Hans Jurgen Moller

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Do features of Mozart's letter-writing style indicate the presence of a neuropsychiatric disorder? Controversies about the Bäsle letters
    H J Moller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 264:367-77. 2014
  2. ncbi Leukocyte elastase and autoantibodies to nerve growth factor in the acute phase of schizophrenia and their relationship to symptomatology
    Irina V Shcherbakova
    Mental Health Research Centre, Russian Academy of Medical Sciences, Moscow, Russia
    World J Biol Psychiatry 5:143-8. 2004
  3. pmc The media and intellectuals' response to medical publications: the antidepressants' case
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, 54636, Thessaloniki, Greece
    Ann Gen Psychiatry 12:11. 2013
  4. ncbi Pharmacotherapy of schizophrenic patients: achievements, unsolved needs, future research necessities
    Hans Jurgen Moller
    Chairman, Department of Psychiatry Ludwig Maximilians University Munchen Nussbaumstrasse 7, 80336 Munich, Germany
    Curr Pharm Biotechnol 13:1476-89. 2012
  5. pmc Is the efficacy of psychopharmacological drugs comparable to the efficacy of general medicine medication?
    Florian Seemüller
    Ludwig Maximilian University of Munich, Department of Psychiatry and Psychotherapy, Nussbaumstr, 7, 80336 Munich, Germany
    BMC Med 10:17. 2012
  6. ncbi How close is evidence to truth in evidence-based treatment of mental disorders?
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 262:277-89. 2012
  7. doi Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression
    H J Moller
    Department of Psychiatry, Ludwig Maximilians University, Germany
    Eur Psychiatry 27:114-28. 2012
  8. pmc Is the PANSS used correctly? a systematic review
    Michael Obermeier
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, Munich, Germany
    BMC Psychiatry 11:113. 2011
  9. pmc A pharmaco-economic analysis of patients with schizophrenia switching to generic risperidone involving a possible compliance loss
    Maarten Treur
    PharMerit BV, Rotterdam, The Netherlands
    BMC Health Serv Res 9:32. 2009
  10. ncbi Evidence for beneficial effects of antidepressants on suicidality in depressive patients: a systematic review
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:329-43. 2006

Collaborators

Detail Information

Publications196 found, 100 shown here

  1. ncbi Do features of Mozart's letter-writing style indicate the presence of a neuropsychiatric disorder? Controversies about the Bäsle letters
    H J Moller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 264:367-77. 2014
    ..There is little evidence for a Tourette syndrome from other sources, such as reports of behavioural abnormalities, and the evidence is not convincing. ..
  2. ncbi Leukocyte elastase and autoantibodies to nerve growth factor in the acute phase of schizophrenia and their relationship to symptomatology
    Irina V Shcherbakova
    Mental Health Research Centre, Russian Academy of Medical Sciences, Moscow, Russia
    World J Biol Psychiatry 5:143-8. 2004
    ....
  3. pmc The media and intellectuals' response to medical publications: the antidepressants' case
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, 54636, Thessaloniki, Greece
    Ann Gen Psychiatry 12:11. 2013
    ..It seems that this line of thought represents another aspect of the stigma attached to people suffering from mental illness...
  4. ncbi Pharmacotherapy of schizophrenic patients: achievements, unsolved needs, future research necessities
    Hans Jurgen Moller
    Chairman, Department of Psychiatry Ludwig Maximilians University Munchen Nussbaumstrasse 7, 80336 Munich, Germany
    Curr Pharm Biotechnol 13:1476-89. 2012
    ..g. negative symptoms will have a chance in the future development...
  5. pmc Is the efficacy of psychopharmacological drugs comparable to the efficacy of general medicine medication?
    Florian Seemüller
    Ludwig Maximilian University of Munich, Department of Psychiatry and Psychotherapy, Nussbaumstr, 7, 80336 Munich, Germany
    BMC Med 10:17. 2012
    ..This article will highlight some of the results of this systematic review and discuss the limitations and the impact of this important approach on the above mentioned debate...
  6. ncbi How close is evidence to truth in evidence-based treatment of mental disorders?
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 262:277-89. 2012
    ..Although EBM might have increased empirically driven rational decision-making in psychiatry/medicine, the current limitations should be carefully considered...
  7. doi Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression
    H J Moller
    Department of Psychiatry, Ludwig Maximilians University, Germany
    Eur Psychiatry 27:114-28. 2012
    ..The ideal that all steps of clinical decision-making can be based on the strict rules of evidence-based medicine is far away from reality. Clinical experience so far still has a great impact...
  8. pmc Is the PANSS used correctly? a systematic review
    Michael Obermeier
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, Munich, Germany
    BMC Psychiatry 11:113. 2011
    ..ratio scale) leads to a set of mathematical problems, potentially resulting in erroneous results concerning the efficacy of the treatment...
  9. pmc A pharmaco-economic analysis of patients with schizophrenia switching to generic risperidone involving a possible compliance loss
    Maarten Treur
    PharMerit BV, Rotterdam, The Netherlands
    BMC Health Serv Res 9:32. 2009
    ..Although compliance losses following generic substitution have not been quantified so far, one can estimate the possible health-economic consequences. The current study aims to do so by considering the case of risperidone in Germany...
  10. ncbi Evidence for beneficial effects of antidepressants on suicidality in depressive patients: a systematic review
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:329-43. 2006
    ....
  11. ncbi Is evidence sufficient for evidence-based medicine?
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S167-72. 2009
    ....
  12. ncbi Antidepressive effects of traditional and second generation antipsychotics: a review of the clinical data
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:83-93. 2005
    ..The positive results from some studies in bipolar depression are especially impressive and underline the antidepressive potencies of novel antipsychotics beyond the spectrum of schizophrenia...
  13. ncbi Factors associated with response in depressed elderly outpatients treated with escitalopram in a naturalistic setting in Germany
    H J Moller
    Psychiatric Clinic Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 43:210-5. 2010
    ..An open, multi-centre study was designed to address the effectiveness and tolerability profile of treatment with escitalopram under naturalistic conditions, in elderly outpatients (above 65 years of age) with depression...
  14. ncbi Long-acting risperidone: focus on safety
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin Ther 28:633-51. 2006
    ..Long-acting risperidone (LAR), the first long-acting injectable atypical anti-psychotic, has been found to be effective in the treatment of schizophrenia and schizoaffective disorder...
  15. ncbi Evidence-based medicine in psychopharmacotherapy: possibilities, problems and limitations
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 260:25-39. 2010
    ....
  16. ncbi Is there evidence for negative effects of antidepressants on suicidality in depressive patients? A systematic review
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:476-96. 2006
    ..However, they should take into account potential risks and manage them by good clinical practice...
  17. doi The Munich 15-year follow-up study (MUFUSSAD) on first-hospitalized patients with schizophrenic or affective disorders: assessing courses, types and time stability of diagnostic classification
    H J Moller
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Psychiatry 26:231-43. 2011
    ....
  18. ncbi Novel antipsychotics in the long-term treatment of schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    World J Biol Psychiatry 5:9-19. 2004
    ..The first depot formulation of an atypical neuroleptic appears to be a further positive step to improve the possibilities of an optimal long-term treatment for schizophrenia...
  19. ncbi [Therapy resistance to antidepressants. Definition, prevalence, predictors, and interventional possibilities]
    H J Moller
    Psychiatrische Klinik, Ludwig Maximilians Universitat, Munchen
    Nervenarzt 75:499-515; quiz 516-7. 2004
    ..This applies particularly when the therapeutic aim is complete relief from symptoms, not merely response. This article presents an overview of the definitions and epidemiologic, predictive, and therapeutic aspects of the problem...
  20. ncbi Efficacy and safety of direct transition to risperidone long-acting injectable in patients treated with various antipsychotic therapies
    Hans Jurgen Moller
    Department of Psychiatry, University of Munich, Germany
    Int Clin Psychopharmacol 20:121-30. 2005
    ..Direct initiation of RLAI was effective and well tolerated. RLAI provides an advancement in the treatment options available for a wide range of patients requiring long-term antipsychotic therapy...
  21. ncbi [Selective serotonin and noradrenaline reuptake inhibitors: a step forward in the treatment of depression?]
    H J Moller
    Psychiatrische Klinik der Ludwig Maximilians Universität München
    MMW Fortschr Med 147:43-5. 2005
    ..The present article the extent to which this particular action mechanism results in an improved clinical efficacy and tolerability profile of the SSNRIs, in particular in comparison with SSRIs...
  22. ncbi Risperidone: a review
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Expert Opin Pharmacother 6:803-18. 2005
    ..The following review gives an overview of the huge clinical database available for risperidone in the field of schizophrenia...
  23. ncbi Antipsychotic agents. Gradually improving treatment from the traditional oral neuroleptics to the first atypical depot
    H J Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaum Strasse 7, 80336 Munich, Germany
    Eur Psychiatry 20:379-85. 2005
    ..One disadvantage of atypical agents has been that they are only available in an oral form. The recent development of a long-acting injectable formulation of risperidone means that a new treatment option is available to physicians...
  24. ncbi Antipsychotic and antidepressive effects of second generation antipsychotics: two different pharmacological mechanisms?
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:190-201. 2005
    ..This might be especially true for direct antidepressive effects, i. e. antidepressive effects that are not mediated by the reduction of positive symptoms...
  25. ncbi Do recent efficacy data on the drug treatment of acute bipolar depression support the position that drugs other than antidepressants are the treatment of choice? A conceptual review
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:1-16. 2006
    ..In addition the regulatory requirements for licensing a drug for the indication "short-term treatment of bipolar depression" are described...
  26. ncbi Problems associated with the classification and diagnosis of psychiatric disorders
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 6:45-56. 2005
    ..Finally the current situation of the international standardisation of psychiatric classification and particuarly the improvement of reliability by using operationalised procedures is discussed...
  27. ncbi Non-neuroleptic approaches to treating negative symptoms in schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:108-16. 2004
    ..The SSRIs seem to have a certain place in the treatment of negative symptoms. Anticonvulsants, oestrogens and glutamatergic drugs can currently only be seen as experimental drugs and require further empirical evaluation...
  28. ncbi Occurrence and treatment of depressive comorbidity/cosyndromality in schizophrenic psychoses: conceptual and treatment issues
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 6:247-63. 2005
    ..Besides treatment with antidepressants, modern neuroleptics are of great importance in this context as they are more efficacious than classical neuroleptics in treating depressive symptoms...
  29. ncbi Escitalopram in clinical practice: results of an open-label trial in outpatients with depression in a naturalistic setting in Germany
    H J Moller
    Klinikum der Ludwig Maximilians Universität München, D 80336 MUnchen, Germany
    Pharmacopsychiatry 40:53-7. 2007
    ..An open, multi-center, study was designed to address the efficacy and tolerability profile of treatment with escitalopram under naturalistic conditions in outpatients with depression...
  30. ncbi [Prospective study using a modified Montgomery-Asberg Depression Scale]
    H J Moller
    Psychiatrische Klinik der Ludwig Maximilians Universität, 80336 Munchen
    Nervenarzt 78:685-90. 2007
    ..A shortened version of the MADRS (sv-MADRS) was therefore developed for use in such situations. The object of this study was to demonstrate indirectly that the sv-MADRS corresponds adequately with the standard MADRS...
  31. ncbi Clinical evaluation of negative symptoms in schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Psychiatry 22:380-6. 2007
    ..This article reviews the definitions and classification of negative symptoms, compares the tools available for their assessment, and offers practical clinical algorithms for sorting through the differential diagnosis...
  32. ncbi Principle standards and problems regarding proof of efficacy in clinical psychopharmacology
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 260:3-16. 2010
    ..Therefore, it seems to be timely and necessary to review the principle standards and problems concerning the proof of efficacy in clinical psychopharmacology...
  33. doi Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Int J Neuropsychopharmacol 11:985-97. 2008
    ..Risperidone has better extrapyramidal tolerability and treatment retention rate than the equivalent dose of haloperidol in these patients...
  34. ncbi Systematic of psychiatric disorders between categorical and dimensional approaches: Kraepelin's dichotomy and beyond
    Hans Jurgen Moller
    Psychiatrische Klinik, Ludwig Maximilians Universitat Munchen, Nubbaumstrabe 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:48-73. 2008
    ..Therefore it might be premature to leave the Kraepelinian dichotomy totally although it has to be modified in the light of new research...
  35. ncbi Do effectiveness ("real world") studies on antipsychotics tell us the real truth?
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:257-70. 2008
    ..The main conclusions of these trials will be questioned on the basis of their severe methodological pitfalls...
  36. pmc Effectiveness studies: advantages and disadvantages
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munchen, Munich, Germany
    Dialogues Clin Neurosci 13:199-207. 2011
    ..Due to these methodological problems, effectiveness studies are on a principally lower level of evidence, adding only a complementary view to the results of phase III trials without falsifying their results...
  37. doi Standardised rating scales in psychiatry: methodological basis, their possibilities and limitations and descriptions of important rating scales
    Hans Jurgen Moller
    Department of Psychiatry, University of Munich, Germany
    World J Biol Psychiatry 10:6-26. 2009
    ..They are widely used, specifically for pragmatic reasons...
  38. ncbi Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:3-23. 2008
    ..It is the major problem facing efforts to identify the possible 'suicidal effects' of antidepressants...
  39. doi Isn't the efficacy of antidepressants clinically relevant? A critical comment on the results of the metaanalysis by Kirsch et al. 2008
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:451-5. 2008
    ..Especially from these derived effect sizes should be interpreted carefully...
  40. ncbi Outcomes in major depressive disorder: the evolving concept of remission and its implications for treatment
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maxmillians University, Munich, Germany
    World J Biol Psychiatry 9:102-14. 2008
    ..Therefore, it represents an unmet need to come up with antidepressant drugs of greater efficacy and improved tolerability as such treatments could lead to more complete remission in more patients...
  41. doi The forthcoming revision of the diagnostic and classificatory system: perspectives based on the European psychiatric tradition
    Hans Jurgen Moller
    Dept of Psychiatry, University of Munich, Nussbaumstrasse 7, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:7-17. 2008
    ..g. in the direction of a purely symptomatical/dimensional systematic, or a totally new classification based on modern new biological findings, might be problematic and premature...
  42. ncbi The Munich 15-year follow-up study (MUFUSSAD) on first-hospitalized patients with schizophrenic or affective disorders: comparison of psychopathological and psychosocial course and outcome and prediction of chronicity
    Hans Jurgen Moller
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 260:367-84. 2010
    ..The Strauss-Carpenter Scale, male gender as well as several psychopathological syndromes are the most relevant predictors for chronicity...
  43. ncbi Long-acting injectable risperidone for the treatment of schizophrenia: clinical perspectives
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Drugs 67:1541-66. 2007
    ....
  44. doi Antidepressants: controversies about their efficacy in depression, their effect on suicidality and their place in a complex psychiatric treatment approach
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    World J Biol Psychiatry 10:180-95. 2009
    ..Individualised decision making is so complex that the rigorous expectations of evidence-based medicine can hardly be fulfilled. Finally, it should be considered that clinical decision making is not only evidence but also value oriented...
  45. ncbi [Problems of evidence-based medicine in psychopharmacotherapy: problems of evidence grading and of the evidence basis for complex clinical decision making]
    H J Moller
    Klinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität, Nussbaumstrasse 7, 80336, Munchen
    Nervenarzt 78:1014-27. 2007
    ..Even in times of evidence based medicine, a large part of complex clinical decision making in psychopharmacotherapy still relies more on a consensus about clinical experience and traditions than on relevant empirical databases...
  46. ncbi Evaluation of the feasibility of switching from immediate release quetiapine to extended release quetiapine fumarate in stable outpatients with schizophrenia
    Hans Jurgen Moller
    Psychiatric Hospital of the University of Munich, Munich, Germany
    Int Clin Psychopharmacol 23:95-105. 2008
    ..In conclusion, efficacy was maintained without compromising safety/tolerability when switching patients with stable schizophrenia from twice-daily quetiapine IR to once-daily quetiapine XR (400-800 mg/day)...
  47. ncbi Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics
    Ilja Spellmann
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:335-44. 2008
    ....
  48. ncbi Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    ..Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics...
  49. doi Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response
    Markus Jager
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 158:297-305. 2008
    ..Therefore, the hypothesis that depressive symptoms are predictive of a favorable treatment response was not supported by the present study...
  50. doi Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, D 40629 Düsseldorf, Germany
    J Clin Psychiatry 72:205-18. 2011
    ..The current study was therefore designed to compare prospectively the relapse preventive efficacy of further maintenance treatment and targeted intermittent treatment in patients with ICD-10-diagnosed first-episode schizophrenia...
  51. doi Remission and recovery and their predictors in schizophrenia spectrum disorder: results from a 1-year follow-up naturalistic trial
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Psychiatr Q 83:187-207. 2012
    ..0113) were found to be significantly predictive of recovery. Our results underline the need to implement more specific treatment strategies to improve long-term outcome...
  52. doi Predictors of relapse in the year after hospital discharge among patients with schizophrenia
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstreet 7, 80336 Munich, Germany
    Psychiatr Serv 63:87-90. 2012
    ..Relapse and its predictors were examined among patients with schizophrenia in the year after hospital discharge...
  53. ncbi World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: acute treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 6:132-91. 2005
    ....
  54. ncbi Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  55. doi Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Biol Psychiatry 67:161-7. 2010
    ..The aim of this study was to compare the functional connectivity of the OFC during emotion processing in patients with major depression and healthy control subjects...
  56. doi Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients
    Ilja Spellmann
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nußbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 45:234-41. 2011
    ..Thus, these data might further help in detecting differential therapy response in individuals with schizophrenia...
  57. ncbi Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  58. doi Quality of life and subjective well-being in schizophrenia and schizophrenia spectrum disorders: valid predictors of symptomatic response and remission?
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 11:729-38. 2010
    ..To examine quality of life and subjective well-being as predictors of symptomatic treatment outcome...
  59. ncbi Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:1406-13. 2003
    ..The aim of this study was to investigate the serotonin transporter availability in patients with OCD as an in vivo marker of the central serotonergic system...
  60. ncbi The influence of concomitant neuroleptic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy
    Caroline Nothdurfter
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 7:162-70. 2006
    ..In these cases, concomitant pharmacotherapy can be a useful augmentation strategy to improve clinical effectiveness. Interestingly, there is not much data about ECT and concomitant neuroleptic medication...
  61. ncbi Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    J Psychiatr Res 40:307-14. 2006
    ..In future, this approach can be used to differentiate specific and non-specific reward-related effects of rTMS on dopaminergic neurotransmission...
  62. ncbi Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: comparing treatment with risperidone and haloperidol
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 13:30-8. 2012
    ..To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol...
  63. ncbi Altered brain activation during a verbal working memory task in subjects with amnestic mild cognitive impairment
    Arun L W Bokde
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Alzheimer Memorial Center, Munich, Germany
    J Alzheimers Dis 21:103-18. 2010
    ..The activation differences between groups may be compensatory mechanisms within the MCI group for the effects of the putative AD neuropathology. This has been the first study that has examined verbal working memory in MCI...
  64. ncbi Kinematical analysis of motor function in schizophrenic patients: a possibility to separate negative symptoms from extrapyramidal dysfunction induced by neuroleptics?
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Pharmacopsychiatry 37:110-8. 2004
    ..In this prospective matched case-control study, hand movement analysis was conducted using a digitizing tablet (kinematical analysis)...
  65. ncbi Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms
    Ulrich W Preuss
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 183:133-9. 2010
    ..In addition, while right hemisphere ACC volumes significantly differ between schizophrenia subgroups, combining measures of event-related potential (ERP) and ACC volumetry does not add additional information...
  66. ncbi Does early improvement in major depression protect against treatment emergent suicidal ideation?
    Florian Seemüller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, Munich, Germany
    J Affect Disord 124:183-6. 2010
    ..To investigate the association of early improvement and treatment emergent suicidal ideation in a large sample (N=705) of naturalistically treated inpatients with major depressive disorder...
  67. ncbi Depression with atypical features in a sample of primary care outpatients: prevalence, specific characteristics and consequences
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    J Affect Disord 83:237-42. 2004
    ....
  68. pmc Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early--and additional memory dysfunction in the late--prodromal state
    Ingo Frommann
    Department of Psychiatry, University Hospital of Bonn, Sigmund Freud Street 25, Bonn, Germany
    Schizophr Bull 37:861-73. 2011
    ..Memory deficits were associated with the onset of psychotic symptoms indicating further disease progression in the trajectory to psychosis and, thus, may be useful in predicting psychosis and targeting early intervention...
  69. ncbi Amygdala volume and depressive symptoms in patients with borderline personality disorder
    Thomas Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 60:302-10. 2006
    ..The aim of this study was to examine whether a co-occurrence of MD is associated with structural changes in the amygdala of BPD patients...
  70. ncbi A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits
    Dan Rujescu
    Department of Psychiatry, Division of Molecular Neurobiology, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:34-9. 2003
    ..Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine inactivation. In this study, we examined the influence of a functional COMT (V158M) polymorphism on suicidal behavior and anger-related traits...
  71. ncbi Effects of risperidone and quetiapine on cognition in patients with schizophrenia and predominantly negative symptoms
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 257:360-70. 2007
    ..Also, the improvements in cognition following treatment with quetiapine and risperidone may enhance long-term outcomes for these patients...
  72. ncbi Prediction of symptom remission in schizophrenia during inpatient treatment
    Markus Jager
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 10:426-34. 2009
    ..The present study applied the symptom-severity component of these criteria to a sample of inpatients in order to determine the rates of remission during inpatient treatment and to explore predictors of remission...
  73. doi Differences in hippocampal volume between major depression and schizophrenia: a comparative neuroimaging study
    Eva M Meisenzahl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 260:127-37. 2010
    ....
  74. ncbi Syndromes and phenomenological subtypes underlying acute mania: a factor analytic study of 576 manic patients
    Tetsuya Sato
    Psychiatrische Klinik der Ludwig Maximilians Universität, Munchen, Germany
    Am J Psychiatry 159:968-74. 2002
    ..There is controversy as to whether atypical manic features such as aggression, psychosis, and depression are likely to coexist among manic patients. The authors' goal was to examine this controversy...
  75. doi Alterations of the early auditory evoked gamma-band response in first-degree relatives of patients with schizophrenia: hints to a new intermediate phenotype
    Gregor Leicht
    University Medical Center Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Psychiatry Neuroimaging Branch PNB, Hamburg, Germany
    J Psychiatr Res 45:699-705. 2011
    ..marker as an intermediate phenotype for schizophrenia, this is the main question of our investigation: Is the early eGBR decreased regarding evoked power and phase locking in first-degree relatives of patients with schizophrenia?..
  76. ncbi Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet 114:530-2. 2002
    ....
  77. doi Neuroanatomical correlates of executive dysfunction in the at-risk mental state for psychosis
    Nikolaos Koutsouleris
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 123:160-74. 2010
    ....
  78. doi Use of neuroanatomical pattern regression to predict the structural brain dynamics of vulnerability and transition to psychosis
    Nikolaos Koutsouleris
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 123:175-87. 2010
    ..To date, it is unknown whether these dynamic brain changes can be predicted at the single-subject level prior to disease transition using MRI-based machine-learning techniques...
  79. ncbi The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
    ..Further analysis are needed to confirm these results...
  80. pmc Reduced hippocampal volume correlates with executive dysfunctioning in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    J Psychiatry Neurosci 31:316-23. 2006
    ..We aimed to investigate whether reduced hippocampal volumes correlate with executive dysfunctioning or memory dysfunctioning or with depression severity...
  81. ncbi Estrogen receptor gene 1 variants are not associated with suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 160:1-7. 2008
    ..In conclusion, our study does not support the hypothesis that estrogen receptor alpha gene variants are major contributors to suicide or to anger- or aggression-related behaviors...
  82. ncbi Outcomes of 1014 naturalistically treated inpatients with major depressive episode
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany
    Eur Neuropsychopharmacol 20:346-55. 2010
    ..Of those who ultimately achieved response more than 40% did so within the first 2weeks. An individualized naturalistic inpatient treatment approach appears to be beneficial in terms of effectiveness...
  83. ncbi Tachykinin receptor 1 variants associated with aggression in suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:757-61. 2007
    ..In conclusion, our study suggests that TACR1 gene variants have no major influence on suicidal behavior but may modulate aggression features...
  84. ncbi Auditory cortex and anterior cingulate cortex sources of the early evoked gamma-band response: relationship to task difficulty and mental effort
    Christoph Mulert
    Department of Psychiatry, LMU, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neuropsychologia 45:2294-306. 2007
    ..These findings are in line with a top-down influence of dACC-activity to the auditory association area 22 during the early evoked GBR...
  85. ncbi Reduced early auditory evoked gamma-band response in patients with schizophrenia
    Gregor Leicht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, 7D 80336 Munich, Germany
    Biol Psychiatry 67:224-31. 2010
    ..power and phase-locking in schizophrenic patients?; and 2) Is this possible decrease a result of reduced activity in the auditory cortex and/or the anterior cingulate cortex (ACC), which were identified as sources of the GBR previously?..
  86. ncbi Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism
    Isabella Braun
    Department of Psychiatry, Division of Molecular and Clinical Neurobiology, Ludwig Maximilians University of Munich, Germany
    Schizophr Res 97:254-63. 2007
    ..Moreover, this study provides further evidence for regional differences in the response of GABAergic interneurons to NMDA receptor antagonism and antipsychotic treatment...
  87. doi Depression-related variation in brain morphology over 3 years: effects of stress?
    Thomas S Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 65:1156-65. 2008
    ..Results of experimental studies suggest that neuroplastic changes may occur during depressive episodes. These effects have not been confirmed in patients with depression, to our knowledge...
  88. doi Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  89. pmc Use of neuroanatomical pattern classification to identify subjects in at-risk mental states of psychosis and predict disease transition
    Nikolaos Koutsouleris
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 66:700-12. 2009
    ..Recently, machine learning algorithms have been successfully used for magnetic resonance imaging-based diagnostic classification of neuropsychiatric patient populations...
  90. ncbi Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity
    Georg Juckel
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 64:115-24. 2003
    ..These results suggest that the loudness dependence of primary auditory cortex evoked activity is well suitable to assess serotonergic dysfunction in schizophrenia...
  91. ncbi Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis
    Dan Rujescu
    Division of Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:465-73. 2003
    ..The most widely studied genetic variations in the TPH gene, which are located in intron 7, yielded conflicting results in individual studies on suicide-related behavior...
  92. ncbi Pharmacological long-term treatment strategies in first episode schizophrenia--study design and preliminary results of an ongoing RCT within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, 40629 Duesseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 254:129-40. 2004
    ..In conclusion, treatment in first episode schizophrenia is effective under both (further on blinded) neuroleptics; however these patients are at high risk for treatment drop-out. This emphasizes the need for a special support program...
  93. doi Neurocognition and its influencing factors in the treatment of schizophrenia-effects of aripiprazole, olanzapine, quetiapine and risperidone
    M Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    Hum Psychopharmacol 25:116-25. 2010
    ..To examine influencing variables of neurocognition in patients with schizophrenia and to predict cognition during antipsychotic treatment...
  94. ncbi SNAP-25 genotype influences NAA/Cho in left hippocampus
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    J Neural Transm 115:1513-8. 2008
    ..The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus...
  95. ncbi White matter alterations in schizophrenic patients with pronounced negative symptomatology and with positive family history for schizophrenia
    Thomas Zetzsche
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:278-84. 2008
    ..The aim of our analysis was to investigate potential changes of white matter in schizophrenic patients compared to controls, and the relationship to clinical characteristics...
  96. ncbi Prevalence and treatment outcome in anxious versus nonanxious depression: results from the German Algorithm Project
    Katja Wiethoff
    Charite Universitatsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Berlin, Germany
    J Clin Psychiatry 71:1047-54. 2010
    ..Furthermore, the efficacy of algorithm-guided treatment versus treatment as usual in patients with anxious versus nonanxious depression was evaluated...
  97. ncbi Efficacy of olanzapine versus quetiapine on cognitive dysfunctions in patients with an acute episode of schizophrenia
    Michael Riedel
    Dept of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 257:402-12. 2007
    ..Furthermore, quetiapine produced a significantly greater improvement in reaction quality/attention than olanzapine...
  98. ncbi Depressive, anxiety, and somatoform disorders in primary care: prevalence and recognition
    Roland Mergl
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Depress Anxiety 24:185-95. 2007
    ..These results confirm assumptions that the current division between depression and anxiety might be debatable. Validity of screeners tested in our study was not affected by comorbid conditions (e.g., anxiety or somatoform disorders)...
  99. ncbi Early improvement as a predictor of remission and response in schizophrenia: Results from a naturalistic study
    M Jager
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Psychiatry 24:501-6. 2009
    ..To examine the predictive validity of early improvement in a naturalistic sample of inpatients and to identify the criterion that best defines early improvement...
  100. doi Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis
    S Ruhrmann
    Department of Psychiatry and Psychotherapy, University Hospital of the University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Br J Psychiatry Suppl 51:s88-95. 2007
    ..People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances...
  101. ncbi No association between the G308A polymorphism of the tumor necrosis factor-alpha gene and schizophrenia
    Michael Riedel
    Psychiatric Hospital, Ludwig Maximilian University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 252:232-4. 2002
    ..9 % polymorphic allele). Moreover, we did not find any association between genotype and psychopathology, as measured by PANSS. The different results between these two studies may be due to ethnic differences...