F Musshoff

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint A gas chromatographic analysis of phosphine in biological material in a case of suicide
    F Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 177:e35-8. 2008
  2. doi request reprint Comparison of urine results concerning co-consumption of illicit heroin and other drugs in heroin and methadone maintenance programs
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111, Bonn, Germany
    Int J Legal Med 124:499-503. 2010
  3. doi request reprint Optimization and validation of CEDIA drugs of abuse immunoassay tests in serum and urine on an Olympus AU 400
    F Musshoff
    University Hospital, Institute of Forensic Medicine, Stiftsplatz 12, 53111, Bonn, Germany
    Drug Test Anal 5:366-71. 2013
  4. doi request reprint Determination of cocaine, cocaine metabolites and cannabinoids in single hairs by MALDI Fourier transform mass spectrometry--preliminary results
    Frank Musshoff
    Institute of Forensic Medicine, University Hospital, Stiftsplatz 12, 53111, Bonn, Germany
    Drug Test Anal 5:361-5. 2013
  5. doi request reprint Lethal neuroleptic malignant syndrome due to amisulpride
    Frank Musshoff
    University Hospital, Institute of Forensic Medicine, Rheinische Friedrich Wilhems University Bonn, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Med Pathol 9:218-20. 2013
  6. doi request reprint Two cases of suicide by asphyxiation due to helium and argon
    Frank Musshoff
    Institute of Forensic Medicine, Rheinische Friedrich Wilhems University, Bonn, Germany
    Forensic Sci Int 223:e27-30. 2012
  7. doi request reprint Driving under the influence of amphetamine-like drugs
    Frank Musshoff
    Institute of Forensic Medicine, Bonn, Germany
    J Forensic Sci 57:413-9. 2012
  8. doi request reprint Evaluation of two immunoassay procedures for drug testing in hair samples
    F Musshoff
    Institute of Forensic Medicine, University Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 215:60-3. 2012
  9. doi request reprint Comparison of post-mortem metabolic changes in sheep brain tissue in isolated heads and whole animals using 1H-MR spectroscopy--preliminary results
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, Bonn, Germany
    Int J Legal Med 125:741-4. 2011
  10. ncbi request reprint Death during patient-controlled analgesia: piritramide overdose and tissue distribution of the drug
    F Musshoff
    Institute of Legal Medicine, University of Bonn, Germany
    Forensic Sci Int 154:247-51. 2005

Detail Information

Publications94

  1. doi request reprint A gas chromatographic analysis of phosphine in biological material in a case of suicide
    F Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 177:e35-8. 2008
    ..At autopsy a direct sampling into airtight headspace vials for a later analysis is recommended. AlP has to be considered a potent pesticide and its use and availability should be restricted as much as possible...
  2. doi request reprint Comparison of urine results concerning co-consumption of illicit heroin and other drugs in heroin and methadone maintenance programs
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111, Bonn, Germany
    Int J Legal Med 124:499-503. 2010
    ..If additional marker substances were examined, the suspicion of a co-use of illicit HER is markedly enhanced...
  3. doi request reprint Optimization and validation of CEDIA drugs of abuse immunoassay tests in serum and urine on an Olympus AU 400
    F Musshoff
    University Hospital, Institute of Forensic Medicine, Stiftsplatz 12, 53111, Bonn, Germany
    Drug Test Anal 5:366-71. 2013
    ..Even if specificity ranged between 83% and 98 %, the tests can be considered useful for forensic purposes. Receiver operating characteristic (ROC) curves, Youden indices, as well as positive and negative predictive values are presented...
  4. doi request reprint Determination of cocaine, cocaine metabolites and cannabinoids in single hairs by MALDI Fourier transform mass spectrometry--preliminary results
    Frank Musshoff
    Institute of Forensic Medicine, University Hospital, Stiftsplatz 12, 53111, Bonn, Germany
    Drug Test Anal 5:361-5. 2013
    ..Different growth rates have to be considered, and particularly the phenomenon of different growth phases (anagen, catagen, telogen) require attention...
  5. doi request reprint Lethal neuroleptic malignant syndrome due to amisulpride
    Frank Musshoff
    University Hospital, Institute of Forensic Medicine, Rheinische Friedrich Wilhems University Bonn, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Med Pathol 9:218-20. 2013
    ..65 mg/l, biperiden 0.12 mg/l, imipramine 0.33 mg/l, and desipramine 0.68 mg/l. An amisulpride-induced neuroleptic malignant syndrome was therefore diagnosed as the patho-physiological mechanism leading to death...
  6. doi request reprint Two cases of suicide by asphyxiation due to helium and argon
    Frank Musshoff
    Institute of Forensic Medicine, Rheinische Friedrich Wilhems University, Bonn, Germany
    Forensic Sci Int 223:e27-30. 2012
    ..In absence of analytical data supporting helium exposure, the causes of death in the actual cases were found to be asphyxia and in both cases the manner was suicide...
  7. doi request reprint Driving under the influence of amphetamine-like drugs
    Frank Musshoff
    Institute of Forensic Medicine, Bonn, Germany
    J Forensic Sci 57:413-9. 2012
    ..Relations between concentration and effect could not be established. The apparent sedation is probably the consequence of sleep deprivation during an amphetamine binge and the after-effects of the drug...
  8. doi request reprint Evaluation of two immunoassay procedures for drug testing in hair samples
    F Musshoff
    Institute of Forensic Medicine, University Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 215:60-3. 2012
    ..02 ng/mg. The DRI enzyme immunoassay test was only useful for morphine and cocaine testing at low recommended new cutoff values (0.1 ng/mg) revealing sensitivities of 94% and 99%, respectively...
  9. doi request reprint Comparison of post-mortem metabolic changes in sheep brain tissue in isolated heads and whole animals using 1H-MR spectroscopy--preliminary results
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, Bonn, Germany
    Int J Legal Med 125:741-4. 2011
    ..In further studies, it should be kept in mind that an isolated head does not represent authentic circumstances and is, therefore, not an ideal model for brain decomposition in intact corpses...
  10. ncbi request reprint Death during patient-controlled analgesia: piritramide overdose and tissue distribution of the drug
    F Musshoff
    Institute of Legal Medicine, University of Bonn, Germany
    Forensic Sci Int 154:247-51. 2005
    ..This case report is a further example that human errors can play a crucial role in the safety of medical equipment. Experts in anesthesia recommended human factors engineering design principles to improve the safety of medical devices...
  11. doi request reprint Cocaine and benzoylecgonine concentrations in fluorinated plasma samples of drivers under suspicion of driving under influence
    F Musshoff
    Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 200:67-72. 2010
    ..A use of fluoride stabilized blood sampling systems is advised. This makes it easier to investigate the state of intoxication or to appraise the temporal connection between COC consumption and incident or blood sampling...
  12. ncbi request reprint Systematic regional study of dopamine, norsalsolinol, and (R/S)-salsolinol levels in human brain areas of alcoholics
    Frank Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Alcohol Clin Exp Res 29:46-52. 2005
    ..In a prospective study, the regional distribution of DA, (R)-salsolinol (SAL), and (S)-SAL, as well as norsalsolinol (NorSAL) was examined systematically in a large collective of human brain samples obtained by autopsy...
  13. ncbi request reprint Validated assay for the determination of markers of illicit heroin in urine samples for the control of patients in a heroin prescription program
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 811:47-52. 2004
    ..g. poppy seeds). Therefore, patients of a heroin prescription program should be advised not to ingest such products...
  14. doi request reprint An uncommon case of a suicide with inhalation of hydrogen cyanide
    F Musshoff
    Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 204:e4-7. 2011
    ..This case report of a person who was not familiar with chemicals demonstrates the acquisition of professional information via the internet, enabling a suicide with a complex procedure...
  15. ncbi request reprint Brain amino acid abnormalities in kidney disease and diabetes mellitus
    P Schmidt
    Institute of Legal Medicine, Bonn, Germany
    Forensic Sci Int 142:221-7. 2004
    ....
  16. ncbi request reprint Postmortem serotonin (5-HT) concentrations in the cerebrospinal fluid of medicolegal cases
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 142:211-9. 2004
    ..However, due to a rather broad overlapping of values between suicides and controls the results failed to define a possible cut-off level in the 5-HT CSF concentration to distinguish between a suicidal and a non-suicidal incident...
  17. doi request reprint Ricin poisoning and forensic toxicology
    Frank Musshoff
    Institute of Forensic Medicine, University Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Drug Test Anal 1:184-91. 2009
    ..The origin, biochemistry, toxicity, and analytical procedures for the determination of ricin are summarized. The homicide of Markov is described as well as recent cases of criminal ricin use...
  18. ncbi request reprint Results of hair analyses for drugs of abuse and comparison with self-reports and urine tests
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 156:118-23. 2006
    ....
  19. ncbi request reprint An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites
    F Musshoff
    Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany
    J Mass Spectrom 41:633-40. 2006
    ..The assay was successfully applied to authentic plasma samples, allowing confirmation of the diagnosis of overdose situations as well as monitoring of patients' compliance, especially in patients under palliative care...
  20. ncbi request reprint Determination of opioid analgesics in hair samples using liquid chromatography/tandem mass spectrometry and application to patients under palliative care
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Bonn, Germany
    Ther Drug Monit 29:655-61. 2007
    ..In summary, hair analyses gave important additional information for the medical treatment of patients, the results often coming as a surprise to even the attending physicians...
  21. doi request reprint Cocaine and opiate concentrations in hair from subjects in a heroin maintenance program in comparison to a methadone substituted group
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111, Bonn, Germany
    Int J Legal Med 123:363-9. 2009
    ..7% and 25.7% (T-1) and 17.1% and 5.7% (T12) in MMP, respectively. The missing of acetylcodeine, in particular at T-1, questions its applicability as a characteristic marker of a preceding consumption of illicit heroin in hair analysis...
  22. doi request reprint Determination of nicotine in hair samples of pre-Columbian mummies
    F Musshoff
    Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 185:84-8. 2009
    ..g. by transfer from smoking visitors or employees during the early collection history of the objects in the 19th century, as well as in their respective lifetime...
  23. ncbi request reprint Analytical pitfalls in hair testing
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Anal Bioanal Chem 388:1475-94. 2007
    ..Many tables containing information related to this topic are provided...
  24. ncbi request reprint Enantiomeric determination of tramadol and O-desmethyltramadol by liquid chromatography- mass spectrometry and application to postoperative patients receiving tramadol
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    J Anal Toxicol 30:463-7. 2006
    ..The 7.7% of the samples that revealed negative results for ODT are likely explained by genetic polymorphisms resulting in absent enzyme activity of CYP2D6...
  25. doi request reprint Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS
    F Musshoff
    Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 186:e1-4. 2009
    ..By exclusion of other causes of death an intoxication was determined as the cause of death with respiratory failure as the pathophysiological mechanism...
  26. ncbi request reprint New trends in hair analysis and scientific demands on validation and technical notes
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Germany
    Forensic Sci Int 165:204-15. 2007
    ..Hair testing in analytical toxicology is still an area in need of further research...
  27. ncbi request reprint Accidental autoerotic death by volatile substance abuse or nonsexually motivated accidents?
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Bonn, Germany
    Am J Forensic Med Pathol 27:188-92. 2006
    ....
  28. ncbi request reprint Review of biologic matrices (urine, blood, hair) as indicators of recent or ongoing cannabis use
    Frank Musshoff
    Institute of Legal Medicine, University Bonn, Bonn, Germany
    Ther Drug Monit 28:155-63. 2006
    ..For the determination of the main metabolite THC-COOH in the picogram or femtogram per milligram range, which indicates an active consumption, special analytical procedures, such as GC/MS/MS techniques, are required...
  29. ncbi request reprint Fatal blood and tissue concentrations of more than 200 drugs
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, Bonn 53111, Germany
    Forensic Sci Int 142:161-210. 2004
    ....
  30. doi request reprint Pharmacogenetics and forensic toxicology
    Frank Musshoff
    Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 203:53-62. 2010
    ..Pharmacogenetics or toxicogenetics can therefore be relevant in forensic toxicology. This review presents relevant aspects together with some examples from daily routines...
  31. doi request reprint Ethyl glucuronide and ethyl sulfate in urine after consumption of various beverages and foods--misleading results?
    Frank Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111, Bonn, Germany
    Int J Legal Med 124:623-30. 2010
    ..With respect to the present results, a 0.1 mg/l cutoff can be considered useful, and misleading results should not be expected from informed subjects within a 24-h waiting period...
  32. ncbi request reprint Demonstration of a chloroquine fatality after 10-month earth-grave
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Int 125:201-4. 2002
    ..Chloroquine has to be considered to be useful for fatal poisoning, which is also recommended in some publications on methods to commit suicide...
  33. ncbi request reprint Fully automated determination of amphetamines and synthetic designer drugs in hair samples using headspace solid-phase microextraction and gas chromatography-mass spectrometry
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Germany
    J Chromatogr Sci 40:359-64. 2002
    ..It uses minimal sample amounts and has the same degree of sensitivity and reproducibility...
  34. ncbi request reprint Automated headspace solid-phase dynamic extraction for the determination of amphetamines and synthetic designer drugs in hair samples
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Germany
    J Chromatogr A 958:231-8. 2002
    ..Results indicated that SPDE is a rapid and sensitive method for the analysis of biological samples. Compared to solid-phase microextraction we found a higher extraction rate coupled with a faster automated operation...
  35. ncbi request reprint Simple determination of 22 organophosphorous pesticides in human blood using headspace solid-phase microextraction and gas chromatography with mass spectrometric detection
    Frank Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    J Chromatogr Sci 40:29-34. 2002
    ....
  36. ncbi request reprint Fatality due to ingestion of tramadol alone
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Int 116:197-9. 2001
    ..The concentration of tramadol in the heart and peripheral blood specimens did not suggest a major difference (ratio of 1.36). Similar to morphine tramadol was accumulated significantly in the bile...
  37. ncbi request reprint Hallucinogenic mushrooms on the German market - simple instructions for examination and identification
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Int 113:389-95. 2000
    ..The alkaloid content was determined with <0.003-1.15% of psilocybin and 0.01-0.90% psilocin. Panaeolus cyanescens was the mushroom with highest levels of psilocybin and psilocin...
  38. ncbi request reprint Determination of dopamine and dopamine-derived (R)-/(S)-salsolinol and norsalsolinol in various human brain areas using solid-phase extraction and gas chromatography/mass spectrometry
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Int 113:359-66. 2000
    ....
  39. ncbi request reprint Fatality caused by a combined trimipramine-citalopram intoxication
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Forensic Sci Int 106:125-31. 1999
    ..The trimipramine to desmethyltrimipramine ratios were calculated to be 2.06 and 3.18, the citalopram to desmethylcitalopram ratios were 1.96 and 2.02...
  40. ncbi request reprint A systematic regional study of dopamine and dopamine-derived salsolinol and norsalsolinol levels in human brain areas
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Forensic Sci Int 105:1-11. 1999
    ..These findings suggest that the concentration of the substrate dopamine may determine the alkaloid level during in vivo formation...
  41. ncbi request reprint Rapid analysis of parathion in biological samples using headspace solid-phase micro-extraction (HS-SPME) and gas chromatography/mass spectrometry (GC/MS)
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Clin Chem Lab Med 37:639-42. 1999
    ..In conclusion, HS-SPME in combination with GC/MS is an effective method for the determination and quantification of parathion-ethyl and parathion-methyl in biological material...
  42. ncbi request reprint An unusual case of driving under the influence of enflurane
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Int 128:187-9. 2002
    ..The way of driving and the accident and the deficiency symptoms could be explained by the central suppressing effects of enflurane. The physician was considered as impaired and not suitable to drive at the time of the incidence...
  43. ncbi request reprint Methadone substitution: medicolegal problems in Germany
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 133:118-24. 2003
    ..In most of the cases, up to five additional drugs were also being taken: benzodiazepines (61%), ethanol (40%), morphine (39%), cannabinoids (35%), cocaine (28%), anti-depressants (3%), and amphetamines (2%)...
  44. ncbi request reprint Simultaneous gas chromatographic-mass spectrometric determination of dopamine, norsalsolinol and salsolinol enantiomers in brain samples of a large human collective
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Cell Mol Biol (Noisy-le-grand) 49:837-49. 2003
    ..Our data can serve as reference for other studies in humans concerning the etiology of alcoholism or other neurodegenerative diseases with the involvement of tetrahydroisoquinolines...
  45. doi request reprint Potential occupational exposures in the Reiss-Engelhorn-Museen Mannheim/Germany
    Frank Musshoff
    Institute of Forensic Medicine, Bonn, Germany
    Bull Environ Contam Toxicol 85:638-41. 2010
    ..Caution has to be made because the presence of hazardous compounds can result in security problems for museum staff as well as for visitors...
  46. ncbi request reprint Brain amino acid abnormalities in liver disease--a postmortem study
    Frank Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    J Forensic Sci 48:1379-84. 2003
    ..Amino acid analysis may contribute to the understanding of pathophysiological mechanisms of liver disease, which are discussed, and may supplement the postmortem diagnosis...
  47. ncbi request reprint Naphazoline intoxication in a child-a clinical and forensic toxicological case
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 134:234-7. 2003
    ..In general, physicians, pharmacists and the public should be educated about the toxicity of over-the-counter preparations...
  48. ncbi request reprint Automated headspace solid-phase dynamic extraction for the determination of cannabinoids in hair samples
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 133:32-8. 2003
    ..Compared to SPME, we found a higher extraction rate, coupled with a faster automated operation and greater stability of the device...
  49. ncbi request reprint Fully automated determination of cannabinoids in hair samples using headspace solid-phase microextraction and gas chromatography-mass spectrometry
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    J Anal Toxicol 26:554-60. 2002
    ..29-2.20 (mean 1.7) ng/mg, CBN 0.55-4.54 (mean 1.2) ng/mg, and CBD 0.53-18.36 (mean 1.3) ng/mg. 11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid could not be detected with this method...
  50. ncbi request reprint Cyanide fatalities: case studies of four suicides and one homicide
    Frank Musshoff
    Institutes of Legal Medicine, Bonn, Germany
    Am J Forensic Med Pathol 23:315-20. 2002
    ..The discussion focuses on the circumstances, metabolic changes, pathophysiology, blood levels, diagnosis, and management of cyanide poisoning...
  51. ncbi request reprint Chromatographic methods for the determination of markers of chronic and acute alcohol consumption
    Frank Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 781:457-80. 2002
    ..The author points out that in many of the reviewed papers validation data of the procedures as well as specificities and sensitivities were not clearly presented and consequently were not comparable...
  52. doi request reprint Combined suicide by oxydemeton-methyl (Metasystox) ingestion and hanging
    A K Gottzein
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 189:e21-5. 2009
    ..Therefore, it is a case of a primary combined suicide...
  53. ncbi request reprint Suicidal yew leave ingestion--phloroglucindimethylether (3,5-dimethoxyphenol) as a marker for poisoning from Taxus baccata
    F Musshoff
    Institute of Legal Medicine, Heinrich Heine University, , Germany
    Int J Legal Med 106:45-50. 1993
    ..None of the Taxus alkoids could be identified. The components detected by TLC have not yet been identified. The results demonstrate that 3,5-dimethoxyphenol can be used as a marker in cases of intoxication by yew ingredients...
  54. ncbi request reprint Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes
    U M Stamer
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Clin Pharmacol Ther 82:41-7. 2007
    ..001). In conclusion, CYP2D6 genotype determined concentrations of O-desmethyltramadol enantiomers and influenced efficacy of tramadol treatment...
  55. doi request reprint A fully validated high-performance liquid chromatography-tandem mass spectrometry method for the determination of ethyl glucuronide in hair for the proof of strict alcohol abstinence
    Maria Elena Albermann
    Institute of Forensic Medicine, University Hospital Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Anal Bioanal Chem 396:2441-7. 2010
    ..However, modified chromatographic conditions help substantiate critical results, especially if the determined EtG concentration is close to a cut-off value...
  56. ncbi request reprint Evaluation of immunochemical drug screenings of whole blood samples. A retrospective optimization of cutoff levels after confirmation-analysis on GC-MS and HPLC-DAD
    Lars Kroener
    Institut of Legal Medicine, Bonn, Germany
    J Anal Toxicol 27:205-12. 2003
    ....
  57. ncbi request reprint Opiate concentrations in hair from subjects in a controlled heroin-maintenance program and from opiate-associated fatalities
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Germany
    J Anal Toxicol 29:345-52. 2005
    ..In addition, the lack of AC, which was also observed in the majority of the deaths, questions its applicability as a characteristic marker of the consumption of illicit heroin...
  58. doi request reprint Estimation of gamma-hydroxybutyrate (GHB) co-consumption in serum samples of drivers positive for amphetamine or ecstasy
    S Lott
    Institute of Forensic Medicine, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 221:98-101. 2012
    ..These results suggest that co-consumption of GHB with amphetamine or ecstasy is relatively low (1%) for the collective of this study...
  59. ncbi request reprint Enantioselective determination of ondansetron and 8-hydroxyondansetron in human plasma from recovered surgery patients by liquid chromatography-tandem mass spectrometry
    F Musshoff
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    J Anal Toxicol 34:581-6. 2010
    ..In further studies CYP2D6 and CYP3A4 genotype dependent metabolism of ondansetron enantiomers as well as of co-administered drugs and clinical efficacy of the medication should be tested...
  60. pmc A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethyl glucuronide and ethyl sulfate in urine validated according to forensic guidelines
    M E Albermann
    Institute of Forensic Medicine, University Hospital Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    J Chromatogr Sci 50:51-6. 2012
    ..Finally, the applicability of the procedure is proven by analysis of 87 human urine samples and by successful participation in interlaboratory comparison tests...
  61. ncbi request reprint Spinal epidural haematoma after blunt trauma to the neck and hyperflection of the cervical spine
    S A Padosch
    Department of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 159:230-4. 2006
    ..Acute respiratory failure caused by impairment of the phrenic nerve following spinal epidural haematoma with potential synergism of alcohol intoxication was ascertained as the cause of death...
  62. ncbi request reprint MOR1 receptor mRNA expression in human brains of drug-related fatalities-a real-time PCR quantification
    J Becker
    Institute of Forensic Medicine, Friedrich Wilhelms University Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 140:13-20. 2004
    ....
  63. doi request reprint Comparison of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) concentrations in hair for testing abstinence
    M E Albermann
    Institute of Forensic Medicine, University Hospital Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Anal Bioanal Chem 400:175-81. 2011
    ..In critical cases FAEE concentrations can be determined for checking purposes, but a negative FAEE result cannot refute a determined EtG concentration >7 pg/mg...
  64. ncbi request reprint Salsolinol and norsalsolinol in human urine samples
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Pharmacol Biochem Behav 58:545-50. 1997
    ..3) and nonalcoholics (median 0.6) were detected. This concentration ratio could serve as a marker for the processor state of the dopaminergic system...
  65. ncbi request reprint Determination of opiates and cocaine in hair using automated enzyme immunoassay screening methodologies followed by gas chromatographic-mass spectrometric (GC-MS) confirmation
    Katrin Lachenmeier
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 159:189-99. 2006
    ..Screening methods provide rapid and inexpensive automated pre-test procedures to detect drugs in hair or other matrices. For forensic purposes screening therefore represents an ideal complement to routinely applied GC-MS procedures...
  66. ncbi request reprint The significance of putative urinary markers of illicit heroin use after consumption of poppy seed products
    Jens Trafkowski
    Institute of Forensic Medicine, University Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Ther Drug Monit 28:552-8. 2006
    ..But it must be kept in mind that in some cases poppy seeds with an unusually high content of these alkaloids could be available, and that these substances are also agents in some pharmaceuticals...
  67. doi request reprint Investigations on the influence of different grinding procedures on measured ethyl glucuronide concentrations in hair determined with an optimized and validated LC-MS/MS method
    M E Albermann
    Institute of Forensic Medicine, University Hospital Bonn, Stiftsplatz 12, 53111, Bonn, Germany
    Anal Bioanal Chem 403:769-76. 2012
    ..The strong impact of sample preparation on the determined EtG concentrations suggests the introduction of a standardized sample preparation method to produce comparable results...
  68. ncbi request reprint Suicide with moclobemide and perazine
    F Musshoff
    Institute of Legal Medicine, Bonn, Germany
    Int J Legal Med 111:196-8. 1998
    ..9 mg/l), perazine (1.27 mg/l) and some metabolites were identified in the blood. A combined drug intoxication resulting in synergistic effects to cardiovascular disorders was proposed as the cause of death...
  69. doi request reprint Variations in vitreous humor chemical values as a result of pre-analytical treatment
    S A Blana
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 210:263-70. 2011
    ..Additionally, the measurement of lactate shows that analytical methods, calibrated for serum and urine, cannot be easily applied for VH...
  70. doi request reprint Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality
    M E Albermann
    Institute of Forensic Medicine, University Hospital Bonn, Bonn, Germany
    Forensic Sci Int 197:35-9. 2010
    ..Excluding other causes of death, the woman is believed to have died from a lethal hyperglycemic coma. Nonetheless, the influence of harmful and toxic substances in food should be taken into consideration in special cases...
  71. ncbi request reprint Determination of cannabinoids in hemp food products by use of headspace solid-phase microextraction and gas chromatography-mass spectrometry
    Dirk W Lachenmeier
    Institut fur Rechtsmedizin, Rheinische Friedrich Wilhelms Universitat, Stiftsplatz 12, 53111 Bonn, Germany
    Anal Bioanal Chem 378:183-9. 2004
    ..In comparison with other studies relatively low THC concentrations between 0.01 and 15.53 mg kg(-1) were determined...
  72. ncbi request reprint Postmortem toxicology
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, Stifsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 142:71-3. 2004
  73. doi request reprint Molecular pathology in forensic medicine--Introduction
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int 203:3-14. 2010
    ....
  74. doi request reprint A fully validated isotope dilution HPLC-MS/MS method for the simultaneous determination of succinylcholine and succinylmonocholine in serum and urine samples
    Uta Kuepper
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    J Mass Spectrom 43:1344-52. 2008
    ..5 and 4.9 ng/ml (SMC).The presented method was successfully applied to authentic samples of two forensic cases investigated in the institute of forensic medicine in Bonn, allowing the diagnosis of SUX intoxications...
  75. ncbi request reprint Area-specific increased density of mu-opioid receptor immunoreactive neurons in the cerebral cortex of drug-related fatalities
    Peter Schmidt
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, FRG, Germany
    Forensic Sci Int 133:204-11. 2003
    ..In the area 11, however, the number of immunolabelled neuronal profiles amounted to 2777+/-206 mm(3) in the drug-related fatalities and to 2320+/-124 mm(3) in the control group and thus was significantly increased...
  76. ncbi request reprint Tasks of research in forensic medicine - different study types in clinical research and forensic medicine
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 165:92-7. 2007
    ..Tasks of research in forensic medicine and study types, which may be applied will be addressed...
  77. doi request reprint Fall downstairs: accident, homicide or natural death?
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, 53111, Bonn, Germany
    Forensic Sci Med Pathol 4:122-8. 2008
    ..Of special importance was that, based on the knowledge of typical autopsy findings in fatal falls downstairs, a lethal fall downstairs could be ruled out. Therefore even negative autopsy findings are of great forensic importance...
  78. doi request reprint Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication
    Ulrike M Stamer
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anesth Analg 107:926-9. 2008
    ....
  79. doi request reprint Unclear loss of consciousness after clobutinol intake
    Katrin M Kirschbaum
    Institute of Forensic Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 189:e37-40. 2009
    ..The accusation of intentional bodily injury raised against the parents could be rebutted, since the boy's unconsciousness could be explained with a rare but harmful side effect of the antitussive clobutinol...
  80. pmc Knock-out drugs: their prevalence, modes of action, and means of detection
    Burkhard Madea
    Institut für Rechtsmedizin der Universität Bonn, Bonn, Germany
    Dtsch Arztebl Int 106:341-7. 2009
    ....
  81. doi request reprint Medical negligence in drug associated deaths
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 190:67-73. 2009
    ....
  82. ncbi request reprint Synthesis and characterization of succinylcholine-d18 and succinylmonocholine-d3 designed for simultaneous use as internal standards in mass spectrometric analyses
    Uta Kuepper
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    J Mass Spectrom 42:929-39. 2007
    ....
  83. ncbi request reprint Postmortem biochemistry
    Burkhard Madea
    Institute of Forensic Medicine, Rheinische Friedrich Wilhelms University Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 165:165-71. 2007
    ..Up to now chemical determinations on alternative fluids have mainly been carried out using instruments calibrated for urine or serum. Developing calibrated methods for analysis of alternative fluids is a further task for the future...
  84. doi request reprint Succinylmonocholine analytics as an example for selectivity problems in high-performance liquid chromatography/tandem mass spectrometry, and resulting implications for analytical toxicology
    Uta Kuepper
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Rapid Commun Mass Spectrom 22:1965-70. 2008
    ....
  85. ncbi request reprint Fatal Candida tropicalis infection in an 8-month-old infant with an aplasia of the thymus as a rare cause of death in infancy
    Annette Thierauf
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 169:228-33. 2007
    ..Autopsy findings and the results of further examinations performed postmortem are discussed in view of the clinical findings, the classification and the cause of death...
  86. ncbi request reprint Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Drug Metab Rev 32:15-44. 2000
    ..In this review, potential precursor compounds are described, including their medical use and major clinical effects and their metabolic profiles, as well as some clues which help to identify the sources...
  87. ncbi request reprint Application of tandem mass spectrometry combined with gas chromatography and headspace solid-phase dynamic extraction for the determination of drugs of abuse in hair samples
    Dirk W Lachenmeier
    Institute of Legal Medicine, University of Bonn, Germany
    Rapid Commun Mass Spectrom 17:472-8. 2003
    ..The main advantage of the SPDE technique in relation to SPME is the robustness of the capillary...
  88. doi request reprint Qualitative screening for volatile organic compounds in human blood using solid-phase microextraction and gas chromatography-mass spectrometry
    Anne Kathrin Gottzein
    Institute of Legal Medicine, Toxicology, University of Bonn, Stiftsplatz 12, Bonn 53111, Germany
    J Mass Spectrom 45:391-7. 2010
    ..5% (benzene), respectively. This procedure can be used to answer various forensic and toxicological questions. The short time taken for the whole analytical procedure may make its eventual adoption for routine analysis attractive...
  89. doi request reprint Post-mortem biochemical investigations of vitreous humor
    Annette Thierauf
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, Bonn, Germany
    Forensic Sci Int 192:78-82. 2009
    ..The precision proved to be mostly unsatisfying and was clearly better in diluted samples than in undiluted aliquots. A comparison of the vitreous humor of the two ocular bulbs did not lead to significant differences...
  90. ncbi request reprint [Suicide with acetylsalicylic acid]
    Heike Wollersen
    Institut für Rechtsmedizin der Universität Bonn
    Arch Kriminol 219:115-23. 2007
    ..e. 762 mg/L in heart blood and 215 mg/L in femoral blood. All tested organs contained equally lethal salicylate levels (e.g. 503 mg/L in the liver and 251 mg/L in the brain)...
  91. ncbi request reprint [Postmortem distribution of sertraline and desmethylsertraline in a fatality]
    Frank Musshoff
    Institut fur Rechtsmedizin, Universitat Bonn
    Arch Kriminol 210:51-6. 2002
    ..Sertraline is suggested to possess a low inherent toxicity, however, a risk of side-effects which may occur in single cases even under moderate dosages should be considered...
  92. ncbi request reprint [Fatal intoxication with amisulpride and presentation of organ distribution]
    Frank Musshoff
    Aus dem Institut für Rechtsmedizin der Universität Bonn
    Arch Kriminol 215:158-63. 2005
    ..After macroscopic and histological exclusion of other causes of death the results of the toxicological analysis were consistent with the assumption of a fatal amisulpride overdose...
  93. ncbi request reprint Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway
    Torsten Loop
    Department of Anesthesiology, University Hospital, Freiburg, Germany
    Anesthesiology 101:710-21. 2004
    ..Several mechanisms have been suggested to account for these effects. The current study was undertaken to examine the molecular mechanisms underlying these observations...
  94. ncbi request reprint Validation of new methods
    Frank T Peters
    Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, Building 46, D 66421 Homburg Saar, Germany
    Forensic Sci Int 165:216-24. 2007
    ..In this paper, important considerations in analytical method validation will be discussed which may be used as guidance by scientists wishing to develop and validate analytical methods...