Christian Morath

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Management of severe recurrent focal segmental glomerulosclerosis through circulating soluble urokinase receptor modification
    Christian Morath
    Department of Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    Am J Ther 20:226-9. 2013
  2. doi request reprint Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapy
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 25:506-17. 2012
  3. doi request reprint Prevention of antibody-mediated kidney transplant rejection
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 25:633-45. 2012
  4. doi request reprint ABO-incompatible kidney transplantation enabled by non-antigen-specific immunoadsorption
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 93:827-34. 2012
  5. doi request reprint Kidney transplantation in highly sensitized patients: are there options to overcome a positive crossmatch?
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    Langenbecks Arch Surg 396:467-74. 2011
  6. doi request reprint Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:53-64. 2009
  7. ncbi request reprint [Renal replacement therapy in the intensive care unit]
    C Morath
    Nierenzentrum Heidelberg, Medizinische Universitatsklinik Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg
    Anaesthesist 55:901-13; quiz 914. 2006
  8. doi request reprint Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:33-6. 2009
  9. ncbi request reprint Sirolimus in renal transplantation
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:viii61-viii65. 2007
  10. doi request reprint An integrative approach for the transplantation of high-risk sensitized patients
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 90:645-53. 2010

Collaborators

Detail Information

Publications54

  1. doi request reprint Management of severe recurrent focal segmental glomerulosclerosis through circulating soluble urokinase receptor modification
    Christian Morath
    Department of Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    Am J Ther 20:226-9. 2013
    ..In summary, we provide an approach for the successful management of severe recurrent FSGS using available therapies with biomarker guidance...
  2. doi request reprint Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapy
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 25:506-17. 2012
    ..We describe a treatment algorithm for desensitization of living donor kidney transplant recipients that allows the rapid elimination of DSA with a low rate of side effects and results in good graft outcome...
  3. doi request reprint Prevention of antibody-mediated kidney transplant rejection
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 25:633-45. 2012
    ..In the current overview, we discuss the currently available measures for the prevention of antibody-mediated kidney graft rejection...
  4. doi request reprint ABO-incompatible kidney transplantation enabled by non-antigen-specific immunoadsorption
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 93:827-34. 2012
    ..ABO-incompatible kidney transplantation performed after desensitization with antigen-specific immunoadsorption (IA) results in good outcomes. However, a unique single-use IA device is required, which creates high costs...
  5. doi request reprint Kidney transplantation in highly sensitized patients: are there options to overcome a positive crossmatch?
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    Langenbecks Arch Surg 396:467-74. 2011
    ..We believe that all available options should be utilized in an integrated manner for the transplantation of kidney transplant recipients who are at a high risk of antibody-mediated rejection...
  6. doi request reprint Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:53-64. 2009
    ..We conclude that LD isotretinoin attenuates progressive renal damage, whereas HD isotretinoin cumulates and aggravates renal damage independent of blood pressure reduction...
  7. ncbi request reprint [Renal replacement therapy in the intensive care unit]
    C Morath
    Nierenzentrum Heidelberg, Medizinische Universitatsklinik Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg
    Anaesthesist 55:901-13; quiz 914. 2006
    ..Furthermore, we discuss timing of the initiation of renal replacement therapy, patient outcome with different renal replacement therapies and the adequate dialysis dose to be delivered...
  8. doi request reprint Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:33-6. 2009
    ..In addition, we review their influence on morphologic and biochemical markers as well as on renal function, graft and patient survival after renal transplantation...
  9. ncbi request reprint Sirolimus in renal transplantation
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:viii61-viii65. 2007
    ..This overview provides a summary of the current literature on inhibitors of the mammalian target of rapamycin, with a special focus on sirolimus...
  10. doi request reprint An integrative approach for the transplantation of high-risk sensitized patients
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 90:645-53. 2010
    ..Sensitized patients have a lower chance of receiving a crossmatch-negative kidney and, if transplanted, are at risk of antibody-mediated allograft rejection...
  11. doi request reprint Simultaneous pancreas-kidney transplantation in type 1 diabetes
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:115-20. 2009
    ..We give a short overview on SPK transplantation, with a focus on the effects of this procedure on diabetic complications as well as patient and kidney graft survival...
  12. doi request reprint Effects of mycophenolic acid on human fibroblast proliferation, migration and adhesion in vitro and in vivo
    C Morath
    Department of Nephrology, University of Heidelberg, Germany
    Am J Transplant 8:1786-97. 2008
    ..The perspective of MPA-induced cytoskeletal dysfunction may go beyond wound healing disturbances and may have beneficial effects on (renal) allografts with respect to scarring...
  13. ncbi request reprint Malignancy in renal transplantation
    Christian Morath
    Department of Nephrology, University of Heidelberg, Bergheimerstrasse 56a, 69115 Heidelberg, Germany
    J Am Soc Nephrol 15:1582-8. 2004
  14. pmc Metabolic control improves long-term renal allograft and patient survival in type 1 diabetes
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 19:1557-63. 2008
    ..55; P = 0.005). In summary, the early survival advantage of LDK over SPK is lost during long-term follow-up, probably as a result of improved glycemic control in SPK recipients...
  15. doi request reprint Living donor kidney transplantation in patients with donor-specific HLA antibodies enabled by anti-CD20 therapy and peritransplant apheresis
    Katrin Klein
    Department of Nephrology, University of Heidelberg, INF 162, 69120 Heidelberg, Germany
    Atheroscler Suppl 14:199-202. 2013
    ..Due to increasing waiting times for deceased donor kidneys, living donor kidney transplantation is increasingly performed in the presence of donor-specific antibodies (DSA)...
  16. doi request reprint Successful deceased-donor kidney transplantation in crossmatch-positive patients with peritransplant plasma exchange and Rituximab
    Jörg H M Beimler
    Department of Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 87:668-71. 2009
    ..Both patients showed good graft outcome at 27 and 21 months after transplantation with serum creatinine values of 1.60 and 1.25 mg/dL, respectively...
  17. doi request reprint Bleeding complications in pediatric ABO-incompatible kidney transplantation
    Betti Schaefer
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 28:327-32. 2013
    ..ABO-incompatible renal transplantation (ABOi-RTx) following preconditioning with immunoadsorption (IA) and rituximab is a promising approach to facilitate living-related RTx. However, clinical experience is limited in pediatric patients...
  18. doi request reprint Cellular infiltrates and NFκB subunit c-Rel signaling in kidney allografts of patients with clinical operational tolerance
    Luis E Becker
    Division of Nephrology, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Transplantation 94:729-37. 2012
    ....
  19. doi request reprint Acute effects of calcineurin inhibitors on kidney allograft microperfusion visualized by contrast-enhanced sonography
    Lars P Kihm
    Department of Nephrology, University Hospital, Heidelberg, Germany
    Transplantation 93:1125-9. 2012
    ..The purpose of the study was to explore whether acute changes of kidney allograft microperfusion due to the administration of cyclosporine A (CsA) and tacrolimus (Tac) can be evidenced using real-time CES...
  20. doi request reprint Contrast enhanced sonography shows superior microvascular renal allograft perfusion in patients switched from cyclosporine A to everolimus
    Lars P Kihm
    Department of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany
    Transplantation 88:261-5. 2009
    ..There is no information on the microperfusion of renal allografts in patients receiving either mammalian target of rapamycin inhibitor or calcineurin inhibitor...
  21. doi request reprint The role of pretransplant dialysis modality on renal allograft outcome
    Vedat Schwenger
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 26:3761-6. 2011
    ..The pretransplant dialysis modality might influence renal allograft and patient survival after transplantation. Studies published to date yielded conflicting results...
  22. doi request reprint RAGE expression in the human peritoneal membrane
    Lars P Kihm
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 23:3302-6. 2008
    ..This study investigates the in vivo expression of RAGE in the peritoneal membrane of uraemic human patients...
  23. ncbi request reprint Real-time contrast-enhanced sonography in renal transplant recipients
    Vedat Schwenger
    Department of Nephrology, Medical University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:51-4. 2006
    ..CES does not provide only quantitative information on microvascular perfusion of the renal allografts but also represents improved diagnostic significance compared with CDUS for the detection of chronic allograft nephropathy...
  24. ncbi request reprint Rapid deterioration of renal function in a long-term allograft recipient with recurrent IgA nephritis--is it the only cause?
    Claudia Sommerer
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, D 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:3079-81. 2007
  25. ncbi request reprint The long-term consequences of living-related or unrelated kidney donation
    Claudia Sommerer
    Department of Medicine, Division of Nephrology, University of Heidelberg, Germany
    Nephrol Dial Transplant 19:iv45-7. 2004
    ..After age adjustment, no increase of blood pressure is noted. The benefit of living kidney transplantation is superceding the potential risks. After careful work-up of the donor short- and long-term risks are minimal...
  26. ncbi request reprint Antifibrotic actions of mycophenolic acid
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:25-9. 2006
    ..MMF is well tolerated and has proven to be a relatively safe drug. Taken together, there is a growing body of evidence pointing to therapeutic applications of MMF other than immunosuppression, in particular the prevention of fibrosis...
  27. doi request reprint Plasmapheresis adjusts inflammatory responses in potential kidney transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 95:1021-9. 2013
    ..The effect of PP on lymphocyte subpopulations, plasma neopterin, and cytokines in renal transplant recipients was investigated in this study...
  28. ncbi request reprint No improvement of patient or graft survival in transplant recipients treated with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 17:3257-62. 2006
    ..It is concluded that recommendations for a widespread use of ACEI/ARB treatment in transplant recipients are unwarranted...
  29. doi request reprint Current pharmacotherapeutical options for the prevention of kidney transplant rejection
    Sebastian M Schaefer
    University of Heidelberg, Nephrology, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Expert Opin Pharmacother 14:1029-41. 2013
    ....
  30. ncbi request reprint Use of erythropoietin after solid organ transplantation
    Vedat Schwenger
    Department of Nephrology, Medical University of Heidelberg, Germany, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:viii47-viii49. 2007
    ..Moreover, further studies will be necessary to clarify whether EPO administration might have haemoglobin-independent beneficial effects...
  31. ncbi request reprint Color doppler ultrasonography in the diagnostic evaluation of renal allografts
    Vedat Schwenger
    Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany
    Nephron Clin Pract 104:c107-12. 2006
    ..The timely diagnosis of vascular damage prior to a rise in S-creatinine offers the possibility of early therapeutic intervention and thus at least the potential for the improvement of allograft survival...
  32. ncbi request reprint Salt--a potential 'uremic toxin'?
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University Heidelberg, Heidelberg, Germany
    Blood Purif 24:63-6. 2006
    ..However, it is possible, and indeed likely, that sodium plays an adverse role in the genesis of target organ damage in terminal renal failure...
  33. ncbi request reprint Deciphering the systems biology of mTOR inhibition by integrative transcriptome analysis
    Sophie Domhan
    Translational Radiation Oncology E210, National Center for Tumor Diseases NCT, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany
    Curr Pharm Des 20:88-100. 2014
    ..In summary, key genetic participants governing anti-tumor and anti-angiogenic effects of mTOR inhibition were identified. ..
  34. doi request reprint Kidney transplantation across HLA and ABO antibody barriers
    Luis E Becker
    Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    Curr Opin Organ Transplant 18:445-54. 2013
    ....
  35. ncbi request reprint Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 16:2456-61. 2005
    ..The endogenous NO synthase inhibitor ADMA is significantly associated with progression of nondiabetic kidney diseases. Lowering plasma ADMA concentrations may be a novel therapeutic target to prevent progressive renal impairment...
  36. ncbi request reprint Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid
    Sophie Domhan
    Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
    Mol Cancer Ther 7:1656-68. 2008
    ..Together, these data provide a molecular basis for the antiangiogenic and antifibrotic effects of MPA, which warrants further clinical investigations...
  37. ncbi request reprint Damage to the peritoneal membrane by glucose degradation products is mediated by the receptor for advanced glycation end-products
    Vedat Schwenger
    Department of Medicine Division of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 17:199-207. 2006
    ..Peritoneal damage by GDP in PDF is dependent at least in part on AGE-RAGE interaction...
  38. ncbi request reprint Late referral--a major cause of poor outcome in the very elderly dialysis patient
    Vedat Schwenger
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Nephrol Dial Transplant 21:962-7. 2006
    ..There is little documentation whether late referral is more frequent in the very elderly (> or =75 years) as compared with non-elderly patients and whether it contributes, at least in part, to their particularly poor outcome...
  39. ncbi request reprint An oral load of the early glycation compound lactuloselysine fails to accumulate in the serum of uraemic patients
    Vedat Schwenger
    Department of Nephrology, University of Heidelberg, Bergheimerstr 56a, 69115 Heidelberg, Germany
    Nephrol Dial Transplant 21:383-8. 2006
    ..It has been hypothesized that in renal failure, exogenous glycation compounds from food accumulate and play a major pathogenetic role when renal excretion is impaired...
  40. ncbi request reprint Procalcitonin as marker of infection in patients with Goodpasture's syndrome is misleading
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:2701-4. 2007
    ..e. in vasculitis. To investigate the value of PCT in Goodpasture's syndrome, we reviewed the charts of patients with Goodpasture's syndrome who were treated from 1996 to 2006...
  41. ncbi request reprint Pulmonary cavernae in Wegener's granulomatosis
    Vedat Schwenger
    Division of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 21:818. 2006
  42. ncbi request reprint Transmission of malignancy with solid organ transplants
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S164-6. 2005
    ..Finally, suggestions are made for screening regimens for living as well as cadaveric donors to minimize the risk of inadvertent tumor transmission...
  43. doi request reprint Intestinal transplantation: review of operative techniques
    Arash Nickkholgh
    Department of General, Visceral and Transplantation Surgery, Ruprecht Karls University, Heidelberg, Germany
    Clin Transplant 27:56-65. 2013
    ....
  44. doi request reprint Emerging drugs for the treatment of transplant rejection
    Lars P Kihm
    University of Heidelberg, Department of Nephrology, Germany
    Expert Opin Emerg Drugs 16:683-95. 2011
    ..Kidney allograft rejection is an important cause of early and late allograft failure. The importance of antibody-mediated rejection especially in the context of late allograft failure has only recently been acknowledged...
  45. ncbi request reprint Acquired Glanzmann's thrombasthenia variant and immune thrombocytopenia in a renal transplant recipient receiving tacrolimus
    Christian Morath
    Department of Nephrology, University Hospital, Universitiy of Heidelberg, Germany
    Thromb Haemost 94:879-80. 2005
  46. ncbi request reprint A generalized seizure in a renal allograft recipient
    Sophie Domhan
    Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 20:834-6. 2005
  47. ncbi request reprint Lymphoid interstitial lung disease in a patient with acute tubulointerstitial nephritis and uveitis: a new facet of a rare syndrome?
    Nina Hofmann
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Am J Kidney Dis 47:e55-9. 2006
    ..A new pulmonary flare-up 3 years later responded to renewed treatment. Accounting for the histological findings, we assume both TINU syndrome and interstitial lung disease to be manifestations of a common autoimmune disorder...
  48. ncbi request reprint Retinoid receptor-specific agonists alleviate experimental glomerulonephritis
    Ingo Lehrke
    Department of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany
    Am J Physiol Renal Physiol 282:F741-51. 2002
    ..Further studies are indicated to define the potential use of retinoid agonists in inflammatory renal disease...
  49. doi request reprint Transplantation: Rituximab induction only for sensitized kidney recipients?
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany
    Nat Rev Nephrol 9:703-5. 2013
    ..questions such an effect. That previous studies included presensitized patients who are more prone to antibody development, might explain this controversy...
  50. doi request reprint Proteinuria and sirolimus after renal transplantation: a retrospective analysis from a large German multicenter database
    Marcel G Naik
    Department of Nephrology, Charité University Mitte, Berlin, Germany
    Clin Transplant 28:67-79. 2014
    ..We conclude that patients without any proteinuria have the greatest benefit from conversion to sirolimus. ..
  51. ncbi request reprint Sodium citrate anticoagulation during sustained low efficiency dialysis (SLED) in patients with acute renal failure and severely impaired liver function
    Christian Morath
    Nephrol Dial Transplant 23:421-2. 2008
  52. ncbi request reprint Protocol biopsy: what is the rationale and what is the evidence?
    Christian Morath
    Nephrol Dial Transplant 18:644-7. 2003
  53. ncbi request reprint Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study
    Bjoern Becker
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 16:1091-8. 2005
    ..Moreover, hypoadiponectinemia is a novel putative CV risk factor in patients with mild and moderate renal failure...
  54. ncbi request reprint Transmission of donor-derived small-cell carcinoma cells by a nontumor-bearing allograft
    Christian Morath
    Transplantation 80:540-2. 2005