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T Nicolai Siegel
Affiliation: University of Munich
Müller L, Cosentino R, Förstner K, Guizetti J, Wedel C, Kaplan N, et al. Genome organization and DNA accessibility control antigenic variation in trypanosomes. Nature. 2018;563:121-125 pubmed publisher
..Our analyses identify histone variants as a molecular link between global genome architecture, local chromatin conformation and antigenic variation. ..
Wedel C, Förstner K, Derr R, Siegel T. GT-rich promoters can drive RNA pol II transcription and deposition of H2A.Z in African trypanosomes. EMBO J. 2017;36:2581-2594 pubmed publisher
..Our findings show that even highly dispersed, unregulated promoters contain specific DNA elements that are able to induce transcription and changes in chromatin structure. ..
Hassan M, Vasquez J, Guo Liang C, Meissner M, Nicolai Siegel T. Comparative ribosome profiling uncovers a dominant role for translational control in Toxoplasma gondii. BMC Genomics. 2017;18:961 pubmed publisher
..We show that most of the Toxoplasma genes that are dysregulated during the lytic cycle are translationally regulated. ..