Beate Niesler

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint 5-HT(3) receptors: potential of individual isoforms for personalised therapy
    Beate Niesler
    Institute of Human Genetics, Department of Human Molecular Genetics, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Curr Opin Pharmacol 11:81-6. 2011
  2. ncbi request reprint Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Pharmacol 72:8-17. 2007
  3. pmc RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits
    Jutta Walstab
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Biol Chem 285:26956-65. 2010
  4. doi request reprint Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
    Christian Hammer
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Pharmacogenomics 11:943-50. 2010
  5. doi request reprint 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Heidelberg, Germany
    Eur J Gastroenterol Hepatol 22:856-61. 2010
  6. pmc Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Germany
    J Comp Neurol 519:420-32. 2011
  7. doi request reprint First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Hum Mol Genet 17:2967-77. 2008
  8. pmc Genotypes and phenotypes in children with short stature: clinical indicators of SHOX haploinsufficiency
    Gudrun Rappold
    Department of Molecular Human Genetics, University of Heidelberg, Heidelberg, Germany
    J Med Genet 44:306-13. 2007
  9. ncbi request reprint The novel human SHOX allelic variant database
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Heidelberg, Germany
    Hum Mutat 28:933-8. 2007
  10. doi request reprint Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders
    Christian Hammer
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld, Germany
    Pharmacogenet Genomics 19:790-9. 2009

Collaborators

Detail Information

Publications23

  1. doi request reprint 5-HT(3) receptors: potential of individual isoforms for personalised therapy
    Beate Niesler
    Institute of Human Genetics, Department of Human Molecular Genetics, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Curr Opin Pharmacol 11:81-6. 2011
    ..Interestingly, HTR3 variants have now been shown to be associated with these conditions. This underlines the potential of 5-HT(3) receptors as therapeutic targets and may enable personalised therapies in the future...
  2. ncbi request reprint Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Pharmacol 72:8-17. 2007
    ..These data show for the first time that the novel 5-HT(3) subunits are able to form heteromeric 5-HT(3) receptors, which exhibit quantitatively different functional properties compared with homomeric 5-HT(3A) receptors...
  3. pmc RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits
    Jutta Walstab
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Biol Chem 285:26956-65. 2010
    ..These data implicate a possible role of RIC-3 in determining 5-HT(3) receptor composition in vivo...
  4. doi request reprint Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
    Christian Hammer
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Pharmacogenomics 11:943-50. 2010
    ..We investigated the correlation of common variants in 5-HT(3) receptor subunit genes with the occurrence of CINV...
  5. doi request reprint 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Heidelberg, Germany
    Eur J Gastroenterol Hepatol 22:856-61. 2010
    ..This may be partly because of small participant numbers and varying ethnic origin and sex within the cohorts studied...
  6. pmc Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Germany
    J Comp Neurol 519:420-32. 2011
    ....
  7. doi request reprint First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Hum Mol Genet 17:2967-77. 2008
    ..This is the first example indicating micro RNA-related expression regulation of a serotonin receptor gene with a cis-regulatory variant affecting this regulation and appearing to be associated with female IBS-D...
  8. pmc Genotypes and phenotypes in children with short stature: clinical indicators of SHOX haploinsufficiency
    Gudrun Rappold
    Department of Molecular Human Genetics, University of Heidelberg, Heidelberg, Germany
    J Med Genet 44:306-13. 2007
    ....
  9. ncbi request reprint The novel human SHOX allelic variant database
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Heidelberg, Germany
    Hum Mutat 28:933-8. 2007
    ..Furthermore, it includes general information about the SHOX gene via links to other resources such as MIM, GDB, HGMD, and HAPMAP, as well as websites of Short Stature Associations...
  10. doi request reprint Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders
    Christian Hammer
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld, Germany
    Pharmacogenet Genomics 19:790-9. 2009
    ....
  11. ncbi request reprint Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature
    Gudrun A Rappold
    Institute of Human Genetics, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 87:1402-6. 2002
    ....
  12. ncbi request reprint Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E
    Beate Niesler
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany
    Gene 310:101-11. 2003
    ....
  13. doi request reprint Serotonin type 3 receptor genes: HTR3A, B, C, D, E
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Pharmacogenomics 9:501-4. 2008
    ..HTR3A and HTR3B polymorphisms may also contribute to the etiology of psychiatric disorders and serve as predictors in CINV and in the medical treatment of psychiatric patients...
  14. doi request reprint 5-HT(3) receptors: role in disease and target of drugs
    Jutta Walstab
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Pharmacol Ther 128:146-69. 2010
    ..This shall point to alternative treatment options modulating the 5-HT(3) receptor system and open new possibilities for drug development in the future...
  15. ncbi request reprint Alteration of DNA binding, dimerization, and nuclear translocation of SHOX homeodomain mutations identified in idiopathic short stature and Leri-Weill dyschondrosteosis
    Katja U Schneider
    Department of Molecular Human Genetics, University of Heidelberg, Germany
    Hum Mutat 26:44-52. 2005
    ..Thus, we demonstrate that single missense mutations in the homeodomain fundamentally impair SHOX key functions, thereby leading to the phenotype observed in patients with LWD and ISS...
  16. ncbi request reprint Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients
    Bernd Frank
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Am J Med Genet B Neuropsychiatr Genet 131:1-5. 2004
    ..49, 95% CI: 0.3-0.82; genotype-wise: 15,5% vs. 29,0%, P = 0.005, OR = 0.45, 95% CI: 0.26-0.77). We suggest that this deletion may influence translational efficiency, thereby possibly affecting the development of bipolar affective disease...
  17. doi request reprint Is there a link between the calcium sensing receptor and Hirschsprung's disease? A mutational analysis
    Philipp Romero
    Department of Surgery, Division of Pediatric Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Pediatr Surg 47:551-5. 2012
    ..In the present study, we investigated the correlation between mutations and polymorphisms in the calcium sensing receptor (CaSR) and HD patients...
  18. pmc Mutational analysis of the PITX2 coding region revealed no common cause for transposition of the great arteries (dTGA)
    Nadja Muncke
    Institut fur Humangenetik, Universitat Heidelberg, INF 366, 69120 Heidelberg, Germany
    BMC Med Genet 6:20. 2005
    ..TGA accounts for 5-7% of all congenital heart diseases affecting 0.2 per 1000 live births, thereby representing the most frequent cyanotic heart defect diagnosed in the neonatal period...
  19. ncbi request reprint Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients
    Bernd Frank
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Clin Rheumatol 23:338-44. 2004
    ..Sequence variants of the serotonin receptor subunit genes HTR3A and HTR3B indicate no obvious significance in the aetiology of fibromyalgia, yet they represent the basis for future studies on their pharmacogenetic relevance...
  20. ncbi request reprint The human SHOX mutation database
    Beate Niesler
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Hum Mutat 20:338-41. 2002
    ..2002]. The database is accessible via the website www.shox.uni-hd.de. It contains general information about the SHOX gene, and allows remote users to search the data and to submit new mutations to the database...
  21. doi request reprint Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors
    Jutta Walstab
    Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 18:793-802. 2008
    ..We have characterized the impact of four naturally occurring variants in the HTR3B gene leading to amino acid exchanges within the respective subunit of heteromeric 5-HT3A/B receptors on a functional and expressional level...
  22. ncbi request reprint Serotonin receptor genes HTR3A and HTR3B are not involved in Gilles de la Tourette syndrome
    Beate Niesler
    Psychiatr Genet 15:303-4. 2005
    ..Statistical analysis rated all variants as probably non-disease-related polymorphisms. Yet a certain effect of the detected variants on the severity of the disease cannot be excluded...
  23. ncbi request reprint Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization
    Jutta Walstab
    Institute of Pharmacology and Toxicology, University of Bonn, 53113 Bonn, Germany
    Anal Biochem 368:185-92. 2007
    ..In conclusion, the aequorin assay described here provides a convenient and highly sensitive method for functional characterization of 5-HT(3) receptors that is well suited for high-throughput screening...