Jens Neumann

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi request reprint Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis
    Jens Neumann
    Department of Pathology, Ludwig Maximilians Universitat Munchen, Thalkirchner Straße 36, 80337, Munich, Germany
    Virchows Arch 463:509-23. 2013
  2. doi request reprint A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Histopathology 60:416-26. 2012
  3. doi request reprint [Prognostic marker profiles for risk of distant metastases in colorectal cancer]
    J Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Thalkirchner Str 36, 80337, Munchen, Deutschland
    Pathologe 33:39-44. 2012
  4. pmc SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
  5. pmc Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study
    Jens Neumann
    Institute of Pathology, University Hospital Freiburg, Breisacher Str 115a, 79106 Freiburg, Germany
    BMC Cancer 10:77. 2010
  6. doi request reprint Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    Jens Neumann
    Department of Pathology, Ludwig Maximilians Universitat Munchen, Thalkirchner Strasse 36, 80337 Munich, Germany
    Pathol Res Pract 205:858-62. 2009
  7. doi request reprint The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
  8. doi request reprint Prognostic value of cetuximab-related skin toxicity in metastatic colorectal cancer patients and its correlation with parameters of the epidermal growth factor receptor signal transduction pathway: results from a randomized trial of the GERMAN AIO CRC Stu
    Sebastian Stintzing
    Department of Haematology and Oncology, Comprehensive Cancer Center, Klinikum Grosshadern, University of Munich, Munich, Germany
    Int J Cancer 132:236-45. 2013
  9. doi request reprint Prognostic role of methylated free circulating DNA in colorectal cancer
    Alexander B Philipp
    Department of Medicine II, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Int J Cancer 131:2308-19. 2012
  10. doi request reprint KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer
    Stefan Boeck
    Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Marchioninistr 15, 81377, Munich, Germany
    J Gastroenterol 48:544-8. 2013

Collaborators

Detail Information

Publications16

  1. doi request reprint Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis
    Jens Neumann
    Department of Pathology, Ludwig Maximilians Universitat Munchen, Thalkirchner Straße 36, 80337, Munich, Germany
    Virchows Arch 463:509-23. 2013
    ..Protein expression of PTEN and EGFR using current protocols yields highly discordant results, and better standardization is needed before these markers can be used for diagnostic purposes. ..
  2. doi request reprint A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut der Ludwig Maximilians Universität München, Germany
    Histopathology 60:416-26. 2012
    ..The aim of this study was to develop a simple and robust test for risk assessment of distant metastases in CC...
  3. doi request reprint [Prognostic marker profiles for risk of distant metastases in colorectal cancer]
    J Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Thalkirchner Str 36, 80337, Munchen, Deutschland
    Pathologe 33:39-44. 2012
    ..Hence, an immunohistochemical algorithm can be defined by the combination of three markers (hMLH1, CD133 and β-catenin) which allows CRC with either a very high or a very low risk of distant spread to be identified...
  4. pmc SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
    ....
  5. pmc Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study
    Jens Neumann
    Institute of Pathology, University Hospital Freiburg, Breisacher Str 115a, 79106 Freiburg, Germany
    BMC Cancer 10:77. 2010
    ....
  6. doi request reprint Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    Jens Neumann
    Department of Pathology, Ludwig Maximilians Universitat Munchen, Thalkirchner Strasse 36, 80337 Munich, Germany
    Pathol Res Pract 205:858-62. 2009
    ..Thus, a mutation frequency of 40% and a cluster of three mutation types (p.G12D, pG12V, and p.G13D) in primaries and metastases can be defined as benchmarks for routine KRAS analyses...
  7. doi request reprint The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
    ..Thus, we conclude that CD133 expression is a marker with high prognostic impact for colon cancer, while it seems to have no obvious functional role as a driving force of this malignancy...
  8. doi request reprint Prognostic value of cetuximab-related skin toxicity in metastatic colorectal cancer patients and its correlation with parameters of the epidermal growth factor receptor signal transduction pathway: results from a randomized trial of the GERMAN AIO CRC Stu
    Sebastian Stintzing
    Department of Haematology and Oncology, Comprehensive Cancer Center, Klinikum Grosshadern, University of Munich, Munich, Germany
    Int J Cancer 132:236-45. 2013
    ..This effect of Cet-ST is independent of the KRAS mutation status, suggesting that Cet-ST rather relates to constitutional factors of the patient than alterations of the EGFR pathway in the tumour...
  9. doi request reprint Prognostic role of methylated free circulating DNA in colorectal cancer
    Alexander B Philipp
    Department of Medicine II, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Int J Cancer 131:2308-19. 2012
    ..Prospective validation is required to determine their usefulness in clinical routine along with the established marker CEA...
  10. doi request reprint KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer
    Stefan Boeck
    Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Marchioninistr 15, 81377, Munich, Germany
    J Gastroenterol 48:544-8. 2013
    ..It has not yet been defined if KRAS has a prognostic value or is a predictive biomarker for the efficacy of erlotinib in advanced pancreatic cancer (PC)...
  11. doi request reprint Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:710-20. 2013
    ..Here, we determined whether epigenetic inactivation of miR-34a and miR-34b/c genes may serve as a prognostic marker for distant metastases in colon cancer...
  12. doi request reprint Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians Universität LMU, Munich, Germany
    Mod Pathol 24:1015-22. 2011
    ..Loss of p16(Ink4a) expression occurs during malignant transformation and is caused mainly by aberrant methylation of the CDKN2A promoter...
  13. ncbi request reprint Impact of the specific mutation in KRAS codon 12 mutated tumors on treatment efficacy in patients with metastatic colorectal cancer receiving cetuximab-based first-line therapy: a pooled analysis of three trials
    Dominik P Modest
    Department of Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany
    Oncology 83:241-7. 2012
    ..This study investigated the impact of specific mutations in codon 12 of the Kirsten-ras (KRAS) gene on treatment efficacy in patients with metastatic colorectal cancer (mCRC)...
  14. ncbi request reprint WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling
    Steffen Ormanns
    Institute of Pathology, Ludwig Maximilians Universitat, Munich, Germany
    Oncotarget 5:2999-3011. 2014
    ..Thus, the detection of high nuclear β-Catenin expression and simultaneous PI3K pathway activation identifies colon cancer patients with a high risk for distant metastasis. ..
  15. doi request reprint Antibody validation by combining immunohistochemistry and protein extraction from formalin-fixed paraffin-embedded tissues
    Claudia Schuster
    Institute of Pathology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Histopathology 60:E37-50. 2012
    ..To ensure the accuracy of specific antigen detection in immunohistochemistry, we introduce a novel approach for antibody validation...
  16. doi request reprint Methylation of NEUROG1 in serum is a sensitive marker for the detection of early colorectal cancer
    Andreas Herbst
    Department of Medicine II, University of Munich, Munich, Germany
    Am J Gastroenterol 106:1110-8. 2011
    ..To identify suitable tumor-derived markers that could detect colorectal cancer in blood samples, we analyzed the methylation status of a panel of genes in sera of affected patients...