Inke Nitz

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    Biochem Biophys Res Commun 353:481-6. 2007
  2. doi request reprint Analysis of the transcriptional regulation of the FABP2 promoter haplotypes by PPARgamma/RXRalpha and Oct-1
    Mike Böhme
    Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Heinrich Hecht Platz 10, Kiel, Germany
    Biochim Biophys Acta 1779:616-21. 2008
  3. ncbi request reprint Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
    Inke Nitz
    Department of Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University, Kiel, Germany
    Mol Nutr Food Res 51:1046-52. 2007
  4. ncbi request reprint Type 2 diabetes-associated fatty acid binding protein 2 promoter haplotypes are differentially regulated by GATA factors
    Maja Klapper
    Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Kiel, Germany
    Hum Mutat 29:142-9. 2008
  5. ncbi request reprint Functional analysis of promoter variants in the microsomal triglyceride transfer protein (MTTP) gene
    Diana Rubin
    Institute of Physiology and Biochemistry of Nutrition, Federal Research Center for Nutrition and Food, Kiel, Germany
    Hum Mutat 29:123-9. 2008
  6. doi request reprint Transcriptional regulation of the fatty acid binding protein 2 (FABP2) gene by the hepatic nuclear factor 1 alpha (HNF-1alpha)
    Maja Klapper
    Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Heinrich Hecht Platz 10, D 24118 Kiel, Germany
    Gene 416:48-52. 2008
  7. doi request reprint Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms
    Inke Nitz
    Institute of Human Nutrition and Food Science, Department of Molecular Prevention, Christian Albrechts University, Kiel, Germany
    J Cell Mol Med 15:909-27. 2011
  8. doi request reprint MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort
    Mike Böhme
    Institute of Human Nutrition and Food Science, Molecular Nutrition, Christian Albrecht University, Heinrich Hecht Platz 10, 24118 Kiel, Germany
    Mol Genet Metab 95:229-32. 2008
  9. doi request reprint Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain
    Andreas H Ludewig
    Institute of Human Nutrition and Food Science, Department of Molecular Prevention, University of Kiel, Kiel, Germany
    IUBMB Life 63:547-52. 2011
  10. ncbi request reprint Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    J Clin Endocrinol Metab 92:3183-8. 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    Biochem Biophys Res Commun 353:481-6. 2007
    ..This is the first study implicating that the Gly482Ser and Thr612Met polymorphisms in PGC-1alpha and Pro12Ala polymorphism in PPARgamma2 do not affect the functional integrity of these proteins...
  2. doi request reprint Analysis of the transcriptional regulation of the FABP2 promoter haplotypes by PPARgamma/RXRalpha and Oct-1
    Mike Böhme
    Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Heinrich Hecht Platz 10, Kiel, Germany
    Biochim Biophys Acta 1779:616-21. 2008
    ..In conclusion, our findings suggest a functional role of PPARgamma/RXRalpha and Oct-1 in the regulation of the FABP2 gene...
  3. ncbi request reprint Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
    Inke Nitz
    Department of Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University, Kiel, Germany
    Mol Nutr Food Res 51:1046-52. 2007
    ..03). In conclusion, we identified a common splice site mutation (rs2291726) of the GIP gene which results in a truncated protein and provide preliminary evidence for an association of the heterozygous GIPR Glu354Gln genotype with CVD...
  4. ncbi request reprint Type 2 diabetes-associated fatty acid binding protein 2 promoter haplotypes are differentially regulated by GATA factors
    Maja Klapper
    Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Kiel, Germany
    Hum Mutat 29:142-9. 2008
    ..80_-79insT. This provides the molecular basis for the variant specific transcriptional regulation of the diabetes type 2-associated FABP2 gene...
  5. ncbi request reprint Functional analysis of promoter variants in the microsomal triglyceride transfer protein (MTTP) gene
    Diana Rubin
    Institute of Physiology and Biochemistry of Nutrition, Federal Research Center for Nutrition and Food, Kiel, Germany
    Hum Mutat 29:123-9. 2008
    ..This suggested that the already described SREBP-dependent modulation of MTTP expression by diet is more effective in -164T than in -164C carriers...
  6. doi request reprint Transcriptional regulation of the fatty acid binding protein 2 (FABP2) gene by the hepatic nuclear factor 1 alpha (HNF-1alpha)
    Maja Klapper
    Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Heinrich Hecht Platz 10, D 24118 Kiel, Germany
    Gene 416:48-52. 2008
    ..Thus, our data suggest a major role of HNF-1alpha in control of FABP2 expression in intestine via a functional HNF-1alpha recognition element within FABP2 promoter region -185 to -165...
  7. doi request reprint Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms
    Inke Nitz
    Institute of Human Nutrition and Food Science, Department of Molecular Prevention, Christian Albrechts University, Kiel, Germany
    J Cell Mol Med 15:909-27. 2011
    ..Furthermore, our findings show that low-abundance transcripts are regulated in a similar mode than their high-abundance counterparts...
  8. doi request reprint MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort
    Mike Böhme
    Institute of Human Nutrition and Food Science, Molecular Nutrition, Christian Albrecht University, Heinrich Hecht Platz 10, 24118 Kiel, Germany
    Mol Genet Metab 95:229-32. 2008
    ..Our association analysis in a large population based study cohort provides evidence that the minor allele of the MTTP H297Q polymorphism is associated with lower BMI, waist circumference and total cholesterol in females but not in males...
  9. doi request reprint Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain
    Andreas H Ludewig
    Institute of Human Nutrition and Food Science, Department of Molecular Prevention, University of Kiel, Kiel, Germany
    IUBMB Life 63:547-52. 2011
    ..Conclusively, we identified a novel ACBP isoforms with an unique C-terminal domain encoded by a high-abundant splice variant...
  10. ncbi request reprint Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    J Clin Endocrinol Metab 92:3183-8. 2007
    ..On the basis of its chromosomal localization and its role in the synthesis of the antilipolytic compound prostaglandin E(2), the prostaglandin E synthase 2 (PTGES2) is a candidate gene for type 2 diabetes...
  11. doi request reprint Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP
    Christina Vock
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    Cell Physiol Biochem 22:515-24. 2008
    ..In conclusion, we provide evidence that ACBP is a transcriptional regulator of the HMGCS1 and HMGCR genes encoding rate-limiting enzymes of cholesterol synthesis pathway...
  12. doi request reprint ACBP knockdown leads to down-regulation of genes encoding rate-limiting enzymes in cholesterol and fatty acid metabolism
    Christina Vock
    Molecular Prevention, Christian Albrechts University of Kiel, D 24118 Kiel, Germany
    Cell Physiol Biochem 25:675-86. 2010
    ..This effect seems to be translated into certain metabolites. The identified 454 ACBP regulated genes present a first reference for further studies to define the ACBP regulon in mammalian cells...
  13. ncbi request reprint The human intestinal fatty acid binding protein (hFABP2) gene is regulated by HNF-4alpha
    Maja Klapper
    Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Heinrich Hecht Platz 10, D 24118 Kiel, Germany
    Biochem Biophys Res Commun 356:147-52. 2007
    ..Studying genotype interactions of hFABP2 and HNF-4alpha, that are both candidate genes for diabetes type 2, may be a powerful approach...
  14. ncbi request reprint Expression analysis of genes involved in fat assimilation in human monocytes
    Maja Klapper
    Molecular Nutrition, Christian Albrechts University, Kiel, Germany
    IUBMB Life 58:435-40. 2006
    ..Ex vivo-derived monocytes could be used in additional studies for analyzing differences in genotype-dependent expression levels of genes involved in fat assimilation such as ACBP, MACS1 or PPARgamma...
  15. ncbi request reprint The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population
    Inka Lindner
    Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
    Mol Nutr Food Res 50:270-4. 2006
    ..Additionally, the higher triglyceride and glucose levels after an oMTT support a possible functional impact of the polymorphism in vivo...
  16. ncbi request reprint Identification of new acyl-CoA binding protein transcripts in human and mouse
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Hermann Weigmann Strasse 1, D 24103 Kiel, Germany
    Int J Biochem Cell Biol 37:2395-405. 2005
    ..Given the fact that the new variant is highly expressed in adipose tissue and a PPARgamma target, it might be relevant for diseases like diabetes and obesity...
  17. ncbi request reprint Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Nutr Food Res 51:185-91. 2007
    ..The results presented here provide preliminary evidence for the association of common variants in genes involved in fat assimilation with the genetic susceptibility of type 2 diabetes. However, they definitely need further verification...
  18. ncbi request reprint Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Nutr Food Res 51:178-84. 2007
    ..72, 95% CI 0.51-1.01) was observed. In summary, we obtained evidence from two Caucasian study populations that the minor allele of ACBP rs2084202 might be associated with reduced risk of T2D...