Matthias J Muller

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Psychiatry Res 89:275-80. 1999
  2. ncbi Differentiating moderate and severe depression using the Montgomery-Asberg depression rating scale (MADRS)
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131, Mainz, Germany
    J Affect Disord 77:255-60. 2003
  3. ncbi Standardized rater training for the Hamilton Depression Rating Scale (HAMD-17) in psychiatric novices
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    J Affect Disord 77:65-9. 2003
  4. ncbi Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions?
    M J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Pharmacopsychiatry 36:98-104. 2003
  5. ncbi Sequentially adjusted randomization to force balance in controlled trials with unknown prevalence of covariates: application to alcoholism research
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Alcohol Alcohol 40:124-31. 2005
  6. ncbi Dose-related effects of amisulpride on five dimensions of psychopathology in patients with acute exacerbation of schizophrenia
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Clin Psychopharmacol 22:554-60. 2002
  7. ncbi Differential effects of high-dose amisulpride versus flupentixol on latent dimensions of depressive and negative symptomatology in acute schizophrenia: an evaluation using confirmatory factor analysis
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Int Clin Psychopharmacol 17:249-61. 2002
  8. ncbi Patients' satisfaction with psychiatric treatment: comparison between an open and a closed ward
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Psychiatr Q 73:93-107. 2002
  9. ncbi Effects of interrater reliability of psychopathologic assessment on power and sample size calculations in clinical trials
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Germany
    J Clin Psychopharmacol 22:318-25. 2002
  10. ncbi Moderate and severe depression. Gradations for the Montgomery-Asberg Depression Rating Scale
    M J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131, Mainz, Germany
    J Affect Disord 60:137-40. 2000

Detail Information

Publications50

  1. ncbi Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Psychiatry Res 89:275-80. 1999
    ..Five patients, four of whom were females, completed the trial. Dropouts were mainly due to treatment failure. Antipsychotic effects were significantly greater in female than male patients...
  2. ncbi Differentiating moderate and severe depression using the Montgomery-Asberg depression rating scale (MADRS)
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131, Mainz, Germany
    J Affect Disord 77:255-60. 2003
    ..MADRS cut-off scores for moderate and severe depression were estimated in relation to the Hamilton Depression Rating Scale (HAMD(17)) and the Clinical Global Impressions Scale (CGI)...
  3. ncbi Standardized rater training for the Hamilton Depression Rating Scale (HAMD-17) in psychiatric novices
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    J Affect Disord 77:65-9. 2003
    ..Despite the long and widespread use of the Hamilton Depression Rating Scale (HAMD), standardized reliability studies in inexperienced raters are not available...
  4. ncbi Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions?
    M J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Pharmacopsychiatry 36:98-104. 2003
    ..The results encourage further studies in order to optimize antidepressant pharmacotherapy when using TDM appropriately...
  5. ncbi Sequentially adjusted randomization to force balance in controlled trials with unknown prevalence of covariates: application to alcoholism research
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Alcohol Alcohol 40:124-31. 2005
    ..This study tested a method for use in clinical alcoholism research, an uncomplicated procedure for satisfactory randomization of patients to different treatments, taking into account relevant background variables...
  6. ncbi Dose-related effects of amisulpride on five dimensions of psychopathology in patients with acute exacerbation of schizophrenia
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Clin Psychopharmacol 22:554-60. 2002
    ....
  7. ncbi Differential effects of high-dose amisulpride versus flupentixol on latent dimensions of depressive and negative symptomatology in acute schizophrenia: an evaluation using confirmatory factor analysis
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Int Clin Psychopharmacol 17:249-61. 2002
    ..CFA-based analyses appear to be suitable for psychotropic drug evaluation when more refined and data-related information on drug efficacy profiles are required...
  8. ncbi Patients' satisfaction with psychiatric treatment: comparison between an open and a closed ward
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Psychiatr Q 73:93-107. 2002
    ..The results thus far strongly support the need for patients' satisfaction with treatment to be taken into account in order to improve psychiatric inpatient services, particularly on closed wards...
  9. ncbi Effects of interrater reliability of psychopathologic assessment on power and sample size calculations in clinical trials
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Germany
    J Clin Psychopharmacol 22:318-25. 2002
    ..Sample size calculations and power analysis should be based on empirical reliability values of outcome parameters as part of quality assurance and cost savings...
  10. ncbi Moderate and severe depression. Gradations for the Montgomery-Asberg Depression Rating Scale
    M J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131, Mainz, Germany
    J Affect Disord 60:137-40. 2000
    ..Despite its importance, no distinction between moderate and severe depression using the Montgomery-Asberg Depression Rating Scale (MADRS) based on a direct comparison with the Hamilton Depression Rating Scale (HAMD-17) is available...
  11. ncbi Depressive factors and their relationships with other symptom domains in schizophrenia, schizoaffective disorder, and psychotic depression
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Schizophr Bull 27:19-28. 2001
    ..A more differentiated assessment, analysis, and treatment of depressive symptoms is therefore recommended for patients with combined depressive and psychotic symptoms...
  12. ncbi Serum levels of sulpiride enantiomers after oral treatment with racemic sulpiride in psychiatric patients: a pilot study
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Pharmacopsychiatry 34:27-32. 2001
    ..66-0.97) in all patients. A slight negative correlation between CGI improvement and the ratio of L:D-SULP (p < 0.10) and a positive correlation between racemic SULP concentrations and side-effects at endpoint was found (p < 0.05)...
  13. ncbi Quality of partnership in patients with erectile dysfunction after sildenafil treatment
    M J Muller
    Department of Psychiatry University of Mainz, Germany
    Pharmacopsychiatry 34:91-5. 2001
    ..A comprehensive investigation on the quality of partnership of male patients with erectile dysfunction (ED) after treatment with sildenafil vs. untreated patients, as perceived by both the patients and their female partners...
  14. ncbi Lower self-reported depression in patients with erectile dysfunction after treatment with sildenafil
    M J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    J Affect Disord 66:255-61. 2001
    ..Depressive symptoms in men with erectile dysfunction (ED) may improve under successful ED treatment. Self-reported depressive symptoms were compared in men with ED after sildenafil treatment to a group of untreated patients...
  15. ncbi Subchronic effects of olanzapine on sleep EEG in schizophrenic patients with predominantly negative symptoms
    M J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Pharmacopsychiatry 37:157-62. 2004
    ..Antipsychotic drugs with serotonin (5-HT2) receptor-antagonistic properties are considered to have delta sleep promoting effects. We have investigated the effects of subchronic olanzapine treatment on sleep EEG in schizophrenic patients...
  16. ncbi A monoamine oxidase B gene variant and short-term antidepressant treatment response
    Andre Tadic
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:1370-7. 2007
    ..If replicated, the MAOB A644G polymorphism could be considered useful for prospective confirmatory pharmacogenetic trials in patients with major depression...
  17. ncbi Functional relevant loss of long association fibre tracts integrity in early Alzheimer's disease
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    Neuropsychologia 46:1698-706. 2008
    ....
  18. ncbi Functional implications of hippocampal degeneration in early Alzheimer's disease: a combined DTI and PET study
    Igor Yakushev
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
    Eur J Nucl Med Mol Imaging 38:2219-27. 2011
    ..Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in subjects with AD, also in relation to episodic memory impairment...
  19. ncbi Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease
    Igor Yakushev
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Dement Geriatr Cogn Disord 30:245-53. 2010
    ....
  20. ncbi Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Germany
    Neurobiol Aging 26:1193-8. 2005
    ..Moreover, ccDTI could serve as in vivo method to investigate age and disease-related myelin alterations as potential morphological substrates of cognitive dysfunction...
  21. ncbi Detection of depression in acute schizophrenia: sensitivity and specificity of 2 standard observer rating scales
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Germany
    Can J Psychiatry 51:387-92. 2006
    ..To compare the psychometric properties of the Calgary Depression Rating Scale (CDRS) and the Hamilton Depression Rating Scale (HDRS) for severity assessment of depression in acute schizophrenia...
  22. ncbi Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer's disease
    Igor Yakushev
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    Neuropsychologia 48:1447-53. 2010
    ..Diffusivity measurements might be highly sensitive to functionally relevant degenerative alterations of the hippocampus...
  23. ncbi FDG-PET and CSF phospho-tau for prediction of cognitive decline in mild cognitive impairment
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    Psychiatry Res 155:167-71. 2007
    ..Pathological FDG-PET and elevated p-tau(181) levels both predicted deterioration. While p-tau(181) was highly sensitive for cognitive decline, FDG-PET was superior in predicting conversion to clinical dementia in MCI patients...
  24. ncbi Predicting conversion to dementia in mild cognitive impairment by volumetric and diffusivity measurements of the hippocampus
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Psychiatry Res 146:283-7. 2006
    ..Hippocampal diffusivity was superior to hippocampal volumes for prediction of conversion to dementia in MCI patients during a 112-year period...
  25. ncbi Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-D-glucose positron emission tomography findings in patients with mild cognitive impairment
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Biol Psychiatry 56:279-83. 2004
    ....
  26. ncbi CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type
    Andreas Fellgiebel
    Department of Psychiatry, Johannes Gutenberg University Mainz, Germany
    J Geriatr Psychiatry Neurol 22:3-9. 2009
    ..Both, an increase in p tau levels and a decrease in cerebrospinal fluid APPs alpha, seem to refer to relevant but functionally different processes in the development of mild cognitive impairment and dementia of Alzheimer's type...
  27. ncbi Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    Neurobiol Aging 28:398-403. 2007
    ..The results demonstrate higher sensitivity of DTI-derived left hippocampal parameters than volume measures in detecting subtle hippocampal abnormalities related to MCI...
  28. ncbi Validating the DemTect with 18-fluoro-2-deoxy-glucose positron emission tomography as a sensitive neuropsychological screening test for early alzheimer disease in patients of a memory clinic
    Armin Scheurich
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Dement Geriatr Cogn Disord 20:271-7. 2005
    ..The first study to validate the diagnostic value of the DemTect, a short neuropsychological screening test for dementia (8-10 min), using 18-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) in patients of a memory clinic...
  29. ncbi Clinical improvement in a case of frontotemporal dementia under aripiprazole treatment corresponds to partial recovery of disturbed frontal glucose metabolism
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Mainz, Germany
    World J Biol Psychiatry 8:123-6. 2007
    ....
  30. ncbi Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    J Psychiatr Res 41:673-9. 2007
    ..Although our results were mainly explorative, TDM of amisulpride seems very useful for clinical decision making...
  31. ncbi Early improvement under mirtazapine and paroxetine predicts later stable response and remission with high sensitivity in patients with major depression
    Armin Szegedi
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Clin Psychiatry 64:413-20. 2003
    ..We aimed to test whether early improvement under antidepressant treatment is a clinically useful predictor of later stable response and remission...
  32. ncbi Hippocampal atrophy as a surrogate of neuronal involvement in Fabry disease
    Andreas Fellgiebel
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str 8, 55131, Mainz, Germany
    J Inherit Metab Dis 35:363-7. 2012
    ..Longitudinal studies are needed to determine whether this degenerative component in FD will progress and, in concert with the individual WML-load, predict subsequent cognitive decline...
  33. ncbi Late structural alterations of cerebral white matter in long-term survivors of childhood leukemia
    Paulo R Dellani
    Institute of Neuroradiology, University Clinic, Mainz, Germany
    J Magn Reson Imaging 27:1250-5. 2008
    ....
  34. ncbi Amisulpride doses and plasma levels in different age groups of patients with schizophrenia or schizoaffective disorder
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Psychopharmacol 23:278-86. 2009
    ....
  35. ncbi The Calgary Depression Rating Scale for schizophrenia in a healthy control group: psychometric properties and reference values
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    J Affect Disord 88:69-74. 2005
    ..However, so far no reference values derived from an adequate healthy sample have been published...
  36. ncbi Gender-specific associations of depression with positive and negative symptoms in acute schizophrenia
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:1095-100. 2007
    ..05) and short hospitalization (P<0.05) were the main factors associated with depression. The study revealed gender-specific differences in the relationship of depression with negative and positive symptoms...
  37. ncbi Pattern of microstructural brain tissue alterations in Fabry disease: a diffusion-tensor imaging study
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    J Neurol 253:780-7. 2006
    ..Moreover, this method could be favorable for longitudinal assessment of brain structure alterations in FD, and for monitoring the cerebral effects of enzyme replacement therapy...
  38. ncbi Association between citalopram serum levels and clinical improvement of patients with major depression
    Elnaz Ostad Haji
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    J Clin Psychopharmacol 31:281-6. 2011
    ....
  39. ncbi The MAOA T941G polymorphism and short-term treatment response to mirtazapine and paroxetine in major depression
    Andre Tadic
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:325-31. 2007
    ..An independent replication of our finding is needed. If replicated, genotyping of this locus could become a promising tool to predict response to mirtazapine treatment in females suffering from major depression...
  40. ncbi Functional implications of hippocampal volume and diffusivity in mild cognitive impairment
    Matthias J Muller
    Department of Psychiatry, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    Neuroimage 28:1033-42. 2005
    ..The combination of macro- and microstructural parameters in hippocampal areas could be promising in early detection of neurodegenerative processes...
  41. ncbi Quantification of brain tissue alterations in Fabry disease using diffusion-tensor imaging
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Mainz, Germany
    Acta Paediatr Suppl 96:33-6. 2007
    ..DTI measurements could provide appropriate surrogate parameters with which to monitor the natural history of structural brain involvement and potential effects of therapy (such as enzyme replacement) in Fabry disease...
  42. ncbi Nocturnal hormone profiles in patients with schizophrenia treated with olanzapine
    Klaus Mann
    Department of Psychiatry, University of Mainz, Untere Zahibacher Strasse 8, Mainz D 55101, Germany
    Psychoneuroendocrinology 31:256-64. 2006
    ....
  43. ncbi Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects
    Katrin M Kirschbaum
    Department of Psychiatry, University of Mainz, Germany
    World J Biol Psychiatry 9:212-8. 2008
    ....
  44. ncbi Therapeutic monitoring of new antipsychotic drugs
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, D 55101 Mainz, Germany
    Ther Drug Monit 26:156-60. 2004
    ..The few reported investigations, however, need to be confirmed and extended...
  45. ncbi Subchronic haloperidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Germany
    Neuropsychopharmacology 28:787-94. 2003
    ..We link an alteration in cerebral catecholamine metabolism in human brain with the therapeutic action of neuroleptic medication...
  46. ncbi Symptom-triggered versus standard chlormethiazole treatment of inpatient alcohol withdrawal: clinical implications from a chart analysis
    Christian Lange-Asschenfeldt
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Eur Addict Res 9:1-7. 2003
    ..In conclusion, an individualized symptom-triggered treatment of alcohol withdrawal with CMZ seems to be equally safe but more efficient than a scheduled regimen...
  47. ncbi [Early interventional group therapy for patients with incipient Alzheimer disease and their relatives]
    Armin Scheurich
    Psychiatrische Klinik und Poliklinik der Universität Mainz
    Psychother Psychosom Med Psychol 58:246-52. 2008
    ..The present study investigates whether scientific progress in terms of earlier time of diagnostic certainty can be used for psychoeducation, maintenance of positive activities and prevention of comorbid depressive episodes...
  48. ncbi Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Dement Geriatr Cogn Disord 18:101-8. 2004
    ..4% (with a specificity set at 80%). Therefore, the DTI technique validates the MCI concept, and diffusion tensor MR measurement can be a helpful tool to quantify MCI pathology in vivo...
  49. ncbi Syndrome profiles in alcoholism and panic disorder with or without agoraphobia: an explorative family study
    Eugen Davids
    Department of Psychiatry University of Mainz, Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 26:1079-87. 2002
    ..The presented method of analyzing syndrome profiles in a family study seems to be a possibility to demonstrate references to genetic links between patients and parents in anxiety- and alcohol-related disorders...
  50. ncbi CNS manifestations of Fabry's disease
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Lancet Neurol 5:791-5. 2006
    ..Finally, a diagnosis of Fabry's disease should always be considered in young patients who have had a stroke...