Affiliation: University of Ulm
von Witzleben A, Goerttler L, Marienfeld R, Barth H, Lechel A, Mellert K, et al
. Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway. Cancer Res. 2015;75:3823-31 pubmed publisher
..Overall, our work offers a valuable new tool for chordoma studies including the development of novel biomarkers and molecular targeting strategies. ..
Steinestel J, Al Ghazal A, Arndt A, Schnoeller T, Schrader A, Moeller P, et al
. The role of histologic subtype, p16(INK4a) expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma. BMC Cancer. 2015;15:220 pubmed publisher
..Since local invasion can be judged without p16(INK4a)/HPV-detection on microscopic evaluation, our study argues against routine testing in the setting of pSCC. ..
von Witzleben A, Goerttler L, Lennerz J, Weissinger S, Kornmann M, Mayer Steinacker R, et al
. In chordoma, metastasis, recurrences, Ki-67 index, and a matrix-poor phenotype are associated with patients' shorter overall survival. Eur Spine J. 2016;25:4016-4024 pubmed
..05 each). We propose to include these parameters in the final pathologic report of the resected chordoma. ..
Jäger D, Barth T, Brüderlein S, Scheuerle A, Rinner B, von Witzleben A, et al
. HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas. Sci Rep. 2017;7:2032 pubmed publisher
..This differential expression of HOX genes in chordomas of the clivus and sacrum suggests an oncofetal mechanism in gene regulation linked to the anatomic site. ..