Max Nedelmann

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Functional and morphological criteria of internal jugular valve insufficiency as assessed by ultrasound
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Neuroimaging 15:70-5. 2005
  2. ncbi request reprint Therapeutic application of 20-kHz transcranial ultrasound in an embolic middle cerebral artery occlusion model in rats: safety concerns
    Thomas Wilhelm-Schwenkmezger
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Stroke 38:1031-5. 2007
  3. ncbi request reprint [The ultrasound contrast medium levovist increases the thrombolytic effect of low frequency ultrasound]
    Max Nedelmann
    Klinik und Poliklinik fur Neurologie, Johannes Gutenberg Universitat Mainz
    Med Klin (Munich) 97:216-20. 2002
  4. ncbi request reprint Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequencies
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Cerebrovasc Dis 20:18-22. 2005
  5. ncbi request reprint Increased incidence of jugular valve insufficiency in patients with transient global amnesia
    Max Nedelmann
    Dept of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Neurol 252:1482-6. 2005
  6. doi request reprint Intravenous immunoglobulin reduces infarct volume but not edema formation in acute stroke
    Maureen Walberer
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Neuroimmunomodulation 17:97-102. 2010
  7. doi request reprint A rat model for cerebral air microembolisation
    Tibo Gerriets
    Department of Neurology, Experimental Neurology Research Group, Justus Liebig University Giessen, Germany
    J Neurosci Methods 190:10-3. 2010
  8. doi request reprint Edema formation in the hyperacute phase of ischemic stroke. Laboratory investigation
    Tibo Gerriets
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    J Neurosurg 111:1036-42. 2009
  9. pmc Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany
    J Cereb Blood Flow Metab 30:1712-20. 2010
  10. doi request reprint Gender-specific differences in stroke knowledge, stroke risk perception and the effects of an educational multimedia campaign
    Juergen J Marx
    Department of Neurology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    J Neurol 257:367-74. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Functional and morphological criteria of internal jugular valve insufficiency as assessed by ultrasound
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Neuroimaging 15:70-5. 2005
    ..This study describes the methodology to detect internal jugular valve insufficiency and establishes functional and morphological criteria to discriminate retrograde flow during valve closure from retro grade insufficiency flow...
  2. ncbi request reprint Therapeutic application of 20-kHz transcranial ultrasound in an embolic middle cerebral artery occlusion model in rats: safety concerns
    Thomas Wilhelm-Schwenkmezger
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Stroke 38:1031-5. 2007
    ..A parameter setting was used that had not previously shown any side effects and interactions with healthy rat brain tissue...
  3. ncbi request reprint [The ultrasound contrast medium levovist increases the thrombolytic effect of low frequency ultrasound]
    Max Nedelmann
    Klinik und Poliklinik fur Neurologie, Johannes Gutenberg Universitat Mainz
    Med Klin (Munich) 97:216-20. 2002
    ..The purpose of this study was to determine, whether the presence of the echo contrast agent Levovist further increases the thrombolytic efficacy of ultrasound...
  4. ncbi request reprint Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequencies
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Cerebrovasc Dis 20:18-22. 2005
    ..The purpose of this study was a direct comparison of different ultrasound frequencies, when otherwise using identical measurement settings and parameters...
  5. ncbi request reprint Increased incidence of jugular valve insufficiency in patients with transient global amnesia
    Max Nedelmann
    Dept of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Neurol 252:1482-6. 2005
    ..Using a direct method for the study of retrograde flow during a Valsalva maneuver, we determined whether jugular valve insufficiency contributes to cerebral venous hypertension in patients with TGA...
  6. doi request reprint Intravenous immunoglobulin reduces infarct volume but not edema formation in acute stroke
    Maureen Walberer
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Neuroimmunomodulation 17:97-102. 2010
    ..Since edema treatment can provide secondary neuroprotective effects, we conducted the present study to evaluate whether edema reduction is the underlying cause of the neuroprotective properties of IVIG in experimental stroke...
  7. doi request reprint A rat model for cerebral air microembolisation
    Tibo Gerriets
    Department of Neurology, Experimental Neurology Research Group, Justus Liebig University Giessen, Germany
    J Neurosci Methods 190:10-3. 2010
    ..In conclusion, the method presented allows injecting air bubbles of defined number and diameter into cerebral arteries of rats. This technique facilitates animal research in the field of air embolisation...
  8. doi request reprint Edema formation in the hyperacute phase of ischemic stroke. Laboratory investigation
    Tibo Gerriets
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    J Neurosurg 111:1036-42. 2009
    ..In the present study, the authors evaluated the natural course of edema formation in the hyperacute phase of focal cerebral ischemia...
  9. pmc Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany
    J Cereb Blood Flow Metab 30:1712-20. 2010
    ..This study shows that CEUS and rt-PA is safe in the situation of reperfusion and displays beneficial effects on the level of the microvasculature...
  10. doi request reprint Gender-specific differences in stroke knowledge, stroke risk perception and the effects of an educational multimedia campaign
    Juergen J Marx
    Department of Neurology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    J Neurol 257:367-74. 2010
    ..Future campaigns should be tailored economically, and should focus different media and educational messages on the two sexes accordingly...
  11. ncbi request reprint RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke
    Maureen Walberer
    Department of Neurology, University Hospital Cologne, Germany
    Curr Neurovasc Res 6:12-9. 2009
    ..The present study introduces a hitherto unrecognized mechanism of ischemic brain damage and a novel neuroprotective approach towards acute stroke treatment...
  12. doi request reprint Low-frequency therapeutic ultrasound with varied duty cycle: effects on the ischemic brain and the inner ear
    Peter Reuter
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Ultrasound Med Biol 36:1188-95. 2010
    ..However, side effects on the auditory system were found to be independent of parameter settings...
  13. ncbi request reprint Cerebral embolic ischemia in rats: correlation of stroke severity and functional deficit as important outcome parameter
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Brain Res 1130:188-96. 2007
    ..We present outcome tests that provide quantitative and objective tools to test functional impairment in rats following embolic stroke...
  14. doi request reprint Venous obstruction and jugular valve insufficiency in idiopathic intracranial hypertension
    Max Nedelmann
    Department of Neurology, Justus Liebig University Giessen, Am Steg 14, 35385, Giessen, Germany
    J Neurol 256:964-9. 2009
    ..Jugular valve insufficiency may facilitate pressure transmission. As transverse sinus stenosis was a concomitant finding, these factors may be complementary...
  15. doi request reprint Impact of bubble size in a rat model of cerebral air microembolization
    Martin Juenemann
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    J Cardiothorac Surg 8:198. 2013
    ..We evaluated the production and application of different strictly defined bubble diameters in a rat model of CAM and assessed functional outcome and infarct volumes in relation to the bubble diameter...
  16. doi request reprint Active regulation of cerebral venous tone: simultaneous arterial and venous transcranial Doppler sonography during a Valsalva manoeuvre
    Erwin Stolz
    Department of Neurology, Justus Liebig University, Am Steg 14, 35385 Giessen, Germany
    Eur J Appl Physiol 109:691-7. 2010
    ..However, the significantly lager venous than the arterial overshoot in phase IV may be explained by the active regulation of the venous tone...
  17. ncbi request reprint Low-frequency ultrasound induces nonenzymatic thrombolysis in vitro
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Ultrasound Med 21:649-56. 2002
    ..To evaluate whether ultrasound, applied over a distance of several centimeters and in the absence of thrombolytic agents, may have a thrombolytic effect on blood clots...
  18. doi request reprint High frequency of silent pulmonary embolism in patients with cryptogenic stroke and patent foramen ovale
    Christian Tanislav
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    Stroke 42:822-4. 2011
    ..Because it has implications in secondary prevention, we investigated the frequency of silent PE in such a cohort of patients...
  19. doi request reprint Sonographic assessment of the optic nerve sheath and transorbital monitoring of treatment effects in a patient with spontaneous intracranial hypotension: case report
    Jochen Bäuerle
    Department of Neurology, Justus Liebig University, Giessen, Germany
    J Neuroimaging 23:237-9. 2013
    ..To investigate the potential of the ultrasound-based evaluation of the optic nerve sheath in a patient with spontaneous intracranial hypotension due to cervical cerebrospinal fluid (CSF) leakage...
  20. doi request reprint Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Stroke 40:3238-44. 2009
    ..The aim of this international consensus procedure was to develop recommendations on the methodology and documentation to be used for assessment of intracranial occlusion and for monitoring of recanalization...
  21. ncbi request reprint Involvement of jugular valve insufficiency in cerebral venous air embolism
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Neuroimaging 17:258-60. 2007
    ..Peripheral air embolism is discussed as a potential cause. However, the mechanism of retrograde passage through internal jugular valves and veins is unclear...
  22. ncbi request reprint Brain edema and intracerebral necrosis caused by transcranial low-frequency 20-kHz ultrasound: a safety study in rats
    Felicitas Schneider
    Department of Neurology, Johannes Gutenberg University, 55101 Mainz, Germany
    Stroke 37:1301-6. 2006
    ..However, little is known about biological interactions of low-frequency ultrasound with brain tissue. The aim of this in vivo MRI study was to assess safety aspects of transcranial low-frequency ultrasound in rats...
  23. doi request reprint Intra- and interobsever reliability of sonographic assessment of the optic nerve sheath diameter in healthy adults
    Jochen Bäuerle
    Department of Neurology, Justus Liebig University, Giessen, Germany
    J Neuroimaging 22:42-5. 2012
    ..The aim of this study was therefore to establish normal values and to assess the intra- and interobserver reliability of this method...
  24. pmc The perfect crime? CCSVI not leaving a trace in MS
    Christoph A Mayer
    Department of Neurology, Goethe University Frankfurt, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    J Neurol Neurosurg Psychiatry 82:436-40. 2011
    ..Recently, a fundamentally different pathomechanism termed 'chronic cerebrospinal venous insufficiency' (CCSVI) was proposed, provoking significant attention in the media and scientific community...
  25. doi request reprint Neuropsychological decline after catheter ablation of atrial fibrillation
    Niko Schwarz
    Department of Neurology, Justus Liebig University Giessen, Germany
    Heart Rhythm 7:1761-7. 2010
    ..Cerebral embolic events represent recognized side effects after catheter ablation in the treatment of recurrent atrial fibrillation (AF)...
  26. ncbi request reprint Analysis of internal jugular vein insufficiency--a comparison of two ultrasound methods
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Ultrasound Med Biol 33:857-62. 2007
    ..This study shows that detection rates of internal jugular valve insufficiency are very similar with both methods. However, this high agreement required modification of the established protocol of ACUV...
  27. pmc Decrease in shunt volume in patients with cryptogenic stroke and patent foramen ovale
    Christian Tanislav
    Department of Neurology, Justus Liebig University, Giessen, Germany
    BMC Neurol 10:123. 2010
    ..Proven, this could have implications for the care of patients with PFO and a history of stroke. The following study addressed this hypothesis in a cohort of patients with stroke and PFO...
  28. doi request reprint Sonographic assessment of the optic nerve sheath in idiopathic intracranial hypertension
    Jochen Bäuerle
    Department of Neurology, Justus Liebig University, Klinikstraße 33, 35385 Giessen, Germany
    J Neurol 258:2014-9. 2011
    ....
  29. doi request reprint An educational multimedia campaign has differential effects on public stroke knowledge and care-seeking behavior
    Juergen J Marx
    Dept of Neurology, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
    J Neurol 255:378-84. 2008
    ..Large educational campaigns seem unsuitable, however, for mediation of detailed information on stroke...
  30. doi request reprint Aggravation of infarct formation by brain swelling in a large territorial stroke: a target for neuroprotection?
    Maureen Walberer
    Experimental Neurology Research Group, Justus Liebig University Giessen, Germany
    J Neurosurg 109:287-93. 2008
    ..In the present study the authors sought to quantify the impact of this space-occupying effect on ischemic lesion formation...
  31. ncbi request reprint Blood-brain barrier disruption by low-frequency ultrasound
    Tibo Gerriets
    Stroke 38:251; author reply 252. 2007