R Naim

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Expression of vascular endothelial growth factor in external auditory canal cholesteatoma
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University of Mannheim, Germany
    Int J Mol Med 11:555-8. 2003
  2. ncbi request reprint Classification of the external auditory canal cholesteatoma
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Laryngoscope 115:455-60. 2005
  3. ncbi request reprint Regulation of apoptosis in external auditory canal cholesteatoma by hepatocyte growth factor/scatter factor
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    ORL J Otorhinolaryngol Relat Spec 67:45-50. 2005
  4. ncbi request reprint Up-regulation of beta-catenin in external auditory canal cholesteatoma
    Ramin Naim
    Universitat HNO Klinik, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Int J Mol Med 15:801-4. 2005
  5. ncbi request reprint [Angiogenic factors in external auditory canal cholesteatoma-fibroblast cell culture]
    R Naim
    Universitäts Hals Nasen Ohren Klinik, Mannheim
    HNO 53:952-6. 2005
  6. ncbi request reprint Influence of hepatocyte growth factor/scatter factor (HGF/SF) on fibroblast growth factor-2 (FGF-2) levels in external auditory canal cholesteatoma (EACC) cell culture
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    In Vivo 19:599-603. 2005
  7. ncbi request reprint The role of S100A1 in external auditory canal cholesteatoma
    Ramin Naim
    Univ HNO Klinik, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Oncol Rep 16:671-5. 2006
  8. ncbi request reprint Chemopreventive alteration of the cell-cell adhesion in head and neck squamous cell cancer
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Oncol Rep 16:273-7. 2006
  9. ncbi request reprint Effect of vascular endothelial growth factor on fibroblasts from external auditory canal cholesteatoma
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Arch Med Res 36:518-23. 2005
  10. ncbi request reprint Hepatocyte growth factor/scatter factor induces VEGF in human external auditory canal cholesteatoma cell culture
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Int J Mol Med 15:67-71. 2005

Detail Information

Publications41

  1. ncbi request reprint Expression of vascular endothelial growth factor in external auditory canal cholesteatoma
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University of Mannheim, Germany
    Int J Mol Med 11:555-8. 2003
    ..This is the first study describing VEGF expression in EACC and its difference to AMS...
  2. ncbi request reprint Classification of the external auditory canal cholesteatoma
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Laryngoscope 115:455-60. 2005
    ..The aim of this article is to classify EACC by different histopathologic and clinical findings of patients presenting to the Department of Otolaryngology at the University of Mannheim, Germany...
  3. ncbi request reprint Regulation of apoptosis in external auditory canal cholesteatoma by hepatocyte growth factor/scatter factor
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    ORL J Otorhinolaryngol Relat Spec 67:45-50. 2005
    ..Apoptosis appears to be important in understanding the pathogenesis of EACC. Here the possible regulatory effect of the apoptosis mediated by hepatocyte growth factor (HGF)/scatter factor (SF)-c-Met-Fas in EACC is discussed...
  4. ncbi request reprint Up-regulation of beta-catenin in external auditory canal cholesteatoma
    Ramin Naim
    Universitat HNO Klinik, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Int J Mol Med 15:801-4. 2005
    ....
  5. ncbi request reprint [Angiogenic factors in external auditory canal cholesteatoma-fibroblast cell culture]
    R Naim
    Universitäts Hals Nasen Ohren Klinik, Mannheim
    HNO 53:952-6. 2005
    ..Many authors reported that FGF-2 acts via VEGF and is induced by hypoxia. Hypoxia seems to be pivotal for establishing EACC. Therefore, human EACC fibroblasts were investigated by incubating with FGF-2 and determining VEGF...
  6. ncbi request reprint Influence of hepatocyte growth factor/scatter factor (HGF/SF) on fibroblast growth factor-2 (FGF-2) levels in external auditory canal cholesteatoma (EACC) cell culture
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    In Vivo 19:599-603. 2005
    ..Here, we investigate how the angiogenic factor hepatocyte growth factor/scatter factor (HGF/SF) influences the level of another angiogenic factor FGF-2...
  7. ncbi request reprint The role of S100A1 in external auditory canal cholesteatoma
    Ramin Naim
    Univ HNO Klinik, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Oncol Rep 16:671-5. 2006
    ..This correlates with our new data concerning S100A1. This is the first study to show the different reactivity pattern of S100A1 in the external auditory canal cholesteatoma...
  8. ncbi request reprint Chemopreventive alteration of the cell-cell adhesion in head and neck squamous cell cancer
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Oncol Rep 16:273-7. 2006
    ..It is not really clear as to, which pathway results in the elevation of the E-Cadherin proteins. However, in epithelial cancer cells, the Cadherin-catenin complex serves as a target for the chemopreventive agent, sulindac sulfone...
  9. ncbi request reprint Effect of vascular endothelial growth factor on fibroblasts from external auditory canal cholesteatoma
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Arch Med Res 36:518-23. 2005
    ..In this study we treat isolated fibroblasts of EACC with VEGF and determine FGF-2 levels. We also treat the fibroblast cultures with FGF-2 and measured VEGF levels...
  10. ncbi request reprint Hepatocyte growth factor/scatter factor induces VEGF in human external auditory canal cholesteatoma cell culture
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Int J Mol Med 15:67-71. 2005
    ..HGF/SF appears to activate cellular pathways inducing release of VEGF. After purification, no fibroblasts were present in our EACC culture so as to exclude possible paracrine effects by fibroblasts...
  11. ncbi request reprint [Middle-ear adenoma]
    R Naim
    Universitäts Hals Nasen Ohren Klinik, Mannheim, Germany
    Laryngorhinootologie 85:46-9. 2006
    ..These lesions are contrast-enhancing on CT and on magnetic resonance imaging (MRI) have brain-like signal intensity T2-weighted images. In this case, the lesion was exenterated...
  12. ncbi request reprint Expression of beta-catenin in external auditory canal cholesteatoma (EACC)
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Biofactors 19:189-95. 2003
    ..Furthermore, this might result in desquamation of keratinocytes and accumulation of dead keratin debrids. In sum, this study should be understood as a descriptive analysis of beta-catenin expression in EACC...
  13. ncbi request reprint [Cell adhesion proteins in external auditory canal cholesteatoma]
    R Naim
    Universitäts Hals Nasen Ohren Klinik Mannheim
    HNO 52:1083-7. 2004
    ..The cause of EACCt is, however, still not clear. The aim of this study was to describe the expression of beta-catenin, MMP-2, and MMP-9 in EACC matrix compared to the normal auditory meatal skin (AMS)...
  14. ncbi request reprint External auditory canal cholesteatoma
    Ramin Naim
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Otol Neurotol 25:412-3. 2004
  15. ncbi request reprint Co-expression of different angiogenic factors in external auditory canal cholesteatoma
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Acta Otolaryngol 124:563-8. 2004
    ..Abnormal regulation of angiogenesis has been implicated in the pathogenesis of several disorders. The aim of this study was to analyse angiogenesis regulator expression in EACC...
  16. ncbi request reprint External auditory canal cholesteatoma: analysis of the integrity of the tissue structure
    Ramin Naim
    Department of Otorhinolaryngology, Universitat HNO Klinik, Klinikum, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Int J Mol Med 14:601-4. 2004
    ..Generating synthetic inhibitors of metalloproteinases for therapeutic use in EACC and other defective diseases with unbalanced tissue conditions seems useful...
  17. ncbi request reprint Sulindac sulfone induces a decrease of beta-catenin in HNSCC
    Alexander Sauter
    Department of Otolaryngology, Head and Neck Surgery, Universitaets HNO Klinik, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Anticancer Res 30:339-43. 2010
    ..Sulindac sulfone has been shown to induce apoptosis in several different tumours. In the present study, we surveyed the concentration of beta-catenin in an HNSCC line after incubation with different concentrations of sulindac sulfone...
  18. ncbi request reprint Targeting TGF-beta1 increases hepatocyte growth factor (HGF/SF) levels in external auditory canal cholesteatoma (EACC) epithelial cell culture
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Regul Pept 130:75-80. 2005
    ..We assume HGF to be a pivotal factor during the pathogenesis of the external auditory canal cholesteatoma (EACC). In this study, we investigate the effect of antisense targeting TGF-beta1 on HGF/SF levels in the epithelial EACC-culture...
  19. ncbi request reprint Transforming growth factor-beta1-antisense modulates the expression of hepatocyte growth factor/scatter factor in keloid fibroblast cell culture
    R Naim
    Department of Otolaryngology, Head and Neck Surgery, University of Saarland, Homburg Saar, Kirrberger Strasse, 66421 Homburg, Germany
    Aesthetic Plast Surg 32:346-52. 2008
    ..Nevertheless, wound healing is the result of many interacting cytokines, so neutralizing or targeting one protein could result in no significant effect...
  20. ncbi request reprint Co-expression of VEGF, c-Met and HGF/SF in secondary pleural tumors
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Int J Mol Med 14:787-91. 2004
    ..VEGF is reported to increase vascular permeability, which in turn causes pleural effusions. The results presented here may be the basis for possible future palliative therapeutical strategies in malignant pleural effusions...
  21. ncbi request reprint Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression
    Haneen Sadick
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Haematologica 90:818-28. 2005
    ..The aim of this study was to evaluate the plasma levels and the expression profiles of angiogenic and angiogenesis-related factors in the context of HHT...
  22. ncbi request reprint Sulindac sulfone modulates beta-catenin in human cholesteatoma cell culture
    Alexander Sauter
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Arch Med Res 38:367-71. 2007
    ..Sulindac sulfone is a new class of targeted and pro-apoptotic drugs. It provokes apoptosis by inducing phosphorylation of beta-catenin, which is a multifunctional protein in the cell-cell adhesion complex...
  23. ncbi request reprint A three-step purification method of large quantities of human recombinant alpha endothelial cellular growth factor for clinical use
    Alexander Sauter
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Int J Mol Med 19:97-103. 2007
    ..Drug trials with rabbits revealed no increase in body temperature after intravenous injections with 1 mg rh-ECGF...
  24. ncbi request reprint Hereditary hemorrhagic telangiectasia: an update on clinical manifestations and diagnostic measures
    Haneen Sadick
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Wien Klin Wochenschr 118:72-80. 2006
    ....
  25. ncbi request reprint Current advances in the basic research and clinical management of sinonasal inverted papilloma (review)
    Alexander Sauter
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Oncol Rep 17:495-504. 2007
    ..Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up...
  26. ncbi request reprint Plasma surgery and topical estriol: effects on the nasal mucosa and long-term results in patients with Osler's disease
    Haneen Sadick
    Department of Otolaryngology, Head and Neck Surgery, University, Hospital Mannheim, Mannheim, Germany
    Otolaryngol Head Neck Surg 129:233-8. 2003
    ..Patient blood samples were obtained to determine the serum estriol levels. Scanning electron microscopy of the nasal mucosa enabled a better understanding concerning the effect of estriol on the nasal mucosa...
  27. ncbi request reprint Estriol induced squamous metaplasia on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia
    Haneen Sadick
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Manheim, Germany
    Arch Med Res 36:468-73. 2005
    ..The aim of this study was to evaluate by light and electron microscopy the effect of topical estriol on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia (HHT)...
  28. ncbi request reprint Serum levels of interleukin-6 in patients with primary head and neck squamous cell carcinoma
    Frank Riedel
    Department of Otolaryngology, Head and Neck Surgery, University Hospital of Heidelberg at Mannheim, D 68135 Mannheim, Germany
    Anticancer Res 25:2761-5. 2005
    ..IL-6 serum determinations might serve as a biological marker and help to identify advanced head and neck tumors...
  29. ncbi request reprint Plasma level and tissue expression of angiogenic factors in patients with hereditary hemorrhagic telangiectasia
    Haneen Sadick
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Int J Mol Med 15:591-6. 2005
    ..Additionally to the angiogenic pro-inflammatory cytokine IL-8, the angiogenic factor VEGF seems to play a major role in HHT pathogenesis...
  30. ncbi request reprint Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density
    Haneen Sadick
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Int J Mol Med 15:15-9. 2005
    ..High VEGF expression in patients with HHT in correlation to their VEGF165 plasma levels and the microvessel density may support the theory that VEGF functions as an important regulator and key protein of angiogenesis, even in HHT...
  31. ncbi request reprint Benign mixed tumor of the lacrimal gland. Clinical diagnosis and surgical management
    Haneen Sadick
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    ORL J Otorhinolaryngol Relat Spec 65:295-9. 2003
    ..The awareness of the clinical and diagnostic features of benign mixed tumors of the orbital lobe should help to avoid complications arising from an incisional biopsy or incomplete tumor resection...
  32. ncbi request reprint [Nasal congestion due to a painless mass of the left choana]
    A Sauter
    Universitäts HNO Klinik, Theodor Kutzer Ufer, 68135 Mannheim
    HNO 54:550-2. 2006
  33. ncbi request reprint Saliva as a biomarker for head and neck squamous cell carcinoma: in vitro detection of cytotoxic effects by using the plating efficiency index
    Marc B Bloching
    Department of Otolaryngology, Head and Neck Surgery, University of Homburg Saar, 66421 Homburg Saar, Germany
    Oncol Rep 18:1551-6. 2007
    ..In combination with several effective biomarkers on cytogenetic end-points, it may help to establish biomonitoring programs for secondary cancer prevention...
  34. ncbi request reprint VCAM-1 increases levels of HGF in eosinophilic chronic rhinosinusitis cell culture
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University of Homburg Saar, Germany
    In Vivo 22:77-81. 2008
    ..Other authors have reported that inflammatory cytokines may mediate changes in the underlying epithelium in the sinuses through hepatocyte growth factor HGF. In our study, the effect of VCAM-1 on HGF levels was investigated...
  35. ncbi request reprint Tumor risk assessment by means of immunocytochemical detection of early pre-malignant changes in buccal smears
    Marc M Bloching
    Department of Otolaryngology, Head and Neck Surgery, University of Saarland, Homburg, Germany
    Oncol Rep 19:1373-9. 2008
    ..05). It could be possible to use the marker MIB1 and cyclin D1 to screen risk groups, since the relative morbidity risk (odds ratio) increases (by 45-62 times) if the threshold value of 4 positively marked cell nuclei is exceeded...
  36. ncbi request reprint Effect of vascular cell adhesion molecule 1 on fibroblasts in human eosinophilic chronic rhinosinusitis
    Alexander Sauter
    Universitaets HNO Klinik, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Int J Mol Med 22:441-6. 2008
    ..The tissue remodelling observed during chronic eosinophilic inflammation offers new insight into the pathogenesis of ECRS...
  37. ncbi request reprint In vitro study of interleukin-5 (IL-5) in human eosinophilic chronic rhinosinusitis cell culture
    Alexander Sauter
    Department of Otolaryngology, Head and Neck Surgery, Ruprecht Karls University Heidelberg, Faculty of Medicine Mannheim, Mannheim, Germany
    In Vivo 22:549-56. 2008
    ..The damage of respiratory epithelium in allergic diseases has a close correlation with the extent of eosinophil infiltration. In our study, we investigated the effect of IL-5 on beta-catenin and E-cadherin levels in ECRS...
  38. ncbi request reprint Ossifying haemangioma of the frontal sinus
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    ORL J Otorhinolaryngol Relat Spec 66:98-100. 2004
    ..We recommend performing a computerized tomography 6-12 months after surgery for follow-up to detect possible tumour regrowth...
  39. ncbi request reprint Human chondrocytes differentially express matrix modulators during in vitro expansion for tissue engineering
    Ulrich Reinhart Goessler
    Department of Otolaryngology, Head and Neck Surgery, Ruprecht Karls University Heidelberg, Germany
    Int J Mol Med 16:509-15. 2005
    ..Improving the basic knowledge in this area may ultimately help clinicians to identify and proactively intervene in an attempt to prevent bioartificial cartilage from losing stability...
  40. ncbi request reprint Regulation of matrix metalloproteinases (MMP)-2/-9 expression in eosinophilic chronic rhinosinusitis--cell culture by interleukin-5 and -13?
    Alexander Sauter
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    In Vivo 22:415-21. 2008
    ..In this study epithelial cultures of CRS were treated with interleukin (IL)-5 or IL-13 and subsequent levels of metalloproteinases were determined...
  41. ncbi request reprint Ossifying fibromyxoid tumor of the nasal septum
    Andreas Blum
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Auris Nasus Larynx 33:325-7. 2006
    ..Complete local resection is the treatment of choice. Because of the high rate of local recurrence, clinical follow-up examinations are necessary...