Ville Mustonen

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. doi request reprint From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Koln, Germany
    Trends Genet 25:111-9. 2009
  2. pmc Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Koln, Germany
    Proc Natl Acad Sci U S A 105:12376-81. 2008
  3. pmc Adaptations to fluctuating selection in Drosophila
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Koln, Germany
    Proc Natl Acad Sci U S A 104:2277-82. 2007
  4. pmc Evolutionary population genetics of promoters: predicting binding sites and functional phylogenies
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Cologne, Germany
    Proc Natl Acad Sci U S A 102:15936-41. 2005
  5. ncbi request reprint Molecular evolution under fitness fluctuations
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zulpicher str 77, 50937 Koln, Germany
    Phys Rev Lett 100:108101. 2008
  6. pmc Fitness flux and ubiquity of adaptive evolution
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, 50937 Koln, Germany
    Proc Natl Acad Sci U S A 107:4248-53. 2010
  7. pmc GraphAlignment: Bayesian pairwise alignment of biological networks
    Michal Kolar
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicher Straße 77, D 50937 Koln, Germany
    BMC Syst Biol 6:144. 2012
  8. pmc Emergent neutrality in adaptive asexual evolution
    Stephan Schiffels
    Institut fur Theoretische Physik, Universitat zu Koln, 50937 Koln, Germany
    Genetics 189:1361-75. 2011

Collaborators

Detail Information

Publications8

  1. doi request reprint From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Koln, Germany
    Trends Genet 25:111-9. 2009
    ..Here, we focus on the evolution of yeast and Drosophila genomes, providing examples where adaptive evolution can and cannot be inferred, despite the presence of positive selection...
  2. pmc Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Koln, Germany
    Proc Natl Acad Sci U S A 105:12376-81. 2008
    ..In a wider context, this study provides an example of inference of selection acting on a quantitative molecular trait...
  3. pmc Adaptations to fluctuating selection in Drosophila
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Koln, Germany
    Proc Natl Acad Sci U S A 104:2277-82. 2007
    ..e., the inference of functional elements can less be based on sequence conservation than for proteins. Our results suggest that selection acts not only as a constraint but as a major driving force of genomic change...
  4. pmc Evolutionary population genetics of promoters: predicting binding sites and functional phylogenies
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstrasse 77, 50937 Cologne, Germany
    Proc Natl Acad Sci U S A 102:15936-41. 2005
    ..We have performed, as an example, a cross-species analysis of E. coli, Salmonella typhimurium, and Yersinia pseudotuberculosis. Detailed lists of predicted sites and their functional phylogenies are available...
  5. ncbi request reprint Molecular evolution under fitness fluctuations
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, Zulpicher str 77, 50937 Koln, Germany
    Phys Rev Lett 100:108101. 2008
    ..The joint statistical theory of reproductive and fitness fluctuations establishes a conceptual connection between evolutionary genetics and statistical physics of disordered systems...
  6. pmc Fitness flux and ubiquity of adaptive evolution
    Ville Mustonen
    Institut fur Theoretische Physik, Universitat zu Koln, 50937 Koln, Germany
    Proc Natl Acad Sci U S A 107:4248-53. 2010
    ..We show that these predictions are in accordance with experiments in bacteria and bacteriophages and with genomic data in Drosophila. Our analysis establishes fitness flux as a universal measure of adaptation in molecular evolution...
  7. pmc GraphAlignment: Bayesian pairwise alignment of biological networks
    Michal Kolar
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicher Straße 77, D 50937 Koln, Germany
    BMC Syst Biol 6:144. 2012
    ..With increased experimental availability and accuracy of bio-molecular networks, tools for their comparative and evolutionary analysis are needed. A key component for such studies is the alignment of networks...
  8. pmc Emergent neutrality in adaptive asexual evolution
    Stephan Schiffels
    Institut fur Theoretische Physik, Universitat zu Koln, 50937 Koln, Germany
    Genetics 189:1361-75. 2011
    ..Our results suggest that interference can severely compromise biological functions in an adapting population, which sets viability limits on adaptive evolution under linkage...