Affiliation: University of Veterinary Medicine
- [Safety of food products updated in perspective--an introduction to the following scientific articles]H Nau
Lebensmitteltoxikologie, Institut für Lebensmitteltoxikologie und Chemische Analytik, Zentrum für Lebensmittelwissenschaften, Tierarztliche Hochschule Hannover
Dtsch Tierarztl Wochenschr 111:272. 2004
- Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acidH Nau
Department of Food Toxicology, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
J Am Acad Dermatol 45:S183-7. 2001....
- [Impacts and impact mechanisms of "dioxins" in humans and animals]H Nau
Institut für Lebensmitteltoxikologie und Chemische Analytik, Lebensmitteltoxikologie, Stiftung Tierarztliche Hochschule Hannover
Dtsch Tierarztl Wochenschr 113:292-7. 2006..This shows that the exposure of the human to dioxins should be minimized wherever possible...
- Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cellsA Lampen
Zentrumsabteilung für Lebensmitteltoxikologie, Tierarztliche Hochschule Hannover, Bischofsholer Damm 15, D 30173, Hannover, Germany
Biochim Biophys Acta 1521:97-106. 2001..This study indicates that food compounds such as phytanic acid and DHA that are RXR-agonists and have an impact on intestinal CYP26 gene expression and metabolism of all-trans-RA in intestinal cells...
- Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cellsA Lampen
Zentrumsabteilung für Lebensmitteltoxikologie, Tierarztliche Hochschule Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
Drug Metab Dispos 29:742-7. 2001..When coadministered, RAR agonists showed the highest potency for CYP26 gene regulation. Receptor-selective retinoids showed enhanced effects on induction of CYP26 gene expression and all-trans-retinoic acid metabolism...
- Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonistM M Elmazar
Department of Food Toxicology, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, Hannover, D-30173, Germany
Toxicol Appl Pharmacol 170:2-9. 2001....
- Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytesA Lampen
Zentrumsabteilung für Lebensmitteltoxikologie, Tierarztliche Hochschule Hannover, Hannover, Germany
J Pharmacol Exp Ther 295:979-85. 2000..It is concluded that in addition to CYP1A1 and CYP3A, CYP26 may be the main CYP enzyme responsible for the metabolism of all-trans-RA in enterocytes. Active ligands such as all-trans-RA are formed in intestinal epithelial cells...
- Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivativesA Lampen
Zentrumsabteilung für Lebensmitteltoxikologie, Tierarztliche Hochschule Hannover, Bischofsholer Damm 15 115, D 30173, Hannover, Germany
Eur J Pharmacol 431:25-33. 2001..In conclusion, in contrast to PPAR-alpha and PPAR-gamma, PPAR-delta shows to be a specific sensor for teratogenic valproic acid-derivatives...
- Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expressionA Lampen
Institut für Lebensmitteltoxikologie, Stiftung Tierarztliche Hochschule Hannover, Germany
Biochim Biophys Acta 1735:30-40. 2005..The results indicate that the preventive effects of CLA in the development of colon cancer may be due to their downregulation of some target genes of the APC-beta-catenin-TCF-4- and PPARdelta signalling pathway...
- Potentiation of the teratogenic effects induced by coadministration of retinoic acid or phytanic acid/phytol with synthetic retinoid receptor ligandsM M A Elmazar
Department of Food Toxicology, School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany
Arch Toxicol 78:660-8. 2004..Thus, certain potentially useful therapeutic agents or nutritional factors such as phytanic acid should be tested for teratogenic risk by coadministration with other retinoid receptor agonists...
- Determination of phoxim residues in eggs by using high-performance liquid chromatography diode array detection after treatment of stocked housing facilities for the poultry red mite (Dermanyssus gallinae)G Hamscher
Institute for Food Toxicology, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D 30173 Hannover, Germany
Anal Chim Acta 586:330-5. 2007..No sample was found containing more than the maximum residue level of 60 microg kg(-1) for phoxim in eggs as given in Annex I of Council Regulation (EEC) No. 2377/90...
- [Effects of animal housing facilities on residues and contaminants in food]G Hamscher
Zentrumsabteilung für Lebensmitteltoxikologie, Zentrum für Lebensmittelwissenschaften, Tierarztliche Hochschule Hannover
Dtsch Tierarztl Wochenschr 110:316-9. 2003..Further research in this field is highly recommended, but there should be more sophisticated evaluation of the data sets from national and international monitoring programs...
- Fully automated determination of selective retinoic acid receptor ligands in mouse plasma and tissue by reversed-phase liquid chromatography coupled on-line with solid-phase extractionH M Arafa
, , Germany
J Chromatogr A 729:125-36. 1996..The small sample size required, the simple sample preparation and the rapid analysis with high degree of automation make this method convenient for microanalysis of biological samples both in animal and human studies...
- Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobeK J Murphy
Department of Pharmacology, The Conway Institute, University College Dublin, Dublin, Ireland
J Neurochem 78:704-14. 2001..The cognition-enhancing qualities of pentyl-4-yn-VPA, combined with its ability to attenuate the age-related loss of the NCAM polysialylation state, suggest that it may effectively slow the onset of cognitive decline...
- Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methodsA Lampen
, , D-Hannover
ALTEX 18:123-6. 2001..The test system allows to replace animal experiments in the preclinical development of new antiepileptics drugs with reduced teratogenic risk. Supported by BgVV-ZEBET (Berlin)...
- Induction of differentiation in F9 cells and activation of peroxisome proliferator-activated receptor delta by valproic acid and its teratogenic derivativesU Werling
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Eggenstein-Leopoldshafen, Germany
Mol Pharmacol 59:1269-76. 2001..In conclusion, our data show that VPA and its teratogenic derivatives induce a specific type of F9 cell differentiation and that PPARdelta is a limiting factor in the control of differentiation...
- Detection of estrogenically active substances in diets for sows by an in vitro bioassay supported by HPLC analysisP Winter
Institute of Animal Nutrition, University of Veterinary Medicine, Hannover Foundation, Hannover, Germany
J Anim Physiol Anim Nutr (Berl) 92:337-44. 2008....