Sebastian Mueller

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Activation of iron regulatory protein-1 by oxidative stress
    Sebastian Mueller
    Department of Internal Medicine IV, University of Heidelberg, 69115 Heidelberg, Germany
    Methods Enzymol 348:324-37. 2002
  2. pmc Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis
    Sebastian Mueller
    Department of Medicine and Center for Alcohol Research, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    World J Gastroenterol 16:966-72. 2010
  3. doi The GOX/CAT system: a novel enzymatic method to independently control hydrogen peroxide and hypoxia in cell culture
    S Mueller
    Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    Adv Med Sci 54:121-35. 2009
  4. pmc Alcoholic liver disease and hepatitis C: a frequently underestimated combination
    Sebastian Mueller
    Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    World J Gastroenterol 15:3462-71. 2009
  5. ncbi IRP1 activation by extracellular oxidative stress in the perfused rat liver
    S Mueller
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Str 58, 69115, Germany
    J Biol Chem 276:23192-6. 2001
  6. ncbi Iron regulatory protein 1 as a sensor of reactive oxygen species
    Sebastian Mueller
    Department of Internal Medicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Biofactors 24:171-81. 2005
  7. ncbi Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1
    Sebine Mütze
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Strasse 58, 69115 Heidelberg, Germany
    J Biol Chem 278:40542-9. 2003
  8. pmc Sensitive and real-time determination of H2O2 release from intact peroxisomes
    Sebastian Mueller
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Strasse 58, 69115 Heidelberg, Germany
    Biochem J 363:483-91. 2002
  9. ncbi Extracellular H2O2 and not superoxide determines the compartment-specific activation of transferrin receptor by iron regulatory protein 1
    Antoni Sureda
    Medical Department, University of Heidelberg, Im Neuenheimer Feld, 410, 69120, Heidelberg, Germany
    Free Radic Res 39:817-24. 2005
  10. ncbi Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network
    Bill Andriopoulos
    Department of Internal Medicine, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    J Biol Chem 282:20301-8. 2007

Collaborators

Detail Information

Publications31

  1. ncbi Activation of iron regulatory protein-1 by oxidative stress
    Sebastian Mueller
    Department of Internal Medicine IV, University of Heidelberg, 69115 Heidelberg, Germany
    Methods Enzymol 348:324-37. 2002
  2. pmc Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis
    Sebastian Mueller
    Department of Medicine and Center for Alcohol Research, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    World J Gastroenterol 16:966-72. 2010
    ..To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS)...
  3. doi The GOX/CAT system: a novel enzymatic method to independently control hydrogen peroxide and hypoxia in cell culture
    S Mueller
    Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    Adv Med Sci 54:121-35. 2009
    ..Several applications are discussed in detail to demonstrate the technical requirements and potentials. In addition, simplified protocols are presented for cell or molecular biology labs without dedicated biophysical equipment...
  4. pmc Alcoholic liver disease and hepatitis C: a frequently underestimated combination
    Sebastian Mueller
    Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    World J Gastroenterol 15:3462-71. 2009
    ..For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs...
  5. ncbi IRP1 activation by extracellular oxidative stress in the perfused rat liver
    S Mueller
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Str 58, 69115, Germany
    J Biol Chem 276:23192-6. 2001
    ..It also provides a link between iron metabolism and the inflammatory response, as H(2)O(2) is a major product of the oxidative burst of neutrophils and macrophages...
  6. ncbi Iron regulatory protein 1 as a sensor of reactive oxygen species
    Sebastian Mueller
    Department of Internal Medicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Biofactors 24:171-81. 2005
    ..These molecular insights open up new therapeutic strategies for the clinical management of chronic inflammation and drug-mediated cardiotoxicity...
  7. ncbi Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1
    Sebine Mütze
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Strasse 58, 69115 Heidelberg, Germany
    J Biol Chem 278:40542-9. 2003
    ..Our findings suggest that HOCl can modulate signaling pathways in a concerted action with H2O2. The GOX/CAT/MPO system provides a valuable tool for studying the regulatory function of HOCl...
  8. pmc Sensitive and real-time determination of H2O2 release from intact peroxisomes
    Sebastian Mueller
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Strasse 58, 69115 Heidelberg, Germany
    Biochem J 363:483-91. 2002
    ..The experimental approach offers new possibilities for functionally studying H(2)O(2) metabolism, substrate transport and turnover in peroxisomes of eukaryotic cells...
  9. ncbi Extracellular H2O2 and not superoxide determines the compartment-specific activation of transferrin receptor by iron regulatory protein 1
    Antoni Sureda
    Medical Department, University of Heidelberg, Im Neuenheimer Feld, 410, 69120, Heidelberg, Germany
    Free Radic Res 39:817-24. 2005
    ..Our findings confirm that extracellular H2O2 determines the functionality of the IRP1 cluster and its downstream targets while the reactivity of O2*- is limited to its compartment of origin...
  10. ncbi Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network
    Bill Andriopoulos
    Department of Internal Medicine, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, 69121 Heidelberg, Germany
    J Biol Chem 282:20301-8. 2007
    ..Our results suggest a novel mechanism of iron accumulation by sustained H(2)O(2), based on the translational activation of TfR1, which could provide an important (patho) physiological link between iron metabolism and inflammation...
  11. doi Exposing cells to H2O2: a quantitative comparison between continuous low-dose and one-time high-dose treatments
    Mirko C Sobotta
    Division of Redox Regulation, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    Free Radic Biol Med 60:325-35. 2013
    ..Thus, different, or even opposing, biological outcomes from differing means of H2O2 delivery may be expected. Cellular responses induced by bolus treatment may not occur under GOX/CAT conditions, and vice versa...
  12. doi Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions
    Gunda Millonig
    Department of Medicine, Salem Medical Centre and Centre of Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 128:533-40. 2011
    ..Our data demonstrate for the first time an induction of CYP2E1 in the esophageal mucosa by ethanol in a dose dependent manner in man and may explain, at least in part, the generation of carcinogenic DNA lesions in this target organ...
  13. doi In vitro-targeted gene identification in patients with hepatitis C using a genome-wide microarray technology
    Susanne Hagist
    Department of Internal Medicine, Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    Hepatology 49:378-86. 2009
    ....
  14. ncbi Liver-homing of purified glucose oxidase: a novel in vivo model of physiological hepatic oxidative stress (H2O2)
    Daniel Rost
    Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Hepatol 46:482-91. 2007
    ..Reactive oxygen species (ROS), such as H2O2, are implicated in normal and pathological liver function. However, due to the lack of suitable in vivo models of ROS generation the (patho) physiological relevance of H2O2 remains controversial...
  15. doi Liver stiffness is directly influenced by central venous pressure
    Gunda Millonig
    Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    J Hepatol 52:206-10. 2010
    ..Since Fibroscan seems to be unreliable in patients with congestive heart failure, it remains to be determined whether hemodynamic changes affect LS irrespective of fibrosis...
  16. pmc Investigation of tumor hypoxia using a two-enzyme system for in vitro generation of oxygen deficiency
    Vasileios Askoxylakis
    Department of Radiooncology and Radiation Therapy, University of Heidelberg, Heidelberg, Germany
    Radiat Oncol 6:35. 2011
    ....
  17. doi Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease
    Ying Wang
    Center of Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Germany
    Hepatology 50:453-61. 2009
    ..CMZ blocked the generation of etheno-DNA adducts by 70%-90% (P < 0.01)...
  18. ncbi Compartment-dependent management of H(2)O(2) by peroxisomes
    Reiner Fritz
    Department of Internal Medicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Free Radic Biol Med 42:1119-29. 2007
    ..Apparently, PO are inefficient detoxifiers of external H(2)O(2) but rather can become an obligatory source of H(2)O(2)--an important signaling molecule and a potential toxin...
  19. pmc Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3)
    Gunda Millonig
    Center for Alcohol Research, University of Heidelberg and Salem Medical Center, 69120 Heidelberg, Germany
    J Biol Chem 287:37472-82. 2012
    ..Our results suggest a novel mechanism of hepcidin regulation by nanomolar levels of sustained H(2)O(2). Thus, similar to cytokines, H(2)O(2) provides an important regulatory link between inflammation and iron metabolism...
  20. doi Association of liver stiffness with hepatic expression of pharmacokinetically important genes in alcoholic liver disease
    Dirk Theile
    Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
    Alcohol Clin Exp Res 37:E17-22. 2013
    ....
  21. doi Assessment of renal allograft fibrosis by transient elastography
    Claudia Sommerer
    Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Transpl Int 26:545-51. 2013
    ..The heterogeneous kidney morphology and several other confounding factors negatively affect measurability of KS by TE. Further technical modifications are required to improve applicability of TE for kidney assessment...
  22. ncbi Cardioprotective effects of the novel selective endothelin-A receptor antagonist BSF 461314 in ischemia-reperfusion injury
    Alexander Hansen
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Echocardiogr 18:1213-20. 2005
    ..015). Therefore, selective endothelin-A receptor antagonism improved microvascular integrity during postischemic reperfusion. Real-time myocardial contrast echocardiography accurately detected changes in microvascular reflow...
  23. ncbi Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography
    Alexander Hansen
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Am Coll Cardiol 44:887-91. 2004
    ..The purpose was to examine the cardioprotective effects of recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) in ischemia-reperfusion injury by real-time myocardial contrast echocardiography (MCE)...
  24. doi Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study
    Gunda Millonig
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Innsbruck, Austria
    Biomarkers 15:297-306. 2010
    ..88 and 0.97. IMR-MS followed by sophisticated statistical analysis is a promising tool for liver diagnostics by breath analysis...
  25. doi Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis
    Gunda Millonig
    Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    Hepatology 48:1718-23. 2008
    ..Once extrahepatic cholestasis is excluded (e.g., by liver imaging and laboratory parameters) transient elastography is a valuable tool to assess liver fibrosis in chronic liver diseases...
  26. doi Current experimental perspectives on the clinical progression of alcoholic liver disease
    Katja Breitkopf
    Molecular Alcohol Research in Gastroenterology, Department of Medicine II, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Alcohol Clin Exp Res 33:1647-55. 2009
    ....
  27. doi The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis
    Hong Lei Weng
    Molecular Alcohol Research in Gastroenterology, Department of Medicine II, Faculty of Medicine at Mannheim, University of Heidelberg, Germany
    Hepatology 50:230-43. 2009
    ..TGF-beta1 predominance is detected in HBV-related liver fibrogenesis and IL-13 predominance in chronic HCV infection. In some instances, the underlying fibrogenic mediator remains enigmatic...
  28. pmc Hyperferritinaemia-cataract syndrome: worldwide mutations and phenotype of an increasingly diagnosed genetic disorder
    Gunda Millonig
    Center for Alcohol Research and Salem Medical Center, University of Heidelberg, Heidelberg, Germany
    Hum Genomics 4:250-62. 2010
    ..Patients diagnosed with HHCS should be counselled regarding the relative harmlessness of this genetic disease, with early cataract surgery as the only clinical consequence...
  29. ncbi Iron, HCV, and liver cancer: hard metal setting the pace?
    Sebastian Mueller
    Gastroenterology 130:2229-34. 2006