L Mohr

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint [Gene therapy: new developments]
    L Mohr
    Medizinische Universitätsklinik II, Freiburg
    Praxis (Bern 1994) 91:2227-35. 2002
  2. ncbi request reprint Cationic liposome-mediated gene delivery to the liver and to hepatocellular carcinomas in mice
    L Mohr
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Hum Gene Ther 12:799-809. 2001
  3. ncbi request reprint Gene therapy for malignant liver disease
    Leonhard Mohr
    Department of Medicine II, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Expert Opin Biol Ther 2:163-75. 2002
  4. ncbi request reprint Adenovirus-mediated gene transfer to orthotopic hepatocellular carcinomas in athymic nude mice
    S K Yoon
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA
    Cancer Gene Ther 8:573-9. 2001
  5. ncbi request reprint Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice
    A Kroger
    Department of Gene Regulation and Differentiation, Gesellschaft fur Biotechnologische Forschung, Freiburg, Germany
    Cancer Res 61:2609-17. 2001
  6. ncbi request reprint Immunotherapy directed against alpha-fetoprotein results in autoimmune liver disease during liver regeneration in mice
    M Geissler
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Gastroenterology 121:931-9. 2001
  7. ncbi request reprint Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection
    J R Wands
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown, USA
    J Gastroenterol Hepatol 12:S354-69. 1997
  8. ncbi request reprint Immunobiology and gene-based immunotherapy of hepatocellular carcinoma
    M Geissler
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Z Gastroenterol 41:1101-10. 2003
  9. ncbi request reprint Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro
    T U Krohne
    Department of Medicine II, University Hospital Freiburg, Germany
    Hepatology 34:511-8. 2001
  10. ncbi request reprint [Colorectal cancer and inhibition of cyclooxygenase-2]
    M Geissler
    Medizinische Klinik II, Universitatsklinik Freiburg, Germany
    Dtsch Med Wochenschr 127:1256-8. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint [Gene therapy: new developments]
    L Mohr
    Medizinische Universitätsklinik II, Freiburg
    Praxis (Bern 1994) 91:2227-35. 2002
    ..Viruses which replicate selectively in tumor cells leading to tumor cell lysis represent a novel generation of viral vectors, which can further be improved by the addition of therapeutic genes resulting in enhanced tumor toxicity...
  2. ncbi request reprint Cationic liposome-mediated gene delivery to the liver and to hepatocellular carcinomas in mice
    L Mohr
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Hum Gene Ther 12:799-809. 2001
    ..Therefore, direct liposome-pDNA complex injection appears far superior to systemic or portal intravenous administration for gene therapy of localized intrahepatic tumors, and may be a useful adjunct in the treatment of human HCCs...
  3. ncbi request reprint Gene therapy for malignant liver disease
    Leonhard Mohr
    Department of Medicine II, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Expert Opin Biol Ther 2:163-75. 2002
    ....
  4. ncbi request reprint Adenovirus-mediated gene transfer to orthotopic hepatocellular carcinomas in athymic nude mice
    S K Yoon
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA
    Cancer Gene Ther 8:573-9. 2001
    ..However, due to the observed transduction of disseminated hepatocytes following intratumoral administration, additional HCC-specific targeting to further enhance the safety of adenoviral vectors may be required...
  5. ncbi request reprint Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice
    A Kroger
    Department of Gene Regulation and Differentiation, Gesellschaft fur Biotechnologische Forschung, Freiburg, Germany
    Cancer Res 61:2609-17. 2001
    ..In conclusion, our data demonstrate that IRF-1 suppresses HCC growth through both a direct antitumor growth effect and enhanced immune cell recognition of the tumor and is a promising candidate for gene therapy of HCC...
  6. ncbi request reprint Immunotherapy directed against alpha-fetoprotein results in autoimmune liver disease during liver regeneration in mice
    M Geissler
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Gastroenterology 121:931-9. 2001
    ..Liver regeneration in humans and mice, however, is also associated with increased AFP expression. Therefore, we evaluated the risk of AFP-directed immunotherapeutic approaches to induce autoimmunity against the regenerating liver...
  7. ncbi request reprint Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection
    J R Wands
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown, USA
    J Gastroenterol Hepatol 12:S354-69. 1997
    ..These experimental approaches may have important implications for the generation of efficient antiviral effects during chronic HBV infection...
  8. ncbi request reprint Immunobiology and gene-based immunotherapy of hepatocellular carcinoma
    M Geissler
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Z Gastroenterol 41:1101-10. 2003
    ..Novel therapeutic strategies and a better understanding of HCC imunobiology are, therefore, urgently required...
  9. ncbi request reprint Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro
    T U Krohne
    Department of Medicine II, University Hospital Freiburg, Germany
    Hepatology 34:511-8. 2001
    ....
  10. ncbi request reprint [Colorectal cancer and inhibition of cyclooxygenase-2]
    M Geissler
    Medizinische Klinik II, Universitatsklinik Freiburg, Germany
    Dtsch Med Wochenschr 127:1256-8. 2002
  11. ncbi request reprint [The hepatocellular carcinoma: alternative therapeutical strategies]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Universitatsklinik, Albert Ludwigs Universitat Freiburg
    Zentralbl Chir 132:322-7. 2007
    ..This review should give an overview of possible alternative therapies in HCC treatment...
  12. ncbi request reprint [Seizures following Billroth II gastrectomy]
    J Harder
    Abteilung Innere Medizin I, Medizinische Klinik, Albert Ludwigs Universitat Freiburg
    Dtsch Med Wochenschr 130:574-6. 2005
    ..Due to similar episodes the patient had been treated with antiepileptics in the past. The patient s past history revealed a partial gastrectomy (Billroth II) more than ten years ago...
  13. ncbi request reprint [Local ablation of malignant lesions of the liver - potential applications and limitations of the different methods]
    I Zuber-Jerger
    Medizinische Universitatsklinik Freiburg
    Z Gastroenterol 42:31-8. 2004
    ..These procedures allow to destroy tumors percutaneously with alcohol, acetic acid, radiofrequency, microwaves or laser. Potential applications and limitations of the methods are discussed...
  14. ncbi request reprint [Regional therapy of liver tumors]
    H C Spangenberg
    Abteilung Innere Medizin II, Medizinische Klinik der Universität, 79106, Hugstetter Strasse 55, Freiburg, Germany
    Internist (Berl) 48:40-5. 2007
    ..In the following we will summarize the regional therapeutic options in primary and secondary liver tumors...
  15. ncbi request reprint An error model for protein quantification
    C Kreutz
    Freiburg Center for Data Analysis and Modeling FDM, Eckerstrasse 1, Freiburg, Germany
    Bioinformatics 23:2747-53. 2007
    ..Here, we present statistical approaches improving reproducibility of protein quantification by immunoprecipitation and immunoblotting...
  16. ncbi request reprint Antibody-directed therapy for human hepatocellular carcinoma
    Leonhard Mohr
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Gastroenterology 127:S225-31. 2004
    ..Therefore, specific antibody targeting of antitumor agents to HCC cells has the potential for therapeutic application in this devastating disease...
  17. doi request reprint Immunotherapy of murine hepatocellular carcinoma by alpha-fetoprotein DNA vaccination combined with adenovirus-mediated chemokine and cytokine expression
    María Matilde Bartolomé Rodríguez
    Department of Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany
    Hum Gene Ther 19:753-9. 2008
    ..This effect may be mediated by attraction of activated effector cells to the tumor tissue...
  18. ncbi request reprint Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma
    Marcus Ritter
    Department of Medicine II, University Hospital Freiburg, Hugstetter Strasse 55, D 79106, Freiburg, Germany
    J Hepatol 41:999-1007. 2004
    ..Alpha-fetoprotein (AFP) may be a target antigen for immunotherapy. Little is known, however, about the immunobiology of AFP. Therefore, the impact of AFP on dendritic cells (DC), CD4+ and CD8+ T cells was studied in detail...
  19. ncbi request reprint Activation of dendritic cells by local ablation of hepatocellular carcinoma
    Mona Y Ali
    Department of Medicine II, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Hepatol 43:817-22. 2005
    ..The aim of the study, therefore, was the analysis whether PEI or RFTA induced injury results in an adjuvant effect for immune responses to HCCs...