Research Topics
| M NedelmannSummaryAffiliation: University of Giessen Country: Germany Publications
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Detail Information
Publications
Decrease in shunt volume in patients with cryptogenic stroke and patent foramen ovaleChristian Tanislav
Department of Neurology, Justus Liebig University, Giessen, Germany
BMC Neurol 10:123. 2010..Proven, this could have implications for the care of patients with PFO and a history of stroke. The following study addressed this hypothesis in a cohort of patients with stroke and PFO...
Venous obstruction and jugular valve insufficiency in idiopathic intracranial hypertensionMax Nedelmann
Department of Neurology, Justus Liebig University Giessen, Am Steg 14, 35385, Giessen, Germany
J Neurol 256:964-9. 2009..Jugular valve insufficiency may facilitate pressure transmission. As transverse sinus stenosis was a concomitant finding, these factors may be complementary...- [Therapeutic ultrasound of acute cerebral artery occlusion]M Nedelmann
Klinik fur Neurologie, Justus Liebig Universitat Giessen, Am Steg 14, 35392, Giessen
Nervenarzt 79:1399-400, 1402-6. 2008..Investigators have shown that the combination with echo contrast agents further improves the thrombolytic potential of ultrasound. This work summarizes the current clinical and experimental knowledge on this therapeutic stroke concept... 
Analysis of internal jugular vein insufficiency--a comparison of two ultrasound methodsMax Nedelmann
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
Ultrasound Med Biol 33:857-62. 2007..This study shows that detection rates of internal jugular valve insufficiency are very similar with both methods. However, this high agreement required modification of the established protocol of ACUV...- Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute strokeMax Nedelmann
Department of Neurology, Justus Liebig University, Giessen, Germany
Stroke 40:3238-44. 2009..The aim of this international consensus procedure was to develop recommendations on the methodology and documentation to be used for assessment of intracranial occlusion and for monitoring of recanalization... - Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusionMax Nedelmann
Department of Neurology, Justus Liebig University, Giessen, Germany
J Cereb Blood Flow Metab 30:1712-20. 2010..This study shows that CEUS and rt-PA is safe in the situation of reperfusion and displays beneficial effects on the level of the microvasculature... - Detrimental effects of 60 kHz sonothrombolysis in rats with middle cerebral artery occlusionMax Nedelmann
Department of Experimental Neurology, Justus Liebig University, Giessen and Kerckhoff Clinic, Bad Nauheim, Germany
Ultrasound Med Biol 34:2019-27. 2008..Although the results are not directly transferable to the human setting, this study clearly demonstrates the potential limitations of low frequency therapeutic ultrasound and the importance of pre-clinical safety assessment... - In vitro evaluation of the sinus sagittalis superior thrombosis model in the rat using 3D micro- and nanocomputed tomographyAlexander Claus Langheinrich
Department of Radiology, Justus Liebig University Giessen, Klinikstrasse 36, Giessen, Germany
Neuroradiology 52:815-21. 2010..Therefore, the purpose of our study was to evaluate a well-established model for sinus sagittalis (SSS) thrombosis using micro- and nanocomputed tomography (CT) imaging... - Active regulation of cerebral venous tone: simultaneous arterial and venous transcranial Doppler sonography during a Valsalva manoeuvreErwin Stolz
Department of Neurology, Justus Liebig University, Am Steg 14, 35385 Giessen, Germany
Eur J Appl Physiol 109:691-7. 2010..However, the significantly lager venous than the arterial overshoot in phase IV may be explained by the active regulation of the venous tone... - Edema formation in the hyperacute phase of ischemic stroke. Laboratory investigationTibo Gerriets
Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
J Neurosurg 111:1036-42. 2009..In the present study, the authors evaluated the natural course of edema formation in the hyperacute phase of focal cerebral ischemia... - High frequency of silent pulmonary embolism in patients with cryptogenic stroke and patent foramen ovaleChristian Tanislav
Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
Stroke 42:822-4. 2011..Because it has implications in secondary prevention, we investigated the frequency of silent PE in such a cohort of patients... - Low-frequency therapeutic ultrasound with varied duty cycle: effects on the ischemic brain and the inner earPeter Reuter
Department of Neurology, Justus Liebig University, Giessen, Germany
Ultrasound Med Biol 36:1188-95. 2010..However, side effects on the auditory system were found to be independent of parameter settings... - Brain edema and intracerebral necrosis caused by transcranial low-frequency 20-kHz ultrasound: a safety study in ratsFelicitas Schneider
Department of Neurology, Johannes Gutenberg University, 55101 Mainz, Germany
Stroke 37:1301-6. 2006..This study indicates therapeutic low-frequency ultrasound as being potentially harmful and underlines the necessity of careful evaluation in further animal models... - Intravenous immunoglobulin reduces infarct volume but not edema formation in acute strokeMaureen Walberer
Department of Neurology, University Hospital Cologne, Cologne, Germany
Neuroimmunomodulation 17:97-102. 2010..Since edema treatment can provide secondary neuroprotective effects, we conducted the present study to evaluate whether edema reduction is the underlying cause of the neuroprotective properties of IVIG in experimental stroke... - Functional and morphological criteria of internal jugular valve insufficiency as assessed by ultrasoundMax Nedelmann
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
J Neuroimaging 15:70-5. 2005..This study describes the methodology to detect internal jugular valve insufficiency and establishes functional and morphological criteria to discriminate retrograde flow during valve closure from retro grade insufficiency flow... - Increased incidence of jugular valve insufficiency in patients with transient global amnesiaMax Nedelmann
Dept of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
J Neurol 252:1482-6. 2005..Using a direct method for the study of retrograde flow during a Valsalva maneuver, we determined whether jugular valve insufficiency contributes to cerebral venous hypertension in patients with TGA... - Aggravation of infarct formation by brain swelling in a large territorial stroke: a target for neuroprotection?Maureen Walberer
Experimental Neurology Research Group, Justus Liebig University Giessen, Germany
J Neurosurg 109:287-93. 2008..In the present study the authors sought to quantify the impact of this space-occupying effect on ischemic lesion formation... - Cerebral embolic ischemia in rats: correlation of stroke severity and functional deficit as important outcome parameterMax Nedelmann
Department of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
Brain Res 1130:188-96. 2007..We present outcome tests that provide quantitative and objective tools to test functional impairment in rats following embolic stroke... - Therapeutic application of 20-kHz transcranial ultrasound in an embolic middle cerebral artery occlusion model in rats: safety concernsThomas Wilhelm Schwenkmezger
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
Stroke 38:1031-5. 2007..A parameter setting was used that had not previously shown any side effects and interactions with healthy rat brain tissue... - Low-frequency ultrasound induces nonenzymatic thrombolysis in vitroMax Nedelmann
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
J Ultrasound Med 21:649-56. 2002..Ultrasound is a promising tool for developing an alternative or additional treatment modality for acute cerebral vessel occlusion... - A rat model for cerebral air microembolisationTibo Gerriets
Department of Neurology, Experimental Neurology Research Group, Justus Liebig University Giessen, Germany
J Neurosci Methods 190:10-3. 2010..In conclusion, the method presented allows injecting air bubbles of defined number and diameter into cerebral arteries of rats. This technique facilitates animal research in the field of air embolisation... - Involvement of jugular valve insufficiency in cerebral venous air embolismMax Nedelmann
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
J Neuroimaging 17:258-60. 2007..Peripheral air embolism is discussed as a potential cause. However, the mechanism of retrograde passage through internal jugular valves and veins is unclear... - RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute strokeMaureen Walberer
Department of Neurology, University Hospital Cologne, Germany
Curr Neurovasc Res 6:12-9. 2009..The present study introduces a hitherto unrecognized mechanism of ischemic brain damage and a novel neuroprotective approach towards acute stroke treatment... - Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequenciesMax Nedelmann
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
Cerebrovasc Dis 20:18-22. 2005..The purpose of this study was a direct comparison of different ultrasound frequencies, when otherwise using identical measurement settings and parameters...