Jan Hendrik Niess

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc NOD2 polymorphism predicts response to treatment in Crohn's disease--first steps to a personalized therapy
    Jan Hendrik Niess
    Department of Medicine I Gastroenterology, Ulm University, Albert Einstein Allee 23, 89081 Ulm, Germany
    Dig Dis Sci 57:879-86. 2012
  2. ncbi request reprint Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Germany
    J Immunol 180:559-68. 2008
  3. pmc What are CX3CR1+ mononuclear cells in the intestinal mucosa?
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Ulm, Germany
    Gut Microbes 1:396-400. 2010
  4. ncbi request reprint Role of gut-resident dendritic cells in inflammatory bowel disease
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Albert Einstein Allee 23, 89081 Ulm, Germany
    Expert Rev Clin Immunol 5:451-61. 2009
  5. doi request reprint Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Ulm, Germany
    J Immunol 184:2026-37. 2010
  6. pmc Role of mucosal dendritic cells in inflammatory bowel disease
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Ulm University Street, Helmholtzstr, 8 1, Ulm 89031, Germany
    World J Gastroenterol 14:5138-48. 2008
  7. pmc The Early Activation Marker CD69 Regulates the Expression of Chemokines and CD4 T Cell Accumulation in Intestine
    Katarina Radulovic
    Department of Internal Medicine I, University of Ulm, Ulm, Germany Institute for Microbiology and Biotechnology, University of Ulm, Ulm, Germany
    PLoS ONE 8:e65413. 2013
  8. pmc Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease
    Carsten Posovszky
    Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Eythstr, 24, Ulm, 89075, Germany
    BMC Gastroenterol 13:77. 2013
  9. doi request reprint CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential
    Katarina Radulovic
    Department of Internal Medicine I, University of Ulm, Ulm D 89081, Germany
    J Immunol 188:2001-13. 2012
  10. doi request reprint Gut microbiota, probiotics and inflammatory bowel disease
    Johannes Stephani
    Department of Internal Medicine I, Ulm University, Helmholtzstr, 8 1, 89031, Ulm, Germany
    Arch Immunol Ther Exp (Warsz) 59:161-77. 2011

Collaborators

Detail Information

Publications13

  1. pmc NOD2 polymorphism predicts response to treatment in Crohn's disease--first steps to a personalized therapy
    Jan Hendrik Niess
    Department of Medicine I Gastroenterology, Ulm University, Albert Einstein Allee 23, 89081 Ulm, Germany
    Dig Dis Sci 57:879-86. 2012
    ..Early introduction of more aggressive therapies to patients at high risk and no introduction of predictable refractory treatments could become possible. We hence tested the influence of the NOD2 carrier status on treatment response...
  2. ncbi request reprint Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Germany
    J Immunol 180:559-68. 2008
    ..Commensal bacteria-driven, local expansion of cLP CD4 Th17 cells may contribute to the pathogenesis of this inflammatory bowel disease...
  3. pmc What are CX3CR1+ mononuclear cells in the intestinal mucosa?
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Ulm, Germany
    Gut Microbes 1:396-400. 2010
    ..Here, I will discuss the ontogeny and function of CX(3)CR1(+) mononuclear cells in the small and large intestine...
  4. ncbi request reprint Role of gut-resident dendritic cells in inflammatory bowel disease
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Albert Einstein Allee 23, 89081 Ulm, Germany
    Expert Rev Clin Immunol 5:451-61. 2009
    ..This review will discuss the function of dendritic cells in the recognition of the enteric flora and their role in the development of intestinal inflammation...
  5. doi request reprint Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Ulm, Germany
    J Immunol 184:2026-37. 2010
    ..The local bacteria-driven accumulation of CX(3)CR1(+) DCs seems to support inflammatory immune responses...
  6. pmc Role of mucosal dendritic cells in inflammatory bowel disease
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Ulm University Street, Helmholtzstr, 8 1, Ulm 89031, Germany
    World J Gastroenterol 14:5138-48. 2008
    ..This review will discuss the emerging role of mucosal DCs in regulating intestinal inflammation and immune responses...
  7. pmc The Early Activation Marker CD69 Regulates the Expression of Chemokines and CD4 T Cell Accumulation in Intestine
    Katarina Radulovic
    Department of Internal Medicine I, University of Ulm, Ulm, Germany Institute for Microbiology and Biotechnology, University of Ulm, Ulm, Germany
    PLoS ONE 8:e65413. 2013
    ..This study showed CD69 as negative regulator of inflammatory responses in intestine as it decreases the expression of chemotactic receptors and ligands and reduces the accumulation of CD4 T cells in cLP during colitis...
  8. pmc Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease
    Carsten Posovszky
    Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Eythstr, 24, Ulm, 89075, Germany
    BMC Gastroenterol 13:77. 2013
    ..Influence of genetic variants in the NOD2 gene may play a more important role in disease activity, behaviour and treatment of pediatric- than adult-onset Crohn's disease (CD)...
  9. doi request reprint CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential
    Katarina Radulovic
    Department of Internal Medicine I, University of Ulm, Ulm D 89081, Germany
    J Immunol 188:2001-13. 2012
    ..Hence, the activation Ag CD69 plays an important role in regulating mucosal immune responses...
  10. doi request reprint Gut microbiota, probiotics and inflammatory bowel disease
    Johannes Stephani
    Department of Internal Medicine I, Ulm University, Helmholtzstr, 8 1, 89031, Ulm, Germany
    Arch Immunol Ther Exp (Warsz) 59:161-77. 2011
    ..A disturbance of either compound can cause intestinal inflammation. This review summarizes extrinsic and intrinsic factors contributing to intestinal dysbiosis and inflammatory bowel disease...
  11. pmc Metabolic alkalosis, acute renal failure and epileptic seizures as unusual manifestations of an upside-down stomach
    Johannes Stephani
    Department of Internal Medicine I, Ulm University, Ulm, Germany
    Case Rep Gastroenterol 6:452-8. 2012
    ..This case report highlights severe metabolic and neurological disorders as unusual and life-threatening complications of an upside-down stomach...
  12. pmc Selection of bifidobacteria based on adhesion and anti-inflammatory capacity in vitro for amelioration of murine colitis
    Julia Preising
    Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany
    Appl Environ Microbiol 76:3048-51. 2010
    ..Two strains were selected for further assessment of their anti-inflammatory capacity in two murine models of colitis. In vivo results confirmed the high anti-inflammatory capacity of a Bifidobacterium bifidum strain...
  13. pmc CD14-Dependent Monocyte Isolation Enhances Phagocytosis of Listeria monocytogenes by Proinflammatory, GM-CSF-Derived Macrophages
    Caroline Neu
    Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany
    PLoS ONE 8:e66898. 2013
    ..Based on these observations, we propose macrophages derived by ex vivo differentiation of negatively selected human primary monocytes as the most suitable model to study Lm infection of macrophages...