W E Muller

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi Review: How was metazoan threshold crossed? The hypothetical Urmetazoa
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    Comp Biochem Physiol A Mol Integr Physiol 129:433-60. 2001
  2. ncbi Conservation of the positions of metazoan introns from sponges to humans
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat Mainz, Duesbergweg 6, 55099, Mainz, Germany
    Gene 295:299-309. 2002
  3. ncbi Gene structure and function of tyrosine kinases in the marine sponge Geodia cydonium: autapomorphic characters in Metazoa
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    Gene 238:179-93. 1999
  4. ncbi Evolution of the innate and adaptive immune systems: relationships between potential immune molecules in the lowest metazoan phylum (Porifera) and those in vertebrates
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    Transplantation 68:1215-27. 1999
  5. ncbi Increased gene expression of a cytokine-related molecule and profilin after activation of Suberites domuncula cells with xenogeneic sponge molecule(s)
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    DNA Cell Biol 18:885-93. 1999
  6. ncbi Oxygen-controlled bacterial growth in the sponge Suberites domuncula: toward a molecular understanding of the symbiotic relationships between sponge and bacteria
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat Mainz, D 55099 Mainz, Germany
    Appl Environ Microbiol 70:2332-41. 2004
  7. ncbi Oxygen as a morphogenic factor in sponges: expression of a tyrosinase gene in the sponge Suberites domuncula
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, Mainz D 55099, Germany
    Micron 35:87-8. 2004
  8. ncbi Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat Mainz, Duesbergweg 6, D 55099, Mainz, Germany
    Mech Ageing Dev 116:193-218. 2000
  9. ncbi Expression of one sponge Iroquois homeobox gene in primmorphs from Suberites domuncula during canal formation
    Sanja Perovic
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    Evol Dev 5:240-50. 2003
  10. ncbi Molecular biodiversity. Case study: Porifera (sponges)
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    Naturwissenschaften 90:103-20. 2003

Collaborators

Detail Information

Publications47

  1. ncbi Review: How was metazoan threshold crossed? The hypothetical Urmetazoa
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    Comp Biochem Physiol A Mol Integr Physiol 129:433-60. 2001
    ....
  2. ncbi Conservation of the positions of metazoan introns from sponges to humans
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat Mainz, Duesbergweg 6, 55099, Mainz, Germany
    Gene 295:299-309. 2002
    ..domuncula and in human. These data show that the intron/exon borders are highly conserved in genes from sponges to human...
  3. ncbi Gene structure and function of tyrosine kinases in the marine sponge Geodia cydonium: autapomorphic characters in Metazoa
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    Gene 238:179-93. 1999
    ..Since cell culture systems of sponges are now available, it can be expected that soon also those mechanisms that control the developmental programs will be unravelled...
  4. ncbi Evolution of the innate and adaptive immune systems: relationships between potential immune molecules in the lowest metazoan phylum (Porifera) and those in vertebrates
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    Transplantation 68:1215-27. 1999
    ..It is concluded that sponges are already provided with a series of elements used in higher vertebrates for both the innate and the adaptive immune recognition...
  5. ncbi Increased gene expression of a cytokine-related molecule and profilin after activation of Suberites domuncula cells with xenogeneic sponge molecule(s)
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    DNA Cell Biol 18:885-93. 1999
    ..These genes have previously been found to be highly expressed in human or echinoderm cells in the presence of xenogeneic proteins. Our data support the hypothesis that a primordial immune response system is present in sponges...
  6. ncbi Oxygen-controlled bacterial growth in the sponge Suberites domuncula: toward a molecular understanding of the symbiotic relationships between sponge and bacteria
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat Mainz, D 55099 Mainz, Germany
    Appl Environ Microbiol 70:2332-41. 2004
    ....
  7. ncbi Oxygen as a morphogenic factor in sponges: expression of a tyrosinase gene in the sponge Suberites domuncula
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, Mainz D 55099, Germany
    Micron 35:87-8. 2004
    ..It is assumed that these products serve as carbon source for symbiotic bacteria to grow...
  8. ncbi Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat Mainz, Duesbergweg 6, D 55099, Mainz, Germany
    Mech Ageing Dev 116:193-218. 2000
    ..g. Alzheimer's disease...
  9. ncbi Expression of one sponge Iroquois homeobox gene in primmorphs from Suberites domuncula during canal formation
    Sanja Perovic
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    Evol Dev 5:240-50. 2003
    ..It is suggested that Iroquois expression is involved in the formation of the aquiferous system, the canals in sponges and the canal-like structures in primmorphs...
  10. ncbi Molecular biodiversity. Case study: Porifera (sponges)
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    Naturwissenschaften 90:103-20. 2003
    ....
  11. ncbi Suppression of allograft rejection in the sponge Suberites domuncula by FK506 and expression of genes encoding FK506-binding proteins in allografts
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    J Exp Biol 204:2197-207. 2001
    ..These data indicate that the drug FK506 suppresses allograft rejection in S. domuncula, most probably via interaction with expression of the gene coding for the FK506-binding proteins...
  12. ncbi Contribution of sponge genes to unravel the genome of the hypothetical ancestor of Metazoa (Urmetazoa)
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099, Mainz, Germany
    Gene 276:161-73. 2001
    ..sapiens than to those of C. elegans or D. melanogaster. Especially surprising was the finding that the Demospongiae are provided with elements of adaptive immunity...
  13. ncbi Cultural heritage: porifera (sponges), a taxon successfully progressing paleontology, biology, biochemistry, biotechnology and biomedicine
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    Adv Exp Med Biol 546:325-58. 2004
  14. ncbi Histocompatibility reaction in tissue and cells of the marine sponge Suberites domuncula in vitro and in vivo: central role of the allograft inflammatory factor 1
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    Immunogenetics 54:48-58. 2002
    ....
  15. ncbi Towards an understanding of the molecular basis of immune responses in sponges: the marine demosponge Geodia cydonium as a model
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg, Mainz, Germany
    Microsc Res Tech 44:219-36. 1999
    ..In addition, it is reported that in the model sponge system of G. cydonium, allogeneic rejection involves an upregulation of phenylalanine hydroxylase, an enzyme initiating the pathway to melanin synthesis...
  16. ncbi Biochemistry and cell biology of silica formation in sponges
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, D 55099 Mainz, Germany
    Microsc Res Tech 62:368-77. 2003
    ..Furthermore, it is proposed that the growing spicules are surrounded by the scavenger receptor which might be considered as a docking molecule for the collagen matrix into which the spicules are embedded...
  17. ncbi Sustainable production of bioactive compounds by sponges--cell culture and gene cluster approach: a review
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    Mar Biotechnol (NY) 6:105-17. 2004
    ..Another promising way to utilize the bioactive potential of the microorganisms is the cloning and heterologous expression of enzymes involved in secondary metabolism, such as the polyketide synthases...
  18. ncbi Matrix-mediated canal formation in primmorphs from the sponge Suberites domuncula involves the expression of a CD36 receptor-ligand system
    Werner E G Muller
    Institut für Physiologische Chemie und Pathobiochemie, Abteilung Angewandte Molekularbiologie, Johannes Gutenberg Universitat Mainz, 55099 Mainz, Germany
    J Cell Sci 117:2579-90. 2004
    ..domuncula CD36/LIMPII; this result is a first indication that this secondary metabolite has a conserved functional activity: the suppression of the formation of the circulation system, from sponges to vertebrates...
  19. ncbi Cloning and expression of the putative aggregation factor from the marine sponge Geodia cydonium
    J Schutze
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    J Cell Sci 114:3189-98. 2001
    ..cydonium galectin. It is concluded that the putative G. cydonium AF--a further autapomorphic molecule characteristic for Metazoa--binds to the AR present on the cell surface in association with the homologous galectin...
  20. ncbi Molecular evolution of the metazoan extracellular matrix: cloning and expression of structural proteins from the demosponges Suberites domuncula and Geodia cydonium
    J Schutze
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    J Mol Evol 53:402-15. 2001
    ..These data indicate that the ECM of sponges is not an unstructured ground substance but provides the basis for integrated cell communication...
  21. ncbi The 2-5A system and HIV infection
    H C Schroder
    Abteilung Angewandte Molekularbiologie, Johannes Gutenberg Universitat, Mainz, Germany
    Prog Mol Subcell Biol 14:176-97. 1994
    ..A further strategy is the inhibition of DNA topoisomerase I by longer 2-5A oligomers...
  22. ncbi Identification and expression of the SOS response, aidB-like, gene in the marine sponge Geodia cydonium: implication for the phylogenetic relationships of metazoan acyl-CoA dehydrogenases and acyl-CoA oxidases
    A Krasko
    Institut fur Physiologische Chemie, Abteilung für Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    J Mol Evol 47:343-52. 1998
    ....
  23. ncbi Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells
    W E Muller
    Abteilung Angewandte Molekularbiologie, Universitat, Mainz, F R G
    Biochim Biophys Acta 1008:208-12. 1989
    ..This could be prevented by coincubation with Zn2+ or Cu2+ (but not Mg2+), which stabilize the mRNA containing nuclear matrix structure...
  24. ncbi Evolutionary relationships of the metazoan beta gamma-crystallins, including that from the marine sponge Geodia cydonium
    A Krasko
    Abteilung für Angewandte Molekularbiologie, Universitat, Duesbergweg, Mainz, Germany
    Proc Biol Sci 264:1077-84. 1997
    ..The data support the view that the beta gamma-crystallin superfamily, present in eukaryotes, evolved from a common ancestor including also the sponge beta gamma-crystallin...
  25. ncbi Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases
    S Perovic
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    Mech Ageing Dev 101:1-19. 1998
    ..g. Alzheimer's disease and prion based diseases, like Creutzfeldt-Jakob disease. This conclusion is corroborated by the favourable pharmacokinetic profile of Flupirtine...
  26. ncbi Modulation of intracellular calcium and proliferative activity of invertebrate and vertebrate cells by ethylene
    S Perovic
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    BMC Cell Biol 2:7. 2001
    ....
  27. ncbi A galectin links the aggregation factor to cells in the sponge (Geodia cydonium) system
    C Wagner-Hülsmann
    Institut fur Physiologische Chemie, Universitat, Mainz, Germany
    Glycobiology 6:785-93. 1996
    ..By laser scanning microscopy, it is shown that both the aggregation factor and the galectin are located at the rim of the cells. From these data we conclude that the G.cydonium aggregation factor binds to the cells via a galectin bridge...
  28. ncbi Kinetics of expression of prion protein in uninfected and scrapie-infected N2a mouse neuroblastoma cells
    K Pfeifer
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    Cell Biochem Funct 11:1-11. 1993
    ..Taken together, these results show that PrPSc and/or PrPc is present in the nucleus (nucleoli) of ScN2a cells but does not display an effect on the expression of the PrP gene...
  29. ncbi Application of cell culture for the production of bioactive compounds from sponges: synthesis of avarol by primmorphs from Dysidea avara
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    J Nat Prod 63:1077-81. 2000
    ..Single cells apparently do not have the potency to produce this secondary metabolite. It is concluded that the primmorph model is a suitable system for the synthesis of bioactive compounds in vitro...
  30. ncbi Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix
    W E Muller
    Institut fur Physiologische Chemie, Universitat, Mainz, West Germany
    J Biol Chem 265:3803-8. 1990
    ..Present studies indicate that Tat may function as a linker by binding of nascent HIV RNAs to the nuclear matrix...
  31. ncbi Molecular evolution of the metazoan protein kinase C multigene family
    M Kruse
    Abteilung Angewandte Molekularbiologie, Institut fur Physiologische Chemie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    J Mol Evol 43:374-83. 1996
    ..These data indicate that metazoan PKCs have a universal common ancestor which they share with the nonmetazoan Ser/Thr kinases with respect to the kinase domain, but they differ from them in overall structural composition...
  32. ncbi Evidence for a direct interaction of Rev protein with nuclear envelop mRNA-translocation system
    K Pfeifer
    Institut fur Physiologische Chemie, Universitat Mainz, Federal Republic of Germany
    Eur J Biochem 199:53-64. 1991
    ..In the vesicle experiments it is demonstrated for the first time that a protein selectively channels a specific mRNA across the nuclear-envelope pore complex...
  33. ncbi Receptor tyrosine kinase, an autapomorphic character of metazoa: identification in marine sponges
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany
    Acta Biol Hung 50:395-411. 1999
    ..Due to the fact that protein tyrosine kinases in general and RTKs in particular have only been identified in Metazoa, they are, as a group qualified, to be considered as an autapomorphic character of all metazoan phyla...
  34. ncbi Sponge Bcl-2 homologous protein (BHP2-GC) confers distinct stress resistance to human HEK-293 cells
    M Wiens
    , Abteilung Angewandte Molekularbiologie, , Duesbergweg 6, D-55099 Mainz, Germany
    Cell Death Differ 8:887-98. 2001
    ..In contrast to mock-transfected cells, GCBHP2-transfected cells activated caspase-3 to a lower extent. Thus, sponges contain gene(s) involved in apoptotic pathway(s) displaying their function also in human cells...
  35. ncbi Differential in vitro anti-HIV activity of natural lignans
    H C Schroder
    Abteilung Angewandte Molekularbiologie, Universitat Mainz, Bundesrepublik Deutschland
    Z Naturforsch C 45:1215-21. 1990
    ..Our results suggest that both compounds prevent the increase of topoisomerase II activity, involved in virus replication, after infection of cells with HIV-1...
  36. ncbi Expression of nuclear lectin carbohydrate-binding protein 35 in human immunodeficiency virus type 1-infected Molt-3 cells
    H C Schroder
    Institut fur Physiologische Chemie, Abteilung für Angewandte Molekularbiologie, Mainz, Germany
    J Acquir Immune Defic Syndr Hum Retrovirol 9:340-8. 1995
    ..CBP35 could also be detected using a novel photoreactive alpha-D-galactose probe designed for the specific detection of CBP...
  37. ncbi Evidence for age-dependent impairment of antiviral 2',5'-oligoadenylate synthetase/ribonuclease L-system in tissues of rat
    K Pfeifer
    Institut fur Physiologische Chemie, Universitat, Mainz, Germany
    Mech Ageing Dev 67:101-14. 1993
    ..From these results we conclude that the antiviral activity of the 2-5A system is impaired in old cells with the consequences that virus production cannot be efficiently suppressed...
  38. ncbi Identification of highly conserved genes: SNZ and SNO in the marine sponge Suberites domuncula: their gene structure and promoter activity in mammalian cells(1)
    J Seack
    , Abteilung Angewandte Molekularbiologie, , Mainz, Germany
    Biochim Biophys Acta 1520:21-34. 2001
    ..The data indicate that in mammalian cells, the activity of the SDSNZERR promoter is associated with the repression of serum-mediated growth arrest...
  39. ncbi Age-correlated changes in the lupus erythematosus antigens Ro, La, Sm and RNP of the thymus gland
    W E Muller
    Institut fur Physiologische Chemie, Universitat, Mainz, West Germany
    Compr Gerontol A 1:40-4. 1987
    ..From these data we conclude that the amounts of the lupus antigens are additional parameters for the age-correlated function of thymocytes...
  40. ncbi Effect of flupirtine on cell death of human umbilical vein endothelial cells induced by reactive oxygen species
    B Lorenz
    Institut fur Biochemie, Universitat, Magdeburg, Germany
    Biochem Pharmacol 56:1615-24. 1998
    ....
  41. ncbi Origin of metazoan adhesion molecules and adhesion receptors as deduced from cDNA analyses in the marine sponge Geodia cydonium: a review
    W E Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D 55099 Mainz, Germany
    Cell Tissue Res 289:383-95. 1997
    ....
  42. ncbi Potential multidrug resistance gene POHL: an ecologically relevant indicator in marine sponges
    A Krasko
    , Abteilung Angewandte Molekularbiologie, , Duesbergweg 6, D-55099 Mainz, Germany
    Environ Toxicol Chem 20:198-204. 2001
    ..cydonium. This report demonstrates that the detoxification POH pathway, here mediated by the G. cydonium GCPOHL gene, is an additional marker for the assessment of the environmental load in a given marine area...
  43. ncbi Correlation between the level of the potential biomarker, heat-shock protein, and the occurrence of DNA damage in the dab, Limanda limanda: a field study in the North Sea and the English Channel
    H C Schroder
    Institut fur Physiologische Chemie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    Mar Environ Res 49:201-15. 2000
    ..Our results suggest that L. limanda may be a useful bioindicator and heat-shock proteins, a useful biomarker for monitoring of environmental pollution...
  44. ncbi Polyphosphate in bone
    H C Schroder
    Institut fur Physiologische Chemie, Universitat, Mainz, D 55099, Germany
    Biochemistry (Mosc) 65:296-303. 2000
    ....
  45. ncbi Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells
    M H Kreuter
    Abteilung Angewandte Molekularbiologie, , Mainz, Bundesrepublik Deutschland
    Z Naturforsch C 44:680-8. 1989
    ..Preliminary toxicology studies revealed an acute LD50 of 202 mg/kg and a subacute LD50 of 150 mg/kg. Aeroplysinin-1 is neither a direct mutagen nor a premutagen in the umu/Salmonella typhimurium test system...
  46. ncbi Accumulation of transcripts coding for prion protein in human astrocytes during infection with human immunodeficiency virus
    W E Muller
    Institut fur Physiologische Chemie, Universitat Mainz, Germany
    Biochim Biophys Acta 1139:32-40. 1992
    ..Infection of astrocytes with HIV-1 resulted in an increased level of PrP mRNA. The data presented led us to assume that certain sequences in the PrP mRNA might be targets for proteins acting in trans...
  47. ncbi Rev protein suppression of complex formation between nuclear proteins and rev-responsive element-containing RNA of human immunodeficiency virus-1
    A Bek
    , , Mainz, Germany
    Int J Biochem Cell Biol 27:1317-29. 1995