M Nedelmann

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. pmc Cerebral hemodynamic failure presenting as limb-shaking transient ischemic attacks
    Max Nedelmann
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    Case Rep Neurol 3:97-102. 2011
  2. ncbi request reprint Ultrasound destruction of air microemboli as a novel approach to brain protection in cardiac surgery
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany Heart and Brain Research Group, Justus Liebig University, Giessen and Kerckhoff Clinic, Bad Nauheim, Germany Electronic address
    J Cardiothorac Vasc Anesth 27:876-83. 2013
  3. pmc Decrease in shunt volume in patients with cryptogenic stroke and patent foramen ovale
    Christian Tanislav
    Department of Neurology, Justus Liebig University, Giessen, Germany
    BMC Neurol 10:123. 2010
  4. doi request reprint Venous obstruction and jugular valve insufficiency in idiopathic intracranial hypertension
    Max Nedelmann
    Department of Neurology, Justus Liebig University Giessen, Am Steg 14, 35385, Giessen, Germany
    J Neurol 256:964-9. 2009
  5. doi request reprint Detrimental effects of 60 kHz sonothrombolysis in rats with middle cerebral artery occlusion
    Max Nedelmann
    Department of Experimental Neurology, Justus Liebig University, Giessen and Kerckhoff Clinic, Bad Nauheim, Germany
    Ultrasound Med Biol 34:2019-27. 2008
  6. doi request reprint [Therapeutic ultrasound of acute cerebral artery occlusion]
    M Nedelmann
    Klinik fur Neurologie, Justus Liebig Universitat Giessen, Am Steg 14, 35392, Giessen
    Nervenarzt 79:1399-400, 1402-6. 2008
  7. doi request reprint Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Stroke 40:3238-44. 2009
  8. ncbi request reprint Analysis of internal jugular vein insufficiency--a comparison of two ultrasound methods
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Ultrasound Med Biol 33:857-62. 2007
  9. pmc Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany
    J Cereb Blood Flow Metab 30:1712-20. 2010
  10. doi request reprint Low-frequency therapeutic ultrasound with varied duty cycle: effects on the ischemic brain and the inner ear
    Peter Reuter
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Ultrasound Med Biol 36:1188-95. 2010

Collaborators

Detail Information

Publications26

  1. pmc Cerebral hemodynamic failure presenting as limb-shaking transient ischemic attacks
    Max Nedelmann
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    Case Rep Neurol 3:97-102. 2011
    ..This case thus documents the magnitude and dynamics of perfusion failure in a rare manifestation of cerebral ischemic disease...
  2. ncbi request reprint Ultrasound destruction of air microemboli as a novel approach to brain protection in cardiac surgery
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany Heart and Brain Research Group, Justus Liebig University, Giessen and Kerckhoff Clinic, Bad Nauheim, Germany Electronic address
    J Cardiothorac Vasc Anesth 27:876-83. 2013
    ..Evaluation of a novel approach to eliminate air microemboli from extracorporeal circulation via ultrasonic destruction...
  3. pmc Decrease in shunt volume in patients with cryptogenic stroke and patent foramen ovale
    Christian Tanislav
    Department of Neurology, Justus Liebig University, Giessen, Germany
    BMC Neurol 10:123. 2010
    ..Proven, this could have implications for the care of patients with PFO and a history of stroke. The following study addressed this hypothesis in a cohort of patients with stroke and PFO...
  4. doi request reprint Venous obstruction and jugular valve insufficiency in idiopathic intracranial hypertension
    Max Nedelmann
    Department of Neurology, Justus Liebig University Giessen, Am Steg 14, 35385, Giessen, Germany
    J Neurol 256:964-9. 2009
    ..Jugular valve insufficiency may facilitate pressure transmission. As transverse sinus stenosis was a concomitant finding, these factors may be complementary...
  5. doi request reprint Detrimental effects of 60 kHz sonothrombolysis in rats with middle cerebral artery occlusion
    Max Nedelmann
    Department of Experimental Neurology, Justus Liebig University, Giessen and Kerckhoff Clinic, Bad Nauheim, Germany
    Ultrasound Med Biol 34:2019-27. 2008
    ..Although the results are not directly transferable to the human setting, this study clearly demonstrates the potential limitations of low frequency therapeutic ultrasound and the importance of pre-clinical safety assessment...
  6. doi request reprint [Therapeutic ultrasound of acute cerebral artery occlusion]
    M Nedelmann
    Klinik fur Neurologie, Justus Liebig Universitat Giessen, Am Steg 14, 35392, Giessen
    Nervenarzt 79:1399-400, 1402-6. 2008
    ..Investigators have shown that the combination with echo contrast agents further improves the thrombolytic potential of ultrasound. This work summarizes the current clinical and experimental knowledge on this therapeutic stroke concept...
  7. doi request reprint Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Stroke 40:3238-44. 2009
    ..The aim of this international consensus procedure was to develop recommendations on the methodology and documentation to be used for assessment of intracranial occlusion and for monitoring of recanalization...
  8. ncbi request reprint Analysis of internal jugular vein insufficiency--a comparison of two ultrasound methods
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Ultrasound Med Biol 33:857-62. 2007
    ..This study shows that detection rates of internal jugular valve insufficiency are very similar with both methods. However, this high agreement required modification of the established protocol of ACUV...
  9. pmc Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion
    Max Nedelmann
    Department of Neurology, Justus Liebig University, Giessen, Germany
    J Cereb Blood Flow Metab 30:1712-20. 2010
    ..This study shows that CEUS and rt-PA is safe in the situation of reperfusion and displays beneficial effects on the level of the microvasculature...
  10. doi request reprint Low-frequency therapeutic ultrasound with varied duty cycle: effects on the ischemic brain and the inner ear
    Peter Reuter
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Ultrasound Med Biol 36:1188-95. 2010
    ..However, side effects on the auditory system were found to be independent of parameter settings...
  11. doi request reprint High frequency of silent pulmonary embolism in patients with cryptogenic stroke and patent foramen ovale
    Christian Tanislav
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    Stroke 42:822-4. 2011
    ..Because it has implications in secondary prevention, we investigated the frequency of silent PE in such a cohort of patients...
  12. doi request reprint In vitro evaluation of the sinus sagittalis superior thrombosis model in the rat using 3D micro- and nanocomputed tomography
    Alexander Claus Langheinrich
    Department of Radiology, Justus Liebig University Giessen, Klinikstrasse 36, Giessen, Germany
    Neuroradiology 52:815-21. 2010
    ..Therefore, the purpose of our study was to evaluate a well-established model for sinus sagittalis (SSS) thrombosis using micro- and nanocomputed tomography (CT) imaging...
  13. doi request reprint Edema formation in the hyperacute phase of ischemic stroke. Laboratory investigation
    Tibo Gerriets
    Department of Neurology, Justus Liebig University Giessen, Giessen, Germany
    J Neurosurg 111:1036-42. 2009
    ..In the present study, the authors evaluated the natural course of edema formation in the hyperacute phase of focal cerebral ischemia...
  14. doi request reprint Active regulation of cerebral venous tone: simultaneous arterial and venous transcranial Doppler sonography during a Valsalva manoeuvre
    Erwin Stolz
    Department of Neurology, Justus Liebig University, Am Steg 14, 35385 Giessen, Germany
    Eur J Appl Physiol 109:691-7. 2010
    ..However, the significantly lager venous than the arterial overshoot in phase IV may be explained by the active regulation of the venous tone...
  15. doi request reprint Intravenous immunoglobulin reduces infarct volume but not edema formation in acute stroke
    Maureen Walberer
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Neuroimmunomodulation 17:97-102. 2010
    ..Since edema treatment can provide secondary neuroprotective effects, we conducted the present study to evaluate whether edema reduction is the underlying cause of the neuroprotective properties of IVIG in experimental stroke...
  16. ncbi request reprint Brain edema and intracerebral necrosis caused by transcranial low-frequency 20-kHz ultrasound: a safety study in rats
    Felicitas Schneider
    Department of Neurology, Johannes Gutenberg University, 55101 Mainz, Germany
    Stroke 37:1301-6. 2006
    ..However, little is known about biological interactions of low-frequency ultrasound with brain tissue. The aim of this in vivo MRI study was to assess safety aspects of transcranial low-frequency ultrasound in rats...
  17. ncbi request reprint Low-frequency ultrasound induces nonenzymatic thrombolysis in vitro
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Ultrasound Med 21:649-56. 2002
    ..To evaluate whether ultrasound, applied over a distance of several centimeters and in the absence of thrombolytic agents, may have a thrombolytic effect on blood clots...
  18. ncbi request reprint Functional and morphological criteria of internal jugular valve insufficiency as assessed by ultrasound
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Neuroimaging 15:70-5. 2005
    ..This study describes the methodology to detect internal jugular valve insufficiency and establishes functional and morphological criteria to discriminate retrograde flow during valve closure from retro grade insufficiency flow...
  19. ncbi request reprint Increased incidence of jugular valve insufficiency in patients with transient global amnesia
    Max Nedelmann
    Dept of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Neurol 252:1482-6. 2005
    ..Using a direct method for the study of retrograde flow during a Valsalva maneuver, we determined whether jugular valve insufficiency contributes to cerebral venous hypertension in patients with TGA...
  20. ncbi request reprint Cerebral embolic ischemia in rats: correlation of stroke severity and functional deficit as important outcome parameter
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Brain Res 1130:188-96. 2007
    ..We present outcome tests that provide quantitative and objective tools to test functional impairment in rats following embolic stroke...
  21. ncbi request reprint Therapeutic application of 20-kHz transcranial ultrasound in an embolic middle cerebral artery occlusion model in rats: safety concerns
    Thomas Wilhelm-Schwenkmezger
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Stroke 38:1031-5. 2007
    ..A parameter setting was used that had not previously shown any side effects and interactions with healthy rat brain tissue...
  22. doi request reprint Aggravation of infarct formation by brain swelling in a large territorial stroke: a target for neuroprotection?
    Maureen Walberer
    Experimental Neurology Research Group, Justus Liebig University Giessen, Germany
    J Neurosurg 109:287-93. 2008
    ..In the present study the authors sought to quantify the impact of this space-occupying effect on ischemic lesion formation...
  23. doi request reprint A rat model for cerebral air microembolisation
    Tibo Gerriets
    Department of Neurology, Experimental Neurology Research Group, Justus Liebig University Giessen, Germany
    J Neurosci Methods 190:10-3. 2010
    ..In conclusion, the method presented allows injecting air bubbles of defined number and diameter into cerebral arteries of rats. This technique facilitates animal research in the field of air embolisation...
  24. ncbi request reprint Involvement of jugular valve insufficiency in cerebral venous air embolism
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    J Neuroimaging 17:258-60. 2007
    ..Peripheral air embolism is discussed as a potential cause. However, the mechanism of retrograde passage through internal jugular valves and veins is unclear...
  25. ncbi request reprint RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke
    Maureen Walberer
    Department of Neurology, University Hospital Cologne, Germany
    Curr Neurovasc Res 6:12-9. 2009
    ..The present study introduces a hitherto unrecognized mechanism of ischemic brain damage and a novel neuroprotective approach towards acute stroke treatment...
  26. ncbi request reprint Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequencies
    Max Nedelmann
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Cerebrovasc Dis 20:18-22. 2005
    ..The purpose of this study was a direct comparison of different ultrasound frequencies, when otherwise using identical measurement settings and parameters...