Carien M Niessen

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
  2. ncbi request reprint Tight junctions/adherens junctions: basic structure and function
    Carien M Niessen
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:2525-32. 2007
  3. ncbi request reprint Another job for the talented p120-catenin
    Carien M Niessen
    Center for Molecular Medicine Cologne CMMC, University of Cologne, Joseph Stelzmannstrasse 9, 50931 Cologne
    Cell 127:875-7. 2006
  4. pmc Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation
    Carien M Niessen
    Department of Dermatology, Center for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany
    Physiol Rev 91:691-731. 2011
  5. pmc Molecular components of the adherens junction
    Carien M Niessen
    Center for Molecular Medicine, University of Cologne, LFI, 05, Room 59, Joseph Stelzmannstrasse 9, D 50931 Cologne, Germany
    Biochim Biophys Acta 1778:562-71. 2008
  6. doi request reprint Cadherin-mediated regulation of tight junctions in stratifying epithelia
    Christian Michels
    Department of Dermatology, Center for Molecular Medicine Cologne, University of Cologne, Colgne, Germany
    Ann N Y Acad Sci 1165:163-8. 2009
  7. pmc Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition
    Christian Günschmann
    Department of Dermatology, University of Cologne, 50931 Cologne, Germany
    Dev Cell 26:176-87. 2013
  8. pmc aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation
    Michaela T Niessen
    Department of Dermatology, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, 50931 Cologne, Germany
    J Cell Biol 202:887-900. 2013
  9. ncbi request reprint Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation
    Iris Helfrich
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:782-91. 2007
  10. pmc Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation
    Heike Stachelscheid
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    EMBO J 27:2091-101. 2008

Collaborators

Detail Information

Publications18

  1. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  2. ncbi request reprint Tight junctions/adherens junctions: basic structure and function
    Carien M Niessen
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:2525-32. 2007
    ..The current review provides an overview of the crucial molecular constituents of these structures and highlights some recent results on their regulation. In particular, I will discuss their importance in skin biology...
  3. ncbi request reprint Another job for the talented p120-catenin
    Carien M Niessen
    Center for Molecular Medicine Cologne CMMC, University of Cologne, Joseph Stelzmannstrasse 9, 50931 Cologne
    Cell 127:875-7. 2006
    ..In this issue of Cell, Wildenberg et al. (2006) reveal that the key effector molecule p120-catenin can mediate crosstalk between the Rac and Rho signaling pathways...
  4. pmc Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation
    Carien M Niessen
    Department of Dermatology, Center for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany
    Physiol Rev 91:691-731. 2011
    ..We discuss current progress and outline issues for further research in these fields...
  5. pmc Molecular components of the adherens junction
    Carien M Niessen
    Center for Molecular Medicine, University of Cologne, LFI, 05, Room 59, Joseph Stelzmannstrasse 9, D 50931 Cologne, Germany
    Biochim Biophys Acta 1778:562-71. 2008
    ..The molecular machineries that organize these adhesion receptor complexes into higher order junction structures, and the functional consequences of this junctional organization will be discussed...
  6. doi request reprint Cadherin-mediated regulation of tight junctions in stratifying epithelia
    Christian Michels
    Department of Dermatology, Center for Molecular Medicine Cologne, University of Cologne, Colgne, Germany
    Ann N Y Acad Sci 1165:163-8. 2009
    ....
  7. pmc Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition
    Christian Günschmann
    Department of Dermatology, University of Cologne, 50931 Cologne, Germany
    Dev Cell 26:176-87. 2013
    ..Collectively, the present study reveals a critical role for IIS-dependent control of p63 activity in coordination of ACD and stratification during epithelial morphogenesis. ..
  8. pmc aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation
    Michaela T Niessen
    Department of Dermatology, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, 50931 Cologne, Germany
    J Cell Biol 202:887-900. 2013
    ....
  9. ncbi request reprint Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation
    Iris Helfrich
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:782-91. 2007
    ..Indeed, inhibition of aPKC function showed that endogenous aPKC is crucial for in vitro barrier function and this required the presence of both the Par3 and Par6 binding sites...
  10. pmc Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation
    Heike Stachelscheid
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    EMBO J 27:2091-101. 2008
    ..Our results identify the small GTPase Rac as a key target of epidermal IR/IGF-1R signalling crucial for proliferative potential and interfollicular morphogenesis...
  11. ncbi request reprint An adhesion-independent, aPKC-dependent function for cadherins in morphogenetic movements
    Karla Seifert
    Center for Molecular Medicine Cologne, University of Cologne, 50923 Cologne, Germany
    J Cell Sci 122:2514-23. 2009
    ..Our results also suggest that increased cadherin shedding, often observed in cancer progression, can regulate migration and invasion by modulating polarity protein activity...
  12. doi request reprint Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization
    Saeed Yadranji Aghdam
    Department of Dermatology, University of Cologne, Germany
    Biochem Biophys Res Commun 421:197-202. 2012
    ..These results show that endothelial insulin/IGF signaling is essential for neo-angiogenesis upon wounding, and imply that reduced endothelial insulin/IGF signaling directly contributes to diabetes-associated impaired healing...
  13. doi request reprint TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function
    Dagmar Fehrenschild
    Center for Molecular Medicine Cologne CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 132:337-45. 2012
    ..Together, our data demonstrate that functional TCF/Lef1 signaling governs important aspects of epidermal differentiation and lipid metabolism, thereby regulating skin barrier function...
  14. doi request reprint Analysis of bulge stem cells from the epidermis using flow cytometry
    Rehan M Villani
    Department of Dermatology, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne, Germany
    Methods Mol Biol 989:33-43. 2013
    ..We use the cell surface markers CD34 and α6-integrin for the enrichment of bulge stem cells. This method also contains notes on how to adjust the cytometer settings for a reproducible analysis...
  15. ncbi request reprint The in vivo function of mammalian cell and tissue polarity regulators--how to shape and maintain the epidermal barrier
    Michaela T Niessen
    Department of Dermatology, Center for Molecular Medicine, Robert Kochstrasse 21, 50931 Cologne, Germany
    J Cell Sci 125:3501-10. 2012
    ..We also describe how altered polarity signaling contributes to skin cancer...
  16. doi request reprint Adherens junctions in mammalian development, homeostasis and disease: lessons from mice
    Barbara Boggetti
    Department of Dermatology, Center for Molecular Medicine, University of Cologne, Room 4A 05, Robert Kochstrasse 21, 50931, Cologne, Germany
    Subcell Biochem 60:321-55. 2012
    ....
  17. doi request reprint Experimental analysis of risk factors for ulcerative dermatitis in mice
    Brit Neuhaus
    Max Planck Institute for Biology of Ageing, Cologne, Germany
    Exp Dermatol 21:712-3. 2012
    ..Our results identify IRS1 as a key determinant of UD pathogenesis and establish a direct link between diet composition, obesity-induced inflammation and chronic ulceration...
  18. pmc Cadherin-mediated cell sorting not determined by binding or adhesion specificity
    Carien M Niessen
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 156:389-399. 2002
    ..These results show that cadherins are far more promiscuous in their adhesive-binding capacity than had been expected and that the ability to sort out must be determined by mechanisms other than simple adhesive-binding specificity...