Jens Neumann

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Histopathology 60:416-26. 2012
  2. ncbi [Prognostic marker profiles for risk of distant metastases in colorectal cancer]
    J Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Thalkirchner Str 36, 80337, Munchen, Deutschland
    Pathologe 33:39-44. 2012
  3. ncbi SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
  4. ncbi Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study
    Jens Neumann
    Institute of Pathology, University Hospital Freiburg, Breisacher Str 115a, 79106 Freiburg, Germany
    BMC Cancer 10:77. 2010
  5. ncbi Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    Jens Neumann
    Department of Pathology, Ludwig Maximilians Universitat Munchen, Thalkirchner Strasse 36, 80337 Munich, Germany
    Pathol Res Pract 205:858-62. 2009
  6. ncbi The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
  7. ncbi Prognostic role of methylated free circulating DNA in colorectal cancer
    Alexander B Philipp
    Department of Medicine II, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Int J Cancer 131:2308-19. 2012
  8. ncbi Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians Universität LMU, Munich, Germany
    Mod Pathol 24:1015-22. 2011
  9. ncbi Impact of the specific mutation in KRAS codon 12 mutated tumors on treatment efficacy in patients with metastatic colorectal cancer receiving cetuximab-based first-line therapy: a pooled analysis of three trials
    Dominik P Modest
    Department of Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany
    Oncology 83:241-7. 2012
  10. ncbi Prognostic value of cetuximab-related skin toxicity in metastatic colorectal cancer patients and its correlation with parameters of the epidermal growth factor receptor signal transduction pathway: results from a randomized trial of the GERMAN AIO CRC Stu
    Sebastian Stintzing
    Department of Haematology and Oncology, Comprehensive Cancer Center, Klinikum Grosshadern, University of Munich, Munich, Germany
    Int J Cancer 132:236-45. 2013

Collaborators

Detail Information

Publications13

  1. ncbi A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Histopathology 60:416-26. 2012
    ..The aim of this study was to develop a simple and robust test for risk assessment of distant metastases in CC...
  2. ncbi [Prognostic marker profiles for risk of distant metastases in colorectal cancer]
    J Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Thalkirchner Str 36, 80337, Munchen, Deutschland
    Pathologe 33:39-44. 2012
    ..Hence, an immunohistochemical algorithm can be defined by the combination of three markers (hMLH1, CD133 and β-catenin) which allows CRC with either a very high or a very low risk of distant spread to be identified...
  3. ncbi SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
    ....
  4. ncbi Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study
    Jens Neumann
    Institute of Pathology, University Hospital Freiburg, Breisacher Str 115a, 79106 Freiburg, Germany
    BMC Cancer 10:77. 2010
    ....
  5. ncbi Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    Jens Neumann
    Department of Pathology, Ludwig Maximilians Universitat Munchen, Thalkirchner Strasse 36, 80337 Munich, Germany
    Pathol Res Pract 205:858-62. 2009
    ..Thus, a mutation frequency of 40% and a cluster of three mutation types (p.G12D, pG12V, and p.G13D) in primaries and metastases can be defined as benchmarks for routine KRAS analyses...
  6. ncbi The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
    ..Thus, we conclude that CD133 expression is a marker with high prognostic impact for colon cancer, while it seems to have no obvious functional role as a driving force of this malignancy...
  7. ncbi Prognostic role of methylated free circulating DNA in colorectal cancer
    Alexander B Philipp
    Department of Medicine II, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Int J Cancer 131:2308-19. 2012
    ..Prospective validation is required to determine their usefulness in clinical routine along with the established marker CEA...
  8. ncbi Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians Universität LMU, Munich, Germany
    Mod Pathol 24:1015-22. 2011
    ..Loss of p16(Ink4a) expression occurs during malignant transformation and is caused mainly by aberrant methylation of the CDKN2A promoter...
  9. ncbi Impact of the specific mutation in KRAS codon 12 mutated tumors on treatment efficacy in patients with metastatic colorectal cancer receiving cetuximab-based first-line therapy: a pooled analysis of three trials
    Dominik P Modest
    Department of Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany
    Oncology 83:241-7. 2012
    ..This study investigated the impact of specific mutations in codon 12 of the Kirsten-ras (KRAS) gene on treatment efficacy in patients with metastatic colorectal cancer (mCRC)...
  10. ncbi Prognostic value of cetuximab-related skin toxicity in metastatic colorectal cancer patients and its correlation with parameters of the epidermal growth factor receptor signal transduction pathway: results from a randomized trial of the GERMAN AIO CRC Stu
    Sebastian Stintzing
    Department of Haematology and Oncology, Comprehensive Cancer Center, Klinikum Grosshadern, University of Munich, Munich, Germany
    Int J Cancer 132:236-45. 2013
    ..This effect of Cet-ST is independent of the KRAS mutation status, suggesting that Cet-ST rather relates to constitutional factors of the patient than alterations of the EGFR pathway in the tumour...
  11. ncbi Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:710-20. 2013
    ..Here, we determined whether epigenetic inactivation of miR-34a and miR-34b/c genes may serve as a prognostic marker for distant metastases in colon cancer...
  12. ncbi Antibody validation by combining immunohistochemistry and protein extraction from formalin-fixed paraffin-embedded tissues
    Claudia Schuster
    Institute of Pathology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Histopathology 60:E37-50. 2012
    ..To ensure the accuracy of specific antigen detection in immunohistochemistry, we introduce a novel approach for antibody validation...
  13. ncbi Methylation of NEUROG1 in serum is a sensitive marker for the detection of early colorectal cancer
    Andreas Herbst
    Department of Medicine II, University of Munich, Munich, Germany
    Am J Gastroenterol 106:1110-8. 2011
    ..To identify suitable tumor-derived markers that could detect colorectal cancer in blood samples, we analyzed the methylation status of a panel of genes in sera of affected patients...