Research Topics
Species | Alexander MunchauSummaryAffiliation: University of Hamburg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS studyT Baumer
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Clin Neurophysiol 120:1724-31. 2009..In macaques, intracortical electrical stimulation of ventral premotor cortex (PMv) can modulate ipsilateral primary motor cortex (M1) excitability at short interstimulus intervals (ISIs)...
Magnetic stimulation of human premotor or motor cortex produces interhemispheric facilitation through distinct pathwaysTobias Bäumer
Department of Neurology, University Medical Centre Hamburg Eppendorf, Germany
J Physiol 572:857-68. 2006..These may correspond to elements involved in the generation of I3 and I1 waves, respectively...- Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndromeTobias Bäumer
Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Mov Disord 25:2828-37. 2010..Our combined TMS-DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure-function relationship in the motor CC... 
Laterality of interhemispheric inhibition depends on handednessT Baumer
Department of Neurology, University of Hamburg, Martinstrasse 52, 20246 Hamburg, Germany
Exp Brain Res 180:195-203. 2007..We hypothesize that IHI is a function of handedness perhaps reflecting predominant usage of the dominant hand, while lateralisation of thresholds and intracortical excitability are determined by other factors...- Fatigue suppresses ipsilateral intracortical facilitationT Baumer
Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Exp Brain Res 146:467-73. 2002..These results indicate interhemispheric interactions between the two motor cortices that are still effective after cessation of movements... - Imitation in patients with Gilles de la Tourette syndrome--a behavioral studyMelanie Jonas
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mov Disord 25:991-9. 2010..Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients... - Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndromeGotz Thomalla
Department of Neurology, University Medial Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Brain 132:765-77. 2009..The negative correlation between higher regional FA values and fewer tics suggests that these alterations of white matter microstructure represent adaptive reorganization of somatosensory processing in GTS... - Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humansTobias Bäumer
Department of Neurology, University of Hamburg, Hamburg, Germany
Neuroimage 20:550-60. 2003.... - Charting the excitability of premotor to motor connections while withholding or initiating a selected movementJohan Kroeger
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Eur J Neurosci 32:1771-9. 2010..Thus, the left premotor cortex is engaged not only in action selection but also in withholding and releasing a preselected movement generated by the right motor cortex... - Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputsMonika Pötter-Nerger
Department of Neurology, Christian Albrechts University, Kiel, Germany
J Neurophysiol 102:3180-90. 2009..These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels.".. - Waking up the brain: a case study of stimulation-induced wakeful unawareness during anaesthesiaChristian K E Moll
Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Prog Brain Res 177:125-45. 2009.... - Effects of DBS, premotor rTMS, and levodopa on motor function and silent period in advanced Parkinson's diseaseTobias Bäumer
Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Mov Disord 24:672-6. 2009..e., only partially reversed abnormal motor network activity... - Functional connectivity of the human premotor and motor cortex explored with TMST Baumer
Neurology Department, Hamburg University, Martinistrasse 52, D 20246 Hamburg, Germany
Suppl Clin Neurophysiol 56:160-9. 2003 - The cortical motor threshold reflects microstructural properties of cerebral white matterStefan Kloppel
Department of Neurology, Neurozentrum, University Clinic Freiburg, Freiburg, Germany
Neuroimage 40:1782-91. 2008.... - The human dorsal premotor cortex facilitates the excitability of ipsilateral primary motor cortex via a short latency cortico-cortical routeSergiu Groppa
Department of Neurology, Christian Albrechts University, Kiel, Germany
Hum Brain Mapp 33:419-30. 2012..This paradigm opens up new possibilities to study context-dependent intrahemispheric PMd-to-M1(HAND) interactions in the intact human brain... - Right hemisphere contributions to imitation tasksKatja Biermann-Ruben
Department of Neurology, MEG Laboratory, Dusseldorf University Hospital, Moorenstrasse 5, 40225 Duesseldorf, Germany
Eur J Neurosci 27:1843-55. 2008.... - Brain iron deposition fingerprints in Parkinson's disease and progressive supranuclear palsyKai Boelmans
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mov Disord 27:421-7. 2012..Regional decreases of T2' relaxation times in parts of the basal ganglia reflecting increased brain iron load in these areas are characteristic for progressive supranuclear palsy but not PD patients... - Clinical neuroimaging and electrophysiological assessment of three DYT6 dystonia familiesSimone Zittel
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mov Disord 25:2405-12. 2010..SN hyperechogenicity on TCS may represent an endophenotype in these patients. Pallidal DBS in two patients was unsatisfactory... - Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer's crampTobias Bäumer
Department of Neurology, University of Hamburg, Hamburg, Germany
Mov Disord 22:81-90. 2007.... - Motor cortex excitability after thalamic infarctionJ Liepert
Department of Neurology, University Hospital Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
Clin Neurophysiol 116:1621-7. 2005..We examined 8 patients with hemihypesthesia due to an ischemic thalamic lesion to explore the effects of a central sensory dysfunction on motor cortex excitability... - Identification and functional analysis of novel THAP1 mutationsKatja Lohmann
Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lubeck, Lubeck, Germany
Eur J Hum Genet 20:171-5. 2012..Speech was affected in four mutation carriers. In conclusion, THAP1 mutations are rare in unselected dystonia patients and functional analysis is necessary to distinguish between benign variants and pathogenic mutations... - Arm tremor in cervical dystonia--is it a manifestation of dystonia or essential tremor?Sarah Schiebler
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mov Disord 26:1789-92. 2011..From this point of view, we outline this tremor debate and add some new clinical data... - Are premonitory urges a prerequisite of tic inhibition in Gilles de la Tourette syndrome?Christos Ganos
Movement Disorders Research Group, Department of Neurology, University Medical Centre Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
J Neurol Neurosurg Psychiatry 83:975-8. 2012..We examined the relation of the trait of premonitory urges with tics and tic suppression. We hypothesised that patients with more urges would be more efficient at inhibiting tics... - Corticospinal system excitability at rest is associated with tic severity in tourette syndromeMichael Orth
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Biol Psychiatry 64:248-51. 2008..However, it is not clear whether these represent abnormalities of specific pathways or reflect a more widespread reduction of motor cortex excitability. Their significance for the clinical phenotype is also unknown... - Motor excitability in a patient with a somatosensory cortex lesionJoachim Liepert
Department of Neurology, University of Hamburg, University Hospital Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
Clin Neurophysiol 114:1003-8. 2003..We report a patient with an ischemic lesion in right somatosensory cortex who developed dystonic posturing and pseudo-athetotic involuntary left-sided finger movements during voluntary muscle contractions... - Interhemispheric effects of high and low frequency rTMS in healthy humansA Gorsler
Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Clin Neurophysiol 114:1800-7. 2003..We investigated whether repetitive transcranial magnetic stimulation (rTMS) applied to the right motor cortex modified the excitability of the unstimulated left motor cortex... - Modulation of motor cortex excitability induced by pinch grip repetitionA Gorsler
Department of Neurology, University Hospital, Hamburg Eppendorf, Germany
J Neural Transm 111:1005-16. 2004..These changes are distinct and independent of each other. Motor training has an interhemispheric effect on intracortical excitability... - Mirtazapine increases cortical excitability in healthy controls and epilepsy patients with major depressionA Munchau
Sobell Department of Motor Neuroscience and Movement Disorders, Dept of Clinical and Experimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 76:527-33. 2005..Epilepsy is often complicated by depression requiring antidepressant treatment. Such treatment might be proconvulsive... - Do simple intransitive finger movements consistently activate frontoparietal mirror neuron areas in humans?M Jonas
NeuroImage Nord, Hamburg Kiel Lübeck, Germany
Neuroimage 36:T44-53. 2007..We propose that the responsiveness of human frontoparietal mirror neuron areas to simple intransitive movements critically depends on the experimental context... - Sensory afferent inhibition within and between limbs in humansR Bikmullina
Department of Neurology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Clin Neurophysiol 120:610-8. 2009..To examine the distribution and inter-limb interaction of short-latency afferent inhibition (SAI) in the arm and leg... - Observation of a finger or an object movement primes imitative responses differentiallyM Jonas
Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Exp Brain Res 177:255-65. 2007..Thus, S1 immediately elicits an imitative response tendency. As an overt imitation of S1 is inadequate in the present setting, the response is inhibited which, in turn, modulates congruency effects... - The pathophysiology of echopraxia/echolalia: relevance to Gilles de la Tourette syndromeChristos Ganos
Department of Neurology, University Medical Center Hamburg Eppendorf UKE, Hamburg, Germany
Mov Disord 27:1222-9. 2012..The neural basis of echophenomena will also be addressed. © 2012 Movement Disorder Society... - Cost of illness in patients with Gilles de la Tourette's syndromeInes Dodel
Department of Neurology, Philipps University Marburg, Rudolf Bultmann Str 8, Marburg, Germany
J Neurol 257:1055-61. 2010..Unfortunately, no cost of illness studies are available for comparison. Further health economic studies, especially cost-effectiveness studies, are necessary for a basis for rational resource allocation... - Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE geneMichael Orth
Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Mov Disord 22:2090-6. 2007..No changes were found in the SLITRK1 gene. The presence of both M-D and GTS in one family, in which all known M-D loci and a recently discovered GTS locus were excluded, suggests a novel susceptibility gene for both M-D and GTS... - Subthreshold 5-Hz repetitive transcranial magnetic stimulation of the human primary motor cortex reduces intracortical paired-pulse inhibitionA Peinemann
Department of Neurology, Technische Universitat Munchen, D 81675, Munich, Germany
Neurosci Lett 296:21-4. 2000..The lasting effect of subthreshold 5-Hz rTMS on intracortical inhibition provides a useful probe for studying short-term plasticity of the human M1(HAND)... - Altered modulation of intracortical excitability during movement preparation in Gilles de la Tourette syndromeK F Heise
Department of Neurology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
Brain 133:580-90. 2010.... - ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndromeAnne Grünewald
Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lubeck, Lubeck, Germany
Neurobiol Aging 33:1843.e1-7. 2012..These findings collectively suggest that ATP13A2 contributes to the maintenance of a healthy mitochondrial pool, supporting the hypothesis that impaired mitochondrial clearance represents an important pathogenic mechanism underlying KRS... - Subthalamotomy in cervical dystonia: A case study of lesion location and clinical outcomeChristian K E Moll
Department of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mov Disord 23:1751-6. 2008.... - How to assess motor impairment in writer's crampKirsten E Zeuner
Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
Mov Disord 22:1102-9. 2007..Future studies need to address which combination of clinical scores and kinematic measures are most appropriate to quantify impairment in writer's cramp... - Abnormal excitability of premotor-motor connections in de novo Parkinson's diseaseC Buhmann
Department of Neurology, University of Hamburg, Hamburg, Germany
Brain 127:2732-46. 2004.... - Transcranial magnetic stimulation studies of sensorimotor networks in Tourette syndromeMichael Orth
Department of Neurology, University of Ulm, Ulm, Germany
Behav Neurol 27:57-64. 2013..In GTS the gain of many motor circuits may be reduced and hence less sensitive to small changes in input from other areas. These cortical changes may constitute an adaptive response to abnormal basal ganglia-motor cortex inputs... - Hirayama disease is a pure spinal motor neuron disorder-a combined DTI and transcranial magnetic stimulation studyKai Boelmans
Department of Psychiatry, Memory Clinic, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
J Neurol 260:540-8. 2013..CMCT was normal in HirD patients. Combined anatomical and functional measurements established normal integrity of the supraspinal CST in HirD patients lending support to the notion that HirD is a pure spinal motor neuron disorder... - Image-based classification of parkinsonian syndromes using T2'-atlasesNils Daniel Forkert
Department of Medical Informatics, University Medical Center Hamburg Eppendorf, Germany
Stud Health Technol Inform 169:465-9. 2011..The evaluation using leave-one-out validation revealed that the proposed method achieves a classification accuracy of 91%. The presented method might serve as the basis for an improved automatic classification of PS in the future... - Implementation of visuospatial cues in response selectionThilo van Eimeren
NeuroImage Nord, Department of Neurology, University Medical Center Hamburg Eppendorf, Germany
Neuroimage 29:286-94. 2006..We propose that the latter set of dorsal parieto-frontal areas subserves rapid implementation of spatial information during visually guided response selection... - Clinical and genetic features of myoclonus-dystonia in 3 cases: a video presentationNorman Kock
Department of Neurology, University of Schleswig Holstein, Lubeck, Germany
Mov Disord 19:231-4. 2004..We describe 3 children with a similar clinical picture of autosomal dominant M-D and an SGCE mutation in only one of them, suggesting that M-D is genetically heterogeneous... - Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS studyT Baumer
Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Neurology 69:1976-81. 2007....