Dimitris Missirlis

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles
    Dimitris Missirlis
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 8:e54611. 2013
  2. pmc Effect of the peptide secondary structure on the peptide amphiphile supramolecular structure and interactions
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, United States
    Langmuir 27:6163-70. 2011
  3. pmc Internalization of p53(14-29) peptide amphiphiles and subsequent endosomal disruption results in SJSA-1 cell death
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Mol Pharm 7:2173-84. 2010
  4. pmc Targeting of albumin-embedded paclitaxel nanoparticles to tumors
    Priya Prakash Karmali
    Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, California 93106 9610, USA
    Nanomedicine 5:73-82. 2009
  5. doi request reprint Thermodynamic and kinetic stability of DSPE-PEG(2000) micelles in the presence of bovine serum albumin
    Mark Kastantin
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    J Phys Chem B 114:12632-40. 2010
  6. ncbi request reprint Structural effects and lipid membrane interactions of the pH-responsive GALA peptide with fatty acid acylation
    Brian F Lin
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Biochemistry 51:4658-68. 2012
  7. ncbi request reprint Linker chemistry determines secondary structure of p5314-29 in peptide amphiphile micelles
    Dimitris Missirlis
    Department of Chemical Engineering and Materials and Materials Research Laboratory, University of California, Santa Barbara, California 93106, and Department of Bioengineering, University of California, Berkeley, California, 94720
    Bioconjug Chem 21:465-75. 2010
  8. pmc Mechanisms of peptide amphiphile internalization by SJSA-1 cells in vitro
    Dimitris Missirlis
    Department of Chemical Engineering and Materials, University of California, Santa Barbara, California 93106, USA
    Biochemistry 48:3304-14. 2009

Collaborators

Detail Information

Publications8

  1. pmc The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles
    Dimitris Missirlis
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 8:e54611. 2013
    ..Understanding the interactions of PAs with cells and the mechanisms of their internalization and intracellular trafficking is critical in their further development for therapeutic delivery applications...
  2. pmc Effect of the peptide secondary structure on the peptide amphiphile supramolecular structure and interactions
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, United States
    Langmuir 27:6163-70. 2011
    ..In the presence of divalent magnesium ions, these a priori formed supramolecular structures interacted in distinct manners, highlighting the importance of peptide amphiphile design in self-assembly...
  3. pmc Internalization of p53(14-29) peptide amphiphiles and subsequent endosomal disruption results in SJSA-1 cell death
    Dimitris Missirlis
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Mol Pharm 7:2173-84. 2010
    ..Our results provide the basis for the construction of novel therapeutic supramolecular nanoparticles and suggest hydrophobic modification of peptides as a promising strategy for enhancing delivery of impermeable peptides...
  4. pmc Targeting of albumin-embedded paclitaxel nanoparticles to tumors
    Priya Prakash Karmali
    Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, California 93106 9610, USA
    Nanomedicine 5:73-82. 2009
    ..These results show that nanoparticles can be effectively targeted into extravascular tumor tissue and that targeting can enhance the activity of a therapeutic nanoparticle...
  5. doi request reprint Thermodynamic and kinetic stability of DSPE-PEG(2000) micelles in the presence of bovine serum albumin
    Mark Kastantin
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    J Phys Chem B 114:12632-40. 2010
    ..These findings give clear guidance concerning the lifetimes of micelles that may be used as diagnostic and therapeutic nanoparticles...
  6. ncbi request reprint Structural effects and lipid membrane interactions of the pH-responsive GALA peptide with fatty acid acylation
    Brian F Lin
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Biochemistry 51:4658-68. 2012
    ..Lauryl-GALA was tolerated well by SJSA-1 osteocarcinoma cells and enhanced cell internalization of the PA was observed. Our findings are discussed with the overarching goal of developing efficient therapeutic delivery systems...
  7. ncbi request reprint Linker chemistry determines secondary structure of p5314-29 in peptide amphiphile micelles
    Dimitris Missirlis
    Department of Chemical Engineering and Materials and Materials Research Laboratory, University of California, Santa Barbara, California 93106, and Department of Bioengineering, University of California, Berkeley, California, 94720
    Bioconjug Chem 21:465-75. 2010
    ..This study provides insight into the mechanisms through which headgroup structuring occurs on peptide amphiphile micelles, with implications on the bioactivity, stability, and morphology of the self-assembled entities. ..
  8. pmc Mechanisms of peptide amphiphile internalization by SJSA-1 cells in vitro
    Dimitris Missirlis
    Department of Chemical Engineering and Materials, University of California, Santa Barbara, California 93106, USA
    Biochemistry 48:3304-14. 2009
    ..We conclude that palmitoylation of peptides is an efficient way to increase peptide permeability inside SJSA-1 cells and that increased micelle stability would be required for intact micelle internalization...