Friedrich Mohr

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Symposium for the future of cardiac surgery. Working Group Report. Integration of catheter-based techniques in cardiac surgery
    Friedrich Mohr
    Klinik fur Herzchirurgie, Herzzentrum Universitaet Leipzig, Strumpellstrasse 39, Leipzig 04289, Germany
    Eur J Cardiothorac Surg 26:S74-5. 2004
  2. ncbi request reprint Gore-tex chordoplasty in degenerative mitral valve repair
    Joerg Seeburger
    Department of Cardiac Surgery, Heartcenter Leipzig University, Leipzig, Germany
    Semin Thorac Cardiovasc Surg 19:111-5. 2007
  3. pmc Interdisciplinary team approach for complicated type B aortic dissection with concomitant hematothorax by endovascular stent grafting and left side mini thoracotomy: a case report
    Marcel Vollroth
    Department of Cardiac Surgery, Heartcenter Leipzig University, Struempellstrasse 39, Leipzig, 04289, Germany
    J Cardiothorac Surg 7:111. 2012
  4. doi request reprint Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial
    Friedrich W Mohr
    Herzzentrum Universität Leipzig, Leipzig, Germany
    Lancet 381:629-38. 2013
  5. pmc Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Germany
    J Cardiothorac Surg 1:17. 2006
  6. doi request reprint Complex coronary anatomy in coronary artery bypass graft surgery: impact of complex coronary anatomy in modern bypass surgery? Lessons learned from the SYNTAX trial after two years
    Friedrich W Mohr
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    J Thorac Cardiovasc Surg 141:130-40. 2011
  7. ncbi request reprint Curative treatment of atrial fibrillation with intraoperative radiofrequency ablation: short-term and midterm results
    Friedrich W Mohr
    Divisions of Cardiac Surgery and Cardiology, Herzzentrum, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 123:919-27. 2002
  8. doi request reprint Minimally invasive hybrid coronary artery revascularization
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Ann Thorac Surg 86:1856-60. 2008
  9. doi request reprint Minimally invasive off-pump valve-in-a-ring implantation: the atrial transcatheter approach for re-operative mitral valve replacement after failed repair
    Joerg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 35:965-9; discussion 969. 2009
  10. doi request reprint Is chronic total coronary occlusion a risk factor for long-term outcome after minimally invasive bypass grafting of the left anterior descending artery?
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 89:1496-501. 2010

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Symposium for the future of cardiac surgery. Working Group Report. Integration of catheter-based techniques in cardiac surgery
    Friedrich Mohr
    Klinik fur Herzchirurgie, Herzzentrum Universitaet Leipzig, Strumpellstrasse 39, Leipzig 04289, Germany
    Eur J Cardiothorac Surg 26:S74-5. 2004
  2. ncbi request reprint Gore-tex chordoplasty in degenerative mitral valve repair
    Joerg Seeburger
    Department of Cardiac Surgery, Heartcenter Leipzig University, Leipzig, Germany
    Semin Thorac Cardiovasc Surg 19:111-5. 2007
    ..The procedure is reliable and reproducible, leading to low morbidity and mortality. Thus, use of Gore-Tex neochordae has become the standard technique for MVR at our institution...
  3. pmc Interdisciplinary team approach for complicated type B aortic dissection with concomitant hematothorax by endovascular stent grafting and left side mini thoracotomy: a case report
    Marcel Vollroth
    Department of Cardiac Surgery, Heartcenter Leipzig University, Struempellstrasse 39, Leipzig, 04289, Germany
    J Cardiothorac Surg 7:111. 2012
    ..This case shows that early mortality of live threatening acute aortic dissection type B with hemorrhagic pleural effusion may be reduced by total endovascular stent grafting and concomitant mini thoracotomy...
  4. doi request reprint Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial
    Friedrich W Mohr
    Herzzentrum Universität Leipzig, Leipzig, Germany
    Lancet 381:629-38. 2013
    ....
  5. pmc Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Germany
    J Cardiothorac Surg 1:17. 2006
    ..Since only little is known on stem cell therapy in non-ischemic heart failure we wanted to know whether a long-term improvement of cardiac function in non-ischemic heart failure can be achieved by stem cell transplantation...
  6. doi request reprint Complex coronary anatomy in coronary artery bypass graft surgery: impact of complex coronary anatomy in modern bypass surgery? Lessons learned from the SYNTAX trial after two years
    Friedrich W Mohr
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    J Thorac Cardiovasc Surg 141:130-40. 2011
    ..This study aims to clarify whether SYNTAX score affects the outcome of bypass grafting as defined by major adverse cerebrovascular and cardiac events (MACCE) and its components over a 2-year follow-up period...
  7. ncbi request reprint Curative treatment of atrial fibrillation with intraoperative radiofrequency ablation: short-term and midterm results
    Friedrich W Mohr
    Divisions of Cardiac Surgery and Cardiology, Herzzentrum, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 123:919-27. 2002
    ....
  8. doi request reprint Minimally invasive hybrid coronary artery revascularization
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Ann Thorac Surg 86:1856-60. 2008
    ..Here we report the short- and long-term results of a minimally invasive hybrid approach in 117 patients...
  9. doi request reprint Minimally invasive off-pump valve-in-a-ring implantation: the atrial transcatheter approach for re-operative mitral valve replacement after failed repair
    Joerg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 35:965-9; discussion 969. 2009
    ....
  10. doi request reprint Is chronic total coronary occlusion a risk factor for long-term outcome after minimally invasive bypass grafting of the left anterior descending artery?
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 89:1496-501. 2010
    ..It is unclear whether CTO is also a negative predictor for long-term outcome in minimally invasive bypass grafting...
  11. doi request reprint The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo
    Michael Schwarzer
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    Basic Res Cardiol 104:547-57. 2009
    ..In conclusion, pharmacologic induction of substrate-switching is associated with changes in myofibrillar isoform expression but does not reverse heart failure in vivo. The improvement of function in vitro deserves further investigation...
  12. doi request reprint Twelve-month patency with the PAS-port proximal connector device: a single center prospective randomized trial
    Jörg Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 85:1579-84. 2008
    ..The intent of this study was to prospectively compare one year graft patency of this system with conventional hand-sewn anastomoses in a prospective, randomized trial...
  13. ncbi request reprint Comparison of stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery
    Anno Diegeler
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    N Engl J Med 347:561-6. 2002
    ..Minimally invasive bypass surgery and coronary-artery stenting are both accepted treatments for isolated stenosis of the proximal left anterior descending coronary artery. We compared the clinical outcomes after these two procedures...
  14. ncbi request reprint Facilitated MIDCAB using a magnetic coupling device
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Ann Thorac Surg 79:691-3. 2005
    ..Postoperative angiogram demonstrated excellent patency and flow...
  15. ncbi request reprint Mid-term results after Epic xenograft implantation for aortic, mitral, and double valve replacement
    Sven Lehmann
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    J Heart Valve Dis 16:641-8; discussion 648. 2007
    ..The study aim was to evaluate the mid-term results after implantation of the stented porcine xenograft (Epic valve with Linx anticalcification treatment) in elderly patients...
  16. doi request reprint Aortic valve replacement in octogenarians: utility of risk stratification with EuroSCORE
    Sergey Leontyev
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 87:1440-5. 2009
    ..We evaluated characteristics and outcomes of elderly patients undergoing isolated AVR with a particular focus on the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk stratification...
  17. ncbi request reprint Transapical approach for sutureless stent-fixed aortic valve implantation: experimental results
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 29:703-8. 2006
    ..Percutaneous aortic valve implantation has been performed in patients with severe aortic stenosis judged as nonsurgical candidates. We evaluated a facilitated transapical antegrade approach for potential use in surgical high-risk patients...
  18. ncbi request reprint Augmented reality for intraoperative guidance in endoscopic coronary artery bypass grafting
    Volkmar Falk
    Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Surg Technol Int 14:231-5. 2005
    ..Qualitative and quantitative analysis demonstrate the potential value during total endoscopic coronary artery bypass grafting...
  19. doi request reprint Eight-year follow-up after prospectively randomized implantation of different mechanical aortic valves
    Sven Lehmann
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Struempellstr 39, 04289 Leipzig, Germany
    Clin Res Cardiol 97:376-82. 2008
    ..The aim of this prospectively randomized study was to evaluate the hemodynamic and functional outcomes after aortic valve replacement with three different bileaflet mechanical valves...
  20. ncbi request reprint Stentless mitral valve replacement by conventional and minimally invasive techniques
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Surg Technol Int 14:236-40. 2005
    ..SMV implantation by way of a sternotomy or lateral minithoracotomy leads to preservation of the annulo-ventricular continuity and similar to physiological hemodynamics. However, long-term durability remains to be proven...
  21. ncbi request reprint Stentless versus conventional xenograft aortic valve replacement: midterm results of a prospectively randomized trial
    Sven Lehmann
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 84:467-72. 2007
    ..The purpose of this study was to analyze the 5- to 8-year clinical results after prospectively randomized stentless versus conventional aortic valve replacement...
  22. ncbi request reprint Restitution of sinus rhythm plus stentless mitral valve replacement at three years
    Sven Lehmann
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    J Heart Valve Dis 13:410-3. 2004
    ..The study aim was to examine results after stentless mitral valve (SMV) replacement (Quattro) and restitution of physiological cardiac rhythm by intraoperative left atrial ablation therapy...
  23. ncbi request reprint Anomalous origin of the right coronary artery from the pulmonary artery combined with aortic valve stenosis
    Torsten Bossert
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    Ann Thorac Surg 79:347-8. 2005
    ..Four cases involving an association of the bicuspid aortic valve and ARCAPA have been reported in the literature. This potential relationship should be considered whenever diagnosing a bicuspid aortic valve...
  24. doi request reprint Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression
    Paulo A Amorim
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    J Thorac Cardiovasc Surg 140:1160-7. 2010
    ..We assessed cardiac insulin sensitivity and mitochondrial and contractile function in rats after ligation of the left coronary artery...
  25. doi request reprint How does the use of polytetrafluoroethylene neochordae for posterior mitral valve prolapse (loop technique) compare with leaflet resection? A prospective randomized trial
    Volkmar Falk
    Heart Center Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 136:1205; discussion 1205-6. 2008
    ..The aim of this prospectively randomized trial was to determine how preservation of leaflet structure in combination with premeasured neochordae compares with the widely adopted technique of leaflet resection...
  26. doi request reprint Comparison of outcomes of minimally invasive mitral valve surgery for posterior, anterior and bileaflet prolapse
    Joerg Seeburger
    Heart Center, University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 36:532-8. 2009
    ..We sought to compare the outcomes of minimally invasive mitral valve (MV) surgery for anterior (anterior mitral leaflet, AML), posterior (posterior mitral leaflet, PML) or bileaflet (BL) MV prolapse...
  27. doi request reprint Echocardiographic identification of iatrogenic injury of the circumflex artery during minimally invasive mitral valve repair
    Joerg Ender
    Department of Anesthesiology and Intensive Care Medicine II, Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 89:1866-72. 2010
    ....
  28. ncbi request reprint Pharmacodynamic monitoring of the immunosuppressive therapy in patients after heart transplantation: whole blood flow cytometric analysis of lymphocyte function
    Markus J Barten
    Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, 04289 Leipzig, Germany
    Comput Biol Med 37:1367-73. 2007
    ..The information from both pharmacokinetic and pharmacodynamic monitoring has the potential to increase the efficacy and safety of individual immunosuppressive therapy after HTx...
  29. ncbi request reprint Affects of immunosuppression on circulating dendritic cells: an adjunct to therapeutic drug monitoring after heart transplantation
    Markus J Barten
    University of Leipzig, Department of Cardiac Surgery, Heart Center Leipzig, 04289 Leipzig, Germany
    Int Immunopharmacol 6:2011-7. 2006
    ....
  30. ncbi request reprint Minimally invasive transapical beating heart aortic valve implantation--proof of concept
    Thomas Walther
    Department of Cardiac Surgery, Heartcenter, University Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 31:9-15. 2007
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  31. doi request reprint Three good reasons for heart surgeons to understand cardiac metabolism
    Torsten Doenst
    Department of Cardiac Surgery, University of Leipzig Heart Center, Strümpellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 33:862-71. 2008
    ....
  32. doi request reprint Transapical minimally invasive aortic valve implantation; the initial 50 patients
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Eur J Cardiothorac Surg 33:983-8. 2008
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  33. doi request reprint Repair of bileaflet prolapse in Barlow syndrome
    Michael A Borger
    Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany
    Semin Thorac Cardiovasc Surg 22:174-8. 2010
    ..We can conclude that a stepwise approach to this MV pathology with extensive use of the loop technique can result in very acceptable outcomes, even in patients undergoing minimal invasive surgery...
  34. ncbi request reprint Bovine jugular vein conduit for right ventricular outflow tract reconstruction: evaluation of risk factors for mid-term outcome
    Ardawan J Rastan
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    Ann Thorac Surg 82:1308-15. 2006
    ..We examined the effect of patient age, conduit size, hemodynamics, and cardiac malformation on early and mid-term outcome...
  35. ncbi request reprint Transapical minimally invasive aortic valve implantation: multicenter experience
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 116:I240-5. 2007
    ..To evaluate initial multicenter results with minimally invasive transapical aortic valve implantation (TAP-AVI) for high risk patients with aortic stenosis...
  36. doi request reprint Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Heart Centre, Struempellstr 39, 04289 Leipzig, Germany
    Circ Res 106:1592-602. 2010
    ..Cyclic mechanical stretch (CMS) is an important physiological and pathological factor in the heart...
  37. ncbi request reprint Selective arterialization of a cardiac vein in a model of cardiac microangiopathy and macroangiopathy in sheep
    Michaela Elisabeth Resetar
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 133:1252-6. 2007
    ..We investigated the benefit of arterialization of a cardiac vein under these circumstances in an acute animal model...
  38. doi request reprint Value of augmented reality-enhanced transesophageal echocardiography (TEE) for determining optimal annuloplasty ring size during mitral valve repair
    Joerg Ender
    Department of Anesthesiology and Intensive Care Medicine II, Leipzig Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 86:1473-8. 2008
    ..This study compared augmented reality-enhanced three-dimensional (3D) transesophageal echocardiography (TEE) for determining MV annuloplasty size with conventional surgical sizing...
  39. doi request reprint Minimally invasive mitral valve surgery after previous sternotomy: experience in 181 patients
    Joerg Seeburger
    Heart Center, Leipzig University, Leipzig, Germany
    Ann Thorac Surg 87:709-14. 2009
    ..This study evaluated the results for minimally invasive mitral valve (MV) surgery in patients who had undergone previous cardiac operations through a sternotomy...
  40. doi request reprint The Toronto Root bioprosthesis: midterm results in 186 patients
    Sven Lehmann
    Department of Cardiac Surgery, University of Leipzig, Heartcenter, Leipzig, Germany
    Ann Thorac Surg 87:1751-6. 2009
    ..Patients included in the initial clinical study with core laboratory data evaluation were reviewed...
  41. doi request reprint Moderate versus deep hypothermia for the arterial switch operation--experience with 100 consecutive patients
    Ardawan J Rastan
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 33:619-25. 2008
    ..To evaluate the impact of moderate versus deep perioperative hypothermia on postoperative morbidity in patients receiving the arterial switch operation (ASO)...
  42. ncbi request reprint 3D-Imaging of cardiac structures using 3D heart models for planning in heart surgery: a preliminary study
    Stephan Jacobs
    Herzzentrum Leipzig, Department of Cardiac Surgery, University Leipzig, Germany
    Interact Cardiovasc Thorac Surg 7:6-9. 2008
    ..The use of the 3D rapid prototyping model (RPT-model) during resection of ventricular aneurysm and malignant cardiac tumors may facilitate the surgical procedure due to better planning and improved orientation...
  43. doi request reprint Mechanical strain and the aortic valve: influence on fibroblasts, extracellular matrix, and potential stenosis
    Sven Lehmann
    Department for Heart Surgery, Universitat Leipzig, Heart Center, Leipzig, Germany
    Ann Thorac Surg 88:1476-83. 2009
    ..Mechanical strain may affect aortic valve cusp, leading to an altered extracellular matrix ultrastructure and eventually aortic stenosis. The aim of this study was to evaluate the affect of these potential relationships on human tissue...
  44. ncbi request reprint Ligation or distortion of the right circumflex artery during minimal invasive mitral valve repair detected by transesophageal echocardiography
    Joerg Ender
    Heartcenter Leipzig, University of Leipzig Anesthesiology and Intensive Care Medicine II, Leipzig, Germany
    J Am Soc Echocardiogr 21:408.e4-5. 2008
    ..During reoperation 4 sutures placed at the P1 segment of the mitral valve annuloplasty were corrected. Transesophageal echocardiography could detect a good flow of the circumflex artery and the electrocardiographic changes disappeared...
  45. ncbi request reprint Surgical atrial septal defect closure after interventional occluder placement: incidence and outcome
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Thorac Cardiovasc Surg 134:731-7. 2007
    ..Closure of ostium secundum atrial septal defects is generally performed by using an interventional approach. We evaluated the outcome of patients requiring secondary surgical therapy...
  46. ncbi request reprint Mitral valve repair in patients with end stage cardiomyopathy: who benefits?
    Jan F Gummert
    Department of Cardiac Surgery, University Leipzig, Heartcenter, Struempellstrasse 39, 04289, Leipzig, Germany
    Eur J Cardiothorac Surg 23:1017-22; discussion 1022. 2003
    ..Patients with end stage cardiomyopathy frequently present with additional severe mitral regurgitation. We analyzed the outcome of mitral valve reconstruction in this high risk patient group...
  47. ncbi request reprint Seven-year follow-up after minimally invasive direct coronary artery bypass: experience with more than 1300 patients
    David M Holzhey
    Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Ann Thorac Surg 83:108-14. 2007
    ..Here we present the experience after more than 1300 MIDCAB procedures with up to 7 years of follow-up...
  48. ncbi request reprint Facilitated minimally invasive left ventricular epicardial lead placement
    Nicolas Doll
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 79:1023-5; discussion 1025. 2005
    ..We used a novel malleable epicardial lead placement tool (Epicardial Lead Implant Tool, Model 10626; Medtronic, Minneapolis, MN) that facilitates lead placement on the posterior aspect of the LV through an anterolateral minithoracotomy...
  49. ncbi request reprint Clinical experience with stentless mitral valve replacement
    Friedrich W Mohr
    Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 79:772-5. 2005
    ..Our aim is to describe the clinical experience with stentless mitral valve (SMV) replacement with special focus on the functionality of the SMV...
  50. ncbi request reprint Primary repair for aortic arch obstruction associated with ventricular septal defect
    Martin Kostelka
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 78:1989-93; discussion 1993. 2004
    ....
  51. ncbi request reprint Early results with stentless mitral valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    J Heart Valve Dis 13:766-770; discussion 770-1. 2004
    ..Implantation of a chordally supported stentless mitral valve (SMV) may be the strategy of choice for patients with severe degenerative mitral valve disease. Herein, the early clinical results of this surgical technique were analyzed...
  52. ncbi request reprint Prospectively randomized evaluation of stented xenograft hemodynamic function in the aortic position
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Germany
    Circulation 110:II74-8. 2004
    ..Standard stented aortic xenograft valves have not yet been compared regarding their hemodynamic function using a stratified intraoperative randomization protocol...
  53. ncbi request reprint Predictors of prolonged ICU stay after on-pump versus off-pump coronary artery bypass grafting
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Intensive Care Med 30:88-95. 2004
    ..To define predictors for prolonged ICU stay in order to improve patient outcome and reduce costs...
  54. ncbi request reprint Intraoperative left atrial ablation (for atrial fibrillation) using a new argon cryocatheter: early clinical experience
    Nicolas Doll
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 76:1711-5; discussion 1715. 2003
    ..This report describes our early experience in treatment of patients with chronic or paroxysmal atrial fibrillation with a new tool for left atrial cryoablation...
  55. ncbi request reprint Facilitated endoscopic beating heart coronary artery bypass grafting using a magnetic coupling device
    Volkmar Falk
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    J Thorac Cardiovasc Surg 126:1575-9. 2003
    ..The potential benefits of the endoscopic Magnetic Vascular Positioner device (Ventrica, Inc, Fremont, Calif) to facilitate construction of a coronary anastomosis in a closed chest environment were evaluated...
  56. ncbi request reprint Five-year results of 219 consecutive patients treated with extracorporeal membrane oxygenation for refractory postoperative cardiogenic shock
    Nicolas Doll
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 77:151-7; discussion 157. 2004
    ..Postcardiotomy cardiogenic shock occurs in approximately 1% of patients. We prospectively evaluated the early and long-term outcome as well as predictors of survival when using temporary extracorporeal membrane oxygenation (ECMO) support...
  57. ncbi request reprint A new cryoprobe for intraoperative ablation of atrial fibrillation
    Nicolas Doll
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 77:1460-2. 2004
    ..The patient was discharged in sinus rhythm. This new argon cryoprobe represents an encouraging technology for the isolated endocardial as well as concomitant treatment of atrial fibrillation...
  58. ncbi request reprint Temporary extracorporeal membrane oxygenation in patients with refractory postoperative cardiogenic shock--a single center experience
    Nicolas Doll
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    J Card Surg 18:512-8. 2003
    ..Such patients are at very high risk for subsequent morbidity and mortality. We evaluated the results of temporary extracorporeal membrane oxygenation (ECMO) support in patients with postcardiotomy cardiogenic shock...
  59. ncbi request reprint Predictors of delirium after cardiac surgery delirium: effect of beating-heart (off-pump) surgery
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    J Thorac Cardiovasc Surg 127:57-64. 2004
    ..Despite improved outcomes after cardiac operations, postoperative delirium remains a common complication that is associated with increased morbidity and prolonged hospital stay...
  60. ncbi request reprint Cardio navigation: planning, simulation, and augmented reality in robotic assisted endoscopic bypass grafting
    Volkmar Falk
    Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 79:2040-7. 2005
    ..The aim of this study is to optimize the set-up and port placement in robotic surgery and enhance intraoperative orientation by video overlay of the angiographic coronary tree...
  61. ncbi request reprint Left ventricular reverse remodeling after surgical therapy for aortic stenosis: correlation to Renin-Angiotensin system gene expression
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Circulation 106:I23-6. 2002
    ..Surgical therapy for aortic stenosis leads to reverse remodeling, with normalization of left ventricular hypertrophy (LVH). The aim of this study was to examine Renin-Angiotensin system (RAS) gene expression in this setting...
  62. ncbi request reprint [Arterial revascularization of coronary vessels]
    Volkmar Falk
    Klinik fur Herzchirurgie, Herzzentrum Leipzig
    Herz 27:426-34. 2002
    ..Recent studies have also demonstrated a survival benefit of double over single ITA graft use. Especially in younger patients bilateral ITA grafting is recommended...
  63. ncbi request reprint Hemodynamic evaluation of stentless mitral valve replacement
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Germany
    Artif Organs 26:847-50. 2002
    ..TEE and TTE are extremely useful to assist SMV implantation as well as for regular follow-up evaluation. The hemodynamic function after SMV implantation with preservation of the annulo-ventricular continuity is promising...
  64. ncbi request reprint Aprotinin decreases reperfusion injury and allograft dysfunction in clinical lung transplantation
    Hartmuth B Bittner
    Division of Thoracic and Cardiovascular Surgery, Heart Center Leipzig of the University of Leipzig, Struempell Strasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 29:210-5. 2006
    ..We hypothesized that the perioperative management with aprotinin decreases the incidence of allograft reperfusion injury and dysfunction after clinical lung transplantation...
  65. ncbi request reprint Experimental evaluation and early clinical results of a new low-profile bileaflet aortic valve
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Artif Organs 26:416-9. 2002
    ..2 +/- 0.4 m/s) and low pressure gradients (20 +/- 6 mm Hg) postoperatively and at 6 months follow-up. In vitro testing and early clinical results are promising; however, long-term performance has to be proven...
  66. ncbi request reprint Synergistic effects of sirolimus with cyclosporine and tacrolimus: analysis of immunosuppression on lymphocyte proliferation and activation in rat whole blood
    Markus J Barten
    University of Leipzig, Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Transplantation 77:1154-62. 2004
    ....
  67. ncbi request reprint Cytokine analysis to predict immunosuppression
    Markus J Barten
    Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, 04289 Leipzig, Germany
    Cytometry A 69:155-7. 2006
    ..However, there is still an incessant need to explore assay conditions and techniques of analyzing cytokines, which are specific and reliable for monitoring drug efficacy...
  68. doi request reprint Human minimally invasive off-pump valve-in-a-valve implantation
    Thomas Walther
    Department of Cardiac Surgery, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 85:1072-3. 2008
    ..Hemodynamic function was excellent and the patient had a fast and uneventful recovery...
  69. doi request reprint New anatomically oriented transapical aortic valve implantation
    Volkmar Falk
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 87:925-6. 2009
    ..Here we report implantation of this new valve in a patient. The valve demonstrated excellent function with a low transvalvular gradient...
  70. doi request reprint Transapical aortic valve implantation: step by step
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Ann Thorac Surg 87:276-83. 2009
    ..Transapical aortic valve implantation is a new minimally invasive technique for beating heart, off-pump, aortic valve implantation in high-risk patients...
  71. doi request reprint Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload
    Torsten Doenst
    Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Cardiovasc Res 86:461-70. 2010
    ..However, it also is a compensatory response to pressure overload, accommodating for increased workload. We tested whether the changes in energy substrate metabolism may be predictive for the development of contractile dysfunction...
  72. doi request reprint Transapical aortic valve implantation in patients requiring redo surgery
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strümpellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 36:231-4; discussion 234-5. 2009
    ..To evaluate the results of minimally invasive transapical aortic valve implantation (TA-AVI) in patients requiring redo surgery...
  73. ncbi request reprint Minimally invasive isolated tricuspid valve surgery
    Joerg Seeburger
    Heart Center, Leipzig University, Leipzig, Germany
    J Heart Valve Dis 19:189-92; discussion 193. 2010
    ..Outcomes after minimally invasive isolated tricuspid valve (TV) surgery have not been well described. Hence, an assessment was made of the authors' results for minimally invasive, isolated TV surgery...
  74. ncbi request reprint In vitro comparison of the new in-line monitor BMU 40 versus a conventional laboratory analyzer
    F Oliver Grosse
    Department of Cardiac Surgery, University of Leipzig, Heart Center, Leipzig, Germany
    J Extra Corpor Technol 42:61-70. 2010
    ..Before the official market launch a new software version of the BMU 40 has been developed. The algorithm to calculate pO2 (37 degrees C) under hypothermic conditions has been improved and the miscalculation eliminated.)..
  75. ncbi request reprint Midterm results after stentless mitral valve replacement
    Thomas Walther
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Circulation 108:II85-9. 2003
    ..To analyze the midterm clinical results after stentless mitral valve (SMV) replacement...
  76. ncbi request reprint Minimal access aortic valve replacement: effects on morbidity and resource utilization
    Nicolas Doll
    Clinic for Heart Surgery, Heart Center, University of Leipzig, Germany
    Ann Thorac Surg 74:S1318-22. 2002
    ..The aim of this study was to compare outcomes in patients undergoing minimal access versus conventional aortic valve replacement (AVR)...
  77. ncbi request reprint Stroke after cardiac surgery: a risk factor analysis of 16,184 consecutive adult patients
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 75:472-8. 2003
    ..The purpose of this study was to determine the predictors of stroke in a large, contemporary cardiac surgery population...
  78. ncbi request reprint Extending the in situ right internal mammary artery graft with retrocaval positioning
    Roberto Battellini
    Clinic for Heart Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 75:1335-6. 2003
    ..With careful surgical technique, this procedure can be performed safely during routine coronary bypass operations...
  79. doi request reprint Effect of preoperative statin therapy on patients undergoing isolated and combined valvular heart surgery
    Michael A Borger
    Department of Cardiac Surgery, Leipzig Heart Center, Struempellstrasse 39, 04289 Leipzig, Germany
    Ann Thorac Surg 89:773-9; discussion 779-80. 2010
    ..It is unknown whether patients undergoing valve surgery benefit from preoperative statin therapy. We examined the effects of statin treatment in a large group of patients undergoing valve surgery...
  80. ncbi request reprint Esophageal perforation during left atrial radiofrequency ablation: Is the risk too high?
    Nicolas Doll
    Clinic for Heart Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 125:836-42. 2003
    ..The purpose of this article is to describe a serious complication of this procedure, namely IRAAF-induced esophageal perforation, in detail to identify possible risk factors...
  81. ncbi request reprint On-pump versus off-pump coronary artery bypass grafting: impact on postoperative renal failure requiring renal replacement therapy
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 77:1250-6. 2004
    ..Despite refinements in perioperative patient management postoperative renal failure requiring hemofiltration or dialysis is still a common complication after coronary artery bypass grafting associated with impaired patient outcome...
  82. ncbi request reprint Beating heart off-pump myocardial revascularization in an infant
    Thomas Walther
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Ann Thorac Surg 79:2151-3. 2005
    ..Thus, closure of the left main stem and left internal mammary artery-left anterior descending coronary artery bypass grafting were performed successfully with the heart beating...
  83. ncbi request reprint Valve-in-a-valve concept for transcatheter minimally invasive repeat xenograft implantation
    Thomas Walther
    Klinik fur Herzchirurgie, Leipzig, Germany
    J Am Coll Cardiol 50:56-60. 2007
    ..This study sought to evaluate the feasibility of minimally invasive transapical repeat valve-in-a-valve (VinV) implantation...
  84. ncbi request reprint Reverse remodeling of cardiac collagen protein expression after surgical therapy for experimental aortic stenosis
    Thomas Walther
    University of Leipzig, Heart Center, Clinic for Heart Surgery, Leipzig, Germany
    J Heart Valve Dis 15:651-6. 2006
    ..Reversal of myocardial collagen gene expression was examined in parallel to left ventricular reverse remodeling after surgical correction of experimental aortic stenosis...
  85. ncbi request reprint Impact of off-pump coronary bypass grafting on the prevalence of adverse perioperative outcome in women undergoing coronary artery bypass grafting surgery
    Jan Bucerius
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 79:807-12; discussion 812-3. 2005
    ..We attempted to determine a potential benefit of off-pump CABG as compared with on-pump CABG (OPCAB) with regard to perioperative outcome in female patients...
  86. ncbi request reprint Patient prosthesis mismatch affects short- and long-term outcomes after aortic valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 30:15-9. 2006
    ..The aim of this study was to evaluate the impact of patient prosthesis mismatch (PPM) and additional risk factors on outcome after aortic valve replacement (AVR)...
  87. ncbi request reprint Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: a 5-year follow-up
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circulation 112:3445-50. 2005
    ..Long-term follow-up data are sparse...
  88. ncbi request reprint Endoscopic internal thoracic artery dissection leads to significant reduction of pain after minimally invasive direct coronary artery bypass graft surgery
    Jan Bucerius
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Germany
    Ann Thorac Surg 73:1180-4. 2002
    ..Results were compared with pain levels associated with conventional cardiac bypass operations through a median sternotomy...
  89. ncbi request reprint The use of an aortic connector system in a patient with severe calcified ascending aorta
    Jan F Gummert
    Department of Cardiac Surgery, University of Leipzig, Heart Center, Germany
    J Card Surg 19:62-4. 2004
    ..The beating heart technique was used for the distal anastomosis and ventriculoplasty. The proximal anastomosis was constructed with an automated aortic connector system, thereby avoiding clamping of the severely diseased aorta...
  90. doi request reprint Transcatheter aortic valve implantation: time to expand?
    Thomas Walther
    Herzzentrum, Klinik für Herzchirurgie und Kardiologie, Universitat Leipzig, Leipzig, Germany
    Curr Opin Cardiol 23:111-6. 2008
    ..Transcatheter aortic valve implantation is a new, emerging technique that has been performed in elderly and higher-risk patients suffering severe, symptomatic aortic stenosis...
  91. doi request reprint Endocardial laser ablation for the treatment of atrial fibrillation in an acute sheep model
    Nicolas Doll
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Card Surg 23:198-203. 2008
    ..The purpose of this study was to test the feasibility, effectiveness, and safety of the use of a new laser energy catheter for linear endocardial ablation in an acute sheep model...
  92. doi request reprint Gender-dependent differences in patients undergoing tricuspid valve surgery
    Bettina Pfannmueller
    Department of Heart Surgery, Heart Centre, University of Leipzig, Leipzig, Germany
    Thorac Cardiovasc Surg 61:37-41. 2013
    ....
  93. ncbi request reprint Minimally invasive surgery for valve disease
    Thomas Walther
    St Jude Medical, Inc
    Curr Probl Cardiol 31:399-437. 2006
    ..Patient recovery is fast leading to a significant improvement in the individual's quality of life. Minimally invasive valve surgery can be considered the standard approach and will reach more widespread clinical application...
  94. ncbi request reprint Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial
    Henning Morawietz
    Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Circulation 114:I296-301. 2006
    ....
  95. ncbi request reprint Robotically assisted repair of a papillary muscle injury due to blunt trauma
    Alan P Kypson
    Division of Cardiothoracic Surgery, The Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Trauma 61:209-10. 2006
  96. ncbi request reprint Aortic valve surgery: time to be open-minded and to rethink
    Thomas Walther
    Eur J Cardiothorac Surg 31:4-6. 2007
  97. ncbi request reprint Transapical aortic valve implantation: an animal feasibility study
    Todd M Dewey
    Cardiopulmonary Research Science and Technology Institute, Dallas, Texas, USA
    Ann Thorac Surg 82:110-6. 2006
    ..We investigated a minimally invasive approach through the left ventricular apex for antegrade placement of a device-deliverable valve...
  98. ncbi request reprint Hemodynamics and early clinical performance of the St. Jude Medical Regent mechanical aortic valve
    David S Bach
    Department of Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA
    Ann Thorac Surg 74:2003-9; discussion 2009. 2002
    ..The present study reports the hemodynamic and early clinical results of an ongoing multicenter trial investigating the performance of the Regent valve...
  99. ncbi request reprint The influence of immunosuppressive drugs on T- and B-cell apoptosis via p53-mediated pathway in vitro and in vivo
    Andreas Boldt
    University of Leipzig Heart Center, Department of Cardiac Surgery and Cardiology, Germany
    Transplantation 82:422-7. 2006
    ..This study was designed to assess the effects of calcineurin and inosine-5-monophosphate-dehydrogenase inhibitors on p53-mediated-apoptosis in T- and B-cells in vitro and in human heart-transplanted recipients (HTx-R)...
  100. ncbi request reprint Intraoperative fracture of the right coronary artery: recognition and management
    Michael A Borger
    Division of Cardiovascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Ann Thorac Surg 79:693-6. 2005
    ..Coronary bypass grafting without cardioplegic arrest was used for definitive diagnosis and treatment. Both patients made a rapid and uneventful recovery...
  101. ncbi request reprint Initial experience with the Toronto Root bioprosthesis
    Tirone E David
    Cardiac Surgical Programs, Toronto General Hospital, Toronto, ON, Canada
    J Heart Valve Dis 13:248-51; discussion 252-3. 2004
    ..The study aim was to assess the safety and efficacy of the Toronto Root bioprosthesis for aortic root or valve replacement during the early postoperative stages...