Olaf Mueller

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs
    Olaf Müller
    Institute of Public Health, Medical School, Ruprecht Karls University, Heidelberg, Germany
    Pharmacoepidemiol Drug Saf 22:376-85. 2013
  2. pmc Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso
    Germain Mandi
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    Malar J 7:58. 2008
  3. pmc Malaria in rural Burkina Faso: local illness concepts, patterns of traditional treatment and influence on health-seeking behaviour
    Claudia Beiersmann
    Department of Tropical Hygiene and Public Health, Medical School, Ruprecht Karls Universitat Heidelberg, INF 324, Heidelberg, Germany
    Malar J 6:106. 2007
  4. pmc Substandard anti-malarial drugs in Burkina Faso
    Maike Tipke
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Malar J 7:95. 2008
  5. pmc Compliance of young children with ITN protection in rural Burkina Faso
    Claudia Frey
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, INF 324, 69124 Heidelberg, Germany
    Malar J 5:70. 2006
  6. pmc Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, INF 324, 69120 Heidelberg, Germany
    Malar J 5:84. 2006
  7. pmc Pattern of cause-specific childhood mortality in a malaria endemic area of Burkina Faso
    Gaël P Hammer
    Department of Epidemiology, Institute for Tropical Hygiene and Public Health, University of Heidelberg, Germany
    Malar J 5:47. 2006
  8. pmc Comparison of all-cause and malaria-specific mortality from two West African countries with different malaria transmission patterns
    Robert P Ndugwa
    Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Malar J 7:15. 2008
  9. pmc Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial
    Bocar Kouyate
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso, Africa
    Malar J 7:50. 2008
  10. pmc Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, INF 324, 69120 Heidelberg, Germany
    Malar J 4:45. 2005

Detail Information

Publications37

  1. doi request reprint Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs
    Olaf Müller
    Institute of Public Health, Medical School, Ruprecht Karls University, Heidelberg, Germany
    Pharmacoepidemiol Drug Saf 22:376-85. 2013
    ..Together with a number of other antimalarials, MB is on the list of drugs which potentially induce haemolysis in patients with G6PD deficiency. Ruling out safety concerns is of major importance during drug development...
  2. pmc Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso
    Germain Mandi
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    Malar J 7:58. 2008
    ..Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are scarce...
  3. pmc Malaria in rural Burkina Faso: local illness concepts, patterns of traditional treatment and influence on health-seeking behaviour
    Claudia Beiersmann
    Department of Tropical Hygiene and Public Health, Medical School, Ruprecht Karls Universitat Heidelberg, INF 324, Heidelberg, Germany
    Malar J 6:106. 2007
    ..Understanding local concepts of illness and their influence on health care-seeking behaviour can complement existing knowledge and lead to the development of more effective malaria control interventions...
  4. pmc Substandard anti-malarial drugs in Burkina Faso
    Maike Tipke
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Malar J 7:95. 2008
    ..This is particularly worrying with regard to the increasing resistance development of Plasmodium falciparum against affordable anti-malarial medications, which has led to a change to more expensive drugs in most endemic countries...
  5. pmc Compliance of young children with ITN protection in rural Burkina Faso
    Claudia Frey
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, INF 324, 69124 Heidelberg, Germany
    Malar J 5:70. 2006
    ..The effectiveness of ITNs is largely influenced by behavioural factors and not much is known regarding such factors under programme conditions...
  6. pmc Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, INF 324, 69120 Heidelberg, Germany
    Malar J 5:84. 2006
    ..5%, 14.0%)] and 24% [95% CI (19.4%, 28.3%)], respectively. MB appears to have efficacy against malaria, but the combination of CQ-MB is clearly not effective in the treatment of malaria in Africa...
  7. pmc Pattern of cause-specific childhood mortality in a malaria endemic area of Burkina Faso
    Gaël P Hammer
    Department of Epidemiology, Institute for Tropical Hygiene and Public Health, University of Heidelberg, Germany
    Malar J 5:47. 2006
    ..Demographic surveillance systems (DSS) implementing the verbal autopsy (VA) method are the only possibility to observe cause-specific mortality of a population on a longitudinal basis in many countries...
  8. pmc Comparison of all-cause and malaria-specific mortality from two West African countries with different malaria transmission patterns
    Robert P Ndugwa
    Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Malar J 7:15. 2008
    ..All-cause and malaria-specific mortality rates for children under-five years old in a mesoendemic malaria area (The Gambia) were compared with those from a hyper/holoendemic area (Burkina Faso)...
  9. pmc Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial
    Bocar Kouyate
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso, Africa
    Malar J 7:50. 2008
    ..Home treatment through mothers of febrile children supported by mother groups and local health workers has the potential to reduce malaria morbidity and mortality...
  10. pmc Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, INF 324, 69120 Heidelberg, Germany
    Malar J 4:45. 2005
    ..Methylene blue (MB) combined with chloroquine (CQ) has been considered as one promising new regimen...
  11. pmc Quality of antenatal care in rural southern Tanzania: a reality check
    Malabika Sarker
    Institute of Public Health, University of Heidelberg, Heidelberg, Germany
    BMC Res Notes 3:209. 2010
    ..The objectives of this study were to identify gaps in the provision of ANC services and knowledge of danger signs as well as the quality of care women receive in case of complications...
  12. ncbi request reprint Evaluation of a prototype long-lasting insecticide-treated mosquito net under field conditions in rural Burkina Faso
    O Muller
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, INF 324, 69120 Heidelberg, Germany
    Trans R Soc Trop Med Hyg 96:483-4. 2002
    ..The technology of 'long-lasting' insecticide-treatment needs much improvement...
  13. ncbi request reprint Clinical efficacy of chloroquine in young children with uncomplicated falciparum malaria--a community-based study in rural Burkina Faso
    Olaf Müller
    Department of Tropical Hygiene and Public Health of the Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Trop Med Int Health 8:202-3. 2003
    ..In this community-based study, the overall treatment failure rate was 12/120 (10%), with no differences between villages. This supports the evidence for a still sufficient efficacy of chloroquine in north-western Burkina Faso...
  14. pmc Distribution systems of insecticide-treated bed nets for malaria control in rural Burkina Faso: cluster-randomized controlled trial
    Olaf Müller
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    PLoS ONE 3:e3182. 2008
    ..The objective of this study was to evaluate the effects of free ITN distribution through antenatal care services in addition to an ITN social marketing programme in an area typical for rural SSA...
  15. pmc Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled trial
    O Muller
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, 69120 Heidelberg, INF 324, Germany
    BMJ 322:1567. 2001
    ..To study the effects of zinc supplementation on malaria and other causes of morbidity in young children living in an area holoendemic for malaria in west Africa...
  16. ncbi request reprint Malaria morbidity, treatment-seeking behaviour, and mortality in a cohort of young children in rural Burkina Faso
    Olaf Müller
    Department of Tropical Hygiene and Public Health of the Ruprecht Karls University, Heidelberg, Germany
    Trop Med Int Health 8:290-6. 2003
    ..To describe the pattern of fever-associated morbidity, treatment-seeking behaviour for fever episodes, and cause-specific mortality in young children of a malaria-holoendemic area in rural Burkina Faso...
  17. pmc Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso
    Olaf Müller
    Department of Tropical Hygiene and Public Health of the Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Malar J 3:10. 2004
    ..These findings provide further evidence for the justification of continued use of pyrimethamine-sulfadoxine as a second-line treatment for malaria in Burkina Faso...
  18. ncbi request reprint Effect of zinc supplementation on growth in West African children: a randomized double-blind placebo-controlled trial in rural Burkina Faso
    O Muller
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, Medical School, Heidelberg, Germany
    Int J Epidemiol 32:1098-102. 2003
    ..Intervention Supplementation with zinc (12.5 mg zinc sulphate) or placebo daily for 6 days a week for 6 months. Outcomes Weight, length/height, mid-arm circumference, and serum zinc...
  19. pmc Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso
    Olaf Mueller
    Department of Tropical Hygiene and Public Health of the Ruprecht Karls University Heidelberg, Germany
    Malar J 3:36. 2004
    ..There is little information on the effectiveness of modern compared to traditional malaria treatment from the rural areas of Africa...
  20. pmc Effects of insecticide-treated bednets during early infancy in an African area of intense malaria transmission: a randomized controlled trial
    Olaf Müller
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Bull World Health Organ 84:120-6. 2006
    ..To clarify this issue, we did a randomized controlled trial to assess the long-term effects of bednet protection during early infancy...
  21. pmc Malnutrition and health in developing countries
    Olaf Müller
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, Heidelberg, Germany
    CMAJ 173:279-86. 2005
    ..To achieve the hunger- and malnutrition-related Millennium Development Goals, we need to address poverty, which is clearly associated with the insecure supply of food and nutrition...
  22. pmc Access to malaria treatment in young children of rural Burkina Faso
    Maike Tipke
    Institute for Public Health, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Malar J 8:266. 2009
    ..The objective of this study was to describe young children's access to malaria treatment in Nouna Health District, Burkina Faso...
  23. doi request reprint Moving towards universal coverage with malaria control interventions: achievements and challenges in rural Burkina Faso
    Manuela De Allegri
    Institute of Public Health, University of Heidelberg, Heidelberg, Germany
    Int J Health Plann Manage 28:102-21. 2013
    ..Future planning of malaria control interventions ought to take into consideration current inadequacies and lead to programmes better designed to overcome them...
  24. pmc Falciparum malaria in young children of rural Burkina Faso: comparison of survey data in 1999 with 2009
    Claudia Beiersmann
    Institute of Public Health, Ruprecht Karls University Heidelberg, INF 324, 69124 Heidelberg, Germany
    Malar J 10:296. 2011
    ..There is conflicting evidence on how much can be achieved under real life conditions with the current interventions in the highly endemic savannah areas of SSA...
  25. pmc Different delivery mechanisms for insecticide-treated nets in rural Burkina Faso: a provider's perspective
    Claudia Beiersmann
    Institute of Public Health, Ruprecht Karls University Heidelberg, INF 324, 69124 Heidelberg, Germany
    Malar J 9:352. 2010
    ....
  26. doi request reprint High absolute bioavailability of methylene blue given as an aqueous oral formulation
    Ingeborg Walter-Sack
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Eur J Clin Pharmacol 65:179-89. 2009
    ..With the aim of excluding treatment failures due to low bioavailability, we have investigated the absolute bioavailability of MB given as an aqueous oral formulation and its interaction with chloroquine (CQ)...
  27. pmc Risk factors of infant and child mortality in rural Burkina Faso
    Heiko Becher
    University of Heidelberg, Department of Tropical Hygiene and Public Health, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Bull World Health Organ 82:265-73. 2004
    ..The aim of the study was to quantify the effect of risk factors for childhood mortality in a typical rural setting in sub-Saharan Africa...
  28. doi request reprint Comparative cost analysis of insecticide-treated net delivery strategies: sales supported by social marketing and free distribution through antenatal care
    Manuela De Allegri
    Department of Tropical Hygiene and Public Health, University of Heidelberg, INF 324, 69120 Heidelberg, Germany
    Health Policy Plan 25:28-38. 2010
    ..Given restricted budgets, however, free distribution programmes are unlikely to be feasible...
  29. doi request reprint Determinants of utilisation of maternal care services after the reduction of user fees: a case study from rural Burkina Faso
    Manuela De Allegri
    Institute of Public Health, Faculty of Medicine, University of Heidelberg, INF 324, Heidelberg, Germany
    Health Policy 99:210-8. 2011
    ..To identify determinants of utilisation for antenatal care (ANC) and skilled attendance at birth after a substantial reduction in user fees...
  30. ncbi request reprint The association between protein-energy malnutrition, malaria morbidity and all-cause mortality in West African children
    Olaf Müller
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, Heidelberg, Germany
    Trop Med Int Health 8:507-11. 2003
    ..There was no association between PEM and malaria morbidity, but malnourished children had a more than two-fold higher risk of dying than non-malnourished children...
  31. ncbi request reprint Assessing the health status of young AIDS and other orphans in Kampala, Uganda
    Malabika Sarker
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University Heidelberg, Germany
    Trop Med Int Health 10:210-5. 2005
    ..Hence it seems that the extended family system still manages to care for young orphans. Paying school fees for older children should be the primary target for HIV/AIDS impact mitigation programs in urban Uganda...
  32. doi request reprint Quantification of cationic anti-malaria agent methylene blue in different human biological matrices using cation exchange chromatography coupled to tandem mass spectrometry
    Jürgen Burhenne
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 863:273-82. 2008
    ..8% CV. After a single oral dose (500 mg) methylene blue concentrations were detectable for 72 h in plasma. The methods were applied within clinical studies to samples from healthy individuals and malaria patients from Burkina Faso...
  33. ncbi request reprint Season of death and birth predict patterns of mortality in Burkina Faso
    Gisela Kynast-Wolf
    University of Heidelberg, Germany, Department of Tropical Hygiene and Public Health, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Int J Epidemiol 35:427-35. 2006
    ..Mortality in developing countries has multiple causes. Some of these causes are linked to climatic conditions that differ over the year. Data on season-specific mortality are sparse...
  34. ncbi request reprint Diagnosis of red cell G6PD deficiency in rural Burkina Faso: comparison of a rapid fluorescent enzyme test on filter paper with polymerase chain reaction based genotyping
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, Heidelberg, Germany
    Br J Haematol 131:395-9. 2005
    ..2% (95.8-99.6%) and the specificity was 97.1% (94.2-99.2%). In conclusion, the NFP assay is a reliable and inexpensive method for large-scale G6PD deficiency screening in rural West Africa...
  35. ncbi request reprint Marked differences in the prevalence of chloroquine resistance between urban and rural communities in Burkina Faso
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, Heidelberg, Germany
    Acta Trop 105:81-6. 2008
    ..Chloroquine (CQ) resistance has reached high levels in Africa in recent years. Little is known about variations of resistance between urban and rural areas...
  36. ncbi request reprint Patterns of malaria: cause-specific and all-cause mortality in a malaria-endemic area of west Africa
    Heiko Becher
    Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, Heidelberg, Germany
    Am J Trop Med Hyg 78:106-13. 2008
    ..It is well described parametrically with a sinusoidal function. In adults, the highest all-cause mortality rates were observed in the dry season. Here, HIV/AIDS has become a leading cause of mortality...
  37. ncbi request reprint Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria
    Jens Rengelshausen
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Eur J Clin Pharmacol 60:709-15. 2004
    ..The aim of this study was to investigate whether methylene blue influences the pharmacokinetics of chloroquine...