R Mischke

..However, the comparatively short t(½) may indicate the necessity of multiple daily injections, which should be verified in clinical trials...

..In contrast, expectations regarding the timely clinical availability of gene therapy (particularly in humans) have not yet been fulfilled...

..84 +/- 2.04, P = 0.0008) as was the number of megakaryocytes. We recommend assessment of thrombopoiesis on the basis of 20-25 fragment-containing low power fields and that age- and sex-related differences should be considered...

..001). The results show that, in contrast to the PT(ST), all three tested commercial prothrombin time variants are suitable for the detection of deficiencies of coagulation factors II, VII, and X in canine plasma...

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..Immunocytochemical techniques are a potentially valuable diagnostic tool to support cytologic diagnosis in dogs. However, detailed studies of staining patterns and intensity in cytologic specimens of mesenchymal tumor types are lacking...

..45 and 2.87. The accurate cytological examination of bone marrow based on the reference ranges presented in this study requires preparation of high-quality bone marrow films with minimal blood contamination...

..0001) will limit the clinical application of the analyser...

..The results of this study indicate the importance of selecting a sensitive reagent and method for PT measurement and for careful interpretation of PT test results using canine plasma...

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..819; FDP Y, rS = 0.795; FDP D, rS = 0.764). The results indicate that RTG is a useful screening test for the detection of increased FDP concentrations...

..In contrast, maximum aggregation was increased in uraemic patients compared to reference values using low concentrations of all three agonists (ADP: 1 micromol/L, collagen: 1 microg/mL, and thrombin: 0.1, 0.2 IU/mL)...

..Remarkable alterations of fibrin generation as measured by the resonance thrombograph are a rare condition in dogs with acute accidental trauma...

..In conclusion, standardisation to reduce inter-batch variability seems unnecessary for the studied reagents. Possibilities for PT standardisation in order to achieve a reagent-independent result are limited...

..Consequently, the use of rhG-CSF in the treatment of dogs with parvoviral enteritis cannot be recommended...

..This was in contrast to group 3. The results of this study indicate that an efficacious interruption of the consumption reaction in cases of severe canine DIC requires high plasma heparin levels...

..Despite the moderately altered platelet aggregation, the lack of change in global primary haemostasis screening tests indicates that dogs with CPSS do not have regularly occurring clinically relevant disorders of primary haemostasis...

..The results of this study illustrate the applicability of commercial APTT test kits as a sensitive screening test of factor VIII:C and IX deficiencies in canine plasma...

..The results demonstrate that for plasma with normal fibrinogen concentration the group tests are only prolonged beyond the reference range at FDP concentrations very rarely found in spontaneous hyperfibrinolysis...

..05). The findings indicate that the analyser is suitable for the investigation of platelet aggregation in dogs and analysis should be performed on hirudin-anticoagulated blood using optimised agonist concentrations...

..The screening tests investigated were not suitable for use in monitoring LMWH treatment of dogs. Assays that use chromogenic substrates are necessary to reliably monitor LMWH plasma concentrations in dogs...

..Functional loss and high percentage of platelets within aggregates which were observed in ovine blood stored at refrigerator temperature have to be considered in blood transfusion in sheep...

..These results show, that blood coagulation tests in general are little or unsuitable for heparin antifactor-Xa activity control...

..Impending embryonic death was not predicted by changes in relaxin concentration, parameters of the fibrinolytic system, or in the perfusion of small uteroplacental vessels...

..05, Friedman-test). The results did not suggest that significant platelet dysfunction was induced by the chemotherapeutic protocol used in the study...

..Flow cytometry is a suitable method for the immunophenotypic analysis of canine lymphoma. Contrary to immunohistochemistry, no surgically produced lymph node biopsy is required and the results are available within a few hours...

..Cytology of these lesions revealed a malignant tumour prompting euthanasia of the dog. Histopathology confirmed the cytological diagnosis and a final diagnosis of a glioblastoma multiforme was made based on immunohistochemistry...

..The study indicated the value of immunocytological labelling for the detection of metastases in cytological specimens of canine lymph node preparations...

..A significant alteration of fibrin generation induced by FDPs may not occur until the serum FDP concentration exceeds 60 mg/l...

..Differences in activities between human and canine plasma and nonparallelism of the standard curves emphasize the necessity for use of species-specific standard curves for accurate determination of coagulation factor activity...

..The results indicate that measurement of anti-FXa activity with chromogenic substrates is the method of choice to control LMWH therapy in dogs, as is the case in humans...

..If FDP X was added, fibrinogen values were also overestimated with the Jacobsson method. Our results demonstrate that the photometric method is the most accurate...

..Thus, long-term dopamine-2 receptor agonistic treatment may lead to a hypothyroid condition in castrated male dogs...

..The authors conclude that cytological and immunocytological examination of bone marrow aspirates should be used more frequently for the detection of distant metastases of carcinomas in small animal medicine...

..The results indicate that adequate sensitivity of PT measurements in equine plasma can be achieved using a standard test procedure as long as a suitable reagent is used...

..This may be caused by the species specificity of certain components of the reagents used, as well as a less optimal test system, i.e. relationship of test reagent to clotting factor concentrations in iguana plasma...

..The prolonged euglobulin lysis time, which is indicative of decreased fibrinolytic activity in pregnancy, is thought to be a laboratory artefact caused by increased fibrinogen concentrations...

..For this reason, a phospholipid complex with PF-3 activity cannot be recommended as a therapeutic agent for platelet-dependent coagulation disorders in the dog...

..The results of this study indicate the high frequency of decompensated consumption of haemostatic components in acutely traumatised dogs...

..The low sensitivity of the RTG towards a reduced activity of the haemophilia factors VIII:C and IX contradicts the exclusive use of the RTG for monitoring haemophilic dogs as well as a global screening test for the haemostasis of dogs...

..CLINICAL SIGNIFICANCE: The two anaesthetic protocols investigated in this study did not induce an increased incidence of severe arrhythmias in healthy dogs in the post-anaesthetic phase...

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..Aim of this study was to investigate epidemiologic and diagnostic characteristics of canine non-hematopoietic gastric neoplasia and to evaluate the surgical outcome of selected cases...

..The results of this study suggest that the detected mutation is responsible for a severe form of haemophilia B in Rhodesian Ridgebacks...

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..The case shows that treating renal lymphoma in cats by adequate combination chemotherapy can achieve long survival times with a good quality of life...

..The specificity of Melan-A was higher compared with S-100. Melan-A, in particular, may be helpful for the cytological diagnosis of canine melanoma...

..As human chromosomes (HSA) 8q and 4q and the canine chromosome (CFA) 13 share high homology, these results suggest that a conserved area on these chromosomes is involved in tumorigenesis in both species...

..However, this cytometry-based assay makes a more objective and standardized detection of canine autoreactive antibodies possible...

..In conclusion short infusion periods of 10 h per day were tolerated by healthy dogs without adverse signs, which could improve practicability of PN also in clinical cases...

..The present case report demonstrates the diagnostic accuracy of computed tomography for the diagnosis of a retrobulbar process of unknown origin...

..The aim of this study was to characterize outcome following surgery and identify independent prognostic factors in canine mammary tumors...

..Measurement of concentrations of acute-phase proteins (APPs) is used as an aid in the diagnosis of a variety of diseases in animals...

..To the authors' knowledge, this is the first case of recurrent bilateral exophthalmos associated with a metastatic thymic carcinoma in a pet rabbit...

..Cardiopulmonary effects and the influence on haematological and biochemical blood parameters were evaluated...

..The results of the studies on storage indicated nearly identical recommendations for storage time before measurement of canine (0.5-2 hours) and human (0.5-3 hours) sample material...

..As a comparison a second recording was performed on the 5th post-operative day. The recorded number of arrhythmias was low and no statistical difference was demonstrated between the 2 patient groups...

..Although many tissue characterizing strategies have been defined, no valid test for thrombogenicity exists. Here we introduce a novel concept for thrombogenicity testing of vascular implants..

..Canine leishmaniasis (CanL) is a common cause of epistaxis in dogs residing in endemic areas. The pathogenesis of CanL-associated epistaxis has not been fully explored because of the limited number of cases reported so far...