Falk Nimmerjahn

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi request reprint FcγRs in health and disease
    Falk Nimmerjahn
    Chair of Genetics, University of Erlangen Nuremberg, Staudtstr 5, 91054, Erlangen, Germany
    Curr Top Microbiol Immunol 350:105-25. 2011
  2. pmc FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
    Falk Nimmerjahn
    Department of Biology, Institute of Genetics, University of Erlangen Nuremberg, 91058 Erlangen, Germany
    Proc Natl Acad Sci U S A 107:19396-401. 2010
  3. pmc Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice
    Michaela Seeling
    Institute of Genetics, Department of Biology, University of Erlangen Nurnberg, 91058 Erlangen, Germany
    Proc Natl Acad Sci U S A 110:10729-34. 2013
  4. doi request reprint Regulatory T cells protect from local and systemic bone destruction in arthritis
    Mario M Zaiss
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 184:7238-46. 2010
  5. doi request reprint Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo
    Markus Biburger
    Department of Biology, University of Erlangen Nuremberg, Erwin Rommel Str 3, 91058 Erlangen, Germany
    Immunity 35:932-44. 2011
  6. doi request reprint The role of sialic acid as a modulator of the anti-inflammatory activity of IgG
    Sybille Böhm
    Institute of Genetics, Department of Biology, University of Erlangen Nuremberg, Erlangen, Germany
    Semin Immunopathol 34:443-53. 2012
  7. doi request reprint Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
    Inessa Schwab
    Institute of Genetics, Department of Biology, University of Erlangen Nurnberg, Erwin Rommelstrasse 3, 91058 Erlangen, Germany
    Nat Rev Immunol 13:176-89. 2013
  8. doi request reprint IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1
    Inessa Schwab
    Institute of Genetics, Department of Biology, University of Erlangen Nurnberg, Erlangen, Germany
    Eur J Immunol 42:826-30. 2012
  9. pmc B cells are critical for autoimmune pathology in Scurfy mice
    Susanne Aschermann
    Institute of Genetics, Department of Biology, University of Erlangen Nuremberg, 91058 Erlangen, Germany
    Proc Natl Acad Sci U S A 110:19042-7. 2013
  10. doi request reprint Mechanisms of action of intravenous immunoglobulins
    Anne Baerenwaldt
    Department of Biology, Institute of Genetics, University of Erlangen Nuremberg, Staudtstr 5, 91058 Erlangen, Germany
    Expert Rev Clin Immunol 6:425-34. 2010

Collaborators

Detail Information

Publications30

  1. doi request reprint FcγRs in health and disease
    Falk Nimmerjahn
    Chair of Genetics, University of Erlangen Nuremberg, Staudtstr 5, 91054, Erlangen, Germany
    Curr Top Microbiol Immunol 350:105-25. 2011
    ..In this review, we discuss how the interaction of these different ligands with classical and novel Fcγ-receptors influences the immune response and which strategies microorganisms have developed to prevent them...
  2. pmc FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
    Falk Nimmerjahn
    Department of Biology, Institute of Genetics, University of Erlangen Nuremberg, 91058 Erlangen, Germany
    Proc Natl Acad Sci U S A 107:19396-401. 2010
    ....
  3. pmc Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice
    Michaela Seeling
    Institute of Genetics, Department of Biology, University of Erlangen Nurnberg, 91058 Erlangen, Germany
    Proc Natl Acad Sci U S A 110:10729-34. 2013
    ..Our results suggest that osteoclastogenesis is directly influenced by IgG autoantibody binding to select activating FcγRs on immature osteoclasts, resulting in enhanced osteoclast generation and, ultimately, bone destruction. ..
  4. doi request reprint Regulatory T cells protect from local and systemic bone destruction in arthritis
    Mario M Zaiss
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 184:7238-46. 2010
    ..Thus, enhancing the activity of Treg cells would be beneficial for the treatment of inflammation-induced bone loss observed in rheumatoid arthritis...
  5. doi request reprint Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo
    Markus Biburger
    Department of Biology, University of Erlangen Nuremberg, Erwin Rommel Str 3, 91058 Erlangen, Germany
    Immunity 35:932-44. 2011
    ..In contrast, IgG-dependent effector functions were selectively impaired in animals lacking the CX(3)CR1(hi)Ly6C(lo)CD11c(int) monocyte subset, which expressed the full set of FcγRs required for IgG activity...
  6. doi request reprint The role of sialic acid as a modulator of the anti-inflammatory activity of IgG
    Sybille Böhm
    Institute of Genetics, Department of Biology, University of Erlangen Nuremberg, Erlangen, Germany
    Semin Immunopathol 34:443-53. 2012
    ....
  7. doi request reprint Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
    Inessa Schwab
    Institute of Genetics, Department of Biology, University of Erlangen Nurnberg, Erwin Rommelstrasse 3, 91058 Erlangen, Germany
    Nat Rev Immunol 13:176-89. 2013
    ..In this Review, we cover the recent insights into the molecular and cellular pathways that are involved in IVIG-mediated immunosuppression, with a particular focus on IVIG as a therapy for IgG-dependent autoimmune diseases...
  8. doi request reprint IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1
    Inessa Schwab
    Institute of Genetics, Department of Biology, University of Erlangen Nurnberg, Erlangen, Germany
    Eur J Immunol 42:826-30. 2012
    ..These results suggest that, similar to the human system, a spleen-independent but sialic acid- and SIGNR1-dependent pathway is responsible for IVIg-mediated suppression of autoantibody-dependent platelet depletion in mice...
  9. pmc B cells are critical for autoimmune pathology in Scurfy mice
    Susanne Aschermann
    Institute of Genetics, Department of Biology, University of Erlangen Nuremberg, 91058 Erlangen, Germany
    Proc Natl Acad Sci U S A 110:19042-7. 2013
    ....
  10. doi request reprint Mechanisms of action of intravenous immunoglobulins
    Anne Baerenwaldt
    Department of Biology, Institute of Genetics, University of Erlangen Nuremberg, Staudtstr 5, 91058 Erlangen, Germany
    Expert Rev Clin Immunol 6:425-34. 2010
    ..This review will discuss which molecular and cellular pathways might be involved in the anti-inflammatory activity of IVIg and for which types of autoimmune diseases they might be relevant...
  11. doi request reprint Antibody-mediated modulation of immune responses
    Falk Nimmerjahn
    Department of Biology, University of Erlangen Nuremberg, Erlangen, Germany
    Immunol Rev 236:265-75. 2010
    ..This review focuses on our current models of how IgG molecules can have this diverse array of activities...
  12. doi request reprint 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance
    Stefan Uderhardt
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Immunity 36:834-46. 2012
    ..Our data reveal an unexpected key role for enzymatic lipid oxidation during the maintenance of self-tolerance...
  13. pmc Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
    Ulrike Harre
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Invest 122:1791-802. 2012
    ..Our data thus suggest that autoantibody formation in response to citrullinated vimentin directly induces bone loss, providing a link between the adaptive immune system and bone...
  14. doi request reprint FcγRIIB: a modulator of cell activation and humoral tolerance
    Birgit Lehmann
    Institute of Genetics, Department of Biology, University of Erlangen Nurnberg, Staudtstr 5, 91058 Erlangen, Germany
    Expert Rev Clin Immunol 8:243-54. 2012
    ....
  15. pmc Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo
    Anne Baerenwaldt
    Department of Biology, Institute of Genetics, University of Erlangen Nurnberg, 91058 Erlangen, Germany
    Proc Natl Acad Sci U S A 108:18772-7. 2011
    ..Our results suggest that the inhibitory FcγRIIB may be an important checkpoint of humoral tolerance in the human immune system...
  16. pmc In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner
    Heike Albert
    Laboratory of Experimental Immunology and Immunotherapy, Medical Department 3, Nikolaus Fiebiger Centre, University of Erlangen Nuremberg, Glueckstrasse 6, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 105:15005-9. 2008
    ..Importantly, however, we observed a differential impact of EndoS-mediated sugar side chain hydrolysis on IgG activity depending on the individual IgG subclass...
  17. doi request reprint B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo
    Inessa Schwab
    Institute of Genetics, Department of Biology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 42:3302-9. 2012
    ..We show that neither B cells nor CD22 are critical for the immediate antiinflammatory activity of IVIgs in mouse models of rheumatoid arthritis and ITP...
  18. doi request reprint Impact of immune complex size and glycosylation on IgG binding to human FcγRs
    Anja Lux
    Department of Biology, University of Erlangen Nuremberg, 91058 Erlangen, Germany
    J Immunol 190:4315-23. 2013
    ....
  19. doi request reprint Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis
    Gisela Ruiz-Heiland
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nurnberg, Erlangen, Germany
    Ann Rheum Dis 71:400-7. 2012
    ..Osteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of osteophytes...
  20. ncbi request reprint Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
    ....
  21. ncbi request reprint Fc-receptors as regulators of immunity
    Falk Nimmerjahn
    Laboratory for Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Erlangen 91054, Germany
    Adv Immunol 96:179-204. 2007
    ..Moreover, we will focus on exogenous factors that can influence the balanced triggering of activating and inhibitory FcRs, such as the cytokine milieu and the role of differential antibody glycosylation...
  22. doi request reprint Analyzing antibody-Fc-receptor interactions
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, University of Erlangen Nuernberg, Nikolaus Fiebiger Center for Molecular Medicine, Erlangen, Germany
    Methods Mol Biol 415:151-62. 2008
    ..The methods described in this chapter include the generation of ICs and soluble FcR variants, as well as ELISA and FACS-based assays to study Ab-FcR interactions...
  23. doi request reprint Anti-inflammatory actions of intravenous immunoglobulin
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Annu Rev Immunol 26:513-33. 2008
    ..In this review, we summarize the clinical use of IVIG for different diseases and discuss recent data on the molecular mechanisms that might explain how this potent drug mediates its activity in vivo...
  24. doi request reprint Immune regulation: FcgammaRIIB--regulating the balance between protective and autoreactive immune responses
    Anne Baerenwaldt
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Centre for Molecular Medicine, Medical Department 3, University of Erlangen, Glueckstrasse, Erlangen, Germany
    Immunol Cell Biol 86:482-4. 2008
  25. doi request reprint Of mice and men: the need for humanized mouse models to study human IgG activity in vivo
    Anja Lux
    Department of Biology, University of Erlangen Nuernberg, Staudtstr 5, Erlangen 91058, Germany
    J Clin Immunol 33:S4-8. 2013
    ....
  26. pmc Translating basic mechanisms of IgG effector activity into next generation cancer therapies
    Falk Nimmerjahn
    Division of Genetics, Department of Biology, University of Erlangen Nuremberg, Erlangen, Germany
    Cancer Immun 12:13. 2012
    ....
  27. doi request reprint Low level of FcγRIII expression on murine natural killer cells
    Markus Biburger
    Institute of Genetics, Department of Biology, University of Erlangen Nuernberg, Erlangen, Germany
    Immunol Lett 143:53-9. 2012
    ..These results highlight the importance of blocking unwanted binding of FACS antibodies to FcγRIV and shed new light on the expression level of FcγRIII on NK cells in mice during the steady state...
  28. pmc Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate
    Hanne Schoenen
    Institute of Clinical Microbiology, Immunology and Hygiene Medical Department, Friedrich Alexander Universität Erlangen Nürnberg and University Clinics of Erlangen, Erlangen, Germany
    J Immunol 184:2756-60. 2010
    ..These results establish that Mincle is a key receptor for the mycobacterial cord factor and controls the Th1/Th17 adjuvanticity of TDM and TDB...
  29. doi request reprint The role of Fc receptors and complement in autoimmunity
    Sidonia Mihai
    Institute of Genetics, Department of Biology, University of Erlangen Nuremberg, Erwin Rommel Str 3, 91058 Erlangen, Germany
    Autoimmun Rev 12:657-60. 2013
    ..Manipulation of these connective pathways might be of therapeutic use to control antibody-mediated autoimmune diseases...
  30. doi request reprint Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation
    Mario M Zaiss
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:2328-38. 2010
    ..The aim of this study was to determine whether immune regulatory mechanisms, such as naturally occurring Treg cells, also extend their protective effects to bone homeostasis in vivo...