Aye Mu Myint

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Network beyond IDO in psychiatric disorders: revisiting neurodegeneration hypothesis
    Aye Mu Myint
    Psychiatric Hospital, Ludwig Maximilian University, Nussbaumstrasse 7 D 80336 Munich, Germany School for Mental Health and Neuroscience, Maastricht University, The Netherlands Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 48:304-13. 2014
  2. doi request reprint Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene
    Aye Mu Myint
    Department of Psychiatry, Ludwig Maximilian University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Brain Behav Immun 31:128-33. 2013
  3. ncbi request reprint Kynurenines: from the perspective of major psychiatric disorders
    Aye M Myint
    Psychiatric Hospital, Ludwig Maximilian University, Munich, Germany
    FEBS J 279:1375-85. 2012
  4. pmc Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention
    Robert D Oades
    Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, 45147 Essen, Germany
    Behav Brain Funct 6:32. 2010
  5. pmc Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism--effects of medication
    Robert D Oades
    Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Behav Brain Funct 6:29. 2010
  6. doi request reprint Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients
    A M Myint
    Division of Cellular Neuroscience, Department of Psychiatry and Neuropsychology, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Brain Behav Immun 25:1576-81. 2011
  7. doi request reprint Neuropsychiatric disorders related to interferon and interleukins treatment
    Aye Mu Myint
    Laboratory Section for Psychoneuroimmunology and Therapeutic Drug Monitoring, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Metab Brain Dis 24:55-68. 2009
  8. doi request reprint Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 13:482-92. 2012
  9. ncbi request reprint Impact of different antipsychotics on cytokines and tryptophan metabolites in stimulated cultures from patients with schizophrenia
    Daniela Krause
    Department of Psychiatry and Psychotherapy Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatr Danub 25:389-97. 2013
  10. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011

Detail Information

Publications28

  1. ncbi request reprint Network beyond IDO in psychiatric disorders: revisiting neurodegeneration hypothesis
    Aye Mu Myint
    Psychiatric Hospital, Ludwig Maximilian University, Nussbaumstrasse 7 D 80336 Munich, Germany School for Mental Health and Neuroscience, Maastricht University, The Netherlands Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 48:304-13. 2014
    ....
  2. doi request reprint Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene
    Aye Mu Myint
    Department of Psychiatry, Ludwig Maximilian University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Brain Behav Immun 31:128-33. 2013
    ..0, p=0.019). The results indicated the association between IFNγ CA repeat allele 2, tryptophan metabolism and the effect of medication...
  3. ncbi request reprint Kynurenines: from the perspective of major psychiatric disorders
    Aye M Myint
    Psychiatric Hospital, Ludwig Maximilian University, Munich, Germany
    FEBS J 279:1375-85. 2012
    ..Moreover, the biomarker role of kynurenine metabolites and future therapeutic opportunities are also discussed...
  4. pmc Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention
    Robert D Oades
    Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, 45147 Essen, Germany
    Behav Brain Funct 6:32. 2010
    ..Therefore we examined predictions of biochemical associations with the major symptom clusters, measures of attention and response variability...
  5. pmc Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism--effects of medication
    Robert D Oades
    Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Behav Brain Funct 6:29. 2010
    ..This could be explained in terms of an impaired glial supply of energy to support neuronal activity...
  6. doi request reprint Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients
    A M Myint
    Division of Cellular Neuroscience, Department of Psychiatry and Neuropsychology, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Brain Behav Immun 25:1576-81. 2011
    ..These results indicate that there is an imbalance in the kynurenine pathway in schizophrenia. The 6-week antipsychotic treatment may partially reverse the imbalance in kynurenine metabolism and that in turn induces clinical response...
  7. doi request reprint Neuropsychiatric disorders related to interferon and interleukins treatment
    Aye Mu Myint
    Laboratory Section for Psychoneuroimmunology and Therapeutic Drug Monitoring, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Metab Brain Dis 24:55-68. 2009
    ....
  8. doi request reprint Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 13:482-92. 2012
    ..It is not clear, however, whether such changes are associated with corresponding neuroinflammatory responses and disturbances of neurotransmission...
  9. ncbi request reprint Impact of different antipsychotics on cytokines and tryptophan metabolites in stimulated cultures from patients with schizophrenia
    Daniela Krause
    Department of Psychiatry and Psychotherapy Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatr Danub 25:389-97. 2013
    ..In this study the impact of cytokines, tryptophan metabolites and antipsychotics was evaluated in schizophrenic patients/ healthy controls and correlated with the psychopathology of schizophrenia...
  10. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
    ..These peripheral immune processes may be accompanied by microglial activation in subregions of the anterior cingulate cortex where depression-associated alterations of glutamatergic neurotransmission have been described...
  11. ncbi request reprint Immunological treatment options for schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Curr Pharm Biotechnol 13:1606-13. 2012
    ..Further options for immunomodulating therapies in schizophrenia will be discussed...
  12. doi request reprint Anti-inflammatory treatment in schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 42:146-53. 2013
    ..Further options for immunomodulating therapies in schizophrenia will be discussed...
  13. ncbi request reprint Tryptophan breakdown pathway in bipolar mania
    Aye Mu Myint
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    J Affect Disord 102:65-72. 2007
    ..406, p=0.044). These findings indicated the involvement of bi-directional tryptophan metabolism and kynurenine pathway in pathophysiology and response to medication in bipolar mania...
  14. ncbi request reprint Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Curr Pharm Des 17:130-6. 2011
    ..Most of the existing data are related to COX-2 inhibitors, which have been tested in animal experiments and in clinical trials, pointing to favourable effects in schizophrenia...
  15. ncbi request reprint Th1, Th2, and Th3 cytokine alterations in major depression
    Aye Mu Myint
    Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands
    J Affect Disord 88:167-73. 2005
    ..The Th3 cytokine, transforming growth factor beta-1 (TGF-beta1), has been shown to regulate the balance between Th-1 and Th-2 cytokines. However, the role of TGF-beta1 in the psychoimmunology of depression has never been explored...
  16. ncbi request reprint Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression
    Aye Mu Myint
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neuroimmunomodulation 14:65-71. 2007
    ..The cyclooxygenase 2 (COX-2) inhibitor celecoxib has been shown to improve the depressive symptoms in patients with major depression...
  17. ncbi request reprint Kynurenine pathway in major depression: evidence of impaired neuroprotection
    Aye Mu Myint
    University of Maastricht, Department of Psychiatry and Neuropsychology, UNS 50, Maastricht, 6200MD, The Netherlands
    J Affect Disord 98:143-51. 2007
    ..044) in those with first episodes. The results suggested that the reduction in neuroprotective markers, which indicated an impaired neuroprotection, might play an important role in pathophysiology of major depression...
  18. ncbi request reprint Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study
    Daniel L A van den Hove
    Department of Psychiatry and Neuropsychology, Research Institute Brain and Behavior, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neonatology 93:52-5. 2008
    ..These results reiterate the need for further research on the effects of paroxetine treatment during gestation...
  19. pmc S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin Resistance
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Cardiovasc Psychiatry Neurol 2010:480707. 2010
    ....
  20. doi request reprint Effects of antidepressants and cyclooxygenase-2 inhibitor on cytokines and kynurenines in stimulated in vitro blood culture from depressed patients
    Daniela L Krause
    Department of Psychiatry, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Inflammopharmacology 20:169-76. 2012
    ..Here, the effects of anti-inflammatory medication and antidepressants on cytokines and tryptophan metabolite changes in blood culture with immune challenge [bacterial mimetic lipopolysaccharide (LPS)] were investigated...
  21. ncbi request reprint Gestational stress leads to depressive-like behavioural and immunological changes in the rat
    Siobhain M O'Mahony
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neuroimmunomodulation 13:82-8. 2006
    ..The stressed group showed higher levels of all three cytokines. No significant differences in the cytokine concentrations were detected in the hypothalamus, hippocampus or pre-frontal cortex...
  22. ncbi request reprint The role of the kynurenine metabolism in major depression
    Aye Mu Myint
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    J Neural Transm 119:245-51. 2012
    ..Moreover, the future therapeutic opportunities are also discussed in this review...
  23. pmc The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders--relation to drug treatment
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Germany
    Dialogues Clin Neurosci 11:319-32. 2009
    ..COX-2 inhibitors have been tested in animal models of depression and in preliminary clinical trials, pointing to favorable effects in schizophrenia and in MD...
  24. doi request reprint Inflammatory biomarkers and depression
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Nußbaumstr 7, 80336 Munchen, Germany
    Neurotox Res 19:308-18. 2011
    ....
  25. doi request reprint Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:509-18. 2010
    ..In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors...
  26. doi request reprint The metabolic syndrome in schizophrenia: is inflammation a contributing cause?
    Brian E Leonard
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    J Psychopharmacol 26:33-41. 2012
    ..It is concluded that the effects of inflammatory mediators on the brain causally contribute to the pathology of schizophrenia and the ill health that accompanies the disorder...
  27. ncbi request reprint S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 42:868-76. 2008
    ..However, no histological study has been published on the cellular distribution of S100B in the brain of individuals with schizophrenia to clarify this hypothesis...
  28. ncbi request reprint Efavirenz induces depressive-like behaviour, increased stress response and changes in the immune response in rats
    Siobhain M O'Mahony
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neuroimmunomodulation 12:293-8. 2005
    ..These symptoms are partially alleviated by chronic treatment with paroxetine...