Hans Dieter Nischalke

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures
    Hans Dieter Nischalke
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42141. 2012
  2. doi request reprint The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Int J Cancer 130:1470-5. 2012
  3. doi request reprint The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    J Hepatol 56:758-64. 2012
  4. ncbi request reprint Regulation of CC chemokine receptor 5 in hepatitis G virus infection
    Jacob Nattermann
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    AIDS 17:1457-62. 2003
  5. ncbi request reprint HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Antivir Ther 10:95-107. 2005
  6. ncbi request reprint The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells
    Daniela Schulte
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 200:1397-401. 2009
  7. doi request reprint The transforming growth factor-beta high-producer genotype is associated with response to hepatitis C virus-specific therapy in HIV-positive patients with acute hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    AIDS 22:1287-92. 2008
  8. doi request reprint Interferon-lambda serum levels in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 54:859-65. 2011
  9. doi request reprint Hepatitis C virus-induced secretion of inflammatory chemokines preferentially recruits NKG2A+CD8+ T cells
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Germany
    J Infect Dis 198:213-7. 2008
  10. pmc The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 6:e27087. 2011

Collaborators

Detail Information

Publications40

  1. pmc Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures
    Hans Dieter Nischalke
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42141. 2012
    ..Here we analyze whether determination of target gene mRNA levels in intraductal brush cytology specimens may be used to improve the diagnosis of bile duct carcinoma...
  2. doi request reprint The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Int J Cancer 130:1470-5. 2012
    ..05). Our data suggest the TLR2 -196 to -174 del allele to affect HCV viral loads and to increase the risk for HCC in HCV genotype1-infected patients...
  3. doi request reprint The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    J Hepatol 56:758-64. 2012
    ..Thus, CXCL1 might contribute to HSC activation and fibrogenesis. Here, we investigated whether the CXCL1 rs4074 polymorphism affects CXCL1 expression and progression of chronic hepatitis C virus (HCV) infection towards cirrhosis...
  4. ncbi request reprint Regulation of CC chemokine receptor 5 in hepatitis G virus infection
    Jacob Nattermann
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    AIDS 17:1457-62. 2003
    ..As down-regulation of CC chemokine receptor 5 (CCR5) delays HIV progression, we investigated whether CCR5 expression is altered by exposure of lymphocytes to HGV proteins...
  5. ncbi request reprint HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Antivir Ther 10:95-107. 2005
    ..These results propose HIV-mediated up-regulation of HLA-E expression as an additional evasion strategy targeting the antiviral activities of NK cells, which may contribute to the capability of the virus in establishing chronic infection...
  6. ncbi request reprint The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells
    Daniela Schulte
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 200:1397-401. 2009
    ..038). Moreover, we found that the HLA-E(R) allelic variant confers protection against chronic infection with HCV genotypes 2 and 3. Taken together, our data indicate an important immunomodulating function of HLA-E in hepatitis C...
  7. doi request reprint The transforming growth factor-beta high-producer genotype is associated with response to hepatitis C virus-specific therapy in HIV-positive patients with acute hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    AIDS 22:1287-92. 2008
    ..Here, we studied whether transforming growth factor-beta gene polymorphisms affect treatment response in HCV/HIV coinfection...
  8. doi request reprint Interferon-lambda serum levels in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 54:859-65. 2011
    ..Thus far, studies have focused on types I and II interferon (IFN). We studied IFN-lambda1 (IL-29) and IFN-lambda2/3 (IL-28A/B) serum levels in patients with different outcomes of HCV infection...
  9. doi request reprint Hepatitis C virus-induced secretion of inflammatory chemokines preferentially recruits NKG2A+CD8+ T cells
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Germany
    J Infect Dis 198:213-7. 2008
    ..Thus, CCR5 is likely to exert immunoregulatory effects in hepatitis C virus infection by preferentially recruiting CD8(+) T cells bearing the inhibitory NKG2A receptor to the liver...
  10. pmc The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 6:e27087. 2011
    ..I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC)...
  11. ncbi request reprint Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Vaccine 24:3066-75. 2006
    ..In contrast, numbers of HLA-A2-pentamer-positive CD8+ T cells and granzyme B-secreting T cells remained unchanged. Thus, up-regulation of TLR2 during immunization with DC enhances functions of CD4+ T cells but not CD8+ T cells...
  12. doi request reprint Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2
    Martin Coenen
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:1375-82. 2011
    ..Manipulating the TLR2 pathway may thus provide a new approach for antifibrotic therapies in HCV infection...
  13. ncbi request reprint Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Hepatology 44:945-54. 2006
    ..In conclusion, migration of DC is markedly affected by interaction of HCV E2 with CD81. Failure of DC to recirculate to lymphoid tissue may be critically involved in impaired T cell priming during HCV infection...
  14. pmc Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 8:e80848. 2013
    ..In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on the occurrence of alcohol induced liver cirrhosis and hepatocellular carcinoma (HCC)...
  15. pmc TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients
    Christian Korner
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str, 25, 53127 Bonn, Germany
    BMC Cancer 12:85. 2012
    ....
  16. pmc Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 203:595-601. 2011
    ..Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C...
  17. doi request reprint Regulation of NK cell trafficking by CD81
    Benjamin Kramer
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Immunol 39:3447-58. 2009
    ..Thus, our data suggest that the tetraspanin CD81 is importantly involved in the regulation of NK cell recruitment...
  18. doi request reprint Impaired CD4⁺ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients
    Andreas Glässner
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 59:427-33. 2013
    ..Of note, NK cells have been shown to display anti-fibrotic activity via killing of activated hepatic stellate cells (HSC). Thus, we speculated that CD4(+) T cells might modulate fibrosis progression by interacting with NK cells...
  19. doi request reprint Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
    Benjamin Kramer
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 56:1201-13. 2012
    ..Conclusions: NKp46(High) expression defines a specific NK-cell subset that may be involved in both the suppression of HCV replication and HCV-associated liver damage underpinning the role of NK cells in the immunopathogenesis of HCV...
  20. doi request reprint The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation
    Jacob Nattermann
    Department of Internal Medicine, University of Bonn, Bonn, Germany
    J Hepatol 55:1201-6. 2011
    ..Here, we investigated the relative genetic contributions of the CCR5Δ32 deletion and the IL28B rs12979860 polymorphisms to spontaneous clearance of hepatitis C in a single-source outbreak...
  21. doi request reprint The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    AIDS 24:2001-7. 2010
    ..Here, we analyzed the potential impact of the CTLA4 polymorphisms on response to hepatitis C virus (HCV)-specific treatment in HIV(+) patients co-infected with HCV...
  22. ncbi request reprint Chemokine mRNA levels in mononucleated cells of HIV-infected patients before and after initiation of PI- versus NNRTI-containing HAART
    Jan Christian Wasmuth
    Department of Medicine I, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Antiviral Res 61:207-12. 2004
    ..A moderate decrease of RANTES was observed in both treatment groups. The data suggest that HAART regimens containing either NNRTI or PI are not equivalent with regard to modification of CC chemokine mRNA profiles...
  23. ncbi request reprint Effect of the interleukin-6 C174G gene polymorphism on treatment of acute and chronic hepatitis C in human immunodeficiency virus coinfected patients
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 46:1016-25. 2007
    ..1; P = 0.004). This effect corresponds to the in vitro observation that in HCV core-transfected HUH7 cells, IL-6 overcomes the HCV core-mediated inhibition of STAT3 activation...
  24. ncbi request reprint An effective interferon-gamma-mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus-positive patients
    Pavlos Kokordelis
    Department of Internal Medicine I, University of Bonn, Bonn, Germany German Center for Infection research DZIF, Bonn, Germany
    Hepatology 59:814-27. 2014
    ..Conclusion: Our data suggest a strong IFN-γ-mediated antiviral NK cell response to be associated with a self-limited course of AHC in HIV(+) patients...
  25. pmc The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C
    Marianne Eisenhardt
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 7:e38846. 2012
    ..Here, we analyzed phenotype and function of CXCR3 expressing NK cells in chronic hepatitis C...
  26. pmc Selective pressures of HLA genotypes and antiviral therapy on human immunodeficiency virus type 1 sequence mutation at a population level
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, 53105 Bonn, Germany
    Clin Vaccine Immunol 14:1266-73. 2007
    ..As several of the HLA-associated mutations lie at positions associated with drug resistance, our results indicate possible negative effects of HLA genotypes on the development of HIV-1 drug resistance...
  27. pmc Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 7:e42094. 2012
    ..Our in vitro data suggest that--in addition to its immunostimulatory effects on TH1 cells--ribavirin can inhibit functions of HCV-specific Tregs and thus reverses Treg-mediated suppression of T effector cells in chronic hepatitis C...
  28. ncbi request reprint The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    J Hepatol 47:348-55. 2007
    ..The G protein beta3 unit (GNB3) C825T polymorphism has been shown to affect treatment response in HCV mono-infection. Here, we analyzed the impact of the GNB3 genotype in the context of HCV/HIV co-infection...
  29. ncbi request reprint Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reaction
    Hans Dieter Nischalke
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, D 53105 Bonn, Germany
    AIDS Res Hum Retroviruses 20:750-4. 2004
    ..We have established a new real-time PCR protocol, which enables fast, cost-saving, and reliable CCR5 genotyping...
  30. ncbi request reprint Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma
    Georg Feldmann
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    Clin Cancer Res 12:4491-8. 2006
    ..To clarify this issue, we studied whether recognition of hepatitis C virus (HCV) proteins by PRR is involved in the pathogenesis of HCV-associated MC or B-NHL...
  31. pmc Between Scylla and Charybdis: the role of the human immune system in the pathogenesis of hepatitis C
    Ulrich Spengler
    Ulrich Spengler, Hans Dieter Nischalke, Jacob Nattermann, Christian P Strassburg, Department of Internal Medicine 1, University of Bonn, 53105 Bonn, Germany
    World J Gastroenterol 19:7852-66. 2013
    ..Thus, avoiding Scylla - a strong, sustained antiviral immune response with inital tissue damage - takes the infected host to virus-triggered immunopathology, which ultimately leads to cirrhosis and liver cancer - the realm of Charybdis. ..
  32. pmc The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells
    Jacob Nattermann
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Am J Pathol 166:443-53. 2005
    ..Our data indicate the existence of T cell epitopes that can be recognized by HLA-A2 and HLA-E. This dual recognition may contribute to viral persistence in hepatitis C...
  33. pmc Impact of rifaximin on the frequency and characteristics of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites
    Philipp Lutz
    Department of Internal Medicine I, University of Bonn, Bonn, Germany German Center for Infection Research
    PLoS ONE 9:e93909. 2014
    ..Rifaximin is a non-absorbable antibiotic used to prevent relapses of hepatic encephalopathy which may also be a candidate for prophylaxis of spontaneous bacterial peritonitis (SBP)...
  34. pmc Semiquantitative analysis of intrahepatic CC-chemokine mRNas in chronic hepatitis C
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Mediators Inflamm 13:357-9. 2004
    ..Recent data propose a correlation of the intrahepatic expression of the CC chemokine RANTES and the degree of periportal and portal inflammatory liver damage...
  35. doi request reprint Intrahepatic IL-8 producing Foxp3⁺CD4⁺ regulatory T cells and fibrogenesis in chronic hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Hepatol 59:229-35. 2013
    ..Regulatory CD4(+) T cells (Tregs) are considered to affect outcomes of HCV infection, because they increase in number during chronic hepatitis C and can suppress T-cell functions...
  36. doi request reprint Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:241-51. 2011
    ..This leads to the decrease in intrahepatic vascular resistance, but also to liver damage in the dosage we used. Therefore, any translation to portal hypertensive patients who may profit from sorafenib should be done with particular care...
  37. ncbi request reprint Altered expression of TGF-beta receptors in hepatocellular carcinoma--effects of a constitutively active TGF-beta type I receptor mutant
    Annemarie Musch
    Department of Medicine I, University of Bonn, Germany
    Digestion 71:78-91. 2005
    ..Hepatocellular carcinomas (HCC) often show resistance to the effects of transforming growth factor-beta (TGF-beta). This study focuses on molecular mechanisms of this resistance to explore ways to overcome it...
  38. ncbi request reprint Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma
    Christoph Jüngst
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 39:1663-72. 2004
    ..In conclusion, these data suggest that ROS generated by chronic inflammation contribute to human hepatocarcinogenesis. The role of DNA repair enzymes appears to be of reactive rather than causative manner...
  39. ncbi request reprint The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Clin Immunol 107:55-9. 2003
    ..Thus, the DC-SIGNR tandem-repeat polymorphism in exon 4 does not have a significant impact on the host's susceptibility to HIV and the clinical progression to AIDS...
  40. ncbi request reprint Hepatitis C virus-derived lipopeptides differentially induce epitope-specific immune responses in vitro
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Infect Dis 189:248-53. 2004
    ..IFN-gamma sfcs could only be induced with lipopeptide aa 20-44 but not by conventional antigens, which indicates that lipopeptides may alter T cell functions, depending on the epitope...