M F Neurath

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Protoc 2:1998-2004. 2007
  2. ncbi request reprint Cytokines in colitis associated cancer: potential drug targets?
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Allergy Drug Targets 7:187-94. 2008
  3. pmc Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 203:1875-81. 2006
  4. pmc The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis
    Benno Weigmann
    Institute of Molecular Medicine, Johanes Gutenberg Univeristy, 55131 Mainz, Germany
    J Exp Med 205:2099-110. 2008
  5. ncbi request reprint Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131, Mainz, Germany
    Trends Immunol 22:21-6. 2001
  6. pmc The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 195:1129-43. 2002
  7. ncbi request reprint 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease
    Markus F Neurath
    Medical Clinic, University of Mainz, Mainz, Germany
    Clin Gastroenterol Hepatol 3:1007-14. 2005
  8. ncbi request reprint T-bet as a possible therapeutic target in autoimmune disease
    Benno Weigmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Expert Opin Ther Targets 6:619-22. 2002
  9. ncbi request reprint Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?
    Markus F Neurath
    I Medical Clinic and Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    Nat Clin Pract Gastroenterol Hepatol 6:134-5. 2009
  10. pmc New therapies for sepsis: focus on the interleukin (IL)12 family member IL27
    Markus F Neurath
    Laboratory of Immunology, 1st Department of Internal Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Ann Rheum Dis 66:iii29-31. 2007

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Protoc 2:1998-2004. 2007
    ..Different scoring systems including number of tumors and tumor size identify factors promoting or inhibiting tumor initiation and/or tumor progression, respectively...
  2. ncbi request reprint Cytokines in colitis associated cancer: potential drug targets?
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Allergy Drug Targets 7:187-94. 2008
    ..However, as already shown in IBD, cytokines may also provide promising therapeutic targets in CAC...
  3. pmc Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 203:1875-81. 2006
    ..Collectively, these data identify IL-27 as a key negative regulator of innate immune cell function in septic peritonitis. Furthermore, in vivo blockade of IL-27 is a novel potential therapeutic target for treatment of sepsis...
  4. pmc The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis
    Benno Weigmann
    Institute of Molecular Medicine, Johanes Gutenberg Univeristy, 55131 Mainz, Germany
    J Exp Med 205:2099-110. 2008
    ..NFATc2 in T cells thus emerges as a potentially new therapeutic target for inflammatory bowel diseases...
  5. ncbi request reprint Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131, Mainz, Germany
    Trends Immunol 22:21-6. 2001
    ..Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD...
  6. pmc The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 195:1129-43. 2002
    ..Specific targeting of this pathway may be a promising novel approach for the treatment of patients with Crohn's disease and other autoimmune diseases mediated by Th1 T lymphocytes...
  7. ncbi request reprint 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease
    Markus F Neurath
    Medical Clinic, University of Mainz, Mainz, Germany
    Clin Gastroenterol Hepatol 3:1007-14. 2005
    ..In this study we assessed the impact of TGTP levels for monitoring of azathioprine therapy...
  8. ncbi request reprint T-bet as a possible therapeutic target in autoimmune disease
    Benno Weigmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Expert Opin Ther Targets 6:619-22. 2002
    ..Here, the authors summarise recent observations of the role of T-bet in controlling chronic inflammatory and autoimmune diseases and discuss the implications of these findings for future therapeutic approaches...
  9. ncbi request reprint Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?
    Markus F Neurath
    I Medical Clinic and Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    Nat Clin Pract Gastroenterol Hepatol 6:134-5. 2009
    ....
  10. pmc New therapies for sepsis: focus on the interleukin (IL)12 family member IL27
    Markus F Neurath
    Laboratory of Immunology, 1st Department of Internal Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Ann Rheum Dis 66:iii29-31. 2007
    ..These findings indicate that IL27 is an important negative regulator of innate immune cells in septic peritonitis. Blockade of IL27 function could be an interesting novel approach for the treatment of patients with sepsis...
  11. ncbi request reprint Mucosal immunity in Crohn's disease
    Markus F Neurath
    Laboratory of Immunology I, Department of Medicine University of Mainz, Langenbeckstrasse 1 55101 Mainz, Germany
    Inflamm Bowel Dis 10:S29-31. 2004
  12. doi request reprint IL-12 family members in experimental colitis
    M F Neurath
    First Department of Medicine, Institute of Molecular Medicine, University of Mainz, Germany
    Mucosal Immunol 1:S28-30. 2008
    ..In particular, the role of IL-23 as a master regulator of effector T-cell activation is highlighted. These findings have important implications for the design of new therapeutic approaches in chronic intestinal inflammation in humans...
  13. ncbi request reprint [Immunopathogenesis of inflammatory bowel diseases]
    M F Neurath
    I Medizinische Klinik Direktor Prof Dr P R Galle der Johannes Gutenberg Universität Mainz
    Chirurg 71:30-40. 2000
    ....
  14. ncbi request reprint Immunotherapy of inflammatory bowel diseases: current concepts and future perspectives
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Arch Immunol Ther Exp (Warsz) 48:81-4. 2000
    ..Such strategies include recombinant antiinflammatory cytokines, neutralizing antibodies or fusion proteins, antisense oligonucleotides and adenoviral gene transfer...
  15. pmc Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
    M C Fantini
    Laboratory of Immunology, I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 55:671-80. 2006
    ..Here, we analysed the in vivo function of TGF-beta induced regulatory T (Ti-Treg) cells in experimental colitis...
  16. pmc In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy
    C Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 54:950-4. 2005
    ..In the past, mice had to be sacrificed in order to analyse colitis activity and tumour development. We have developed a safe method for high resolution endoscopic monitoring of living mice...
  17. doi request reprint In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy
    C Fottner
    Department of Endocrinology and Metabolism, I Medical Clinic, University of Mainz, Mainz, Germany
    Endocrinology 151:2179-88. 2010
    ..CLM with OcF permits real-time molecular, functional, and morphological imaging of sstr-expressing cell structures, allowing the specific visualization of pancreatic islet cells and neuroendocrine tumors in vivo...
  18. ncbi request reprint Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    J Immunol 168:411-20. 2002
    ....
  19. ncbi request reprint Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 132:874-82. 2007
    ..In this study we assessed the value of combined chromoscopy and endomicroscopy for the diagnosis of intraepithelial neoplasias in a randomized controlled trial...
  20. doi request reprint Dynamic in vivo imaging of microvasculature and perfusion by miniaturized confocal laser microscopy
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Eur Surg Res 41:290-7. 2008
    ..We evaluated a novel miniaturized confocal laser scanning probe for in vivo visualization of blood vessels, blood flow, cell tracking and perfusion in both healthy rodents and disease models...
  21. pmc Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications
    J Mudter
    Laboratory of Immunology, First Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Gut 56:293-303. 2007
  22. ncbi request reprint Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo
    Martin H Holtmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 32:3142-51. 2002
    ..Taken together with the increased expression of TNF-R2 in CD, selective targeting of TNF-R2 signaling thus emerges as a potentially novel approach to the treatment of CD...
  23. pmc The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    Jonas Mudter
    1st Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 118:2415-26. 2008
    ..Taken together, our data identify IRF4 as a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for IBDs...
  24. ncbi request reprint TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    Christoph Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Immunity 21:491-501. 2004
    ..Taken together, our data provide novel insights into TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-beta-dependent IL-6 trans-signaling...
  25. ncbi request reprint Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 37:1663-77. 2007
    ..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma...
  26. pmc Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression
    S Finotto
    Laboratory of Immunology, University of Mainz, 55099 Mainz, Germany
    J Exp Med 193:1247-60. 2001
    ..This approach has the potential advantage of suppressing the expression of various proinflammatory Th2 cytokines simultaneously rather than suppressing the activity of a single cytokine...
  27. pmc T-bet and mucosal Th1 responses in the gastrointestinal tract
    B Weigmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Gut 51:301-3. 2002
    ..In particular, we have focused on the role of T-bet in controlling mucosal Th1 responses in the gastrointestinal tract...
  28. ncbi request reprint IL-6 signaling promotes tumor growth in colorectal cancer
    C Becker
    Lab of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Cell Cycle 4:217-20. 2005
    ..In summary, our data provide novel insights into the role of TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on an inhibition of TGF-beta-dependent IL-6 trans-signaling...
  29. ncbi request reprint Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    Sabine Dominitzki
    Laboratory of Immunology, Medical Clinic I, University of Mainz, Mainz, Germany
    J Immunol 179:2041-5. 2007
    ....
  30. pmc Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    R Kiesslich
    Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 61:1146-53. 2012
    ..The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD...
  31. ncbi request reprint Gene transfer approaches for the treatment of inflammatory bowel disease
    S Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Gene Ther 10:854-60. 2003
    ..Furthermore, we summarize the results of recent preclinical studies for intestinal gene transfer and discuss future perspectives...
  32. doi request reprint High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a prospective randomized controlled trial
    A Hoffman
    I Med Clinic, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Endoscopy 42:827-33. 2010
    ..standard video colonoscopy. The primary endpoint was the detection of patients having colon cancer or at least one adenoma...
  33. ncbi request reprint IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet
    Juergen Siebler
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Lasngenbeckstrasse 1, 55131 Mainz, Germany
    Gastroenterology 132:358-71. 2007
    ..T-cell-mediated fulminant hepatitis is a potentially life-threatening event for which the underlying pathogenic mechanisms are not fully understood. Here, we demonstrate a key regulatory role of IL-28A in T-cell-mediated hepatitis...
  34. ncbi request reprint A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis
    Jonas Mudter
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pathobiology 70:170-6. 2002
    ....
  35. pmc T helper cell polarisation in coeliac disease: any (T-)bet ?
    M H Holtmann
    1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Gut 53:1065-7. 2004
  36. doi request reprint In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real time
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Endoscopy 40:554-62. 2008
    ..We have developed a rigid miniaturized probe for confocal endomicroscopy of the human liver during laparoscopy...
  37. ncbi request reprint Confocal laser endomicroscopy: technical status and current indications
    A Hoffman
    First Dept of Medicine, Johannes Gutenberg University, Mainz, Germany
    Endoscopy 38:1275-83. 2006
    ..Molecular imaging is becoming feasible, and this will shortly open the door to new indications in gastrointestinal endoscopy (e.g., in vivo receptor analysis)...
  38. pmc Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo
    S Finotto
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Gut 53:392-400. 2004
    ..Interleukin 18 (IL-18) is a cytokine with pleiotropic activity that augments T helper 1 responses and cytotoxic activity of natural killer cells...
  39. doi request reprint Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Bowel Dis 16:559-67. 2010
    ..In the present study we aimed at assessing the role of perforin-dependent effector mechanisms in the immune response in a murine model of colitis-associated colon cancer...
  40. pmc The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 115:313-25. 2005
    ..Furthermore, inhibition of IL-6 signaling emerges as a novel molecular approach for the treatment of allergic asthma...
  41. ncbi request reprint Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies
    M F Neurath
    Department of Medicine, University of Mainz, Germany
    Am J Gastroenterol 97:1978-85. 2002
    ..In addition, a recent case report indicated the potential of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to assess CD activity. However, comparative prospective studies are lacking...
  42. ncbi request reprint Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
    R Atreya
    Lab of Immunology and Section Pathophysiology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Med 6:583-8. 2000
    ..These data indicate that a pathway of T-cell activation driven by IL-6-sIL-6R contributes to the perpetuation of chronic intestinal inflammation. Specific targeting of this pathway may be a promising new approach for the treatment of CD...
  43. ncbi request reprint In-vivo confocal real-time mini-microscopy in animal models of human inflammatory and neoplastic diseases
    M Goetz
    Medical Clinic I, University of Mainz, Mainz, Germany
    Endoscopy 39:350-6. 2007
    ..In this study we evaluated a newly developed, handheld, miniaturized confocal laser microscopy probe for real-time in-vivo molecular and subsurface imaging in rodent models of human disease...
  44. doi request reprint Imaging techniques in inflammatory bowel disease: recent trends, questions and answers
    M Goetz
    I Med Clinic, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Gastroenterol Clin Biol 33:S174-82. 2009
    ..The current data from endoscopic studies should result in an integrated approach to both identify and characterize a suspicious lesion during ongoing endoscopy for reliable, accurate diagnosis and targeted, immediate therapy...
  45. ncbi request reprint Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Eur J Immunol 27:1743-50. 1997
    ....
  46. pmc Surveillance colonoscopy in ulcerative colitis: magnifying chromoendoscopy in the spotlight
    R Kiesslich
    I Med Clinic, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 53:165-7. 2004
  47. ncbi request reprint Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2)
    C Becker
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Germany
    J Immunol 167:2608-18. 2001
    ..Regulation of GAP-12 binding may thus modulate IL-12 p40 gene expression...
  48. ncbi request reprint IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 181:1917-26. 2008
    ..These findings provide novel insights into the functional role of IL-2 signaling in experimental asthma and suggest that blockade of the IL-2R beta-chain might be useful for therapy of allergic asthma in humans...
  49. ncbi request reprint A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver inflammation
    Jurgen Siebler
    Labor für Klinische Immunologie I, I Medizinische Klinik, Johannes Gutenberg Universitat, Mainz, Germany
    Hepatology 38:1573-80. 2003
    ..In conclusion, these findings suggest a key pathogenic role for the STAT1/T-bet signaling pathway for T-cell activation in the Con A model of T-cell-mediated liver pathology...
  50. doi request reprint Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastrointest Endosc 70:959-68. 2009
    ..Usually fluorescein then serves as a contrast agent for CLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects...
  51. ncbi request reprint EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation
    Stefan Wirtz
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 174:2814-24. 2005
    ..Thus, EBI3 gene transcription in DCs is induced rapidly by TLR signaling during innate immune responses preceding cytokine driven Th cell development...
  52. doi request reprint A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes
    Joachim H Maxeiner
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Mainz, Germany
    Cancer Res 69:3069-76. 2009
    ....
  53. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
    ..In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing...
  54. doi request reprint In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    Gastroenterology 138:435-46. 2010
    ..Confocal laser endomicroscopy (CLE) enables accurate microscopic visualization of CRC in patients during endoscopy. We evaluated the ability to use CLE in vivo for instantaneous molecular imaging of EGFR in CRC models...
  55. ncbi request reprint Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator
    Jonas Mudter
    First Medical Clinic, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 51:711-7. 2006
  56. doi request reprint Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy
    Sebastian Foersch
    Medical Clinic I, University of Mainz, Mainz, Germany
    Gut 59:1046-55. 2010
    ..The aim of the study was to evaluate CLE for in vivo molecular imaging of VEGF in GiC...
  57. ncbi request reprint Long-term evaluation of a rat model of chronic cholangitis resembling human primary sclerosing cholangitis
    M Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Scand J Immunol 58:533-40. 2003
    ..Our findings suggest that a single initial insult is not sufficient to trigger chronic progressive inflammation. Rather, perpetuation of inflammation probably requires additional stimuli...
  58. ncbi request reprint Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer
    R Atreya
    Institute of Molecular Medicine, I Medical Clinic, University of Mainz, Mainz, Germany
    Curr Drug Targets 9:369-74. 2008
    ..Furthermore it evaluates the possible therapeutic potential of targeting this pathway for the therapy of IBD and CRC...
  59. ncbi request reprint Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patients
    Martin H Holtmann
    First Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 51:1516-24. 2006
    ..In all other CD patients and for UC patients in general, continuation seems beneficial. These results support a novel differential algorithm for long-term azathioprine therapy in IBD...
  60. doi request reprint Methylene blue-aided cholangioscopy in patients with biliary strictures: feasibility and outcome analysis
    A Hoffman
    Medical Clinic I, Johannes Gutenberg University of Mainz, Mainz, Germany
    Endoscopy 40:563-71. 2008
    ..We tested the value of chromoendoscopy during choledochoscopy for characterization of local inflammation, neoplasias, and other alterations in patients with biliary strictures...
  61. pmc Transplanting the genetic susceptibility to Crohn's disease
    M H Holtmann
    1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Gut 52:1394-6. 2003
  62. doi request reprint NF-kappaB in inflammatory bowel disease
    I Atreya
    Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Mainz, Germany
    J Intern Med 263:591-6. 2008
    ....
  63. doi request reprint New therapeutic strategies for treatment of inflammatory bowel disease
    R Atreya
    Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Mainz, Germany
    Mucosal Immunol 1:175-82. 2008
    ..These compounds give hope for the development of new strategies aiming at more effective and less toxic therapies for IBD...
  64. ncbi request reprint Novel signal transduction pathways: analysis of STAT-3 and Rac-1 signaling in inflammatory bowel disease
    R Atreya
    Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Ann N Y Acad Sci 1072:98-113. 2006
    ....
  65. ncbi request reprint Functional relevance of soluble TNF-alpha, transmembrane TNF-alpha and TNF-signal transduction in gastrointestinal diseases with special reference to inflammatory bowel diseases
    M H Holtmann
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Z Gastroenterol 40:587-600. 2002
    ..Finally, the implications for future research efforts will be discussed...
  66. ncbi request reprint Acetic acid-guided biopsies after magnifying endoscopy compared with random biopsies in the detection of Barrett's esophagus: a prospective randomized trial with crossover design
    A Hoffman
    I Med Clinic und Poliklinik, Institute for Statistics, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gastrointest Endosc 64:1-8. 2006
    ..In contrast to standard video endoscopy, magnifying endoscopy after local acetic acid application enables recognition of mucosal surface architecture...
  67. ncbi request reprint Endoscopic detection of early lower gastrointestinal cancer
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstr 1, Germany
    Best Pract Res Clin Gastroenterol 19:941-61. 2005
    ..This review summarises newly available technologies and clinical data about the diagnosis of early lower gastrointestinal cancers...
  68. ncbi request reprint Diagnosing Helicobacter pylori in vivo by confocal laser endoscopy
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 128:2119-23. 2005
    ..Confocal laser endomicroscopy enables subsurface microscopic imaging of living tissue during ongoing endoscopy. This case report describes the in vivo detection of Helicobacter pylori by endomicroscopy...
  69. ncbi request reprint A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis
    Benno Weigmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    J Immunol 173:3446-55. 2004
    ..Targeting of c-Maf in memory T cells in CD appears to be an attractive target for therapeutic interventions...
  70. doi request reprint Virtual histology
    Ralf Kiesslich
    I Med Department, Johannes Gutenberg University of Mainz, Germany
    Best Pract Res Clin Gastroenterol 22:883-97. 2008
    ..This chapter reviews the currently rapidly expanding clinical data about endomicroscopy and gives a look into future research...
  71. ncbi request reprint A genetic basis for IFN-gamma production and T-bet expression in humans
    Thomas Höhler
    Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
    J Immunol 175:5457-62. 2005
    ..This concept is highlighted by the recent finding that inactivation of the T-bet gene in mice results in development of clinical hallmark features of asthma...
  72. ncbi request reprint In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
    ..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia...
  73. ncbi request reprint Confocal laser endomicroscopy
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
    Gastrointest Endosc Clin N Am 15:715-31. 2005
    ..This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy...
  74. doi request reprint A 9-year retained T-tube fragment encased within a stone as a rare cause of jaundice
    A Hoffman
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Z Gastroenterol 46:700-3. 2008
    ..This case suggests that plastic material accidentally left in the common bile duct favours the development of large biliary casts when present over long periods of time...
  75. ncbi request reprint The many roads to inflammatory bowel diseases
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Immunity 25:189-91. 2006
  76. ncbi request reprint [Endomicroscopy--technology with future]
    R Kiesslich
    I Medizinische Klinik, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz
    Internist (Berl) 47:8-17. 2006
    ....
  77. ncbi request reprint Immunotherapeutic approaches to inflammatory bowel diseases
    M H Holtmann
    First Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Expert Opin Biol Ther 1:455-66. 2001
    ....
  78. pmc Endoscopic mucosal resection: an evolving therapeutic strategy for non-polypoid colorectal neoplasia
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 53:1222-4. 2004
  79. ncbi request reprint [Immunopathogenesis of bronchial asthma]
    S Finotto
    Labor Immunologie I, I Medizinische Klinik der Johannes Gutenberg Universität Mainz
    Pneumologie 54:412-8. 2000
    ..However, the clinical value of these novel therapeutic approaches remains to be determined. In particular, long term efficacy and safety of immunomodulatory therapy has to be studied more in detail...
  80. ncbi request reprint Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major
    Sabine Zahn
    Department of Dermatology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Eur J Immunol 35:1106-12. 2005
    ..In conclusion, our data show that DC-derived IL-27 is critical for the timely initiation of efficient anti-parasite Th1 immunity early in infections...
  81. ncbi request reprint TGF-beta as a T cell regulator in colitis and colon cancer
    Christoph Becker
    Laboratory of Clinical Immunology, I Department of Medicine, University of Mainz, Obere Zahlbacher Str 63, 55131 Mainz, Germany
    Cytokine Growth Factor Rev 17:97-106. 2006
    ..TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25- cells...
  82. ncbi request reprint [The Inflammatory Bowel Disease Stress Inventory (IBD-SI). A measure of psychosocial stress in patients with IBD]
    Frank Petrak
    Klinik und Poliklinik fur Psychosomatische Medizin und Psychotherapie, Johannes Gutenberg Universitat, Mainz, Germany
    Psychother Psychosom Med Psychol 52:436-43. 2002
    ..76 - 0.89) and a high retest reliability (r = 0.75 - 0.92). Significant correlations with medical and psychological variables supports the external validity of this questionnaire...
  83. ncbi request reprint The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders
    Martin H Holtmann
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Arch Immunol Ther Exp (Warsz) 50:279-88. 2002
    ..This will lead to a better understanding of the pathogenesis of these diseases and potentially reveal new, more specific therapeutic targets...
  84. ncbi request reprint Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 124:880-8. 2003
    ..We performed a randomized, controlled trial to test whether chromoendoscopy (CE) might facilitate early detection of IN and CRC in UC...
  85. doi request reprint Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    J Hepatol 53:84-90. 2010
    ..The aim of the current study was to evaluate a novel near-infrared (NIR) light probe with indocyanine green (ICG) contrast for in vivo confocal imaging of the human liver during mini-laparoscopy...
  86. doi request reprint Confocal laser endomicroscopy for gastrointestinal diseases
    Ralf Kiesslich
    First Department of Internal Medicine, Klinik und Poliklinik, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Gastrointest Endosc Clin N Am 18:451-66, viii. 2008
    ..Molecular imaging is becoming feasible, which will enable new indications in gastrointestinal endoscopy. This article reviews the current and rapidly expanding clinical data on endomicroscopy and gives a look into future research...
  87. ncbi request reprint The role of Th1/Th2 polarization in mucosal immunity
    Markus F Neurath
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    Nat Med 8:567-73. 2002
    ..Mucosal immunity relies on the delicate balance between antigen responsiveness and tolerance. The polarization of T helper cells plays a key role in maintaining or disrupting this equilibrium...
  88. ncbi request reprint Anti-TNF strategies in stenosing and fistulizing Crohn's disease
    Martin H Holtmann
    First Department of Medicine, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Int J Colorectal Dis 20:1-8. 2005
    ..The availability of novel, anti-TNF strategies for therapy has raised the question as to what extent these new treatment options have impact on the clinical decision-making process regarding the necessity for surgery...
  89. doi request reprint Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implications
    Imke Atreya
    Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Expert Rev Gastroenterol Hepatol 2:23-34. 2008
    ..This article aims to summarize traditional and current concepts of azathioprine-mediated effects and endeavors to discuss the resulting clinical implications...
  90. pmc CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
    Imke Tiede
    Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Clin Invest 111:1133-45. 2003
    ..These findings explain the immunosuppressive effects of azathioprine and suggest that 6-Thio-GTP derivates may be useful as potent immunosuppressive agents in autoimmune diseases and organ transplantation...
  91. doi request reprint Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells
    Christian Becker
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Blood 114:1263-9. 2009
    ..Our findings demonstrate that stimulation via the CD4 receptor represents a T-cell receptor-independent Treg activating pathway with potential to induce immunologic tolerance in vivo...
  92. doi request reprint Colitis-associated cancer: the role of T cells in tumor development
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Semin Immunopathol 31:249-56. 2009
    ..This review discusses the role of the adaptive immune response and especially T cells in the pathogenesis CAC and possible implications for the therapeutic applications...
  93. doi request reprint Significant differences between Crohn's disease and ulcerative colitis regarding the impact of body mass index and initial disease activity on responsiveness to azathioprine: results from a European multicenter study in 1,176 patients
    Martin H Holtmann
    1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 55:1066-78. 2010
    ..This observation may support data favouring a "hit hard and early" regime in CD. Finally, we were able to demonstrate a decrease in the incidence of CD-related complications requiring surgery through treatment with AZA...
  94. ncbi request reprint Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo
    Ralf Kiesslich
    First Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 127:706-13. 2004
    ..The aim of the present study was to assess its potential for prediction of histology during screening colonoscopy for colorectal cancer...
  95. pmc Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    Christoph Becker
    Laboratory of Immunology I, Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 112:693-706. 2003
    ....
  96. ncbi request reprint IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 37:1809-16. 2007
    ..Our data thus demonstrate that IL-27 controls the development of Th17 and iTreg cells via differential effects on STAT1...
  97. ncbi request reprint Mucosal immunoregulation: transcription factors as possible therapeutic targets
    Aysefa Doganci
    Laboratory of Cellular and Molecular Lung Immunology and and Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Curr Drug Targets Inflamm Allergy 4:565-75. 2005
    ..g. allergic asthma) and chronic intestinal inflammation (e.g. inflammatory bowel diseases (IBD)) such as the control of the expression of transcription factors to redirect pathological immune responses...
  98. ncbi request reprint Mouse models of inflammatory bowel disease
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Adv Drug Deliv Rev 59:1073-83. 2007
    ..In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD...
  99. ncbi request reprint Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Germany
    Int Immunol 19:685-93. 2007
    ..Local targeting of IL-6R signaling could be a novel approach for inducing Th2 T cell death in allergic airways via regulatory T cells...
  100. ncbi request reprint Enhanced sensitivity to CD95-induced apoptosis in ob/ob mice
    Juergen Siebler
    Department of Medicine, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Dig Dis Sci 52:2396-402. 2007
    ..CD95 expression was similar in ob/ob and control mice. However, hepatocytes from ob/ob mice revealed a decreased mitochondrial membrane potential, suggesting that mitochondria play a potential role in this increased susceptibility...
  101. ncbi request reprint In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy
    Martin Goetz
    I Medical Clinic, Johannes Gutenberg Universitat, Mainz 55131, Germany
    World J Gastroenterol 13:2160-5. 2007
    ..To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents...