sensed by the ER, as indicated by a pH-sensitive ER probe, as in the wild type. ..
  2. Stumpf M, Muller R, Gaßen B, Wehrstedt R, Fey P, Karow M, et al. A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium. Dis Model Mech. 2017;10:897-907 pubmed publisher
  3. Karakesisoglou I, Mroß C, Noegel A. Functional Analysis of LINC Complexes in the Skin. Methods Mol Biol. 2018;1840:295-306 pubmed publisher
    ..Herein, we focus on the LINC complex roles in the skin and describe methods that enable the successful isolation of primary embryonic fibroblast and newborn skin cells, which can be then investigated functionally in vitro. ..
  4. Schilde C, Lawal H, Noegel A, Eichinger L, Schaap P, Glockner G. A set of genes conserved in sequence and expression traces back the establishment of multicellularity in social amoebae. BMC Genomics. 2016;17:871 pubmed
    ..Both mechanisms provide robustness to the developmental program, but impose a limit on the information that can be obtained from deleting single genes. ..
  5. Sultana H, Neelakanta G, Rivero F, Blau Wasser R, Schleicher M, Noegel A. Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells. BMC Dev Biol. 2012;12:3 pubmed publisher
    ..Collectively, our data shows a novel role of CAP in regulating cell adhesion mechanisms during development that might be envisioned to unravel the functions of mammalian CAP during animal embryogenesis. ..
  6. Prabhu Y, Muller R, Anjard C, Noegel A. GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development. BMC Dev Biol. 2007;7:44 pubmed
    ..Expression of a GFP-tagged full length GrlJ rescued the phenotype. Our data suggest that GrlJ acts at several stages of Dictyostelium development and that it is a negative regulator in Dictyostelium development. ..
  7. Mondal S, Neelamegan D, Rivero F, Noegel A. GxcDD, a putative RacGEF, is involved in Dictyostelium development. BMC Cell Biol. 2007;8:23 pubmed
    ..We provide evidence for a Calponin Homology domain acting as a membrane association domain. GxcDD can bind to several Rac GTPases, but its function as a nucleotide exchange factor needs to be studied further. ..
  8. Omosigho N, Swaminathan K, Plomann M, Müller Taubenberger A, Noegel A, Riyahi T. The Dictyostelium discoideum RACK1 orthologue has roles in growth and development. Cell Commun Signal. 2014;12:37 pubmed publisher
    ..DdRACK1 interacts with heterotrimeric G proteins and can through these interactions impact on processes specifically regulated by these proteins. ..
  9. Li P, Noegel A. Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export. Nucleic Acids Res. 2015;43:9874-88 pubmed publisher

More Information


  1. Szczepanski S, Hussain M, Sur I, Altmüller J, Thiele H, Abdullah U, et al. A novel homozygous splicing mutation of CASC5 causes primary microcephaly in a large Pakistani family. Hum Genet. 2016;135:157-70 pubmed publisher
    ..Our findings substantiate the proposed role of CASC5 for primary microcephaly and suggest that it also might be relevant for genome stability. ..
  2. Sukumaran S, Stumpf M, Salamon S, Ahmad I, Bhattacharya K, Fischer S, et al. CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Mol Genet Genomics. 2017;292:365-383 pubmed publisher
  3. Li P, Stumpf M, Muller R, Eichinger L, Glockner G, Noegel A. The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation. Sci Rep. 2017;7:9157 pubmed publisher
    ..This effect might be independent of SUN1 as expression of a GFP tagged SUN-domain deficient SUN1, which no longer can interact with Nesprin-2, did not affect mRNA export. ..