N Muller

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Neuroimmune-endocrine crosstalk in schizophrenia and mood disorders
    Norbert Muller
    Ludwig Maximilians Universitat Munchen, Hospital for Psychiatry and Psychotherapy, 80336 Munchen, Germany
    Expert Rev Neurother 6:1017-38. 2006
  2. ncbi request reprint Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Curr Pharm Des 17:130-6. 2011
  3. ncbi request reprint The role of anti-inflammatory treatment in psychiatric disorders
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatr Danub 25:292-8. 2013
  4. doi request reprint Anti-inflammatory treatment in schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 42:146-53. 2013
  5. doi request reprint Impaired monocyte activation in schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatry Res 198:341-6. 2012
  6. doi request reprint Inflammation in schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Adv Protein Chem Struct Biol 88:49-68. 2012
  7. ncbi request reprint Immunological treatment options for schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Curr Pharm Biotechnol 13:1606-13. 2012
  8. pmc Altered monocyte activation markers in Tourette's syndrome: a case-control study
    Judith Matz
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich, Germany
    BMC Psychiatry 12:29. 2012
  9. pmc Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Munich, Germany
    Dialogues Clin Neurosci 9:161-71. 2007
  10. doi request reprint Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: all make sense now?
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Munich, Germany
    J Psychopharmacol 25:713-4. 2011

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Neuroimmune-endocrine crosstalk in schizophrenia and mood disorders
    Norbert Muller
    Ludwig Maximilians Universitat Munchen, Hospital for Psychiatry and Psychotherapy, 80336 Munchen, Germany
    Expert Rev Neurother 6:1017-38. 2006
    ..The limitations of this concept, however, are critically discussed...
  2. ncbi request reprint Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Curr Pharm Des 17:130-6. 2011
    ..Most of the existing data are related to COX-2 inhibitors, which have been tested in animal experiments and in clinical trials, pointing to favourable effects in schizophrenia...
  3. ncbi request reprint The role of anti-inflammatory treatment in psychiatric disorders
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatr Danub 25:292-8. 2013
    ..Another study in fifty patients with MD also showed a statistically significant better outcome with celecoxib. This paper will discuss immune-based therapeutic approaches in both schizophrenia and depression. ..
  4. doi request reprint Anti-inflammatory treatment in schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 42:146-53. 2013
    ..Further options for immunomodulating therapies in schizophrenia will be discussed...
  5. doi request reprint Impaired monocyte activation in schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatry Res 198:341-6. 2012
    ..The immunological dysfunctions might be associated with a poor clearance of pathogens in schizophrenia, which in turn could lead to a low-grade inflammatory process...
  6. doi request reprint Inflammation in schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Adv Protein Chem Struct Biol 88:49-68. 2012
    ..Further options for immunomodulating therapies in schizophrenia will be discussed...
  7. ncbi request reprint Immunological treatment options for schizophrenia
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Curr Pharm Biotechnol 13:1606-13. 2012
    ..Further options for immunomodulating therapies in schizophrenia will be discussed...
  8. pmc Altered monocyte activation markers in Tourette's syndrome: a case-control study
    Judith Matz
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich, Germany
    BMC Psychiatry 12:29. 2012
    ..To determine possible common underlying immunological mechanisms, we focused on innate immunity and studied markers of inflammation, monocytes, and monocyte-derived cytokines...
  9. pmc Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Munich, Germany
    Dialogues Clin Neurosci 9:161-71. 2007
    ..Moreover, therapeutic strategies using typical and atypical antipsychotics, and also experimental therapies such as repetitive transcranial magnetic stimulation and deep brain stimulation, are critically discussed...
  10. doi request reprint Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: all make sense now?
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Munich, Germany
    J Psychopharmacol 25:713-4. 2011
    ..This field, therefore, should focus more on further schizophrenia research...
  11. ncbi request reprint Mechanisms of relapse prevention in schizophrenia
    N Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Pharmacopsychiatry 37:S141-7. 2004
    ..Moreover, the risk for chronic disorder increases with every relapse of the patient. Therefore relapse prevention is a primary focus in the treatment of schizophrenia...
  12. ncbi request reprint Anti-inflammatory therapy with a COX-2 inhibitor in Tourette's syndrome
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, D 80336 MUnchen, Germany
    Inflammopharmacology 12:271-5. 2004
    ..This result of the treatment with a COX-2 inhibitor supports the view that COX-2 inhibitors show therapeutic benefit in patients suffering from psychiatric disorders in which an inflammatory process is involved in the pathophysiology...
  13. doi request reprint Duloxetine in the treatment of major psychiatric and neuropathic disorders
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians University, 80336 Munich, Germany
    Expert Rev Neurother 8:527-36. 2008
    ..Due to duloxetine's properties, a wide range of use will be encountered in the mid-to-long term...
  14. doi request reprint A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major depression as inflammatory CNS disorders
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Nubbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:97-106. 2008
    ....
  15. ncbi request reprint COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence
    Norbert Muller
    Ludwig Maximilians Universitat, Department of Psychiatry, Nussbaumstrasse 7, 80336 Munchen, Germany
    Curr Opin Investig Drugs 11:31-42. 2010
    ..The potential inflammatory mechanism in schizophrenia and MD, and the possible therapeutic advantages of targeting this mechanism in the treatment of these disorders is discussed in this review...
  16. pmc The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders--relation to drug treatment
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Germany
    Dialogues Clin Neurosci 11:319-32. 2009
    ..COX-2 inhibitors have been tested in animal models of depression and in preliminary clinical trials, pointing to favorable effects in schizophrenia and in MD...
  17. ncbi request reprint COX-2 inhibition in schizophrenia and major depression
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Germany
    Curr Pharm Des 14:1452-65. 2008
    ....
  18. ncbi request reprint Clinical effects of COX-2 inhibitors on cognition in schizophrenia
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 255:149-51. 2005
    ..In schizophrenia, the effect on cognition contributes to the therapeutic effect of COX-2 inhibitors...
  19. ncbi request reprint [Immunological aspects of depressive disorders]
    N Muller
    Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336 Munchen
    Nervenarzt 78:1261-73. 2007
    ..The further search for new antidepressant therapeutic mechanisms should take into regard anti-inflammatory substances, e.g. cyclo-oxygenase-2 (COX-2)-inhibitors...
  20. doi request reprint Celecoxib treatment in an early stage of schizophrenia: results of a randomized, double-blind, placebo-controlled trial of celecoxib augmentation of amisulpride treatment
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Germany
    Schizophr Res 121:118-24. 2010
    ..In future, further trials are needed to investigate the effect of COX-2 inhibitors on prodromal and negative symptoms of schizophrenia...
  21. ncbi request reprint [Immunology in schizophrenic disorders]
    N Muller
    Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336 Munchen
    Nervenarzt 78:253-6, 258-60, 262-3. 2007
    ..This model describes the pathway of immune-mediated glutamatergic-dopaminergic dysregulation, which may lead to the clinical symptoms of schizophrenia. Therapeutic consequences (e.g. cyclo-oxygenase-2 inhibitors) are discussed...
  22. ncbi request reprint Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission
    N Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, 80336 Munchen, Germany
    Neurotox Res 10:131-48. 2006
    ..Therapeutic consequences, e.g., the use of anti-inflammatory cyclo-oxygenase-2 inhibitors, which can also decrease KYNA directly, are discussed...
  23. ncbi request reprint The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
    N Muller
    Department for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Mol Psychiatry 12:988-1000. 2007
    ....
  24. ncbi request reprint Inflammation and the glutamate system in schizophrenia: implications for therapeutic targets and drug development
    Norbert Muller
    Ludwig Maximilians University, Hospital for Psychiatry and Psychotherapy, Nussbaumstr 7, 80336 Munich, Germany
    Expert Opin Ther Targets 12:1497-507. 2008
    ..Therefore, other therapeutic targets than dopaminergic and serotonergic neurotransmitters are being considered...
  25. doi request reprint Inflammatory biomarkers and depression
    Norbert Muller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universitat Munchen, Nußbaumstr 7, 80336 Munchen, Germany
    Neurotox Res 19:308-18. 2011
    ....
  26. ncbi request reprint The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
    N Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Munchen, Germany
    Mol Psychiatry 11:680-4. 2006
    ..Moreover, the fact that treatment with an anti-inflammatory drug showed beneficial effects on MD indicates that inflammation is related to the pathomechanism of the disorder, although the exact mechanisms remain to become elucidated...
  27. ncbi request reprint Psychotropic effects of COX-2 inhibitors--a possible new approach for the treatment of psychiatric disorders
    N Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336 Munich, Germany
    Pharmacopsychiatry 37:266-9. 2004
    ..These preliminary clinical data are encouraging for therapeutic effects of the selective COX-2 inhibitors in psychiatric disorders, although these effects have to be confirmed in bigger clinical studies...
  28. doi request reprint Effect of aripiprazole on cognition in the treatment of patients with schizophrenia
    M Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 43:50-7. 2010
    ..The aim of this study was to assess the cognitive effects of aripiprazole in inpatients with schizophrenia...
  29. doi request reprint Elevated macrophage migration inhibitory factor and decreased transforming growth factor-beta levels in major depression--no influence of celecoxib treatment
    R Musil
    Psychiatric Clinic of University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Affect Disord 134:217-25. 2011
    ....
  30. ncbi request reprint Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130
    S Stubner
    Department of Psychiatry, Ludwig Maximillian University, Munich, Germany
    Neurosci Lett 259:145-8. 1999
    ..We found statistically significant decreased CSF concentrations of IL-6 (P<0.001) and of the sIL-6R (P<0.001) of patients with MD. Levels of sgp130 showed no statistically significant difference between patients and controls...
  31. ncbi request reprint Risperidone plasma levels, clinical response and side-effects
    Michael Riedel
    Dept of Psychiatry and Psychotherapy, University of Munich, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:261-8. 2005
    ..We thus prospectively investigated risperidone serum concentrations in relation to clinical efficacy and side-effects and genotyped major CYP2D6 polymorphisms to determine their effect upon these parameters...
  32. ncbi request reprint Soluble interleukin-2 receptors increase during the active periods in cluster headache
    M Empl
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Headache 43:63-8. 2003
    ..To investigate whether cytokines are altered during the active period of cluster headache...
  33. ncbi request reprint First-episode schizophrenics show normal duration and topography of quasistationary EEG segments as compared to controls, during rest as well as during active tasks
    A Stevens
    Klinik fur Psychiatrie und Psychotherapie, Universitat Tubingen, Germany
    Psychiatry Res 91:111-20. 1999
    ....
  34. ncbi request reprint Zotepine versus placebo in the treatment of schizophrenic patients with stable primary negative symptoms: a randomized double-blind multicenter trial
    H J Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Pharmacopsychiatry 37:270-8. 2004
    ..Zotepine, a D (2)5HT (2A) antagonist, was compared to placebo in this clinical trial to address these issues...
  35. ncbi request reprint Interleukin-6 is not altered in cerebrospinal fluid of first-degree relatives and patients with Alzheimer's disease
    H Hampel
    Department of Psychiatry, Ludwig Maximilian University, School of Medicine, Munich, Germany
    Neurosci Lett 228:143-6. 1997
    ..We suggest that combined measurement of all parameters of the IL-6-receptor complex could yield more insight in a probably altered IL-6 function...
  36. ncbi request reprint Cellular and humoral immune system in schizophrenia: a conceptual re-evaluation
    N Muller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    World J Biol Psychiatry 1:173-9. 2000
    ..During therapy with antipsychotics, the specific TH-1 related immune answer becomes activated, but the B-cell system and the antibody production become activated too...
  37. doi request reprint Neurocognition and its influencing factors in the treatment of schizophrenia-effects of aripiprazole, olanzapine, quetiapine and risperidone
    M Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    Hum Psychopharmacol 25:116-25. 2010
    ..To examine influencing variables of neurocognition in patients with schizophrenia and to predict cognition during antipsychotic treatment...
  38. ncbi request reprint Digitized analysis of abnormal hand-motor performance in schizophrenic patients
    P Tigges
    Department of Psychiatry, Ludwig Maximilians University Munich, Clinical Neurophysiology Section, Nussbaumstrasse 7, D 80336, Munich, Germany
    Schizophr Res 45:133-43. 2000
    ..Our findings show NSS in schizophrenic patients, independently of neuroleptics. Further, the hypothesis of lateralization of cerebral structures generating NSS towards the right hemisphere in schizophrenia is supported...
  39. ncbi request reprint The role of immune function in schizophrenia: an overview
    N Muller
    Psychiatrische Klinik, Ludwig Maximilians Universitat, Munchen
    Eur Arch Psychiatry Clin Neurosci 249:62-8. 1999
    ..During antipsychotic therapy with neuroleptics, the specific TH-1 related immune answer becomes activated, but also the B-cell system and the antibody production increases...
  40. ncbi request reprint The immune system and schizophrenia. An integrative view
    N Muller
    Psychiatric Hospital, Ludwig Maximilian University, Munich, Germany
    Ann N Y Acad Sci 917:456-67. 2000
    ..During antipsychotic therapy with neuroleptics, the specific TH-1-related immune answer becomes activated, but in addition the B cell system and antibody production increase...
  41. ncbi request reprint Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease
    H Hampel
    Department of Psychiatry, Geriatric Psychiatry Branch, Dementia Research Section, Ludwig Maximilian University Munich, Nussbaumstr 7, 80336, Munich, Germany
    Brain Res 823:104-12. 1999
    ....
  42. ncbi request reprint Increase in expression of adhesion molecule receptors on T helper cells during antipsychotic treatment and relationship to blood-brain barrier permeability in schizophrenia
    N Muller
    Psychiatric Hospital, Ludwig Maximillian University, Munich, Germany
    Am J Psychiatry 156:634-6. 1999
    ....
  43. ncbi request reprint Increased anti-streptococcal antibodies in patients with Tourette's syndrome
    N Muller
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Psychiatry Res 94:43-9. 2000
    ..Our findings support the theory that a postinfectious immune mechanism may play a role in the pathogenesis of TS. The mechanism still needs to be elucidated...
  44. doi request reprint Dopaminergic neurotransmission in patients with schizophrenia in relation to positive and negative symptoms
    O Pogarell
    Department of Psychiatry, University of Munich, Munich, Germany
    Pharmacopsychiatry 45:S36-41. 2012
    ....
  45. ncbi request reprint Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity
    Georg Juckel
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 64:115-24. 2003
    ..These results suggest that the loudness dependence of primary auditory cortex evoked activity is well suitable to assess serotonergic dysfunction in schizophrenia...
  46. ncbi request reprint Increased titers of antibodies against streptococcal M12 and M19 proteins in patients with Tourette's syndrome
    N Muller
    Psychiatric Hospital, Ludwig Maximilian University, Nussbaumstr 7, D 80336, Munchen, Germany
    Psychiatry Res 101:187-93. 2001
    ..The finding of a possible autoimmune origin of TS has implications for both pathophysiology and future therapeutic strategies...
  47. ncbi request reprint P300 and symptom improvement in schizophrenia
    J Gallinat
    Department of Psychiatry, Laboratory of Clinical Psychophysiology, Free University Berlin, Eschenallee 3, 14050 Berlin, Germany
    Psychopharmacology (Berl) 158:55-65. 2001
    ..A reduced amplitude of the auditory evoked P300 was interpreted as a trait marker of schizophrenia but reports about correlations between schizophrenic psychopathology and P300 amplitude indicate also a state character...
  48. ncbi request reprint Detection of the novel cell adhesion molecule MUC18 in human brain tissue
    H Hampel
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuroimmunomodulation 4:57-61. 1997
    ....
  49. ncbi request reprint No association between the G308A polymorphism of the tumor necrosis factor-alpha gene and schizophrenia
    Michael Riedel
    Psychiatric Hospital, Ludwig Maximilian University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 252:232-4. 2002
    ..9 % polymorphic allele). Moreover, we did not find any association between genotype and psychopathology, as measured by PANSS. The different results between these two studies may be due to ethnic differences...
  50. ncbi request reprint How representative of everyday clinical populations are schizophrenia patients enrolled in clinical trials?
    M Riedel
    Ludwig Maximilians University Munich, Dept of Psychiatry and Psychotherapy, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:143-8. 2005
    ..Therefore, translation into psychiatric practice may be difficult...
  51. ncbi request reprint CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis
    F Padberg
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Neuroimmunol 99:218-23. 1999
    ..Furthermore, sgp130 CSF levels were decreased in MS, suggesting a possibly altered IL-6 regulation in the CSF...
  52. ncbi request reprint Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia
    N Muller
    Psychiatric Hospital, Ludwig Maximilian University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 247:308-13. 1997
    ..This suggests that neuroleptic therapy has a differentiated immunomodulatory effect...
  53. ncbi request reprint The Th2-hypothesis of schizophrenia: a strategy to identify a subgroup of schizophrenia caused by immune mechanisms
    M J Schwarz
    Psychiatric Hospital, University of Munich, Munich, Germany
    Med Hypotheses 56:483-6. 2001
    ..Besides the immunological abnormalities, this subgroup is further characterized by more pronounced negative symptoms and poor therapy outcome. There is evidence that this subgroup might be caused by a prenatal viral infection...
  54. ncbi request reprint Antibodies to heat shock proteins in schizophrenic patients: implications for the mechanism of the disease
    M J Schwarz
    Psychiatric Hospital, Department of Neurochemistry, Psychiatric Hospital, Ludwig Maximilian University Munich, Germany
    Am J Psychiatry 156:1103-4. 1999
    ..To elucidate their role in schizophrenia, the authors investigated antibody titers to heat shock proteins in unmedicated and medicated patients with schizophrenia...
  55. ncbi request reprint Blood-cerebrospinal fluid barrier impairment as indicator for an immune process in schizophrenia
    M J Schwarz
    Department of Neurochemistry, University of Munich, Germany
    Neurosci Lett 253:201-3. 1998
    ..A BCB impairment was associated with high levels of sICAM-1. Our data indicate an inflammatory mechanism of BCB impairment in schizophrenics and should enrich the discussion on an expanded immunological diagnosis in schizophrenia...
  56. ncbi request reprint T-cell subsets and expression of integrins in peripheral blood of patients with migraine
    M Empl
    Department of Neurology, University of Munich, Germany
    Cephalalgia 19:713-7; discussion 697. 1999
    ..5 +/- 12.0%; p < 0.01). These preliminary results support the hypothesis that immunological mechanisms (such as an enhanced lymphocyte endothelium interaction) could be part of the migraine pathophysiology in humans...
  57. ncbi request reprint Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator mader in normal human CNS
    M J Schwarz
    Department of Neurochemistry, Psychiatric Hospital, University of Munich, Germany
    Neuroimmunomodulation 5:270-6. 1998
    ..These observations may have important implications for further studies investigating their possible roles in cell adhesion and proliferation control within the CNS...
  58. doi request reprint Therapy-refractory Tourette syndrome: beneficial outcome with globus pallidus internus deep brain stimulation
    Sandra Dehning
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Mov Disord 23:1300-2. 2008
    ..We report on a female patient with Tourette syndrome and a 12-month follow-up after chronic deep brain stimulation in the globus pallidus internus which resulted in excellent remission of motor and vocal tics...
  59. ncbi request reprint Quetiapine has equivalent efficacy and superior tolerability to risperidone in the treatment of schizophrenia with predominantly negative symptoms
    Michael Riedel
    Ludwig Maximilians University of Munich, Dept of Psychiatry and Psychotherapy, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:432-7. 2005
    ..Quetiapine is also well tolerated, with a lower incidence of EPS and prolactin increase than risperidone...
  60. doi request reprint Health-related quality of life in patients with Gilles de la Tourette's syndrome
    Kirsten Muller-Vahl
    Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany
    Mov Disord 25:309-14. 2010
    ..The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co-morbidities such as depression should be diagnosed and treated vigorously...
  61. doi request reprint The association of infectious agents and schizophrenia
    Daniela Krause
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 11:739-43. 2010
    ..However most of the studies have only focused on one single pathogen and not on the impact of different infectious agents. We investigated the association between schizophrenia and various neurotophic infectious agents...
  62. doi request reprint Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics
    Ilja Spellmann
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:335-44. 2008
    ....
  63. doi request reprint SNAP-25 gene polymorphisms and weight gain in schizophrenic patients
    Richard Musil
    Psychiatric Clinic of University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 42:963-70. 2008
    ..In conclusion our study can at least partly replicate the previous findings concerning the impact of SNAP-25 gene polymorphisms on weight gain during antipsychotic treatment...
  64. ncbi request reprint [Schizophrenic patients in the family practice]
    Michael Riedel
    Klinik für Psychiatrie und Psychotherapie der Universität München
    MMW Fortschr Med 149:98-101. 2007
    ..Negative symptoms still represent a therapeutic challenge, especially in conjunction with chronic residual symptoms...
  65. ncbi request reprint Effects of risperidone and quetiapine on cognition in patients with schizophrenia and predominantly negative symptoms
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 257:360-70. 2007
    ..Also, the improvements in cognition following treatment with quetiapine and risperidone may enhance long-term outcomes for these patients...
  66. ncbi request reprint Efficacy of olanzapine versus quetiapine on cognitive dysfunctions in patients with an acute episode of schizophrenia
    Michael Riedel
    Dept of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 257:402-12. 2007
    ..Furthermore, quetiapine produced a significantly greater improvement in reaction quality/attention than olanzapine...
  67. ncbi request reprint T- and B-lymphocytes in patients with schizophrenia in acute psychotic episode and the course of the treatment
    Katja Maino
    Department of Psychiatry and Psychotherapy Ludwig Maximilians University, Munchen, Germany
    Psychiatry Res 152:173-80. 2007
    ....
  68. ncbi request reprint Investigating disease susceptibility and the negative correlation of schizophrenia and rheumatoid arthritis focusing on MIF and CD14 gene polymorphisms
    Larissa de la Fontaine
    Klinik fur Psychiatrie und Psychotherapie, Nussbaumstr 7, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    Psychiatry Res 144:39-47. 2006
    ....
  69. doi request reprint Association between intracellular infectious agents and Tourette's syndrome
    Daniela Krause
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 260:359-63. 2010
    ..It still remains unclear whether tic symptoms are partly due to the infection or to changes in the immune balance caused by an infection...
  70. doi request reprint Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients
    Ilja Spellmann
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nußbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 45:234-41. 2011
    ..Thus, these data might further help in detecting differential therapy response in individuals with schizophrenia...
  71. ncbi request reprint Comorbidity of Tourette's syndrome and schizophrenia--biological and physiological parallels
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, D 80336 Munich 2, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 26:1245-52. 2002
    ..Both disorders show disturbances of the multiple functional pathways, which seem to be involved in the pathophysiology of both. The clinical overlap of TS and of schizophrenia may be due to a final common pathophysiological pathway...
  72. ncbi request reprint Mycoplasma pneumoniae infection and Tourette's syndrome
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, D 80336 MUnchen, Germany
    Psychiatry Res 129:119-25. 2004
    ..An autoimmune reaction, however, has to be taken into account. In predisposed persons, infection with various agents including M. pneumoniae should be considered as at least an aggravating factor in TS...
  73. ncbi request reprint COX-2 inhibitors as adjunctive therapy in schizophrenia
    Norbert Muller
    Ludwig Maximilans University, Department of Psychiatry and Psychotherapy, Nussbaumstrasse 7, D 80336 Munich, Germany
    Expert Opin Investig Drugs 13:1033-44. 2004
    ..These preliminary clinical data are encouraging for clinical therapeutic effects of the selective COX-2 inhibitors in psychiatric disorders, although these effects have to be confirmed in larger clinical studies...
  74. ncbi request reprint COX-2 inhibition as a treatment approach in schizophrenia: immunological considerations and clinical effects of celecoxib add-on therapy
    Norbert Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:14-22. 2004
    ....
  75. ncbi request reprint Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia
    Norbert Muller
    Psychiatric and Psychotherapeutic Hospital, Ludwig Maximilians University, Munich, Germany
    Am J Psychiatry 159:1029-34. 2002
    ..The authors conducted a trial of the new selective cyclooxygenase-2 inhibitor celecoxib, an immunomodulatory drug, in schizophrenic patients to evaluate its therapeutic effects...
  76. ncbi request reprint Internally and externally guided voluntary saccades in unmedicated and medicated schizophrenic patients. Part II. Saccadic latency, gain, and fixation suppression errors
    N Muller
    Psychiatric Hospital, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 249:7-14. 1999
    ....
  77. doi request reprint Effects of experimentally induced panic attacks on neuroimmunological markers
    L de la Fontaine
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Neural Transm 116:699-702. 2009
    ..Herein we conducted for the first time a new approach to immunological research in panic disorder, suggesting immune changes are more related to long term disease stress...
  78. ncbi request reprint [Immunoglobulin therapy in Gilles de la Tourette syndrome]
    N Muller
    Psychiatrische Klinik, Ludwig Maximilians Universitat, Munchen
    Nervenarzt 68:914-6. 1997
    ..These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system, at least in a subgroup of GTS...
  79. ncbi request reprint Decreased T cellular immune response in schizophrenic patients
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 41:3-7. 2007
    ..Our findings demonstrate a markedly attenuated in vivo type-1 mediated cellular immune response in schizophrenic patients, further confirming the hypothesis of a relative Th2 shift in schizophrenia...
  80. ncbi request reprint IL-2 and IL-4 polymorphisms as candidate genes in schizophrenia
    Markus J Schwarz
    Psychiatric Hospital, Ludwig Maximilian University Munich, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:72-6. 2006
    ....
  81. ncbi request reprint COX-2 inhibitors as adjunctive therapy in schizophrenia: rationale for use and evidence to date
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilan University of Munich, Munich, Germany
    CNS Drugs 19:805-19. 2005
    ..While the first trial using celecoxib as add-on therapy to an atypical antipsychotic showed a significant beneficial effect, recent studies demonstrated that this effect may be limited to patients with recent-onset schizophrenia...
  82. ncbi request reprint Psychomotor disturbances in psychiatric patients as a possible basis for new attempts at differential diagnosis and therapy. Part VI. Evaluation of psychomotor training programs in schizophrenic patients
    W Gunther
    Psychiatrische Universitatsklinik, Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 245:288-98. 1995
    ..A final version of our complete training programs will be published as an appendix to this paper along with information regarding the abbreviated test battery...
  83. ncbi request reprint Functional EEG mapping and SPECT in detoxified male alcoholics
    W Gunther
    Psychiatric University Hospital, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 247:128-36. 1997
    ..All findings point to organic brain dysfunctions in these patients which extend beyond the period of withdrawal...
  84. doi request reprint Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
    Gerald Stober
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 10:127-55. 2009
    ....
  85. doi request reprint The work of Emil Kraepelin and his research group in München
    Hanns Hippius
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Nubbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:3-11. 2008
    ..This contribution shows that Kraepelin himself questioned his dichotomy of dementia praecox and manic depressive insanity, a discussion which is lively still today--more than 80 years later...
  86. ncbi request reprint ICAM G241A polymorphism and soluble ICAM-1 serum levels: evidence for an active immune process in schizophrenia
    Holger Kronig
    Psychiatric Hospital, Ludwig Maximilian University Munich, Munich, Germany
    Neuroimmunomodulation 12:54-9. 2005
    ..The G-->A SNP results in a nonsynonymous amino acid exchange of the ICAM-1 protein, and the A allele was shown to be also associated with several immunological disorders like rheumatoid arthritis...
  87. ncbi request reprint Electroconvulsive therapy in a patient with Tourette's syndrome and co-morbid Obsessive Compulsive Disorder
    Martin Strassnig
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 5:164-6. 2004
    ..Monthly outpatient ECT sessions were arranged in order to sustain the positive treatment outcome. Since then, remission of both disorders has been maintained successfully for more than a year...
  88. ncbi request reprint Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 8:141-74. 2007
    ....
  89. ncbi request reprint Immunological and infectious aspects of schizophrenia
    Norbert Muller
    Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:1-3. 2004