Markus F Neurath

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines
    Steffen Zopf
    Department of Medicine 1, University Hospital Erlangen, Ulmenweg 18, Erlangen, 91054, Germany
    BMC Cancer 12:386. 2012
  2. doi request reprint The emerging role of T cell cytokines in non-small cell lung cancer
    Markus F Neurath
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Cytokine Growth Factor Rev 23:315-22. 2012
  3. ncbi request reprint Mucosal healing in inflammatory bowel diseases: a systematic review
    Markus F Neurath
    Professor of Medicine, Department of Medicine I, University of Erlangen Nuremberg, Ulmenweg 18, Erlangen, Germany
    Gut 61:1619-35. 2012
  4. pmc Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases
    Emilia Licarete
    Department of Dermatology, University of Freiburg, Hauptstr, 7, Freiburg 79104, Germany
    BMC Immunol 13:16. 2012
  5. doi request reprint IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    Markus F Neurath
    1st Medical Clinic, University of Erlangen Nurnberg, Germany
    Cytokine Growth Factor Rev 22:83-9. 2011
  6. doi request reprint Translating inflammatory bowel disease research into clinical medicine
    Markus F Neurath
    Department of Medicine, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    Immunity 31:357-61. 2009
  7. pmc The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    Jonas Mudter
    1st Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 118:2415-26. 2008
  8. doi request reprint IRF4 selectively controls cytokine gene expression in chronic intestinal inflammation
    Jonas Mudter
    1st Medical Clinic, University of Erlangen Nurnberg, D 91054, Erlangen, Germany
    Arch Immunol Ther Exp (Warsz) 57:369-76. 2009
  9. doi request reprint The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons
    Matthias A Engel
    Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Universitätsstr 17, 91054 Erlangen, Germany
    J Gastroenterol 47:256-65. 2012
  10. pmc Confocal laser endomicroscopy for in vivo diagnosis of Clostridium difficile associated colitis - a pilot study
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 8:e58753. 2013

Detail Information

Publications81

  1. pmc Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines
    Steffen Zopf
    Department of Medicine 1, University Hospital Erlangen, Ulmenweg 18, Erlangen, 91054, Germany
    BMC Cancer 12:386. 2012
    ..Inhibitors of protein and histone deacetylases (DACi) have been demonstrated to possess strong anti-tumor effects in HCC models...
  2. doi request reprint The emerging role of T cell cytokines in non-small cell lung cancer
    Markus F Neurath
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Cytokine Growth Factor Rev 23:315-22. 2012
    ..As modulation of T cell cytokines such as IL-17A has been recently shown to suppress tumor growth in experimental models, anti-cytokine agents emerge as a promising new approach for treatment of lung cancer...
  3. ncbi request reprint Mucosal healing in inflammatory bowel diseases: a systematic review
    Markus F Neurath
    Professor of Medicine, Department of Medicine I, University of Erlangen Nuremberg, Ulmenweg 18, Erlangen, Germany
    Gut 61:1619-35. 2012
    ..Finally, the implications of mucosal healing for subsequent clinical management in patients with IBD are highlighted...
  4. pmc Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases
    Emilia Licarete
    Department of Dermatology, University of Freiburg, Hauptstr, 7, Freiburg 79104, Germany
    BMC Immunol 13:16. 2012
    ..The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors...
  5. doi request reprint IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    Markus F Neurath
    1st Medical Clinic, University of Erlangen Nurnberg, Germany
    Cytokine Growth Factor Rev 22:83-9. 2011
    ..In this review article, we discuss the latest findings on the role of IL-6 in experimental models of autoimmunity and cancer, as well as clinical perspectives...
  6. doi request reprint Translating inflammatory bowel disease research into clinical medicine
    Markus F Neurath
    Department of Medicine, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    Immunity 31:357-61. 2009
    ..It is expected that improved translational research will lead to optimized therapy and new individualized treatment options...
  7. pmc The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    Jonas Mudter
    1st Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 118:2415-26. 2008
    ..Taken together, our data identify IRF4 as a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for IBDs...
  8. doi request reprint IRF4 selectively controls cytokine gene expression in chronic intestinal inflammation
    Jonas Mudter
    1st Medical Clinic, University of Erlangen Nurnberg, D 91054, Erlangen, Germany
    Arch Immunol Ther Exp (Warsz) 57:369-76. 2009
    ..IRF4 therefore emerges as an attractive target for the therapy of chronic intestinal inflammation. Blocking IRF4 might be an interesting option to modulate inflammation in the advanced state of inflammation...
  9. doi request reprint The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons
    Matthias A Engel
    Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Universitätsstr 17, 91054 Erlangen, Germany
    J Gastroenterol 47:256-65. 2012
    ..We investigated whether innervation density and neuropeptide release were responsible for the proximodistal aggravation of murine dextran-sulfate-sodium-salt (DSS) colitis...
  10. pmc Confocal laser endomicroscopy for in vivo diagnosis of Clostridium difficile associated colitis - a pilot study
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 8:e58753. 2013
    ..difficile associated histological changes. Second objective was to prove the presence of intramucosal bacteria using CLE...
  11. doi request reprint Endocytoscopy allows accurate in vivo differentiation of mucosal inflammatory cells in IBD: a pilot study
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Inflamm Bowel Dis 19:356-62. 2013
    ..The aim of our study was to determine the reliability of EC for the discrimination of mucosal inflammatory cells and intestinal inflammatory disease activity in patients with IBD...
  12. pmc VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer
    Maximilian J Waldner
    Department of Medicine I, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    J Exp Med 207:2855-68. 2010
    ..Thus, VEGFR-signaling acts as a direct growth factor for tumor cells in CAC, providing a molecular link between inflammation and the development of colon cancer...
  13. doi request reprint IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo
    Jonas Mudter
    1st Medical Clinic, University of Erlangen, Germany
    Inflamm Bowel Dis 17:1343-58. 2011
    ..To elucidate the mechanisms for pathological cytokine production in colitis, we addressed the role of the IRF transcription factors in human inflammatory bowel disease (IBD) and experimental colitis...
  14. pmc Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK
    Clemens Neufert
    Medical Clinic 1, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Clin Invest 123:1428-43. 2013
    ..In conclusion, our data indicate that EREG and tumor-associated fibroblasts play a crucial role in controlling tumor growth in colitis-associated neoplasms...
  15. doi request reprint Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis
    Matthias A Engel
    Institute of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Dig Liver Dis 44:24-9. 2012
    ..SP levels increase whilst CGRP levels decrease in colon specimens from patients with inflammatory bowel disease; thus suggesting the pro- and anti-inflammatory roles, respectively, of these neuropeptides...
  16. doi request reprint Assessment of Crohn's disease activity by confocal laser endomicroscopy
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Inflamm Bowel Dis 18:2261-9. 2012
    ..However, there are no data on the utility of CLE for in vivo diagnosis of Crohn's disease (CD). The aim was to assess the clinical utility of CLE in patients with CD and to determine whether disease activity can be graded using CLE...
  17. pmc Granulomatous lung disease requiring mechanical ventilation induced by a single application of oxaliplatin-based chemotherapy for colorectal cancer: a case report
    Dane Wildner
    Department of Medicine 1, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
    Case Rep Oncol Med 2013:683948. 2013
    ..In addition to the known side effects of oxaliplatin-containing combination chemotherapy, unexpected serious adverse events in the form of pulmonary toxicities should also be taken into account...
  18. doi request reprint Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
    Tamar McHedlidze
    Medical Department 1, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Immunity 39:357-71. 2013
    ..Our data reveal key immunological networks implicated in hepatic fibrosis and support the concept of modulation of IL-33 bioactivity for therapeutic purposes. ..
  19. pmc In vivo detection of mucosal healing-involved histiocytes by confocal laser endomicroscopy
    Gheorghe Hundorfean
    Medical ClinicI, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    World J Gastroenterol 18:4447-9. 2012
    ..In conclusion, by describing these colonic histiocytes, we highlight the clinical usefulness of CLE in describing the entity of histiocytes in vivo and in real-time during the process of post-infectious mucosal healing in the colon...
  20. pmc Cancer risk in IBD: how to diagnose and how to manage DALM and ALM
    Helmut Neumann
    Department of Medicine 1, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    World J Gastroenterol 17:3184-91. 2011
    ..The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures...
  21. doi request reprint Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice
    Maximilian J Waldner
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Nat Protoc 6:1471-81. 2011
    ..Mouse NBI endoscopy and CLE represent reliable and fast high-quality techniques for the endoscopic characterization and molecular imaging of the mucosa in colitis and colon cancer...
  22. doi request reprint Virtual chromoendoscopy for prediction of severity and disease extent in patients with inflammatory bowel disease: a randomized controlled study
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Inflamm Bowel Dis 19:1935-42. 2013
    ..Aim was to determine whether computed virtual chromoendoscopy has the potential to enhance assessment of disease severity and extent in patients with mild or inactive IBD in comparison to high-definition white-light endoscopy...
  23. ncbi request reprint Activation of epithelial STAT3 regulates intestinal homeostasis
    Clemens Neufert
    Medical Clinic I, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Cell Cycle 9:652-5. 2010
    ..Thus, our data suggest that targeting the STAT3 signaling pathway in IEC is a promising therapeutic approach in situations when the intestinal homeostasis is disturbed, e.g., as seen in Crohn's disease or Ulcerative colitis...
  24. doi request reprint Assessment of tumor development and wound healing using endoscopic techniques in mice
    Markus F Neurath
    Medical Clinic 1, Friedrich Alexander University, Erlangen, Germany
    Gastroenterology 139:1837-1843.e1. 2010
    ..Finally, mouse endoscopy can help to reduce animal numbers needed to gain significant experimental data...
  25. pmc Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut
    Nadine Wittkopf
    Medical Clinic 1, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Clin Dev Immunol 2012:278059. 2012
    ..However, this was dispensable for gut immune homeostasis and had no effect on susceptibility in mouse models of experimentally induced colitis...
  26. doi request reprint A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling
    Heike Dornhoff
    Department of Medicine, University of Erlangen Nuremberg, Erlangen and Nuremberg, Germany
    Gastroenterology 142:1183-1194.e4. 2012
    ..We identified a splice variant of Smurf2 (ΔE2Smurf2) and investigated its role in colon carcinogenesis in mice...
  27. doi request reprint Allergen-induced IgE-dependent gut inflammation in a human PBMC-engrafted murine model of allergy
    Benno Weigmann
    University of Erlangen Nurnberg, Erlangen, Germany
    J Allergy Clin Immunol 129:1126-35. 2012
    ..Humanized murine models comprise a new tool to analyze novel therapeutic strategies for allergic diseases of the intestine...
  28. doi request reprint Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8
    Nadine Wittkopf
    Department of Medicine 1, Friedrich Alexander University, Erlangen, Germany
    Gastroenterology 145:1369-79. 2013
    ..Dysregulation of epithelial cell death has been implicated in barrier dysfunction and in the pathogenesis of intestinal inflammation. We investigated mechanisms of cell-death regulation in the intestinal epithelium of mice...
  29. doi request reprint Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium
    Claudia Günther
    Department of Medicine, University of Erlangen Nuremberg, Hartmannstrasse 14, 91 054 Erlangen, Germany
    Gut 62:1062-71. 2013
    ..The following article reviews previous studies on cell death regulation in IEC and a potential role of necroptosis for gut homeostasis...
  30. pmc Interleukin-6--a key regulator of colorectal cancer development
    Maximilian J Waldner
    Department of Medicine 1, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Biol Sci 8:1248-53. 2012
    ..This review discusses the molecular mechanisms and possible therapeutic targets involved in IL-6 signaling in CRC...
  31. doi request reprint Learning curve of virtual chromoendoscopy for the prediction of hyperplastic and adenomatous colorectal lesions: a prospective 2-center study
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Gastrointest Endosc 78:115-20. 2013
    ..Previous studies have shown that CVC yields an improved detection rate of colorectal lesions. However, the learning curve for interpretation of CVC images is unknown...
  32. pmc Characterization of lymphoid follicles with red ring signs as first manifestation of early Crohn's disease by conventional histopathology and confocal laser endomicroscopy
    Ekaterina Krauss
    Department of Medicine 1, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Clin Exp Pathol 5:411-21. 2012
    ..The aim of this study was to compare the morphology of LFs in CD, ulcerative colitis (UC) and control patients using confocal laser endomicroscopy (CLE) in correlation to histological and immunohistochemical findings of biopsies...
  33. doi request reprint Novel cytokine-targeted therapies and intestinal inflammation
    Maximilian J Waldner
    I Department of Medicine, University of Erlangen, Erlangen, Germany
    Curr Opin Pharmacol 9:702-7. 2009
    ....
  34. doi request reprint Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages
    Raja Atreya
    Department of Medicine 1, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Gastroenterology 141:2026-38. 2011
    ..Here, we assessed the effects of anti-TNF antibodies on apoptosis in inflammatory bowel disease (IBD)...
  35. doi request reprint Colitis and colorectal cancer
    Sebastian Foersch
    Department of Medicine I, Friedrich Alexander University, Erlangen, Germany
    Dig Dis 30:469-76. 2012
    ..Last, we briefly address different types of concepts for prevention (i.e. anti-inflammatory agents) and treatment (i.e. surgical resection) of CAC and give an outlook on this important aspect of IBD...
  36. ncbi request reprint Enhanced sensitivity to CD95-induced apoptosis in ob/ob mice
    Juergen Siebler
    Department of Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Dig Dis Sci 52:2396-402. 2007
    ..CD95 expression was similar in ob/ob and control mice. However, hepatocytes from ob/ob mice revealed a decreased mitochondrial membrane potential, suggesting that mitochondria play a potential role in this increased susceptibility...
  37. doi request reprint Potential avenues for immunotherapy of colitis-associated neoplasia
    Maximilian J Waldner
    Department of Medicine 1, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Immunotherapy 4:397-405. 2012
    ..In particular, cytokines such as TNF-α or IL-6, which are involved in the pathogenesis of inflammation and cancer development, could be promising targets for the molecular prevention of colitis-associated cancer...
  38. ncbi request reprint Prospective evaluation of the learning curve of confocal laser endomicroscopy in patients with IBD
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Histol Histopathol 26:867-72. 2011
    ..Currently, there are no data available on the learning curve of CLE, which was therefore the aim of our study...
  39. ncbi request reprint Gene therapy using IL 12 family members in infection, auto immunity, and cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Curr Gene Ther 9:239-47. 2009
    ..In this review, we discuss therapeutic strategies using IL-12 family members in infection, autoimmunity, and cancer with special focus on gene administration...
  40. doi request reprint Innovative techniques in evaluating the esophagus; imaging of esophageal morphology and function; and drugs for esophageal disease
    Helmut Neumann
    Department of Medicine I, University of Erlangen, Erlangen, Germany
    Ann N Y Acad Sci 1300:11-28. 2013
    ....
  41. doi request reprint Confocal laser endomicroscopy for diagnosing lung cancer in vivo
    Florian S Fuchs
    Dept of Medicine 1, University of Erlangen Nuremberg, Erlangen, Germany
    Eur Respir J 41:1401-8. 2013
    ..This technique may enable the rapid diagnosis of neoplasia during ongoing endoscopy in patients with suspected lung cancer...
  42. doi request reprint Antiemetic prophylaxis and frequency of chemotherapy-induced nausea and vomiting in palliative first-line treatment of colorectal cancer patients: the Northern Bavarian IVOPAK I Project
    Sonja Koch
    Pharmacy Department, Erlangen University Hospital, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Support Care Cancer 21:2395-402. 2013
    ..This study aims to evaluate adherence to guidelines of antiemetic prophylaxis and frequency of chemotherapy-induced nausea and vomiting (CINV) in the palliative first-line treatment of colorectal cancer (CRC) patients in Northern Bavaria...
  43. pmc Advanced endoscopic imaging for diagnosis of Crohn's disease
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Gastroenterol Res Pract 2012:301541. 2012
    ....
  44. doi request reprint Targeting the VEGF signaling pathway in cancer therapy
    Maximilian J Waldner
    University of Erlangen Nuremberg, Department of Medicine I, Ulmenweg 18, Erlangen, Germany
    Expert Opin Ther Targets 16:5-13. 2012
    ..During recent years, the discovery of VEGF as the main mediator of tumor angiogenesis enabled the specific and successful inhibition of angiogenesis in several experimental and clinical studies...
  45. doi request reprint TRPA1 and substance P mediate colitis in mice
    Matthias A Engel
    Institute of Physiology and Pathophysiology, First Department of Medicine, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Gastroenterology 141:1346-58. 2011
    ..We investigated the mechanisms of colitis in 2 different models, the involvement of the irritant receptor transient receptor potential of the ankyrin type-1 (TRPA1), and the effects of CGRP and substance P...
  46. doi request reprint Description of a new, endoscopic technique to remove the over-the-scope-clip in an ex vivo porcine model (with video)
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Gastrointest Endosc 76:1009-13. 2012
    ..Endoscopic removal of the OTSC was previously described in a series of 3 patients by using the Nd:YAG laser...
  47. pmc Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis
    Stefan Wirtz
    Medical Department 1, University of Erlangen Nuremberg, Erlangen, Germany
    Gastroenterology 141:1875-86. 2011
    ..We investigated the roles of IL-27 and IL-35 in chronic inflammation of the intestine...
  48. ncbi request reprint Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance
    Jonas Mudter
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Inflamm Bowel Dis 13:1016-23. 2007
    ..This review highlights the role of IL-6 in IBD immunopathogenesis and its clinical relevance in IBD therapy and diagnostics...
  49. doi request reprint Refinement of ERCP by using the Olympus V-scope system with a 0.025 in. compatible and complete fixable Visiglide(®) guidewire
    Martin Raithel
    Department of Medicine 1, University Erlangen Nuremberg, Erlangen, Germany
    Dig Liver Dis 43:788-91. 2011
    ..Prospective evaluation of the new 0.025 in. Visiglide(®) guidewire to facilitate endoscopic retrograde cholangiopancreaticography using the Olympus V-scope...
  50. pmc Double-balloon-enteroscopy-based endoscopic retrograde cholangiopancreatography in post-surgical patients
    Martin Raithel
    Department of Medicine 1, University of Erlangen Nurnberg, Ulmenweg 18, 91054 Erlangen, Germany
    World J Gastroenterol 17:2302-14. 2011
    ..To evaluate double balloon enteroscopy (DBE) in post-surgical patients to perform endoscopic retrograde cholangiopancreatography (ERCP) and interventions...
  51. doi request reprint Inflammation, peptides and biological therapy
    Raja Atreya
    Medical Clinic 1, University of Erlangen, Erlangen, Germany
    Dig Dis 27:42-7. 2009
    ..The advent of other biological therapies, such as the anti-IL-6R antibody, offers hope for new strategies that may result in more effective and less toxic therapy...
  52. doi request reprint Fluorescein-aided confocal laser endomicroscopy of the lung
    Florian S Fuchs
    Department of Medicine 1, University of Erlangen Nuremberg, Erlangen, Germany
    Respiration 81:32-8. 2011
    ..There are only few reports about confocal laser endomicroscopy (CLE) for pulmonary imaging. In these studies, in contrast to gastrointestinal endoscopy, CLE was performed without fluorescein...
  53. doi request reprint Public spirometry for primary prevention of COPD
    Sabine Zirlik
    Division of Respiratory Medicine, Department of Medicine 1, University of Erlangen Nuremberg, Erlangen, Germany
    J Eval Clin Pract 20:43-7. 2014
    ..In secondary prevention, smokers with airway obstruction were more likely to quit smoking. The aim of this study was to evaluate the impact of a public spirometry on smoking habits in terms of primary prevention...
  54. ncbi request reprint Perforation during esophageal dilatation: a 10-year experience
    Alexander F Hagel
    Department of Medicine 1, University of Erlangen, Erlangen, Germany
    J Gastrointestin Liver Dis 22:385-9. 2013
    ..Endoscopic treatment options consist primarily of balloon dilatation and bougination. Both interventions carry a certain risk of further complications such as perforations. We aimed to evaluate this risk in our patients...
  55. doi request reprint Review article on current applications and future concepts of capsule endoscopy
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Digestion 87:91-9. 2013
    ..In this review we will focus on the current clinical applications of CE for imaging of the esophagus, small bowel and colon and will additionally give an outlook on future concepts and developments of CE...
  56. pmc CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
    Imke Tiede
    Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Clin Invest 111:1133-45. 2003
    ..These findings explain the immunosuppressive effects of azathioprine and suggest that 6-Thio-GTP derivates may be useful as potent immunosuppressive agents in autoimmune diseases and organ transplantation...
  57. doi request reprint Complex roles of caspases in the pathogenesis of inflammatory bowel disease
    Christoph Becker
    Department of Medicine 1, University of Erlangen Nuremberg, Erlangen, Germany
    Gastroenterology 144:283-93. 2013
    ..Improving our understanding of the regulation and function of caspases in the intestine might lead to new therapeutics for chronic intestinal inflammation and inflammation-associated cancer...
  58. doi request reprint Insight into Crohn's disease pathomorphology
    Jonas Mudter
    Medical Clinic 1, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Abdom Imaging 37:921-6. 2012
    ..This article reviews current knowledge of the pathomorphology of mucosal inflammation in CD focusing especially on the immune mechanisms of T-cell homing, extraintestinal manifestations and fibrogenesis...
  59. ncbi request reprint Antitumoral efficacy of four histone deacetylase inhibitors in hepatoma in vitro and in vivo
    Marion Ganslmayer
    Department of Medicine I, University Hospital Erlangen, Ulmenweg 18, D 91054 Erlangen, Germany
    Anticancer Res 32:5263-9. 2012
    ..Histone deacetylase (HDAC) inhibitors are promising antitumoral drugs. Currently there are no data regarding the comparison of different HDAC inhibitors on hepatoma cells...
  60. pmc Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer
    Sebastian Foersch
    Department of Medicine 1, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Diagn Ther Endosc 2013:250641. 2013
    ..This could improve early detection and stratification of chemoprevention in patients with CRC...
  61. pmc New endoscopic approaches in IBD
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    World J Gastroenterol 17:63-8. 2011
    ..This review offers an overview about new endoscopic techniques, including chromoendoscopy, magnification endoscopy, spectroscopy, confocal laser endomicroscopy and endocytoscopy in the face of IBD...
  62. pmc Long-Term Relapse-Free Survival by Interdisciplinary Collaboration in a Patient with Metastatic Pancreatic Cancer (UICC IV)
    Sandra Roehrig
    Department of Internal Medicine 1, University of Erlangen, Erlangen, Witten, Germany
    Case Rep Oncol 4:413-9. 2011
    ..The prognostic outlook for patients suffering from pancreatic cancer is generally poor. Particularly in cases of advanced and metastatic disease, long-term relapse-free survival may be achieved only in a few cases...
  63. pmc Confocal Laser Endomicroscopy for Diagnosis of Barrett's Esophagus
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg Erlangen, Germany
    Front Oncol 2:42. 2012
    ..In addition, we will critically discuss the technique of CLE and provide some tricks and hints for the daily routine practice of CLE for diagnosis of BE...
  64. doi request reprint Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut
    Matthias A Engel
    Institute of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Inflamm Bowel Dis 17:1030-3. 2011
    ..These findings highlight a new role of sensory neurons in chronic intestinal inflammation and suggest new avenues for therapy of IBD...
  65. doi request reprint Molecular imaging: interaction between basic and clinical science
    Raja Atreya
    Medical Clinic I, University of Erlangen Nuremberg, Ulmenweg 18, 91056 Erlangen, Germany
    Gastroenterol Clin North Am 39:911-22. 2010
    ..Novel studies based on fluorescent antibody imaging pave the road toward clinical translation and give hope for improved diagnosis and targeted therapies in gastrointestinal diseases...
  66. ncbi request reprint Confocal laser endomicroscopy
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
    Gastrointest Endosc Clin N Am 15:715-31. 2005
    ..This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy...
  67. ncbi request reprint The role of signal transducers and activators of transcription in T inflammatory bowel diseases
    Jonas Mudter
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Inflamm Bowel Dis 9:332-7. 2003
    ..In particular, an activation of STAT-4 and STAT-3 in T cells seems to play a key pathogenic role in Crohn's disease...
  68. doi request reprint Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases
    Alexander F Hagel
    Functional Tissue Diagnostics, Department of Medicine I, University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:789-93. 2013
    ....
  69. ncbi request reprint A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis
    Jonas Mudter
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pathobiology 70:170-6. 2002
    ....
  70. ncbi request reprint Highlights in inflammatory bowel disease--from bench to bedside
    Matthias A Engel
    First Department of Medicine, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Clin Chem Lab Med 50:1229-35. 2012
    ..In this review, the current knowledge on the epidemiology and genetics of IBD is summarized, and new pathogenetic insights as well as promising future therapeutic options are described...
  71. pmc Palliative first-line therapy with weekly high-dose 5-fluorouracil and sodium folinic acid as a 24-hour infusion (AIO regimen) combined with weekly irinotecan in patients with metastatic adenocarcinoma of the stomach or esophagogastric junction followed b
    Kathrin Koucky
    Department of Internal Medicine 1 of Erlangen University, Erlangen, Germany
    Med Sci Monit 17:CR248-58. 2011
    ....
  72. pmc Metastatic insulinoma - prolonged survival after multimodal approach
    Alexander F Hagel
    Department of Medicine 1, University of Erlangen Nuremberg, Erlangen, Germany
    Med Sci Monit 17:CS103-107. 2011
    ..Metastatic insulinoma is a disease associated with a poor life expectancy...
  73. doi request reprint The molecular therapy of colorectal cancer
    Maximilian J Waldner
    Department of Medicine, University of Erlangen, Erlangen, Germany
    Mol Aspects Med 31:171-8. 2010
    ..This article will review new molecular targets for the treatment of CRC and discuss possible implications for clinical therapy...
  74. doi request reprint Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease
    Gheorghe Hundorfean
    Medical Clinic, University of Erlangen Nuremberg, Germany
    Inflamm Bowel Dis 18:180-6. 2012
    ..In this review article we discuss the latest findings on the role of Th17 cells and IL-17 family members in IBD immunopathology, as well as research perspectives...
  75. pmc Posttranslationally modified proteins as mediators of sustained intestinal inflammation
    Martin Andrassy
    Department of Medicine I, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Am J Pathol 169:1223-37. 2006
    ..Thus, CML-mps generated in inflammatory lesions have the capacity to elicit a RAGE-dependent intestinal inflammatory response...
  76. doi request reprint New pathophysiological insights and modern treatment of IBD
    Matthias A Engel
    First Department of Medicine, University of Erlangen Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany
    J Gastroenterol 45:571-83. 2010
    ..This review summarizes current epidemiology, pathogenesis and diagnostic strategies in IBD. It also provides insight in today's differentiated clinical therapy and describes mechanisms of promising future medicinal approaches...
  77. pmc Methylene blue-aided in vivo staining of central airways during flexible bronchoscopy
    Sabine Zirlik
    Department of Medicine, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    ScientificWorldJournal 2012:625867. 2012
    ..Intravital staining techniques are not new. Previous small case series suggested that analysis of the bronchial mucosal surface using chromoendoscopy allows a prediction between neoplastic and nonneoplastic lesions...
  78. pmc Complete Long-Term Remission of an Inflammatory Pseudotumor under Corticosteroid Therapy
    Lukas Pfeifer
    Department of Internal Medicine 1, University of Erlangen, Erlangen, Germany
    Case Rep Oncol 4:304-10. 2011
    ..To our knowledge this is the first report of IPT involving the skeletal back muscle and complete resolution under corticosteroid treatment...
  79. ncbi request reprint Differential TNF-signaling in chronic inflammatory disorders
    Martin H Holtmann
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Curr Mol Med 4:439-44. 2004
    ....
  80. ncbi request reprint Chromoendoscopy and magnifying endoscopy in patients with gastroesophageal reflux disease. Useful or negligible?
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Dig Dis 22:142-7. 2004
    ..However, these techniques have significant potential to improve diagnostic accuracy in patients with Barrett's esophagus...
  81. ncbi request reprint The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders
    Martin H Holtmann
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Arch Immunol Ther Exp (Warsz) 50:279-88. 2002
    ..This will lead to a better understanding of the pathogenesis of these diseases and potentially reveal new, more specific therapeutic targets...