H Neumann

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc Microglia: a cellular vehicle for CNS gene therapy
    Harald Neumann
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn, and LIFE and BRAIN Center and Hertie Foundation, Bonn, Germany
    J Clin Invest 116:2857-60. 2006
  2. pmc Debris clearance by microglia: an essential link between degeneration and regeneration
    H Neumann
    Neural Regeneration, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Brain 132:288-95. 2009
  3. ncbi request reprint Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
    Harald Neumann
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn LIFE and BRAIN Center and Hertie Foundation, Sigmund Freud Str 25, 53127 Bonn, Germany
    J Neuroimmunol 184:92-9. 2007
  4. pmc TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
    Kazuya Takahashi
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn Life and Brain Center and Hertie Foundation, Bonn, Germany
    PLoS Med 4:e124. 2007
  5. ncbi request reprint Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro
    Luisa Klotz
    Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Neuroimmunol 190:34-43. 2007
  6. doi request reprint Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis
    C Beutner
    Neural Regeneration, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Gene Ther 20:797-806. 2013
  7. doi request reprint Alleviation of neurotoxicity by microglial human Siglec-11
    Yiner Wang
    Neural Regeneration Group, Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany
    J Neurosci 30:3482-8. 2010
  8. doi request reprint Microglial clearance function in health and disease
    I Napoli
    Institute of Reconstructive Neurobiology, University Bonn Life and Brain Center, University Bonn and Hertie Foundation, Sigmund Freud Str 25, 53127 Bonn, Germany
    Neuroscience 158:1030-8. 2009
  9. doi request reprint Microglial precursors derived from mouse embryonic stem cells
    Isabella Napoli
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Glia 57:1660-71. 2009
  10. doi request reprint Generation of microglial cells from mouse embryonic stem cells
    Clara Beutner
    Neural Regeneration Group, Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany
    Nat Protoc 5:1481-94. 2010

Collaborators

Detail Information

Publications30

  1. pmc Microglia: a cellular vehicle for CNS gene therapy
    Harald Neumann
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn, and LIFE and BRAIN Center and Hertie Foundation, Bonn, Germany
    J Clin Invest 116:2857-60. 2006
    ..Microglia served as a cellular vehicle to effectively deliver the enzyme to other brain cells while hepatocytes overexpressing ARSA increased plasma ARSA levels but failed to deliver ARSA into the CNS...
  2. pmc Debris clearance by microglia: an essential link between degeneration and regeneration
    H Neumann
    Neural Regeneration, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Brain 132:288-95. 2009
    ..Thus, understanding the mechanism and functional significance of microglial-mediated clearance of tissue debris following injury may open up exciting new therapeutic avenues...
  3. ncbi request reprint Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
    Harald Neumann
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn LIFE and BRAIN Center and Hertie Foundation, Sigmund Freud Str 25, 53127 Bonn, Germany
    J Neuroimmunol 184:92-9. 2007
    ....
  4. pmc TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
    Kazuya Takahashi
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn Life and Brain Center and Hertie Foundation, Bonn, Germany
    PLoS Med 4:e124. 2007
    ..We investigated whether myeloid precursor cells genetically modified to express TREM2 affect the disease course of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis...
  5. ncbi request reprint Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro
    Luisa Klotz
    Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Neuroimmunol 190:34-43. 2007
    ..We therefore propose that PPARgamma in brain EC may be exploited to target detrimental EC-T cell interactions under inflammatory conditions...
  6. doi request reprint Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis
    C Beutner
    Neural Regeneration, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Gene Ther 20:797-806. 2013
    ..Thus, genetically modified ESdM represent a suitable tool to introduce therapeutic neuroprotective and repair-promoting proteins into the CNS in neuroinflammatory diseases. ..
  7. doi request reprint Alleviation of neurotoxicity by microglial human Siglec-11
    Yiner Wang
    Neural Regeneration Group, Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany
    J Neurosci 30:3482-8. 2010
    ....
  8. doi request reprint Microglial clearance function in health and disease
    I Napoli
    Institute of Reconstructive Neurobiology, University Bonn Life and Brain Center, University Bonn and Hertie Foundation, Sigmund Freud Str 25, 53127 Bonn, Germany
    Neuroscience 158:1030-8. 2009
    ..Insufficient clearance by microglia appears to be prevalent in neurodegenerative diseases such as Alzheimer's disease...
  9. doi request reprint Microglial precursors derived from mouse embryonic stem cells
    Isabella Napoli
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Glia 57:1660-71. 2009
    ..Thus, ESdM are stable proliferating cells substantially having most characteristics of primary microglia and therefore being a suitable tool to study microglial function in vitro and in vivo...
  10. doi request reprint Generation of microglial cells from mouse embryonic stem cells
    Clara Beutner
    Neural Regeneration Group, Institute of Reconstructive Neurobiology, University of Bonn, Bonn, Germany
    Nat Protoc 5:1481-94. 2010
    ..Furthermore, ESdMs are capable of chemokine-directed migration and phagocytosis, which are major functional features of microglia...
  11. doi request reprint Accumulation of tau induced in neurites by microglial proinflammatory mediators
    Philipp Gorlovoy
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    FASEB J 23:2502-13. 2009
    ..These data demonstrate that activated microglia and the microglial-derived proinflammatory cytokine TNF can induce accumulation of the aggregation-prone tau molecules in neurites via reactive oxygen species...
  12. doi request reprint Immune-mediated CNS damage
    Katrin Kierdorf
    Institute of Reconstructive Neurobiology, University Bonn Life and Brain Center, University Bonn and Hertie Foundation, Sigmund Freud Str 25, 53127, Bonn, Germany
    Results Probl Cell Differ 51:173-96. 2010
    ..Understanding the mechanisms of immune-mediated neuronal damage might help to design novel therapy strategies for MS...
  13. ncbi request reprint Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway
    Massimiliano Stagi
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn Life and Brain Center, University Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    FASEB J 20:2573-5. 2006
    ..Thus, TNF produced by activated glial cells in inflammatory or degenerative neurological diseases acts on neurites by acting on the kinesin-tubulin complex and inhibits axonal mitochondria and synaptophysin transport via JNK...
  14. pmc Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease
    Sadanand Gaikwad
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University Bonn and Hertie Foundation, Bonn, Germany
    Am J Pathol 175:2528-39. 2009
    ..Thus, SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis...
  15. doi request reprint Protective effects of microglia in multiple sclerosis
    Isabella Napoli
    Neural Regeneration, Institute of Reconstructive Neurobiology, University Bonn, Bonn, Germany
    Exp Neurol 225:24-8. 2010
    ..These findings suggest that microglia play a major role in creating a microenvironment for repair and regenerative processes in demyelinating neuroinflammatory diseases...
  16. ncbi request reprint Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteins
    Hrvoje Miletic
    Abteilung für Neuropathologie, Universitat zu Koln, D 50931 Cologne, Germany
    Hum Gene Ther 15:1091-100. 2004
    ..In conclusion, lentiviral vectors pseudotyped with LCMV glycoproteins represent an attractive option for gene therapy of malignant glioma...
  17. pmc Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    Kazuya Takahashi
    Neuroimmunology Unit, European Neuroscience Institute Göttingen, Germany
    J Exp Med 201:647-57. 2005
    ....
  18. doi request reprint Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury
    Sönke Schwarting
    Department of Neurology, Cerebral Ischemia Research Group, University of Gottingen Medical School, Gottingen, Germany
    Stroke 39:2867-75. 2008
    ..In this study we analyzed the effect of lineage-negative bone marrow-derived hematopoietic stem and precursor cells (Lin(-)-HSCs) on ischemic brain injury in mice...
  19. ncbi request reprint Neuronal 'On' and 'Off' signals control microglia
    Knut Biber
    Department of Medical Physiology, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Trends Neurosci 30:596-602. 2007
    ..Various neuronal signaling molecules thus actively control microglia function, thereby contribute to the inflammatory milieu of the central nervous system. Thus, neurons should be envisaged as key immune modulators in the brain...
  20. ncbi request reprint Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
    Harald Neumann
    Neuroimmunology Unit, European Neuroscience Institute Göttingen, Waldweg 33, 37073 Gottingen, Germany
    Trends Neurosci 25:313-9. 2002
    ..In MS, damage of axons is closely linked to the CD8(+) CTLs, and protection against CTL-mediated damage should be considered as a new therapeutic approach in MS and other neuroinflammatory diseases...
  21. ncbi request reprint Molecular mechanisms of axonal damage in inflammatory central nervous system diseases
    Harald Neumann
    Neuroimmunology Unit, European Neuroscience Institute Göttingen, Gottingen, Germany
    Curr Opin Neurol 16:267-73. 2003
    ..Axonal injury has attracted considerable interest during the past few years because the degree of axonal damage appears to determine long-term clinical outcome...
  22. ncbi request reprint Neuroscience. Microglia: the enemy within?
    Gerd Kempermann
    Neuronal Stem Cells Research Group, Max Delbrück Centrum für Molekulare Medizin Berlin Buch, 13125 Berlin, Germany
    Science 302:1689-90. 2003
  23. ncbi request reprint Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9)
    Asparouh I Iliev
    Neuroimmunology Unit, European Neuroscience Institute Göttingen, Gottingen, Germany
    FASEB J 18:412-4. 2004
    ..The data suggest that stimulation of microglia via TLR9 and subsequent release of NO and TNF-alpha is a major source of neurotoxicity in bacterial and autoimmune brain tissue injury...
  24. ncbi request reprint Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide
    Massimiliano Stagi
    Neuroimmunology Group, European Neuroscience Institute Göttingen, 37073 Gottingen, Germany
    J Neurosci 25:352-62. 2005
    ..Thus, overt production of reactive NO by activated microglia blocks the axonal transport of synaptic vesicle precursors via phosphorylation of JNK and could cause axonal and synaptic dysfunction...
  25. ncbi request reprint LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide
    Yang Liu
    Department of Neurology, University of Gottingen, Germany
    Brain 128:1778-89. 2005
    ....
  26. ncbi request reprint Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species
    Yang Liu
    Department of Neurology, University of the Saarland, 66421 Homburg Saar, Germany
    J Neurosci 26:12904-13. 2006
    ..These results suggest that intervention in ROS generation could represent a novel therapeutic strategy to reduce neuroinflammation in MS...
  27. ncbi request reprint Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene
    Hrvoje Miletic
    Abteilung für Neuropathologie, Universitat zu Koln, Koln, Germany
    Mol Ther 15:1373-81. 2007
    ..In conclusion, BM-TICs expressing a suicide gene were highly effective in the treatment of malignant glioma in a rat model and therefore hold great potential for the therapy of malignant brain tumors in humans...
  28. ncbi request reprint A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells
    Yvonne Heidemarie Fischer
    University of Lund, Stem Cell Center, BMC B10, 22184 Lund, Sweden
    J Gene Med 9:335-44. 2007
    ....
  29. ncbi request reprint Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism
    Harald Neumann
    Departments of Neuroimmunology and Neurobiochemistry, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 22:854-62. 2002
    ..These results suggest that glia-derived TNF, as part of an injury or inflammatory process, can inhibit neurite elongation and branching during development and regeneration...