Nikoghosyan A, Rauch G, Munter M, Jensen A, Combs S, Kieser M, et al. Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study. BMC Cancer. 2010;10:606 pubmed publisher
..Additionally, we expect less toxicity in the carbon ion treatment arm. ClinicalTrials.gov identifier: NCT01182753. ..
Nikoghosyan A, Karapanagiotou Schenkel I, Munter M, Jensen A, Combs S, Debus J. Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study. BMC Cancer. 2010;10:607 pubmed publisher
..Proton therapy is the gold standard in the treatment of skull base chordomas. However, high-LET beams such as carbon ions theoretically offer biologic advantages by enhanced biologic effectiveness in slow-growing tumors...
Blattmann C, Oertel S, Schulz Ertner D, Rieken S, Haufe S, Ewerbeck V, et al. Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma. BMC Cancer. 2010;10:96 pubmed publisher
..Secondary objectives are tumor response, disease free survival and overall survival. The aim is to improve outcome for patients with non-resectable osteosarcoma. Registration number (ClinicalTrials.gov): NCT01005043. ..