Research Topics
Genomes and Genes
| Markus F NeurathSummaryAffiliation: University of Mainz Country: Germany Publications
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Detail Information
Publications
The role of Th1/Th2 polarization in mucosal immunityMarkus F Neurath
Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
Nat Med 8:567-73. 2002..Mucosal immunity relies on the delicate balance between antigen responsiveness and tolerance. The polarization of T helper cells plays a key role in maintaining or disrupting this equilibrium...- Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthmaMichael Hausding
Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Eur J Immunol 37:1663-77. 2007..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma... 
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6Jonas Mudter
1st Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 118:2415-26. 2008..Taken together, our data identify IRF4 as a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for IBDs...- Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cellsSabine Dominitzki
Laboratory of Immunology, Medical Clinic I, University of Mainz, Mainz, Germany
J Immunol 179:2041-5. 2007.... 
Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancerMaximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Inflamm Bowel Dis 16:559-67. 2010..In the present study we aimed at assessing the role of perforin-dependent effector mechanisms in the immune response in a murine model of colitis-associated colon cancer...- Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cellsSusetta Finotto
Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
Int Immunol 19:685-93. 2007..Local targeting of IL-6R signaling could be a novel approach for inducing Th2 T cell death in allergic airways via regulatory T cells... - IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-betJuergen Siebler
Laboratory of Immunology, I Medical Clinic, University of Mainz, Lasngenbeckstrasse 1, 55131 Mainz, Germany
Gastroenterology 132:358-71. 2007..T-cell-mediated fulminant hepatitis is a potentially life-threatening event for which the underlying pathogenic mechanisms are not fully understood. Here, we demonstrate a key regulatory role of IL-28A in T-cell-mediated hepatitis... - Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulatorJonas Mudter
First Medical Clinic, Johannes-Gutenberg-University, Mainz, Germany
Dig Dis Sci 51:711-7. 2006 - IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivoAysefa Doganci
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 181:1917-26. 2008..These findings provide novel insights into the functional role of IL-2 signaling in experimental asthma and suggest that blockade of the IL-2R beta-chain might be useful for therapy of allergic asthma in humans... - A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytesJoachim H Maxeiner
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
Cancer Res 69:3069-76. 2009.... - In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptorMartin Goetz
I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
Gastroenterology 138:435-46. 2010..Confocal laser endomicroscopy (CLE) enables accurate microscopic visualization of CRC in patients during endoscopy. We evaluated the ability to use CLE in vivo for instantaneous molecular imaging of EGFR in CRC models... - Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopySebastian Foersch
Medical Clinic I, University of Mainz, Mainz, Germany
Gut 59:1046-55. 2010..The aim of the study was to evaluate CLE for in vivo molecular imaging of VEGF in GiC... - TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signalingChristoph Becker
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Immunity 21:491-501. 2004..Taken together, our data provide novel insights into TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-beta-dependent IL-6 trans-signaling... - Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitisJuergen Siebler
First Department of Medicine, University of Mainz, Mainz, Germany
J Immunol 180:30-3. 2008..Taken together, these data demonstrate a key pathogenic role of IL-27 in T cell-mediated liver injury. Furthermore, in vivo blockade of IL-27 emerges as a novel potential therapy for T cell-mediated hepatitis... - Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violetMartin Goetz
I Medical Clinic, University of Mainz, Mainz, Germany
Gastrointest Endosc 70:959-68. 2009..Usually fluorescein then serves as a contrast agent for CLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects... - The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivoAysefa Doganci
Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 115:313-25. 2005..Furthermore, inhibition of IL-6 signaling emerges as a novel molecular approach for the treatment of allergic asthma... - Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteinsDaniela Poppe
Laboratory of Immunology, I. Department of Medicine, University of Mainz, Mainz, Germany
J Immunol 176:640-51. 2006..These findings provide novel insights into the immunosuppressive effects of azathioprine and suggest that antagonists of the Vav-Rac signaling pathway may be useful for suppression of T cell-dependent pathogenic immune responses... - Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27Stefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
J Exp Med 203:1875-81. 2006..Collectively, these data identify IL-27 as a key negative regulator of innate immune cell function in septic peritonitis. Furthermore, in vivo blockade of IL-27 is a novel potential therapeutic target for treatment of sepsis... - Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitisChristoph Becker
Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 177:2760-4. 2006..Taken together, our data identify cross-regulation of IL-12 expression by IL-23 as novel key regulatory pathway during initiation of T cell dependent colitis... - IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1Clemens Neufert
Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
Eur J Immunol 37:1809-16. 2007..Our data thus demonstrate that IL-27 controls the development of Th17 and iTreg cells via differential effects on STAT1... - The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancerImke Atreya
I Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Gut 56:1572-8. 2007..These data provide novel insights into control mechanisms governing the functional activity of human CD8 T lymphocytes via T-box transcription factors in cancer... - Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNAStefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, Mainz, Germany
J Immunol 168:411-20. 2002.... - Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritisKai M Hildner
Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, Mainz, Germany
J Immunol 178:3427-36. 2007..These data suggest a key regulatory role of STAT4 in the pathogenesis and manifestation of murine collagen-induced arthritis. Furthermore, the targeting of STAT4 emerges as a novel approach to therapy for chronic arthritis... - RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17FMoritz Leppkes
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Gastroenterology 136:257-67. 2009..We analyzed the roles of Th17 cells and the transcription factor retinoic acid receptor-related organ receptor (ROR)gamma, which regulates Th17 differentiation, in chronic intestinal inflammation... - EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activationStefan Wirtz
Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 174:2814-24. 2005..Thus, EBI3 gene transcription in DCs is induced rapidly by TLR signaling during innate immune responses preceding cytokine driven Th cell development... - A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver inflammationJurgen Siebler
Labor für Klinische Immunologie I, I Medizinische Klinik, Johannes Gutenberg Universitat, Mainz, Germany
Hepatology 38:1573-80. 2003..In conclusion, these findings suggest a key pathogenic role for the STAT1/T-bet signaling pathway for T-cell activation in the Con A model of T-cell-mediated liver pathology... - Enhanced sensitivity to CD95-induced apoptosis in ob/ob miceJuergen Siebler
Department of Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
Dig Dis Sci 52:2396-402. 2007..CD95 expression was similar in ob/ob and control mice. However, hepatocytes from ob/ob mice revealed a decreased mitochondrial membrane potential, suggesting that mitochondria play a potential role in this increased susceptibility... - A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitisBenno Weigmann
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Germany
J Immunol 173:3446-55. 2004..Targeting of c-Maf in memory T cells in CD appears to be an attractive target for therapeutic interventions... - Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depthMartin Goetz
I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
J Hepatol 53:84-90. 2010..The aim of the current study was to evaluate a novel near-infrared (NIR) light probe with indocyanine green (ICG) contrast for in vivo confocal imaging of the human liver during mini-laparoscopy... - Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cellsSamuel Huber
I. Medizinische Klinik, , Mainz, Germany
J Immunol 173:6526-31. 2004..These data indicate that TGF-beta signaling in CD4(+)CD25(+) Treg is required for their in vivo expansion and suppressive capacity... - TGF-beta as a T cell regulator in colitis and colon cancerChristoph Becker
Laboratory of Clinical Immunology, I Department of Medicine, University of Mainz, Obere Zahlbacher Str 63, 55131 Mainz, Germany
Cytokine Growth Factor Rev 17:97-106. 2006..TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25- cells... - Mucosal immunoregulation: transcription factors as possible therapeutic targetsAysefa Doganci
Laboratory of Cellular and Molecular Lung Immunology and and Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Curr Drug Targets Inflamm Allergy 4:565-75. 2005..g. allergic asthma) and chronic intestinal inflammation (e.g. inflammatory bowel diseases (IBD)) such as the control of the expression of transcription factors to redirect pathological immune responses... - Significant differences between Crohn's disease and ulcerative colitis regarding the impact of body mass index and initial disease activity on responsiveness to azathioprine: results from a European multicenter study in 1,176 patientsMartin H Holtmann
1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Dig Dis Sci 55:1066-78. 2010..This observation may support data favouring a "hit hard and early" regime in CD. Finally, we were able to demonstrate a decrease in the incidence of CD-related complications requiring surgery through treatment with AZA... - Confocal laser endomicroscopy for gastrointestinal diseasesRalf Kiesslich
First Department of Internal Medicine, Klinik und Poliklinik, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
Gastrointest Endosc Clin N Am 18:451-66, viii. 2008..Molecular imaging is becoming feasible, which will enable new indications in gastrointestinal endoscopy. This article reviews the current and rapidly expanding clinical data on endomicroscopy and gives a look into future research... - Cytokines in colitis associated cancer: potential drug targets?Maximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Inflamm Allergy Drug Targets 7:187-94. 2008..However, as already shown in IBD, cytokines may also provide promising therapeutic targets in CAC... - Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptorsChristoph Becker
Laboratory of Immunology, I. Department of Medicine, University of Mainz, Germany
Inflamm Bowel Dis 11:755-64. 2005..This review focuses on these novel cytokines and their role in cell-mediated immune responses and discusses differences and common features within the family of IL-12-related cytokines... - Technology insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancerRalf Kiesslich
I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
Nat Clin Pract Oncol 4:480-90. 2007..Taken together, CLE has led colorectal cancer endoscopy into a new era. CLE can no longer be regarded as just another endoscopic technique, but emerges as a crucial novel imaging technique for in vivo diagnosis of colorectal cancer... - A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosisJonas Mudter
1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Pathobiology 70:170-6. 2002.... - A genetic basis for IFN-gamma production and T-bet expression in humansThomas Höhler
Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
J Immunol 175:5457-62. 2005..This concept is highlighted by the recent finding that inactivation of the T-bet gene in mice results in development of clinical hallmark features of asthma... - Colitis-associated cancer: the role of T cells in tumor developmentMaximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Semin Immunopathol 31:249-56. 2009..This review discusses the role of the adaptive immune response and especially T cells in the pathogenesis CAC and possible implications for the therapeutic applications... - Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania majorSabine Zahn
Department of Dermatology, Johannes Gutenberg University of Mainz, Mainz, Germany
Eur J Immunol 35:1106-12. 2005..In conclusion, our data show that DC-derived IL-27 is critical for the timely initiation of efficient anti-parasite Th1 immunity early in infections... - Novel cytokine-targeted therapies and intestinal inflammationMaximilian J Waldner
I Department of Medicine, University of Erlangen, Erlangen, Germany
Curr Opin Pharmacol 9:702-7. 2009.... - Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patientsMartin H Holtmann
First Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Dig Dis Sci 51:1516-24. 2006..In all other CD patients and for UC patients in general, continuation seems beneficial. These results support a novel differential algorithm for long-term azathioprine therapy in IBD... - 18F-Fluorodeoxyglucose positron-emission tomography (PET) can be used to assess inflammation non-invasively in Crohn's diseaseMartin H Holtmann
1st Department of Medicine, Johannes Gutenberg University, 55131 Mainz, Langenbeckstrasse 1, Mainz, Germany
Dig Dis Sci 57:2658-68. 2012..Differential therapy requires repeated diagnostic assessment for mapping and monitoring of disease activity in Crohn's disease (CD)... - Mouse models of inflammatory bowel diseaseStefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
Adv Drug Deliv Rev 59:1073-83. 2007..In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD... - Endoscopic surveillance in ulcerative colitis: smart biopsies do it betterRalf Kiesslich
Johannes Gutenberg University of Mainz, Mainz, Germany
Gastroenterology 133:742-5. 2007 - Confocal laser endomicroscopyRalf Kiesslich
1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
Gastrointest Endosc Clin N Am 15:715-31. 2005..This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy... - Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7Massimo C Fantini
Laboratory of Immunology, I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
J Immunol 172:5149-53. 2004..In summary, we demonstrate that TGF-beta induces a regulatory phenotype in CD4(+)CD25(-) T cells through the induction of Foxp3 and a positive autoregulatory loop of TGF-beta signaling due to the absence of Smad7... - Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replicationJurgen Siebler
Labor für Klinische Immunologie I, I Medizinische Klinik, University of Mainz, Mainz, Germany
Eur J Gastroenterol Hepatol 18:167-74. 2006..We analysed whether the overexpression of STAT-1 protein enhances the biological interferon response and whether it elicits antiviral activity against HBV in vitro... - Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cellsChristoph Becker
Laboratory of Immunology I, Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 112:693-706. 2003.... - Identification of epithelial gaps in human small and large intestine by confocal endomicroscopyRalf Kiesslich
I Medical Clinic, University of Mainz, Mainz, Germany
Gastroenterology 133:1769-78. 2007..The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding... - CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytesImke Tiede
Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
J Clin Invest 111:1133-45. 2003..These findings explain the immunosuppressive effects of azathioprine and suggest that 6-Thio-GTP derivates may be useful as potent immunosuppressive agents in autoimmune diseases and organ transplantation... - An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progressionClemens Neufert
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
Nat Protoc 2:1998-2004. 2007..Different scoring systems including number of tumors and tumor size identify factors promoting or inhibiting tumor initiation and/or tumor progression, respectively... - Immune cells in colorectal cancer: prognostic relevance and therapeutic strategiesImke Atreya
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Expert Rev Anticancer Ther 8:561-72. 2008..Considering the clinical impact of this increased insight into tumor-associated immunology, resulting innovative approaches in the treatment of colorectal cancer are summarized and discussed immunotherapeutic critically... - Gene therapy using IL 12 family members in infection, auto immunity, and cancerMaximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Curr Gene Ther 9:239-47. 2009..In this review, we discuss therapeutic strategies using IL-12 family members in infection, autoimmunity, and cancer with special focus on gene administration... - Exacerbation of ulcerative colitis after rituximab salvage therapyMartin Goetz
I Medical Clinic, University of Mainz, Germany
Inflamm Bowel Dis 13:1365-8. 2007..Here we report on a patient with intractable UC who suffered from a severe exacerbation of UC after salvage therapy with rituximab, a B-cell-depleting anti-CD20-antibody... - Chemically induced mouse models of colitisMaximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Curr Protoc Pharmacol . 2009..Detailed in this unit is a description of the most commonly used chemically induced mouse models of IBD. These include trinitrobenzene sulfonic acid (TNBS), oxazolone, and acute or chronic dextran sodium sulfate (DSS) colitis models... - 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's diseaseMarkus F Neurath
Medical Clinic, University of Mainz, Mainz, Germany
Clin Gastroenterol Hepatol 3:1007-14. 2005..In this study we assessed the impact of TGTP levels for monitoring of azathioprine therapy... - Chemically induced mouse models of intestinal inflammationStefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
Nat Protoc 2:541-6. 2007..The procedures for the hapten models of colitis and acute DSS colitis can be accomplished in about 2 weeks but the protocol for chronic DSS colitis takes about 2 months... - New therapies for sepsis: focus on the interleukin (IL)12 family member IL27Markus F Neurath
Laboratory of Immunology, 1st Department of Internal Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
Ann Rheum Dis 66:iii29-31. 2007..These findings indicate that IL27 is an important negative regulator of innate immune cells in septic peritonitis. Blockade of IL27 function could be an interesting novel approach for the treatment of patients with sepsis... - Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophagesRaja Atreya
Department of Medicine 1, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
Gastroenterology 141:2026-38. 2011..Here, we assessed the effects of anti-TNF antibodies on apoptosis in inflammatory bowel disease (IBD)... - Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implicationsImke Atreya
Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Expert Rev Gastroenterol Hepatol 2:23-34. 2008..This article aims to summarize traditional and current concepts of azathioprine-mediated effects and endeavors to discuss the resulting clinical implications... - Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cellsChristian Becker
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Blood 114:1263-9. 2009..Our findings demonstrate that stimulation via the CD4 receptor represents a T-cell receptor-independent Treg activating pathway with potential to induce immunologic tolerance in vivo... - Chromoendoscopy and magnifying endoscopy in patients with gastroesophageal reflux disease. Useful or negligible?Ralf Kiesslich
1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Dig Dis 22:142-7. 2004..However, these techniques have significant potential to improve diagnostic accuracy in patients with Barrett's esophagus... - Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivoMartin H Holtmann
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Mainz, Germany
Eur J Immunol 32:3142-51. 2002..Taken together with the increased expression of TNF-R2 in CD, selective targeting of TNF-R2 signaling thus emerges as a potentially novel approach to the treatment of CD... - Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitisRalf Kiesslich
I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Gastroenterology 124:880-8. 2003..We performed a randomized, controlled trial to test whether chromoendoscopy (CE) might facilitate early detection of IN and CRC in UC... - Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?Markus F Neurath
I Medical Clinic and Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
Nat Clin Pract Gastroenterol Hepatol 6:134-5. 2009.... - Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevanceJonas Mudter
1st Medical Clinic, Johannes Gutenberg University of Mainz, Germany
Inflamm Bowel Dis 13:1016-23. 2007..This review highlights the role of IL-6 in IBD immunopathogenesis and its clinical relevance in IBD therapy and diagnostics... - T-bet as a possible therapeutic target in autoimmune diseaseBenno Weigmann
Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Expert Opin Ther Targets 6:619-22. 2002..Here, the authors summarise recent observations of the role of T-bet in controlling chronic inflammatory and autoimmune diseases and discuss the implications of these findings for future therapeutic approaches... - [The Inflammatory Bowel Disease Stress Inventory (IBD-SI). A measure of psychosocial stress in patients with IBD]Frank Petrak
Klinik und Poliklinik fur Psychosomatische Medizin und Psychotherapie, Johannes Gutenberg Universitat, Mainz, Germany
Psychother Psychosom Med Psychol 52:436-43. 2002..76 - 0.89) and a high retest reliability (r = 0.75 - 0.92). Significant correlations with medical and psychological variables supports the external validity of this questionnaire... - The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disordersMartin H Holtmann
Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Arch Immunol Ther Exp (Warsz) 50:279-88. 2002..This will lead to a better understanding of the pathogenesis of these diseases and potentially reveal new, more specific therapeutic targets... - Confocal laser endoscopy: new approach to the early diagnosis of tumors of the esophagus and stomachMartin Goetz
Johannes Gutenberg University Mainz, I Med Clinic, Langenbeckstr1, 55131 Mainz, Germany
Future Oncol 2:469-76. 2006..Based on recent experiences from animal models, future studies will approach in vivo molecular imaging of human cancer... - Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissueBenno Weigmann
I Med Clinic, Immunological Laboratory, Johannes Gutenberg University, Obere Zahlbacherstrasse 63, 55131 Mainz, Germany
Nat Protoc 2:2307-11. 2007..Finally, the isolated cells can be used for further investigations like comparative studies of mRNA expression, cell-proliferation assay or protein analysis. This protocol can be completed within 6-7 h... - In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver diseaseMartin Goetz
I Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
J Hepatol 48:91-7. 2008..Therefore a newly developed miniaturised confocal probe was evaluated for in vivo microscopic imaging in rodent models of human liver diseases... - Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivoRalf Kiesslich
First Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Gastroenterology 127:706-13. 2004..The aim of the present study was to assess its potential for prediction of histology during screening colonoscopy for colorectal cancer... - Mucosal immunity in Crohn's diseaseMarkus F Neurath
Laboratory of Immunology I, Department of Medicine University of Mainz, Langenbeckstrasse 1 55101 Mainz, Germany
Inflamm Bowel Dis 10:S29-31. 2004 - In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopyMartin Goetz
I Medical Clinic, Johannes Gutenberg Universitat, Mainz 55131, Germany
World J Gastroenterol 13:2160-5. 2007..To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents... - Development of spontaneous airway changes consistent with human asthma in mice lacking T-betSusetta Finotto
Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 295:336-8. 2002..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma... - In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopyRalf Kiesslich
Medical Clinic, Johannes Gutenberg University Mainz, Germany
Clin Gastroenterol Hepatol 4:979-87. 2006..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia... - Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte functionAtsushi Nakajima
Gastroenterology Division, Departments of Medicine and Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:1028-35. 2002..These studies support a role for CEACAM1 as a novel class of immunoreceptor tyrosine-based inhibition motif-bearing regulatory molecules on T cells that are active during early phases of the immune response in mice... - Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibodyIvan J Fuss
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Inflamm Bowel Dis 12:9-15. 2006..These molecules contain an identical p40 chain that is bound to a p35 chain in IL-12 and a p19 chain in IL-23, making both potentially susceptible to modulation by an anti-IL-12p40 monoclonal antibody (mAb)... - A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tractAdrian L Polglase
Cabrini Monash University Department of Surgery, Cabrini Medical Centre, Malvern, Victoria, Australia
Gastrointest Endosc 62:686-95. 2005..The results represent a major technical advance in the development of this new optical imaging modality for the in vivo examination of GI tissue... - An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cellsAndrea J Gerth
Department of Internal Medicine Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
Gastroenterology 126:1115-21. 2004..We describe here a specific role for nuclear factor of activated T cells c2 in the pathogenesis of murine inflammatory bowel disease... - Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient miceEdward E S Nieuwenhuis
Gastroenterology Division and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:16951-6. 2002..Thus, EBI3 plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function... - Chromo- and magnifying endoscopy for colorectal lesionsRalf Kiesslich
Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
Eur J Gastroenterol Hepatol 17:793-801. 2005..This review summarizes the value of magnifying endoscopy in the lower gastrointestinal tract and focuses on colorectal lesions... - Diagnosing Helicobacter pylori in vivo by confocal laser endoscopyRalf Kiesslich
I. Medical Clinic, Johannes Gutenberg University of Mainz, Germany
Gastroenterology 128:2119-23. 2005..CONCLUSIONS: Endomicroscopy is a new diagnostic approach, which enables the immediate diagnosis of Helicobacter pylori in vivo during standard video endoscopy... - Anti-TNF strategies in stenosing and fistulizing Crohn's diseaseMartin H Holtmann
First Department of Medicine, Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany
Int J Colorectal Dis 20:1-8. 2005..Prospective trials of medical therapy and a combination of medical and surgical therapy for complex fistulas and internal fistulas are needed to define the potential and the limitations of these novel therapeutic approaches... - IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cellsMassimo C Fantini
Division of Gastroenterology, University of Rome Tor Vergata, Rome, Italy
Eur J Immunol 37:3155-63. 2007..Therefore, IL-21 emerges as a key modulator of TGF-beta signaling, leading to the reciprocal differentiation of T(reg) and Th17 cells... - Inflammatory bowel disorders: gene therapy solutionsStefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Curr Opin Mol Ther 5:495-502. 2003..Future studies analyzing the effects of cytokine-targeted gene therapy in patients are eagerly awaited... - The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitisBenno Weigmann
Institute of Molecular Medicine, Johanes Gutenberg Univeristy, 55131 Mainz, Germany
J Exp Med 205:2099-110. 2008..NFATc2 in T cells thus emerges as a potentially new therapeutic target for inflammatory bowel diseases... - Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1Hideki Iijima
Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Exp Med 199:471-82. 2004.... - Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitisRalf Kiesslich
I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
Gastroenterology 132:874-82. 2007..In this study we assessed the value of combined chromoscopy and endomicroscopy for the diagnosis of intraepithelial neoplasias in a randomized controlled trial...