Affiliation: University of Munich
Neumann J, Wehweck L, Maatz S, Engel J, Kirchner T, Jung A. Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis. Virchows Arch. 2013;463:509-23 pubmed publisher
..Protein expression of PTEN and EGFR using current protocols yields highly discordant results, and better standardization is needed before these markers can be used for diagnostic purposes. ..
Neumann J, Jung A, Kirchner T. [Molecular pathology of colorectal cancer]. Pathologe. 2015;36:137-44 pubmed publisher
..In patients with positive Bethesda criteria a stepwise immunohistochemical and molecular diagnostic scheme is proposed. ..
Michl M, Heinemann V, Jung A, Engel J, Kirchner T, Neumann J. Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system. Pathol Res Pract. 2015;211:601-9 pubmed publisher
..These data implicate that in CRC other mechanisms than deregulation of Wnt/Î²-catenin-signaling and acquisition of cancer stemness are required for formation of CNS metastasis. ..
Neumann J, Heinemann V, Engel J, Kirchner T, Stintzing S. The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer. Virchows Arch. 2018;473:199-207 pubmed publisher
..Furthermore, our data indicate that the prognostic impact of CDX2 depends on the MMR status and the BRAF mutational status of the tumors. Thus, it could be concluded that CDX2 is not an independent prognostic biomarker in CRC. ..
Neumann J. [Prognostic biomarkers for metastatic colorectal cancer]. Pathologe. 2016;37:180-185 pubmed
..It can be concluded from these results that for CRC with different patterns of distant spread alternative molecular mechanisms must play a role. ..
Neumann J, Zeindl Eberhart E, Kirchner T, Jung A. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol Res Pract. 2009;205:858-62 pubmed publisher
..Thus, a mutation frequency of 40% and a cluster of three mutation types (p.G12D, pG12V, and p.G13D) in primaries and metastases can be defined as benchmarks for routine KRAS analyses. ..
Neumann J, Bahr F, Horst D, Kriegl L, Engel J, Luque R, et al
. SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer. BMC Cancer. 2011;11:518 pubmed publisher
..Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread. ..
Link H, Angele M, SchÃ¼ller M, Ganschow P, Machetanz L, Guba M, et al
. Extra-capsular growth of lymph node metastasis correlates with poor prognosis and high SOX9 expression in gastric cancer. BMC Cancer. 2018;18:483 pubmed publisher
..However, the fact that SOX2 failed to show significant results indicate that ECG is not associated with a distinct cancer stem cell phenotype in gastric cancer. ..
Neumann J, Feuerhake F, Kayser G, Wiech T, Aumann K, Passlick B, et al
. Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study. BMC Cancer. 2010;10:77 pubmed publisher
..Published gene sets showed association with patient survival; however, the small sample size of this study limited the options for a comprehensive validation of previously reported prognostic gene expression signatures. ..