Research Topics
Genomes and Genes | Jan Hendrik NiessSummaryAffiliation: University of Ulm Country: Germany Publications
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Detail Information
Publications
NOD2 polymorphism predicts response to treatment in Crohn's disease--first steps to a personalized therapyJan Hendrik Niess
Department of Medicine I Gastroenterology, Ulm University, Albert Einstein Allee 23, 89081 Ulm, Germany
Dig Dis Sci 57:879-86. 2012..Early introduction of more aggressive therapies to patients at high risk and no introduction of predictable refractory treatments could become possible. We hence tested the influence of the NOD2 carrier status on treatment response...
Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditionsJan Hendrik Niess
Department of Internal Medicine I, Ulm University, Germany
J Immunol 180:559-68. 2008..Commensal bacteria-driven, local expansion of cLP CD4 Th17 cells may contribute to the pathogenesis of this inflammatory bowel disease...
Role of mucosal dendritic cells in inflammatory bowel diseaseJan Hendrik Niess
Department of Internal Medicine I, Ulm University, Ulm University Street, Helmholtzstr, 8 1, Ulm 89031, Germany
World J Gastroenterol 14:5138-48. 2008..This review will discuss the emerging role of mucosal DCs in regulating intestinal inflammation and immune responses...
Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditionsJan Hendrik Niess
Department of Internal Medicine I, Ulm University, Ulm, Germany
J Immunol 184:2026-37. 2010..The local bacteria-driven accumulation of CX(3)CR1(+) DCs seems to support inflammatory immune responses...
Role of gut-resident dendritic cells in inflammatory bowel diseaseJan Hendrik Niess
Department of Internal Medicine I, Ulm University, Albert Einstein Allee 23, 89081 Ulm, Germany
Expert Rev Clin Immunol 5:451-61. 2009..This review will discuss the function of dendritic cells in the recognition of the enteric flora and their role in the development of intestinal inflammation...
What are CX3CR1+ mononuclear cells in the intestinal mucosa?Jan Hendrik Niess
Department of Internal Medicine I, Ulm University, Ulm, Germany
Gut Microbes 1:396-400. 2010..Here, I will discuss the ontogeny and function of CX(3)CR1(+) mononuclear cells in the small and large intestine...
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potentialKatarina Radulovic
Department of Internal Medicine I, University of Ulm, Ulm D 89081, Germany
J Immunol 188:2001-13. 2012..Hence, the activation Ag CD69 plays an important role in regulating mucosal immune responses...
Gut microbiota, probiotics and inflammatory bowel diseaseJohannes Stephani
Department of Internal Medicine I, Ulm University, Helmholtzstr, 8 1, 89031, Ulm, Germany
Arch Immunol Ther Exp (Warsz) 59:161-77. 2011..A disturbance of either compound can cause intestinal inflammation. This review summarizes extrinsic and intrinsic factors contributing to intestinal dysbiosis and inflammatory bowel disease...
Metabolic alkalosis, acute renal failure and epileptic seizures as unusual manifestations of an upside-down stomachJohannes Stephani
Department of Internal Medicine I, Ulm University, Ulm, Germany
Case Rep Gastroenterol 6:452-8. 2012..This case report highlights severe metabolic and neurological disorders as unusual and life-threatening complications of an upside-down stomach...
Selection of bifidobacteria based on adhesion and anti-inflammatory capacity in vitro for amelioration of murine colitisJulia Preising
Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany
Appl Environ Microbiol 76:3048-51. 2010..Two strains were selected for further assessment of their anti-inflammatory capacity in two murine models of colitis. In vivo results confirmed the high anti-inflammatory capacity of a Bifidobacterium bifidum strain...
