Research Topics
Genomes and Genes | M F NeurathSummaryAffiliation: University of Mainz Country: Germany Publications
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Publications
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progressionClemens Neufert
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
Nat Protoc 2:1998-2004. 2007..Different scoring systems including number of tumors and tumor size identify factors promoting or inhibiting tumor initiation and/or tumor progression, respectively...- Cytokines in colitis associated cancer: potential drug targets?Maximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Inflamm Allergy Drug Targets 7:187-94. 2008..However, as already shown in IBD, cytokines may also provide promising therapeutic targets in CAC... 
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's diseaseM F Neurath
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
J Exp Med 195:1129-43. 2002..Specific targeting of this pathway may be a promising novel approach for the treatment of patients with Crohn's disease and other autoimmune diseases mediated by Th1 T lymphocytes...- T-bet as a possible therapeutic target in autoimmune diseaseBenno Weigmann
Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Expert Opin Ther Targets 6:619-22. 2002..Here, the authors summarise recent observations of the role of T-bet in controlling chronic inflammatory and autoimmune diseases and discuss the implications of these findings for future therapeutic approaches... - Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?Markus F Neurath
I Medical Clinic and Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
Nat Clin Pract Gastroenterol Hepatol 6:134-5. 2009.... - New therapies for sepsis: focus on the interleukin (IL)12 family member IL27Markus F Neurath
Laboratory of Immunology, 1st Department of Internal Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
Ann Rheum Dis 66:iii29-31. 2007..These findings indicate that IL27 is an important negative regulator of innate immune cells in septic peritonitis. Blockade of IL27 function could be an interesting novel approach for the treatment of patients with sepsis... - Mucosal immunity in Crohn's diseaseMarkus F Neurath
Laboratory of Immunology I, Department of Medicine University of Mainz, Langenbeckstrasse 1 55101 Mainz, Germany
Inflamm Bowel Dis 10:S29-31. 2004 
IL-12 family members in experimental colitisM F Neurath
First Department of Medicine, Institute of Molecular Medicine, University of Mainz, Germany
Mucosal Immunol 1:S28-30. 2008..In particular, the role of IL-23 as a master regulator of effector T-cell activation is highlighted. These findings have important implications for the design of new therapeutic approaches in chronic intestinal inflammation in humans...- Immunotherapy of inflammatory bowel diseases: current concepts and future perspectivesM F Neurath
Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Arch Immunol Ther Exp (Warsz) 48:81-4. 2000..Such strategies include recombinant antiinflammatory cytokines, neutralizing antibodies or fusion proteins, antisense oligonucleotides and adenoviral gene transfer... - [Immunopathogenesis of inflammatory bowel diseases]M F Neurath
I Medizinische Klinik Direktor Prof Dr P R Galle der Johannes Gutenberg Universität Mainz
Chirurg 71:30-40. 2000.... - 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's diseaseMarkus F Neurath
Medical Clinic, University of Mainz, Mainz, Germany
Clin Gastroenterol Hepatol 3:1007-14. 2005..In this study we assessed the impact of TGTP levels for monitoring of azathioprine therapy... - Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal questionM F Neurath
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131, Mainz, Germany
Trends Immunol 22:21-6. 2001..Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD... - In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopyC Becker
Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Gut 54:950-4. 2005..CONCLUSIONS: In summary, chromoendoscopy in mice allows monitoring of the development of colitis and colon cancer with high resolution. Manipulations such as local injection of reagents or taking biopsies can be performed easily... - Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitisM C Fantini
Laboratory of Immunology, I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Gut 55:671-80. 2006..In addition to Tr1 and thymic CD4+CD25+ T cells, peripheral Ti-Treg cells emerge as a class of regulatory T cells with therapeutic potential in T cell mediated chronic intestinal inflammation... - In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopyC Fottner
Department of Endocrinology and Metabolism, I Medical Clinic, University of Mainz, Mainz, Germany
Endocrinology 151:2179-88. 2010..CLM with OcF permits real-time molecular, functional, and morphological imaging of sstr-expressing cell structures, allowing the specific visualization of pancreatic islet cells and neuroendocrine tumors in vivo... - Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNAStefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, Mainz, Germany
J Immunol 168:411-20. 2002.... - Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitisRalf Kiesslich
I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
Gastroenterology 132:874-82. 2007..In this study we assessed the value of combined chromoscopy and endomicroscopy for the diagnosis of intraepithelial neoplasias in a randomized controlled trial... - Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implicationsJ Mudter
Laboratory of Immunology, First Medical Clinic, University of Mainz, 55131 Mainz, Germany
Gut 56:293-303. 2007 - Dynamic in vivo imaging of microvasculature and perfusion by miniaturized confocal laser microscopyM Goetz
First Medical Clinic, University of Mainz, Mainz, Germany
Eur Surg Res 41:290-7. 2008..We evaluated a novel miniaturized confocal laser scanning probe for in vivo visualization of blood vessels, blood flow, cell tracking and perfusion in both healthy rodents and disease models... - Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthmaMichael Hausding
Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Eur J Immunol 37:1663-77. 2007..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma... - The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6Jonas Mudter
1st Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 118:2415-26. 2008..Taken together, our data identify IRF4 as a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for IBDs... - Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivoMartin H Holtmann
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Mainz, Germany
Eur J Immunol 32:3142-51. 2002..Taken together with the increased expression of TNF-R2 in CD, selective targeting of TNF-R2 signaling thus emerges as a potentially novel approach to the treatment of CD... - TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signalingChristoph Becker
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Immunity 21:491-501. 2004..Taken together, our data provide novel insights into TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-beta-dependent IL-6 trans-signaling... - Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expressionS Finotto
Laboratory of Immunology, University of Mainz, 55099 Mainz, Germany
J Exp Med 193:1247-60. 2001..This approach has the potential advantage of suppressing the expression of various proinflammatory Th2 cytokines simultaneously rather than suppressing the activity of a single cytokine... - IL-6 signaling promotes tumor growth in colorectal cancerC Becker
Lab. of Immunology, I. Medical Clinic, University of Mainz, Mainz, Germany
Cell Cycle 4:217-20. 2005..In summary, our data provide novel insights into the role of TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on an inhibition of TGF-beta-dependent IL-6 trans-signaling... - T-bet and mucosal Th1 responses in the gastrointestinal tractB Weigmann
Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Gut 51:301-3. 2002..In particular, we have focused on the role of T-bet in controlling mucosal Th1 responses in the gastrointestinal tract... - Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cellsSabine Dominitzki
Laboratory of Immunology, Medical Clinic I, University of Mainz, Mainz, Germany
J Immunol 179:2041-5. 2007.... - Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel diseaseR Kiesslich
Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
Gut 61:1146-53. 2012..The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD... - High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a prospective randomized controlled trialA Hoffman
I Med Clinic, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
Endoscopy 42:827-33. 2010..standard video colonoscopy. The primary endpoint was the detection of patients having colon cancer or at least one adenoma... - Gene transfer approaches for the treatment of inflammatory bowel diseaseS Wirtz
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Germany
Gene Ther 10:854-60. 2003..Furthermore, we summarize the results of recent preclinical studies for intestinal gene transfer and discuss future perspectives... - IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-betJuergen Siebler
Laboratory of Immunology, I Medical Clinic, University of Mainz, Lasngenbeckstrasse 1, 55131 Mainz, Germany
Gastroenterology 132:358-71. 2007..T-cell-mediated fulminant hepatitis is a potentially life-threatening event for which the underlying pathogenic mechanisms are not fully understood. Here, we demonstrate a key regulatory role of IL-28A in T-cell-mediated hepatitis... - A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosisJonas Mudter
1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Pathobiology 70:170-6. 2002.... - Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivoS Finotto
Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Gut 53:392-400. 2004..Interleukin 18 (IL-18) is a cytokine with pleiotropic activity that augments T helper 1 responses and cytotoxic activity of natural killer cells... - Confocal laser endomicroscopy: technical status and current indicationsA Hoffman
First Dept of Medicine, Johannes Gutenberg University, Mainz, Germany
Endoscopy 38:1275-83. 2006..Molecular imaging is becoming feasible, and this will shortly open the door to new indications in gastrointestinal endoscopy (e.g., in vivo receptor analysis)... - The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivoAysefa Doganci
Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 115:313-25. 2005..Furthermore, inhibition of IL-6 signaling emerges as a novel molecular approach for the treatment of allergic asthma... - Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancerMaximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Inflamm Bowel Dis 16:559-67. 2010..In the present study we aimed at assessing the role of perforin-dependent effector mechanisms in the immune response in a murine model of colitis-associated colon cancer... - Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2)C Becker
Laboratory of Immunology, First Medical Clinic, University of Mainz, Germany
J Immunol 167:2608-18. 2001..Regulation of GAP-12 binding may thus modulate IL-12 p40 gene expression... - Imaging techniques in inflammatory bowel disease: recent trends, questions and answersM Goetz
I Med Clinic, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
Gastroenterol Clin Biol 33:S174-82. 2009..The current data from endoscopic studies should result in an integrated approach to both identify and characterize a suspicious lesion during ongoing endoscopy for reliable, accurate diagnosis and targeted, immediate therapy... - In-vivo confocal real-time mini-microscopy in animal models of human inflammatory and neoplastic diseasesM Goetz
Medical Clinic I, University of Mainz, Mainz, Germany
Endoscopy 39:350-6. 2007..In this study we evaluated a newly developed, handheld, miniaturized confocal laser microscopy probe for real-time in-vivo molecular and subsurface imaging in rodent models of human disease... - Surveillance colonoscopy in ulcerative colitis: magnifying chromoendoscopy in the spotlightR Kiesslich
I Med Clinic, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Gut 53:165-7. 2004 - Predominant pathogenic role of tumor necrosis factor in experimental colitis in miceM F Neurath
Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Eur J Immunol 27:1743-50. 1997.... - In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real timeM Goetz
First Medical Clinic, University of Mainz, Mainz, Germany
Endoscopy 40:554-62. 2008..We have developed a rigid miniaturized probe for confocal endomicroscopy of the human liver during laparoscopy... - Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulatorJonas Mudter
First Medical Clinic, Johannes-Gutenberg-University, Mainz, Germany
Dig Dis Sci 51:711-7. 2006 - Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27Stefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
J Exp Med 203:1875-81. 2006..Collectively, these data identify IL-27 as a key negative regulator of innate immune cell function in septic peritonitis. Furthermore, in vivo blockade of IL-27 is a novel potential therapeutic target for treatment of sepsis... - Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopySebastian Foersch
Medical Clinic I, University of Mainz, Mainz, Germany
Gut 59:1046-55. 2010..The aim of the study was to evaluate CLE for in vivo molecular imaging of VEGF in GiC... - EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activationStefan Wirtz
Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 174:2814-24. 2005..Thus, EBI3 gene transcription in DCs is induced rapidly by TLR signaling during innate immune responses preceding cytokine driven Th cell development... - In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptorMartin Goetz
I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
Gastroenterology 138:435-46. 2010..Confocal laser endomicroscopy (CLE) enables accurate microscopic visualization of CRC in patients during endoscopy. We evaluated the ability to use CLE in vivo for instantaneous molecular imaging of EGFR in CRC models... - A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytesJoachim H Maxeiner
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
Cancer Res 69:3069-76. 2009.... - A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver inflammationJurgen Siebler
Labor für Klinische Immunologie I, I Medizinische Klinik, Johannes Gutenberg Universitat, Mainz, Germany
Hepatology 38:1573-80. 2003..In conclusion, these findings suggest a key pathogenic role for the STAT1/T-bet signaling pathway for T-cell activation in the Con A model of T-cell-mediated liver pathology... - Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violetMartin Goetz
I Medical Clinic, University of Mainz, Mainz, Germany
Gastrointest Endosc 70:959-68. 2009..Usually fluorescein then serves as a contrast agent for CLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects... - IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivoAysefa Doganci
Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 181:1917-26. 2008..These findings provide novel insights into the functional role of IL-2 signaling in experimental asthma and suggest that blockade of the IL-2R beta-chain might be useful for therapy of allergic asthma in humans... - STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healingGeethanjali Pickert
Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
J Exp Med 206:1465-72. 2009..In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing... - Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancerR Atreya
Institute of Molecular Medicine, I Medical Clinic, University of Mainz, Mainz, Germany
Curr Drug Targets 9:369-74. 2008..Furthermore it evaluates the possible therapeutic potential of targeting this pathway for the therapy of IBD and CRC... - Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodiesM F Neurath
Department of Medicine, University of Mainz, Germany
Am J Gastroenterol 97:1978-85. 2002..FDG-PET can be used to detect disease activity in the terminal ileum and colon of CD patients with high sensitivity and specificity... - Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivoR Atreya
Lab of Immunology and Section Pathophysiology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
Nat Med 6:583-8. 2000..These data indicate that a pathway of T-cell activation driven by IL-6-sIL-6R contributes to the perpetuation of chronic intestinal inflammation. Specific targeting of this pathway may be a promising new approach for the treatment of CD... - Long-term evaluation of a rat model of chronic cholangitis resembling human primary sclerosing cholangitisM Goetz
I Medical Clinic, University of Mainz, Mainz, Germany
Scand J Immunol 58:533-40. 2003..Our findings suggest that a single initial insult is not sufficient to trigger chronic progressive inflammation. Rather, perpetuation of inflammation probably requires additional stimuli... - T helper cell polarisation in coeliac disease: any (T-)bet ?M H Holtmann
1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Gut 53:1065-7. 2004 - Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patientsMartin H Holtmann
First Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Dig Dis Sci 51:1516-24. 2006..In all other CD patients and for UC patients in general, continuation seems beneficial. These results support a novel differential algorithm for long-term azathioprine therapy in IBD... - The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitisBenno Weigmann
Institute of Molecular Medicine, Johanes Gutenberg Univeristy, 55131 Mainz, Germany
J Exp Med 205:2099-110. 2008..NFATc2 in T cells thus emerges as a potentially new therapeutic target for inflammatory bowel diseases... - Novel signal transduction pathways: analysis of STAT-3 and Rac-1 signaling in inflammatory bowel diseaseR Atreya
Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Ann N Y Acad Sci 1072:98-113. 2006.... - NF-kappaB in inflammatory bowel diseaseI Atreya
Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Mainz, Germany
J Intern Med 263:591-6. 2008.... - Methylene blue-aided cholangioscopy in patients with biliary strictures: feasibility and outcome analysisA Hoffman
Medical Clinic I, Johannes Gutenberg University of Mainz, Mainz, Germany
Endoscopy 40:563-71. 2008..We tested the value of chromoendoscopy during choledochoscopy for characterization of local inflammation, neoplasias, and other alterations in patients with biliary strictures... - New therapeutic strategies for treatment of inflammatory bowel diseaseR Atreya
Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Mainz, Germany
Mucosal Immunol 1:175-82. 2008..These compounds give hope for the development of new strategies aiming at more effective and less toxic therapies for IBD... - Transplanting the genetic susceptibility to Crohn's diseaseM H Holtmann
1st Department of Medicine, Johannes Gutenberg-University, Mainz, Germany
Gut 52:1394-6. 2003 - Acetic acid-guided biopsies after magnifying endoscopy compared with random biopsies in the detection of Barrett's esophagus: a prospective randomized trial with crossover designA Hoffman
I Med. Clinic und Poliklinik, Institute for Statistics, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Gastrointest Endosc 64:1-8. 2006.... - Endoscopic detection of early lower gastrointestinal cancerR Kiesslich
I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstr 1, Germany
Best Pract Res Clin Gastroenterol 19:941-61. 2005..This review summarises newly available technologies and clinical data about the diagnosis of early lower gastrointestinal cancers... - Functional relevance of soluble TNF-alpha, transmembrane TNF-alpha and TNF-signal transduction in gastrointestinal diseases with special reference to inflammatory bowel diseasesM H Holtmann
Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Z Gastroenterol 40:587-600. 2002..Finally, the implications for future research efforts will be discussed... - Virtual histologyRalf Kiesslich
I Med Department, Johannes Gutenberg University of Mainz, Germany
Best Pract Res Clin Gastroenterol 22:883-97. 2008..This chapter reviews the currently rapidly expanding clinical data about endomicroscopy and gives a look into future research... - A genetic basis for IFN-gamma production and T-bet expression in humansThomas Höhler
Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
J Immunol 175:5457-62. 2005..This concept is highlighted by the recent finding that inactivation of the T-bet gene in mice results in development of clinical hallmark features of asthma... - In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopyRalf Kiesslich
Medical Clinic, Johannes Gutenberg University Mainz, Germany
Clin Gastroenterol Hepatol 4:979-87. 2006..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia... - A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitisBenno Weigmann
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Germany
J Immunol 173:3446-55. 2004..Targeting of c-Maf in memory T cells in CD appears to be an attractive target for therapeutic interventions... - Diagnosing Helicobacter pylori in vivo by confocal laser endoscopyRalf Kiesslich
I. Medical Clinic, Johannes Gutenberg University of Mainz, Germany
Gastroenterology 128:2119-23. 2005..CONCLUSIONS: Endomicroscopy is a new diagnostic approach, which enables the immediate diagnosis of Helicobacter pylori in vivo during standard video endoscopy... - Confocal laser endomicroscopyRalf Kiesslich
1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
Gastrointest Endosc Clin N Am 15:715-31. 2005..This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy... - Endoscopic mucosal resection: an evolving therapeutic strategy for non-polypoid colorectal neoplasiaR Kiesslich
I Med Klinik und Poliklinik, , Langenbeckstrasse 1, 55101 Mainz, Germany
Gut 53:1222-4. 2004 - [Endomicroscopy--technology with future]R Kiesslich
I Medizinische Klinik, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz
Internist (Berl) 47:8-17. 2006.... - A 9-year retained T-tube fragment encased within a stone as a rare cause of jaundiceA Hoffman
1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Z Gastroenterol 46:700-3. 2008..This case suggests that plastic material accidentally left in the common bile duct favours the development of large biliary casts when present over long periods of time... - The many roads to inflammatory bowel diseasesM F Neurath
Laboratory of Immunology, I. Medical Clinic, University of Mainz, 55131 Mainz, Germany
Immunity 25:189-91. 2006 - Immunotherapeutic approaches to inflammatory bowel diseasesM H Holtmann
First Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Expert Opin Biol Ther 1:455-66. 2001.... - [Immunopathogenesis of bronchial asthma]S Finotto
Labor Immunologie I, I Medizinische Klinik der Johannes Gutenberg Universität Mainz
Pneumologie 54:412-8. 2000..However, the clinical value of these novel therapeutic approaches remains to be determined. In particular, long term efficacy and safety of immunomodulatory therapy has to be studied more in detail... - Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implicationsImke Atreya
Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Expert Rev Gastroenterol Hepatol 2:23-34. 2008..This article aims to summarize traditional and current concepts of azathioprine-mediated effects and endeavors to discuss the resulting clinical implications... - [The Inflammatory Bowel Disease Stress Inventory (IBD-SI). A measure of psychosocial stress in patients with IBD]Frank Petrak
Klinik und Poliklinik fur Psychosomatische Medizin und Psychotherapie, Johannes Gutenberg Universitat, Mainz, Germany
Psychother Psychosom Med Psychol 52:436-43. 2002..76 - 0.89) and a high retest reliability (r = 0.75 - 0.92). Significant correlations with medical and psychological variables supports the external validity of this questionnaire... - Significant differences between Crohn's disease and ulcerative colitis regarding the impact of body mass index and initial disease activity on responsiveness to azathioprine: results from a European multicenter study in 1,176 patientsMartin H Holtmann
1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Dig Dis Sci 55:1066-78. 2010..This observation may support data favouring a "hit hard and early" regime in CD. Finally, we were able to demonstrate a decrease in the incidence of CD-related complications requiring surgery through treatment with AZA... - Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cellsChristoph Becker
Laboratory of Immunology I, Medical Clinic, University of Mainz, Mainz, Germany
J Clin Invest 112:693-706. 2003.... - CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytesImke Tiede
Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
J Clin Invest 111:1133-45. 2003..These findings explain the immunosuppressive effects of azathioprine and suggest that 6-Thio-GTP derivates may be useful as potent immunosuppressive agents in autoimmune diseases and organ transplantation... - Confocal laser endomicroscopy for gastrointestinal diseasesRalf Kiesslich
First Department of Internal Medicine, Klinik und Poliklinik, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
Gastrointest Endosc Clin N Am 18:451-66, viii. 2008..Molecular imaging is becoming feasible, which will enable new indications in gastrointestinal endoscopy. This article reviews the current and rapidly expanding clinical data on endomicroscopy and gives a look into future research... - Colitis-associated cancer: the role of T cells in tumor developmentMaximilian J Waldner
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Semin Immunopathol 31:249-56. 2009..This review discusses the role of the adaptive immune response and especially T cells in the pathogenesis CAC and possible implications for the therapeutic applications... - The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disordersMartin H Holtmann
Department of Medicine, Johannes Gutenberg University, Mainz, Germany
Arch Immunol Ther Exp (Warsz) 50:279-88. 2002..This will lead to a better understanding of the pathogenesis of these diseases and potentially reveal new, more specific therapeutic targets... - Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitisRalf Kiesslich
I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Gastroenterology 124:880-8. 2003..We performed a randomized, controlled trial to test whether chromoendoscopy (CE) might facilitate early detection of IN and CRC in UC... - Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depthMartin Goetz
I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
J Hepatol 53:84-90. 2010..The aim of the current study was to evaluate a novel near-infrared (NIR) light probe with indocyanine green (ICG) contrast for in vivo confocal imaging of the human liver during mini-laparoscopy... - The role of Th1/Th2 polarization in mucosal immunityMarkus F Neurath
Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
Nat Med 8:567-73. 2002..Mucosal immunity relies on the delicate balance between antigen responsiveness and tolerance. The polarization of T helper cells plays a key role in maintaining or disrupting this equilibrium... - Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cellsChristian Becker
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Blood 114:1263-9. 2009..Our findings demonstrate that stimulation via the CD4 receptor represents a T-cell receptor-independent Treg activating pathway with potential to induce immunologic tolerance in vivo... - Immune cells in colorectal cancer: prognostic relevance and therapeutic strategiesImke Atreya
Institute of Molecular Medicine, University of Mainz, Mainz, Germany
Expert Rev Anticancer Ther 8:561-72. 2008..Considering the clinical impact of this increased insight into tumor-associated immunology, resulting innovative approaches in the treatment of colorectal cancer are summarized and discussed immunotherapeutic critically... - Enhanced sensitivity to CD95-induced apoptosis in ob/ob miceJuergen Siebler
Department of Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
Dig Dis Sci 52:2396-402. 2007..CD95 expression was similar in ob/ob and control mice. However, hepatocytes from ob/ob mice revealed a decreased mitochondrial membrane potential, suggesting that mitochondria play a potential role in this increased susceptibility... - Mucosal immunoregulation: transcription factors as possible therapeutic targetsAysefa Doganci
Laboratory of Cellular and Molecular Lung Immunology and and Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
Curr Drug Targets Inflamm Allergy 4:565-75. 2005..g. allergic asthma) and chronic intestinal inflammation (e.g. inflammatory bowel diseases (IBD)) such as the control of the expression of transcription factors to redirect pathological immune responses... - Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania majorSabine Zahn
Department of Dermatology, Johannes Gutenberg University of Mainz, Mainz, Germany
Eur J Immunol 35:1106-12. 2005..In conclusion, our data show that DC-derived IL-27 is critical for the timely initiation of efficient anti-parasite Th1 immunity early in infections... - Anti-TNF strategies in stenosing and fistulizing Crohn's diseaseMartin H Holtmann
First Department of Medicine, Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany
Int J Colorectal Dis 20:1-8. 2005..Prospective trials of medical therapy and a combination of medical and surgical therapy for complex fistulas and internal fistulas are needed to define the potential and the limitations of these novel therapeutic approaches... - Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivoRalf Kiesslich
First Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
Gastroenterology 127:706-13. 2004..The aim of the present study was to assess its potential for prediction of histology during screening colonoscopy for colorectal cancer... - In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopyMartin Goetz
I Medical Clinic, Johannes Gutenberg Universitat, Mainz 55131, Germany
World J Gastroenterol 13:2160-5. 2007..To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents... - Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cellsSusetta Finotto
Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
Int Immunol 19:685-93. 2007..Local targeting of IL-6R signaling could be a novel approach for inducing Th2 T cell death in allergic airways via regulatory T cells... - Technology insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancerRalf Kiesslich
I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
Nat Clin Pract Oncol 4:480-90. 2007..Taken together, CLE has led colorectal cancer endoscopy into a new era. CLE can no longer be regarded as just another endoscopic technique, but emerges as a crucial novel imaging technique for in vivo diagnosis of colorectal cancer... - Mouse models of inflammatory bowel diseaseStefan Wirtz
Laboratory of Immunology, I Medical Clinic, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
Adv Drug Deliv Rev 59:1073-83. 2007..In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD...