Dimitris Missirlis

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles
    Dimitris Missirlis
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 8:e54611. 2013
  2. ncbi Effect of the peptide secondary structure on the peptide amphiphile supramolecular structure and interactions
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, United States
    Langmuir 27:6163-70. 2011
  3. ncbi Thermodynamic and kinetic stability of DSPE-PEG(2000) micelles in the presence of bovine serum albumin
    Mark Kastantin
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    J Phys Chem B 114:12632-40. 2010
  4. ncbi Structural effects and lipid membrane interactions of the pH-responsive GALA peptide with fatty acid acylation
    Brian F Lin
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Biochemistry 51:4658-68. 2012
  5. ncbi Internalization of p53(14-29) peptide amphiphiles and subsequent endosomal disruption results in SJSA-1 cell death
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Mol Pharm 7:2173-84. 2010
  6. ncbi Targeting of albumin-embedded paclitaxel nanoparticles to tumors
    Priya Prakash Karmali
    Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, California 93106 9610, USA
    Nanomedicine 5:73-82. 2009

Collaborators

  • Tambet Teesalu
  • Erkki Ruoslahti
  • Matthew Tirrell
  • Mark Kastantin
  • Brian F Lin
  • Matthew Black
  • Priya Prakash Karmali
  • Daniel V Krogstad
  • David Peters
  • Badriprasad Ananthanarayanan
  • Venkata Ramana Kotamraju

Detail Information

Publications6

  1. ncbi The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles
    Dimitris Missirlis
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 8:e54611. 2013
    ..Understanding the interactions of PAs with cells and the mechanisms of their internalization and intracellular trafficking is critical in their further development for therapeutic delivery applications...
  2. ncbi Effect of the peptide secondary structure on the peptide amphiphile supramolecular structure and interactions
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, United States
    Langmuir 27:6163-70. 2011
    ..In the presence of divalent magnesium ions, these a priori formed supramolecular structures interacted in distinct manners, highlighting the importance of peptide amphiphile design in self-assembly...
  3. ncbi Thermodynamic and kinetic stability of DSPE-PEG(2000) micelles in the presence of bovine serum albumin
    Mark Kastantin
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    J Phys Chem B 114:12632-40. 2010
    ..These findings give clear guidance concerning the lifetimes of micelles that may be used as diagnostic and therapeutic nanoparticles...
  4. ncbi Structural effects and lipid membrane interactions of the pH-responsive GALA peptide with fatty acid acylation
    Brian F Lin
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Biochemistry 51:4658-68. 2012
    ..Lauryl-GALA was tolerated well by SJSA-1 osteocarcinoma cells and enhanced cell internalization of the PA was observed. Our findings are discussed with the overarching goal of developing efficient therapeutic delivery systems...
  5. ncbi Internalization of p53(14-29) peptide amphiphiles and subsequent endosomal disruption results in SJSA-1 cell death
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Mol Pharm 7:2173-84. 2010
    ..Our results provide the basis for the construction of novel therapeutic supramolecular nanoparticles and suggest hydrophobic modification of peptides as a promising strategy for enhancing delivery of impermeable peptides...
  6. ncbi Targeting of albumin-embedded paclitaxel nanoparticles to tumors
    Priya Prakash Karmali
    Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, California 93106 9610, USA
    Nanomedicine 5:73-82. 2009
    ..These results show that nanoparticles can be effectively targeted into extravascular tumor tissue and that targeting can enhance the activity of a therapeutic nanoparticle...