Markus F Neurath

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint The role of Th1/Th2 polarization in mucosal immunity
    Markus F Neurath
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    Nat Med 8:567-73. 2002
  2. ncbi request reprint Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 37:1663-77. 2007
  3. pmc The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    Jonas Mudter
    1st Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 118:2415-26. 2008
  4. ncbi request reprint Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    Sabine Dominitzki
    Laboratory of Immunology, Medical Clinic I, University of Mainz, Mainz, Germany
    J Immunol 179:2041-5. 2007
  5. doi request reprint Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Bowel Dis 16:559-67. 2010
  6. ncbi request reprint Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
    Int Immunol 19:685-93. 2007
  7. ncbi request reprint IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet
    Juergen Siebler
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Lasngenbeckstrasse 1, 55131 Mainz, Germany
    Gastroenterology 132:358-71. 2007
  8. ncbi request reprint Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator
    Jonas Mudter
    First Medical Clinic, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 51:711-7. 2006
  9. ncbi request reprint IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 181:1917-26. 2008
  10. doi request reprint A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes
    Joachim H Maxeiner
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    Cancer Res 69:3069-76. 2009

Detail Information

Publications92

  1. ncbi request reprint The role of Th1/Th2 polarization in mucosal immunity
    Markus F Neurath
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    Nat Med 8:567-73. 2002
    ..Mucosal immunity relies on the delicate balance between antigen responsiveness and tolerance. The polarization of T helper cells plays a key role in maintaining or disrupting this equilibrium...
  2. ncbi request reprint Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 37:1663-77. 2007
    ..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma...
  3. pmc The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    Jonas Mudter
    1st Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 118:2415-26. 2008
    ..Taken together, our data identify IRF4 as a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for IBDs...
  4. ncbi request reprint Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    Sabine Dominitzki
    Laboratory of Immunology, Medical Clinic I, University of Mainz, Mainz, Germany
    J Immunol 179:2041-5. 2007
    ....
  5. doi request reprint Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Bowel Dis 16:559-67. 2010
    ..In the present study we aimed at assessing the role of perforin-dependent effector mechanisms in the immune response in a murine model of colitis-associated colon cancer...
  6. ncbi request reprint Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
    Int Immunol 19:685-93. 2007
    ..Local targeting of IL-6R signaling could be a novel approach for inducing Th2 T cell death in allergic airways via regulatory T cells...
  7. ncbi request reprint IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet
    Juergen Siebler
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Lasngenbeckstrasse 1, 55131 Mainz, Germany
    Gastroenterology 132:358-71. 2007
    ..T-cell-mediated fulminant hepatitis is a potentially life-threatening event for which the underlying pathogenic mechanisms are not fully understood. Here, we demonstrate a key regulatory role of IL-28A in T-cell-mediated hepatitis...
  8. ncbi request reprint Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator
    Jonas Mudter
    First Medical Clinic, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 51:711-7. 2006
  9. ncbi request reprint IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 181:1917-26. 2008
    ..These findings provide novel insights into the functional role of IL-2 signaling in experimental asthma and suggest that blockade of the IL-2R beta-chain might be useful for therapy of allergic asthma in humans...
  10. doi request reprint A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes
    Joachim H Maxeiner
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    Cancer Res 69:3069-76. 2009
    ....
  11. doi request reprint In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    Gastroenterology 138:435-46. 2010
    ..Confocal laser endomicroscopy (CLE) enables accurate microscopic visualization of CRC in patients during endoscopy. We evaluated the ability to use CLE in vivo for instantaneous molecular imaging of EGFR in CRC models...
  12. doi request reprint Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy
    Sebastian Foersch
    Medical Clinic I, University of Mainz, Mainz, Germany
    Gut 59:1046-55. 2010
    ..The aim of the study was to evaluate CLE for in vivo molecular imaging of VEGF in GiC...
  13. ncbi request reprint TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    Christoph Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Immunity 21:491-501. 2004
    ..Taken together, our data provide novel insights into TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-beta-dependent IL-6 trans-signaling...
  14. ncbi request reprint Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitis
    Juergen Siebler
    First Department of Medicine, University of Mainz, Mainz, Germany
    J Immunol 180:30-3. 2008
    ..Taken together, these data demonstrate a key pathogenic role of IL-27 in T cell-mediated liver injury. Furthermore, in vivo blockade of IL-27 emerges as a novel potential therapy for T cell-mediated hepatitis...
  15. doi request reprint Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastrointest Endosc 70:959-68. 2009
    ..Usually fluorescein then serves as a contrast agent for CLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects...
  16. pmc The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 115:313-25. 2005
    ..Furthermore, inhibition of IL-6 signaling emerges as a novel molecular approach for the treatment of allergic asthma...
  17. pmc Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins
    Daniela Poppe
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    J Immunol 176:640-51. 2006
    ..These findings provide novel insights into the immunosuppressive effects of azathioprine and suggest that antagonists of the Vav-Rac signaling pathway may be useful for suppression of T cell-dependent pathogenic immune responses...
  18. pmc Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 203:1875-81. 2006
    ..Collectively, these data identify IL-27 as a key negative regulator of innate immune cell function in septic peritonitis. Furthermore, in vivo blockade of IL-27 is a novel potential therapeutic target for treatment of sepsis...
  19. ncbi request reprint Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis
    Christoph Becker
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 177:2760-4. 2006
    ..Taken together, our data identify cross-regulation of IL-12 expression by IL-23 as novel key regulatory pathway during initiation of T cell dependent colitis...
  20. ncbi request reprint IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 37:1809-16. 2007
    ..Our data thus demonstrate that IL-27 controls the development of Th17 and iTreg cells via differential effects on STAT1...
  21. pmc The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer
    Imke Atreya
    I Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 56:1572-8. 2007
    ..These data provide novel insights into control mechanisms governing the functional activity of human CD8 T lymphocytes via T-box transcription factors in cancer...
  22. ncbi request reprint Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    J Immunol 168:411-20. 2002
    ....
  23. ncbi request reprint Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis
    Kai M Hildner
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    J Immunol 178:3427-36. 2007
    ..These data suggest a key regulatory role of STAT4 in the pathogenesis and manifestation of murine collagen-induced arthritis. Furthermore, the targeting of STAT4 emerges as a novel approach to therapy for chronic arthritis...
  24. doi request reprint RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
    Moritz Leppkes
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Gastroenterology 136:257-67. 2009
    ..We analyzed the roles of Th17 cells and the transcription factor retinoic acid receptor-related organ receptor (ROR)gamma, which regulates Th17 differentiation, in chronic intestinal inflammation...
  25. ncbi request reprint EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation
    Stefan Wirtz
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 174:2814-24. 2005
    ..Thus, EBI3 gene transcription in DCs is induced rapidly by TLR signaling during innate immune responses preceding cytokine driven Th cell development...
  26. ncbi request reprint A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver inflammation
    Jurgen Siebler
    Labor für Klinische Immunologie I, I Medizinische Klinik, Johannes Gutenberg Universitat, Mainz, Germany
    Hepatology 38:1573-80. 2003
    ..In conclusion, these findings suggest a key pathogenic role for the STAT1/T-bet signaling pathway for T-cell activation in the Con A model of T-cell-mediated liver pathology...
  27. ncbi request reprint Enhanced sensitivity to CD95-induced apoptosis in ob/ob mice
    Juergen Siebler
    Department of Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Dig Dis Sci 52:2396-402. 2007
    ..CD95 expression was similar in ob/ob and control mice. However, hepatocytes from ob/ob mice revealed a decreased mitochondrial membrane potential, suggesting that mitochondria play a potential role in this increased susceptibility...
  28. ncbi request reprint A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis
    Benno Weigmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    J Immunol 173:3446-55. 2004
    ..Targeting of c-Maf in memory T cells in CD appears to be an attractive target for therapeutic interventions...
  29. doi request reprint Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    J Hepatol 53:84-90. 2010
    ..The aim of the current study was to evaluate a novel near-infrared (NIR) light probe with indocyanine green (ICG) contrast for in vivo confocal imaging of the human liver during mini-laparoscopy...
  30. ncbi request reprint Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells
    Samuel Huber
    I Medizinische Klinik, Johannes Gutenberg Universitat, Mainz, Germany
    J Immunol 173:6526-31. 2004
    ..These data indicate that TGF-beta signaling in CD4(+)CD25(+) Treg is required for their in vivo expansion and suppressive capacity...
  31. ncbi request reprint TGF-beta as a T cell regulator in colitis and colon cancer
    Christoph Becker
    Laboratory of Clinical Immunology, I Department of Medicine, University of Mainz, Obere Zahlbacher Str 63, 55131 Mainz, Germany
    Cytokine Growth Factor Rev 17:97-106. 2006
    ..TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25- cells...
  32. ncbi request reprint Mucosal immunoregulation: transcription factors as possible therapeutic targets
    Aysefa Doganci
    Laboratory of Cellular and Molecular Lung Immunology and and Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Curr Drug Targets Inflamm Allergy 4:565-75. 2005
    ..g. allergic asthma) and chronic intestinal inflammation (e.g. inflammatory bowel diseases (IBD)) such as the control of the expression of transcription factors to redirect pathological immune responses...
  33. doi request reprint Significant differences between Crohn's disease and ulcerative colitis regarding the impact of body mass index and initial disease activity on responsiveness to azathioprine: results from a European multicenter study in 1,176 patients
    Martin H Holtmann
    1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 55:1066-78. 2010
    ..This observation may support data favouring a "hit hard and early" regime in CD. Finally, we were able to demonstrate a decrease in the incidence of CD-related complications requiring surgery through treatment with AZA...
  34. doi request reprint Confocal laser endomicroscopy for gastrointestinal diseases
    Ralf Kiesslich
    First Department of Internal Medicine, Klinik und Poliklinik, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Gastrointest Endosc Clin N Am 18:451-66, viii. 2008
    ..Molecular imaging is becoming feasible, which will enable new indications in gastrointestinal endoscopy. This article reviews the current and rapidly expanding clinical data on endomicroscopy and gives a look into future research...
  35. ncbi request reprint Cytokines in colitis associated cancer: potential drug targets?
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Allergy Drug Targets 7:187-94. 2008
    ..However, as already shown in IBD, cytokines may also provide promising therapeutic targets in CAC...
  36. ncbi request reprint Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors
    Christoph Becker
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Germany
    Inflamm Bowel Dis 11:755-64. 2005
    ..This review focuses on these novel cytokines and their role in cell-mediated immune responses and discusses differences and common features within the family of IL-12-related cytokines...
  37. ncbi request reprint Technology insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancer
    Ralf Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Nat Clin Pract Oncol 4:480-90. 2007
    ..Taken together, CLE has led colorectal cancer endoscopy into a new era. CLE can no longer be regarded as just another endoscopic technique, but emerges as a crucial novel imaging technique for in vivo diagnosis of colorectal cancer...
  38. ncbi request reprint A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis
    Jonas Mudter
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pathobiology 70:170-6. 2002
    ....
  39. ncbi request reprint A genetic basis for IFN-gamma production and T-bet expression in humans
    Thomas Höhler
    Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
    J Immunol 175:5457-62. 2005
    ..This concept is highlighted by the recent finding that inactivation of the T-bet gene in mice results in development of clinical hallmark features of asthma...
  40. doi request reprint Colitis-associated cancer: the role of T cells in tumor development
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Semin Immunopathol 31:249-56. 2009
    ..This review discusses the role of the adaptive immune response and especially T cells in the pathogenesis CAC and possible implications for the therapeutic applications...
  41. ncbi request reprint Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major
    Sabine Zahn
    Department of Dermatology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Eur J Immunol 35:1106-12. 2005
    ..In conclusion, our data show that DC-derived IL-27 is critical for the timely initiation of efficient anti-parasite Th1 immunity early in infections...
  42. doi request reprint Novel cytokine-targeted therapies and intestinal inflammation
    Maximilian J Waldner
    I Department of Medicine, University of Erlangen, Erlangen, Germany
    Curr Opin Pharmacol 9:702-7. 2009
    ....
  43. ncbi request reprint Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patients
    Martin H Holtmann
    First Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 51:1516-24. 2006
    ..In all other CD patients and for UC patients in general, continuation seems beneficial. These results support a novel differential algorithm for long-term azathioprine therapy in IBD...
  44. ncbi request reprint 18F-Fluorodeoxyglucose positron-emission tomography (PET) can be used to assess inflammation non-invasively in Crohn's disease
    Martin H Holtmann
    1st Department of Medicine, Johannes Gutenberg University, 55131 Mainz, Langenbeckstrasse 1, Mainz, Germany
    Dig Dis Sci 57:2658-68. 2012
    ..Differential therapy requires repeated diagnostic assessment for mapping and monitoring of disease activity in Crohn's disease (CD)...
  45. ncbi request reprint Mouse models of inflammatory bowel disease
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Adv Drug Deliv Rev 59:1073-83. 2007
    ..In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD...
  46. ncbi request reprint Endoscopic surveillance in ulcerative colitis: smart biopsies do it better
    Ralf Kiesslich
    Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 133:742-5. 2007
  47. ncbi request reprint Confocal laser endomicroscopy
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
    Gastrointest Endosc Clin N Am 15:715-31. 2005
    ..This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy...
  48. ncbi request reprint Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    Massimo C Fantini
    Laboratory of Immunology, I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Immunol 172:5149-53. 2004
    ..In summary, we demonstrate that TGF-beta induces a regulatory phenotype in CD4(+)CD25(-) T cells through the induction of Foxp3 and a positive autoregulatory loop of TGF-beta signaling due to the absence of Smad7...
  49. ncbi request reprint Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication
    Jurgen Siebler
    Labor für Klinische Immunologie I, I Medizinische Klinik, University of Mainz, Mainz, Germany
    Eur J Gastroenterol Hepatol 18:167-74. 2006
    ..We analysed whether the overexpression of STAT-1 protein enhances the biological interferon response and whether it elicits antiviral activity against HBV in vitro...
  50. pmc Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    Christoph Becker
    Laboratory of Immunology I, Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 112:693-706. 2003
    ....
  51. ncbi request reprint Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy
    Ralf Kiesslich
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastroenterology 133:1769-78. 2007
    ..The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding...
  52. pmc CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
    Imke Tiede
    Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Clin Invest 111:1133-45. 2003
    ..These findings explain the immunosuppressive effects of azathioprine and suggest that 6-Thio-GTP derivates may be useful as potent immunosuppressive agents in autoimmune diseases and organ transplantation...
  53. ncbi request reprint An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Protoc 2:1998-2004. 2007
    ..Different scoring systems including number of tumors and tumor size identify factors promoting or inhibiting tumor initiation and/or tumor progression, respectively...
  54. doi request reprint Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies
    Imke Atreya
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Expert Rev Anticancer Ther 8:561-72. 2008
    ..Considering the clinical impact of this increased insight into tumor-associated immunology, resulting innovative approaches in the treatment of colorectal cancer are summarized and discussed immunotherapeutic critically...
  55. ncbi request reprint Gene therapy using IL 12 family members in infection, auto immunity, and cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Curr Gene Ther 9:239-47. 2009
    ..In this review, we discuss therapeutic strategies using IL-12 family members in infection, autoimmunity, and cancer with special focus on gene administration...
  56. ncbi request reprint Exacerbation of ulcerative colitis after rituximab salvage therapy
    Martin Goetz
    I Medical Clinic, University of Mainz, Germany
    Inflamm Bowel Dis 13:1365-8. 2007
    ..Here we report on a patient with intractable UC who suffered from a severe exacerbation of UC after salvage therapy with rituximab, a B-cell-depleting anti-CD20-antibody...
  57. doi request reprint Chemically induced mouse models of colitis
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Curr Protoc Pharmacol . 2009
    ..Detailed in this unit is a description of the most commonly used chemically induced mouse models of IBD. These include trinitrobenzene sulfonic acid (TNBS), oxazolone, and acute or chronic dextran sodium sulfate (DSS) colitis models...
  58. ncbi request reprint 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease
    Markus F Neurath
    Medical Clinic, University of Mainz, Mainz, Germany
    Clin Gastroenterol Hepatol 3:1007-14. 2005
    ..In this study we assessed the impact of TGTP levels for monitoring of azathioprine therapy...
  59. ncbi request reprint Chemically induced mouse models of intestinal inflammation
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Nat Protoc 2:541-6. 2007
    ..The procedures for the hapten models of colitis and acute DSS colitis can be accomplished in about 2 weeks but the protocol for chronic DSS colitis takes about 2 months...
  60. pmc New therapies for sepsis: focus on the interleukin (IL)12 family member IL27
    Markus F Neurath
    Laboratory of Immunology, 1st Department of Internal Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Ann Rheum Dis 66:iii29-31. 2007
    ..These findings indicate that IL27 is an important negative regulator of innate immune cells in septic peritonitis. Blockade of IL27 function could be an interesting novel approach for the treatment of patients with sepsis...
  61. doi request reprint Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages
    Raja Atreya
    Department of Medicine 1, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Gastroenterology 141:2026-38. 2011
    ..Here, we assessed the effects of anti-TNF antibodies on apoptosis in inflammatory bowel disease (IBD)...
  62. doi request reprint Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implications
    Imke Atreya
    Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Expert Rev Gastroenterol Hepatol 2:23-34. 2008
    ..This article aims to summarize traditional and current concepts of azathioprine-mediated effects and endeavors to discuss the resulting clinical implications...
  63. doi request reprint Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells
    Christian Becker
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Blood 114:1263-9. 2009
    ..Our findings demonstrate that stimulation via the CD4 receptor represents a T-cell receptor-independent Treg activating pathway with potential to induce immunologic tolerance in vivo...
  64. ncbi request reprint Chromoendoscopy and magnifying endoscopy in patients with gastroesophageal reflux disease. Useful or negligible?
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Dig Dis 22:142-7. 2004
    ..However, these techniques have significant potential to improve diagnostic accuracy in patients with Barrett's esophagus...
  65. ncbi request reprint Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo
    Martin H Holtmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 32:3142-51. 2002
    ..Taken together with the increased expression of TNF-R2 in CD, selective targeting of TNF-R2 signaling thus emerges as a potentially novel approach to the treatment of CD...
  66. ncbi request reprint Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 124:880-8. 2003
    ..We performed a randomized, controlled trial to test whether chromoendoscopy (CE) might facilitate early detection of IN and CRC in UC...
  67. ncbi request reprint Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?
    Markus F Neurath
    I Medical Clinic and Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    Nat Clin Pract Gastroenterol Hepatol 6:134-5. 2009
    ....
  68. ncbi request reprint Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance
    Jonas Mudter
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Inflamm Bowel Dis 13:1016-23. 2007
    ..This review highlights the role of IL-6 in IBD immunopathogenesis and its clinical relevance in IBD therapy and diagnostics...
  69. ncbi request reprint T-bet as a possible therapeutic target in autoimmune disease
    Benno Weigmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Expert Opin Ther Targets 6:619-22. 2002
    ..Here, the authors summarise recent observations of the role of T-bet in controlling chronic inflammatory and autoimmune diseases and discuss the implications of these findings for future therapeutic approaches...
  70. ncbi request reprint [The Inflammatory Bowel Disease Stress Inventory (IBD-SI). A measure of psychosocial stress in patients with IBD]
    Frank Petrak
    Klinik und Poliklinik fur Psychosomatische Medizin und Psychotherapie, Johannes Gutenberg Universitat, Mainz, Germany
    Psychother Psychosom Med Psychol 52:436-43. 2002
    ..76 - 0.89) and a high retest reliability (r = 0.75 - 0.92). Significant correlations with medical and psychological variables supports the external validity of this questionnaire...
  71. ncbi request reprint The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders
    Martin H Holtmann
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Arch Immunol Ther Exp (Warsz) 50:279-88. 2002
    ..This will lead to a better understanding of the pathogenesis of these diseases and potentially reveal new, more specific therapeutic targets...
  72. ncbi request reprint Confocal laser endoscopy: new approach to the early diagnosis of tumors of the esophagus and stomach
    Martin Goetz
    Johannes Gutenberg University Mainz, I Med Clinic, Langenbeckstr1, 55131 Mainz, Germany
    Future Oncol 2:469-76. 2006
    ..Based on recent experiences from animal models, future studies will approach in vivo molecular imaging of human cancer...
  73. ncbi request reprint Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue
    Benno Weigmann
    I Med Clinic, Immunological Laboratory, Johannes Gutenberg University, Obere Zahlbacherstrasse 63, 55131 Mainz, Germany
    Nat Protoc 2:2307-11. 2007
    ..Finally, the isolated cells can be used for further investigations like comparative studies of mRNA expression, cell-proliferation assay or protein analysis. This protocol can be completed within 6-7 h...
  74. ncbi request reprint In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    J Hepatol 48:91-7. 2008
    ..Therefore a newly developed miniaturised confocal probe was evaluated for in vivo microscopic imaging in rodent models of human liver diseases...
  75. ncbi request reprint Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo
    Ralf Kiesslich
    First Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 127:706-13. 2004
    ..The aim of the present study was to assess its potential for prediction of histology during screening colonoscopy for colorectal cancer...
  76. ncbi request reprint Mucosal immunity in Crohn's disease
    Markus F Neurath
    Laboratory of Immunology I, Department of Medicine University of Mainz, Langenbeckstrasse 1 55101 Mainz, Germany
    Inflamm Bowel Dis 10:S29-31. 2004
  77. ncbi request reprint In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy
    Martin Goetz
    I Medical Clinic, Johannes Gutenberg Universitat, Mainz 55131, Germany
    World J Gastroenterol 13:2160-5. 2007
    ..To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents...
  78. ncbi request reprint Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
    ..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...
  79. ncbi request reprint In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
    ..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia...
  80. ncbi request reprint Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function
    Atsushi Nakajima
    Gastroenterology Division, Departments of Medicine and Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1028-35. 2002
    ..These studies support a role for CEACAM1 as a novel class of immunoreceptor tyrosine-based inhibition motif-bearing regulatory molecules on T cells that are active during early phases of the immune response in mice...
  81. ncbi request reprint Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    Ivan J Fuss
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Inflamm Bowel Dis 12:9-15. 2006
    ..These molecules contain an identical p40 chain that is bound to a p35 chain in IL-12 and a p19 chain in IL-23, making both potentially susceptible to modulation by an anti-IL-12p40 monoclonal antibody (mAb)...
  82. ncbi request reprint A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract
    Adrian L Polglase
    Cabrini Monash University Department of Surgery, Cabrini Medical Centre, Malvern, Victoria, Australia
    Gastrointest Endosc 62:686-95. 2005
    ..The work assessed the feasibility of performing in vivo microscopy at endoscopic examination and evaluated fluorescence imaging protocols...
  83. ncbi request reprint An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells
    Andrea J Gerth
    Department of Internal Medicine Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gastroenterology 126:1115-21. 2004
    ..We describe here a specific role for nuclear factor of activated T cells c2 in the pathogenesis of murine inflammatory bowel disease...
  84. pmc Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
    Edward E S Nieuwenhuis
    Gastroenterology Division and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:16951-6. 2002
    ..Thus, EBI3 plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function...
  85. ncbi request reprint Chromo- and magnifying endoscopy for colorectal lesions
    Ralf Kiesslich
    Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    Eur J Gastroenterol Hepatol 17:793-801. 2005
    ..This review summarizes the value of magnifying endoscopy in the lower gastrointestinal tract and focuses on colorectal lesions...
  86. ncbi request reprint Diagnosing Helicobacter pylori in vivo by confocal laser endoscopy
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 128:2119-23. 2005
    ..Confocal laser endomicroscopy enables subsurface microscopic imaging of living tissue during ongoing endoscopy. This case report describes the in vivo detection of Helicobacter pylori by endomicroscopy...
  87. ncbi request reprint Anti-TNF strategies in stenosing and fistulizing Crohn's disease
    Martin H Holtmann
    First Department of Medicine, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Int J Colorectal Dis 20:1-8. 2005
    ..The availability of novel, anti-TNF strategies for therapy has raised the question as to what extent these new treatment options have impact on the clinical decision-making process regarding the necessity for surgery...
  88. ncbi request reprint IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells
    Massimo C Fantini
    Division of Gastroenterology, University of Rome Tor Vergata, Rome, Italy
    Eur J Immunol 37:3155-63. 2007
    ..Therefore, IL-21 emerges as a key modulator of TGF-beta signaling, leading to the reciprocal differentiation of T(reg) and Th17 cells...
  89. ncbi request reprint Inflammatory bowel disorders: gene therapy solutions
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Curr Opin Mol Ther 5:495-502. 2003
    ..Future studies analyzing the effects of cytokine-targeted gene therapy in patients are eagerly awaited...
  90. pmc The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis
    Benno Weigmann
    Institute of Molecular Medicine, Johanes Gutenberg Univeristy, 55131 Mainz, Germany
    J Exp Med 205:2099-110. 2008
    ..NFATc2 in T cells thus emerges as a potentially new therapeutic target for inflammatory bowel diseases...
  91. pmc Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1
    Hideki Iijima
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Exp Med 199:471-82. 2004
    ....
  92. ncbi request reprint Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 132:874-82. 2007
    ..In this study we assessed the value of combined chromoscopy and endomicroscopy for the diagnosis of intraepithelial neoplasias in a randomized controlled trial...