Barbara Nebe


Affiliation: University of Rostock
Country: Germany


  1. Bittig A, Matschegewski C, Nebe J, Stählke S, Uhrmacher A. Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model. BMC Syst Biol. 2014;8:106 pubmed publisher
  2. Nebe J, Müller L, Lüthen F, Ewald A, Bergemann C, Conforto E, et al. Osteoblast response to biomimetically altered titanium surfaces. Acta Biomater. 2008;4:1985-95 pubmed publisher
    ..The TiCT and the TiHCA surfaces reveal the tendency to increase the differentiated cell function of MG-63 osteoblasts. Thus, chemical pre-treatment of titanium seems to be a promising method to generate osteoconductive surfaces. ..
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    Nebe B, Finke B, Lüthen F, Bergemann C, Schröder K, Rychly J, et al. Improved initial osteoblast functions on amino-functionalized titanium surfaces. Biomol Eng. 2007;24:447-54 pubmed
    ..Our results demonstrate that functionalization of titanium with positively charged amino-groups is sufficiently enough to significantly improve initial steps of the cellular contact to the material surface. ..
  4. Staehlke S, Koertge A, Nebe B. Intracellular calcium dynamics dependent on defined microtopographical features of titanium. Biomaterials. 2015;46:48-57 pubmed publisher
    ..The topography-dependent calcium dynamics observed here provide new insights into how topographical cues alter cell functions - via the intracellular Ca(2+) signaling. ..
  5. Moerke C, Mueller P, Nebe B. Attempted caveolae-mediated phagocytosis of surface-fixed micro-pillars by human osteoblasts. Biomaterials. 2016;76:102-14 pubmed publisher
    ..We conclude that stochastically structured implants used in orthopedic surgery should avoid any topographical heights which induce phagocytosis to prevent their successful ingrowth. ..
  6. Bergemann C, Cornelsen M, Quade A, Laube T, Schnabelrauch M, Rebl H, et al. Continuous cellularization of calcium phosphate hybrid scaffolds induced by plasma polymer activation. Mater Sci Eng C Mater Biol Appl. 2016;59:514-523 pubmed publisher
    ..The whole TCP/PLA hybrid scaffold was continuously colonized due to plasma polymerized allylamine activation inducing the migration potential of osteoblasts. ..
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    Nebe B, Kunz F, Peters A, Rychly J, Noack T, Beck R. Induction of apoptosis by the calcium antagonist mibefradil correlates with depolarization of the membrane potential and decreased integrin expression in human lens epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2004;242:597-604 pubmed
    ..Thus, mibefradil seems to be a suitable drug to prevent cell adhesion, migration and proliferation. ..
  8. Rebl H, Finke B, Schmidt J, Mohamad H, Ihrke R, Helm C, et al. Accelerated cell-surface interlocking on plasma polymer-modified porous ceramics. Mater Sci Eng C Mater Biol Appl. 2016;69:1116-24 pubmed publisher
    ..This multilayer composite material guarantees enhanced interlocking of the cells with the porous surface. ..
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    Nebe B, Peters A, Duske K, Richter D, Briese V. Influence of phytoestrogens on the proliferation and expression of adhesion receptors in human mammary epithelial cells in vitro. Eur J Cancer Prev. 2006;15:405-15 pubmed

More Information


  1. Walschus U, Hoene A, Patrzyk M, Lucke S, Finke B, Polak M, et al. A Cell-Adhesive Plasma Polymerized Allylamine Coating Reduces the In Vivo Inflammatory Response Induced by Ti6Al4V Modified with Plasma Immersion Ion Implantation of Copper. J Funct Biomater. 2017;8: pubmed publisher
    ..In conclusion, PPAAm reduced the inflammatory reactions caused by Cu-PIII. Combining both plasma processes could be useful to create antibacterial and tissue compatible Ti-based implants. ..
  2. Moerke C, Mueller P, Nebe J. Sensing of micropillars by osteoblasts involves complex intracellular signaling. J Mater Sci Mater Med. 2017;28:171 pubmed publisher
  3. Moerke C, Staehlke S, Rebl H, Finke B, Nebe J. Restricted cell functions on micropillars are alleviated by surface-nanocoating with amino groups. J Cell Sci. 2018;131: pubmed publisher
    ..These results highlight that it is important for osteoblasts to establish cell surface contact for them to perform their functions. ..