Alexandra Nieters

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Multiple Myeloma and lifetime occupation: results from the EPILYMPH study
    Carla Perrotta
    Medicina Familiar y Comunitaria, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
    J Occup Med Toxicol 7:25. 2012
  2. pmc A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis
    Alexandra Nieters
    Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 128:1481-5. 2011
  3. doi request reprint Serum undercarboxylated osteocalcin as biomarker of vitamin K intake and risk of prostate cancer: a nested case-control study in the Heidelberg cohort of the European prospective investigation into cancer and nutrition
    Katharina Nimptsch
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg DE 69120, Germany
    Cancer Epidemiol Biomarkers Prev 18:49-56. 2009
  4. doi request reprint Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Eur J Cancer 45:2860-6. 2009
  5. doi request reprint Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition
    Silke Hermann
    Division of Cancer Epidemiology C020, German Cancer Research Center, Heidelberg, Germany
    J Cancer Res Clin Oncol 136:71-7. 2010
  6. doi request reprint Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph
    Nikolaus Becker
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    J Cancer Res Clin Oncol 138:1993-2001. 2012
  7. doi request reprint Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph)
    Katja Butterbach
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Br J Haematol 153:318-33. 2011
  8. doi request reprint Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk
    Birgit Hoeft
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:466-72. 2010
  9. doi request reprint The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
  10. ncbi request reprint Medical history and risk of lymphoma: results of a European case-control study (EPILYMPH)
    Nikolaus Becker
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Cancer Res Clin Oncol 135:1099-107. 2009

Collaborators

Detail Information

Publications35

  1. pmc Multiple Myeloma and lifetime occupation: results from the EPILYMPH study
    Carla Perrotta
    Medicina Familiar y Comunitaria, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
    J Occup Med Toxicol 7:25. 2012
    ..abstract:..
  2. pmc A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis
    Alexandra Nieters
    Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 128:1481-5. 2011
    ..6; p for linear trend = 0.002) and follicular lymphoma (OR = 1.6; p for linear trend = 0.001). These data suggest a possible role of this functional polymorphism in lymphomas originating within the germinal center...
  3. doi request reprint Serum undercarboxylated osteocalcin as biomarker of vitamin K intake and risk of prostate cancer: a nested case-control study in the Heidelberg cohort of the European prospective investigation into cancer and nutrition
    Katharina Nimptsch
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg DE 69120, Germany
    Cancer Epidemiol Biomarkers Prev 18:49-56. 2009
    ..37). The increased risks of advanced-stage and high-grade prostate cancer with higher serum ucOC/iOC ratio strengthen the findings for dietary menaquinone intake...
  4. doi request reprint Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Eur J Cancer 45:2860-6. 2009
    ..There is increasing evidence of frequent clearance of the infection during progression of CAG. We aimed to assess the association between host inflammatory polymorphisms and H. pylori seropositivity among CAG patients from Germany...
  5. doi request reprint Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition
    Silke Hermann
    Division of Cancer Epidemiology C020, German Cancer Research Center, Heidelberg, Germany
    J Cancer Res Clin Oncol 136:71-7. 2010
    ..We explored the association between education and the incidence of lymphoma in the prospective EPIC study...
  6. doi request reprint Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph
    Nikolaus Becker
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    J Cancer Res Clin Oncol 138:1993-2001. 2012
    ....
  7. doi request reprint Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph)
    Katja Butterbach
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Br J Haematol 153:318-33. 2011
    ..The results implicate a relevant role of certain pathway-related genes in lymphomagenesis, but still need to be approved by independent studies...
  8. doi request reprint Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk
    Birgit Hoeft
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:466-72. 2010
    ..Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk...
  9. doi request reprint The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  10. ncbi request reprint Medical history and risk of lymphoma: results of a European case-control study (EPILYMPH)
    Nikolaus Becker
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Cancer Res Clin Oncol 135:1099-107. 2009
    ..Lymphomas are a heterogeneous group of immune-cell malignancies. Immunology-related conditions are among the few factors for which consistent evidence exists relating them to lymphoma risk...
  11. doi request reprint Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 32:190-6. 2011
    ..82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC...
  12. doi request reprint Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 45:428-34. 2009
    ..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study...
  13. pmc A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:803-12. 2012
    ..0004), which could be replicated in an independent population. These results suggest a role for this gene in B-NHL susceptibility, especially for CLL...
  14. ncbi request reprint Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma
    Birgit Hoeft
    Molecular Tumour Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cancer Causes Control 19:163-73. 2008
    ..To further research in this area, we investigated the role of genetic variants in key inflammatory factors, non-steroidal anti-inflammatory drug [NSAID] use, and their joint effect in lymphomagenesis...
  15. doi request reprint Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Mol Carcinog 49:869-73. 2010
    ..pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms...
  16. ncbi request reprint Birth order, allergies and lymphoma risk: results of the European collaborative research project Epilymph
    Nikolaus Becker
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Leuk Res 31:1365-72. 2007
    ..Our findings on birth order and lymphoma increase the inconsistency of findings across studies and suggest a critical reappraisal of potential underlying mechanisms...
  17. doi request reprint Smoking and lymphoma risk in the European prospective investigation into cancer and nutrition
    Alexandra Nieters
    Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Am J Epidemiol 167:1081-9. 2008
    ..Future analysis should involve viral biomarkers and genetic susceptibility markers to elucidate potential mechanisms of smoking-induced carcinogenesis, particularly for Hodgkin's lymphoma...
  18. pmc Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld, 69120 Heidelberg, Germany
    Breast Cancer Res 10:R31. 2008
    ..Effect modification by serum 25-hydroxyvitamin D (25 [OH]D), the biomarker for vitamin D status in humans, has rarely been examined...
  19. doi request reprint The association of circulating adiponectin levels with pancreatic cancer risk: a study within the prospective EPIC cohort
    Verena A Grote
    German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 130:2428-37. 2012
    ..Therefore, further studies are needed to clarify the role of adiponectin in pancreatic cancer development...
  20. pmc Cell proliferation-related genetic polymorphisms and gastric cancer risk: systematic review and meta-analysis
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Hum Genet 17:1658-67. 2009
    ..Larger studies are warranted to clarify the effect of cell proliferation-related genetic polymorphisms on gastric carcinogenesis...
  21. ncbi request reprint Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Sabine Rohrmann
    Division of Clinical Epidemiology C020, German Cancer Research Centre, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
    Cancer Causes Control 18:537-49. 2007
    ..The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology...
  22. ncbi request reprint Tobacco and alcohol consumption and risk of lymphoma: results of a population-based case-control study in Germany
    Alexandra Nieters
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 118:422-30. 2006
    ..In conclusion, this investigation suggests a positive association between tobacco smoking and lymphoma risk and finds decreased odds ratios among consumers of alcohol...
  23. doi request reprint The associations of advanced glycation end products and its soluble receptor with pancreatic cancer risk: a case-control study within the prospective EPIC Cohort
    Verena A Grote
    Division of Cancer Epidemiology C020, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 21:619-28. 2012
    ..However, prospective data on their association with cancer of specific sites, including pancreatic cancer, are limited...
  24. ncbi request reprint Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Jakob Linseisen
    Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Int J Cancer 121:1103-14. 2007
    ..In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers...
  25. doi request reprint Insulin-like growth factor-II methylation status in lymphocyte DNA and colon cancer risk in the Northern Sweden Health and Disease cohort
    Rudolf Kaaks
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 69:5400-5. 2009
    ..The results from this study population do not support the hypothesis that colon cancer can be predicted from the different degrees of methylation of DMR in the IGFII gene from lymphocyte DNA...
  26. ncbi request reprint Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH
    Alexandra Nieters
    German Cancer Research Center, Heidelberg, Germany
    Gastroenterology 131:1879-86. 2006
    ..However, previous epidemiologic studies were limited in size to establish an association between HCV infection and specific lymphoma subtypes. We performed a large, multicenter, case-control study to address this question...
  27. ncbi request reprint Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association
    Alexandra Nieters
    Department of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer 103:740-8. 2005
    ..However, only a minority of HBV carriers eventually develop hepatocellular carcinoma. The authors hypothesized that cytokine genotypes may be important codeterminants of the risk of HBV-related hepatocellular carcinoma...
  28. ncbi request reprint The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype
    Katharina Nimptsch
    Unit of Nutritional Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg DE 69120, Germany
    Br J Nutr 101:1812-20. 2009
    ..Thus, the results show that the inverse association between dietary vitamin K intake and serum ucOC depends on a functionally relevant allelic variant of the VKORC1 gene...
  29. ncbi request reprint Medical history and risk for lymphoma: results of a population-based case-control study in Germany
    Nikolaus Becker
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Eur J Cancer 41:133-42. 2005
    ..These results are compatible with the notion that persistent immunological alterations contribute to the aetiology of lymphoma, but partially inconsistent with the Th1/Th2-shift paradigm...
  30. pmc Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy
    Silvia Funke
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cancer Epidemiol 2009:302047. 2009
    ....
  31. ncbi request reprint Plasma protein analysis of patients with different B-cell lymphomas using high-content antibody microarrays
    Christoph Schröder
    Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Proteomics Clin Appl 7:802-12. 2013
    ..In this study, plasma samples from a multicentric case-control study on lymphoma were analyzed for the identification of proteins useful for diagnosis...
  32. doi request reprint MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP
    Julie George
    Toll Like Receptors and Cancer Division, German Cancer Research Center, Heidelberg, Germany
    J Immunol 184:3025-32. 2010
    ..97%. Our data add rs8177400 (D96N) to the list of functionally important variants of Mal and warrant further research into its immunological, epidemiological, and diagnostic relevance...
  33. ncbi request reprint Genetic polymorphisms in TP53, nonsteroidal anti-inflammatory drugs and the risk of colorectal cancer: evidence for gene-environment interaction?
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Pharmacogenet Genomics 17:639-45. 2007
    ..We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use...
  34. ncbi request reprint Reproductive and dietary determinants of the age at menopause in EPIC-Heidelberg
    Gabriele Nagel
    Division of Clinical Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Maturitas 52:337-47. 2005
    ..The aim of the study was to explore the influence of reproductive and dietary factors on the age at menopause...
  35. ncbi request reprint Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort
    Alexandra Nieters
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nutr 41:210-21. 2002
    ....