Karl Mischke

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint Dilatation of the pulmonary veins in atrial fibrillation: a transesophageal echocardiographic evaluation
    Christian Knackstedt
    Technical University RWTH Aachen, Department of Cardiology, Aachen, Germany
    Pacing Clin Electrophysiol 26:1371-8. 2003
  2. pmc Anticoagulant and antiplatelet therapy in patients with atrial fibrillation and coronary artery disease
    Karl Mischke
    Department of Cardiology, Pneumology, Angiology and Intensive Care Medicine, University Hospital, RWTH Aachen University, 52072 Aachen, Germany
    Thrombosis 2012:184573. 2012
  3. pmc Rate control in atrial fibrillation by cooling: effect of temperature on dromotropy in perfused rabbit hearts
    Karl Mischke
    Department of Cardiology, University Hospital, RWTH Aachen University, Pauwelsstrase 30, 52074 Aachen, Germany
    Cardiol Res Pract 2011:162984. 2011
  4. ncbi request reprint Insights into atrial fibrillation
    K Mischke
    Department of Cardiology, Pneumology Angiology and Intensive Care Medicine University Hospital, RWTH Aachen University Aachen, Germany
    Minerva Med 104:119-30. 2013
  5. ncbi request reprint Potential benefit of transesophageal defibrillation: an experimental evaluation
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, 52074 Aachen, Germany
    Am J Emerg Med 24:418-22. 2006
  6. doi request reprint Efficacy of transesophageal defibrillation in ventricular fibrillation of long duration
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, 52074 Aachen, Germany
    Am J Emerg Med 26:287-90. 2008
  7. ncbi request reprint Initial experience with remote magnetic navigation for left ventricular lead placement
    Karl Mischke
    Department of Cardiology, Department of Cardiothoracic Surgery, RWTH Aachen University, Aachen, Germany
    Acta Cardiol 64:467-75. 2009
  8. ncbi request reprint Telephonic transmission of 12-lead electrocardiograms during acute myocardial infarction
    K Mischke
    Department of Cardiology, University Hospital, RWTH Aachen University, Aachen, Germany
    J Telemed Telecare 11:185-90. 2005
  9. ncbi request reprint [Cardiogenic shock in a 61 year old female with recurrent panic attacks]
    K Mischke
    Medizinische Klinik I, Universitatsklinikum Aachen
    Internist (Berl) 46:580-5. 2005
  10. ncbi request reprint Electrical remodelling in cardiac resynchronization therapy: decrease in intrinsic QRS duration
    Karl Mischke
    Department of Cardiology, Pneumatology and Angiology, RWTH Aachen University, Germany
    Acta Cardiol 66:175-80. 2011

Detail Information

Publications48

  1. ncbi request reprint Dilatation of the pulmonary veins in atrial fibrillation: a transesophageal echocardiographic evaluation
    Christian Knackstedt
    Technical University RWTH Aachen, Department of Cardiology, Aachen, Germany
    Pacing Clin Electrophysiol 26:1371-8. 2003
    ..There is no correlation between LAD and PV diameters. This raises the question whether PV dilatation in patients with AF is a cause or a consequence of AF and whether it may contribute to the development and perpetuation of AF...
  2. pmc Anticoagulant and antiplatelet therapy in patients with atrial fibrillation and coronary artery disease
    Karl Mischke
    Department of Cardiology, Pneumology, Angiology and Intensive Care Medicine, University Hospital, RWTH Aachen University, 52072 Aachen, Germany
    Thrombosis 2012:184573. 2012
    ..This review addresses some of the critical points of the guidelines and discusses potential advantages of new anticoagulants in patients with atrial fibrillation after stent implantation...
  3. pmc Rate control in atrial fibrillation by cooling: effect of temperature on dromotropy in perfused rabbit hearts
    Karl Mischke
    Department of Cardiology, University Hospital, RWTH Aachen University, Pauwelsstrase 30, 52074 Aachen, Germany
    Cardiol Res Pract 2011:162984. 2011
    ..Negative chronotropy and dromotropy induced by moderate cardiac hypothermia might be a feasible therapeutic approach in patients with hemodynamically relevant tachyarrhythmias in a CCU/ICU setting...
  4. ncbi request reprint Insights into atrial fibrillation
    K Mischke
    Department of Cardiology, Pneumology Angiology and Intensive Care Medicine University Hospital, RWTH Aachen University Aachen, Germany
    Minerva Med 104:119-30. 2013
    ..However, challenges remain with respect to lack of specific antidotes and high costs...
  5. ncbi request reprint Potential benefit of transesophageal defibrillation: an experimental evaluation
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, 52074 Aachen, Germany
    Am J Emerg Med 24:418-22. 2006
    ..We assessed the defibrillation threshold (DFT) of transesophageal defibrillation compared with standard transthoracic defibrillation...
  6. doi request reprint Efficacy of transesophageal defibrillation in ventricular fibrillation of long duration
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, 52074 Aachen, Germany
    Am J Emerg Med 26:287-90. 2008
    ..We evaluated the efficacy of transesophageal defibrillation compared with standard transthoracic defibrillation after long episodes of VF...
  7. ncbi request reprint Initial experience with remote magnetic navigation for left ventricular lead placement
    Karl Mischke
    Department of Cardiology, Department of Cardiothoracic Surgery, RWTH Aachen University, Aachen, Germany
    Acta Cardiol 64:467-75. 2009
    ..This system may be used for left ventricular lead placement for cardiac resynchronization therapy (CRT). We sought to evaluate the feasibility and safety of magnetic guidewire navigation for CRT procedures...
  8. ncbi request reprint Telephonic transmission of 12-lead electrocardiograms during acute myocardial infarction
    K Mischke
    Department of Cardiology, University Hospital, RWTH Aachen University, Aachen, Germany
    J Telemed Telecare 11:185-90. 2005
    ....
  9. ncbi request reprint [Cardiogenic shock in a 61 year old female with recurrent panic attacks]
    K Mischke
    Medizinische Klinik I, Universitatsklinikum Aachen
    Internist (Berl) 46:580-5. 2005
    ..In patients with recurrent panic attacks and hypertension a pheochromocytoma should be included in the differential diagnosis...
  10. ncbi request reprint Electrical remodelling in cardiac resynchronization therapy: decrease in intrinsic QRS duration
    Karl Mischke
    Department of Cardiology, Pneumatology and Angiology, RWTH Aachen University, Germany
    Acta Cardiol 66:175-80. 2011
    ..Structural myocardial remodelling due to CRT has been described extensively. We hypothesized that CRT might also induce electrical remodelling, thus decreasing the intrinsic QRS duration...
  11. ncbi request reprint Single-step atrial thrombus exclusion and transesophageal cardioversion in atrial fibrillation
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany
    Expert Rev Med Devices 4:549-57. 2007
    ..This review presents preliminary data on the clinical use of devices for simultaneous transesophageal echocardiography and transesophageal cardioversion...
  12. doi request reprint Rate and irregularity of electrical activation during atrial fibrillation affect myocardial NGF expression via different signalling routes
    Erol Saygili
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    Cell Signal 24:99-105. 2012
    ..Whether this translates into different degrees of NGF expression and possibly neural sympathetic growth in various forms of ventricular rate control during AF remains to be elucidated in further studies...
  13. doi request reprint Augmentation of left ventricular contractility by cardiac sympathetic neural stimulation
    Christian Meyer
    Division of Cardiology, RWTH Aachen University, Aachen, Germany
    Circulation 121:1286-94. 2010
    ..The aim of this study was to identify sympathetic neural structures inside the heart that selectively control left ventricular inotropy and can be accessed by transvenous catheter stimulation...
  14. doi request reprint Chronic augmentation of the parasympathetic tone to the atrioventricular node: a nonthoracotomy neurostimulation technique for ventricular rate control during atrial fibrillation
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    J Cardiovasc Electrophysiol 21:193-9. 2010
    ..We sought to assess the feasibility of chronic parasympathetic stimulation for ventricular rate control during AF with a nonthoracotomy intracardiac neurostimulation approach...
  15. ncbi request reprint Registration of coronary venous anatomy to the site of the latest mechanical contraction
    Christian Knackstedt
    Department of Cardiology, RWTH Aachen University, Germany
    Acta Cardiol 65:161-70. 2010
    ....
  16. ncbi request reprint Simultaneous transesophageal cardioversion and echocardiography: feasibility and safety
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    Heart Rhythm 4:304-7. 2007
    ..Because the TEE probe lies adjacent to the atria, cardioversion using an electrode attached to the TEE probe should allow for immediate low-energy transesophageal cardioversion...
  17. doi request reprint Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial fibrillation
    Christian Knackstedt
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    Cardiovasc Pathol 17:318-24. 2008
    ..To investigate the effect of AF and CHF on atrial dilatation and fibrosis, and to estimate whether echocardiographically determined atrial size may be used as a marker for atrial fibrosis...
  18. ncbi request reprint Semi-automated 3-dimensional intracardiac echocardiography: development and initial clinical experience of a new system to guide ablation procedures
    Christian Knackstedt
    Department of Cardiology, RWTH University Aachen, Aachen, Germany
    Heart Rhythm 3:1453-9. 2006
    ..However, updates of 3D-imaging modalities with high soft-tissue contrast are not available during ablation procedures...
  19. doi request reprint Targeting of cardiac autonomic plexus for modulation of intracardiac neural tone
    Christopher Gemein
    Department of Cardiology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Europace 11:1090-6. 2009
    ..This study describes the development of a technique to reliably implant a chronic lead inside the RIGP...
  20. doi request reprint Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway
    Obaida R Rana
    Department of Cardiology, Angiology and Pulmonology, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    J Mol Cell Cardiol 46:568-78. 2009
    ..Nevertheless, the calcineurin-NFAT pathway may provide promising starting points for new pharmacological strategies to prevent SNS in the heart...
  21. doi request reprint Imaging of the coronary venous system: validation of three-dimensional rotational venous angiography against dual-source computed tomography
    Christian Knackstedt
    Department of Cardiology, Pulmonology and Vascular Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Cardiovasc Intervent Radiol 31:1150-8. 2008
    ..On-site 3D visualization might improve decision making during cardiac interventions. In contrast to DSCT, rotational CSA does not demonstrate the anatomy of the mitral annulus or the course of the left circumflex artery...
  22. doi request reprint Beat to beat 3-dimensional intracardiac echocardiography: theoretical approach and practical experiences
    Daniel Stapf
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    Int J Cardiovasc Imaging 29:753-64. 2013
    ..However, shape and dimension of static and moving objects cannot always be displayed with necessary steadiness as needed in the clinical setting. As catheter depiction is also limited, clinical use seems impossible...
  23. doi request reprint Functional and topographic concordance of right atrial neural structures inducing sinus tachycardia
    Christian Eickholt
    Department of Cardiology, Pulmology and Angiology, Medical Faculty, Heinrich Heine University Duesseldorf, 5 Moorenstrasse, 40225, Duesseldorf, Germany
    Adv Exp Med Biol 788:273-82. 2013
    ..In conclusion, our findings suggest a functional and topographic concordance of right atrial neural structures inducing sinus tachycardia. This might open up new avenues in the treatment of heart rate related disorders. ..
  24. ncbi request reprint [Morphology and function of the intrinsic cardiac nervous system]
    Patrick Schauerte
    Medizinische Klinik I, Universitätsklinikum der RWTH, Aachen
    Herz 31:96-100. 2006
    ..The present article provides examples of this new technique in acute and chronic models but also first human applications...
  25. ncbi request reprint Imaging of the coronary venous system: retrograde coronary sinus angiography versus venous phase coronary angiograms
    Karl Mischke
    Department of Cardiology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Int J Cardiol 119:339-43. 2007
    ..The aim of this study was to assess the quality of venous phase coronary sinus angiography...
  26. ncbi request reprint Postfibrillatory enhancement of left atrial contractility after short paroxysms of atrial fibrillation
    Markus Zarse
    Department of Cardiology, University Hospital Aachen, Aachen, Germany
    Pacing Clin Electrophysiol 27:579-85. 2004
    ..The observed phenomenon seems to be related to an increased Ca(2+) influx through the L-type Ca(2+) channel...
  27. ncbi request reprint Selective increase of cardiac neuronal sympathetic tone: a catheter-based access to modulate left ventricular contractility
    Markus Zarse
    Department of Cardiology, University of Technology, Aachen, Germany
    J Am Coll Cardiol 46:1354-9. 2005
    ..This study was designed to develop a technique to selectively increase the sympathetic tone to the heart by cardiac sympathetic nerve stimulation (SNS)...
  28. doi request reprint Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes
    Erol Saygili
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    Biochem Biophys Res Commun 413:432-5. 2011
    ..Thus, we aimed to investigate the expression of catecholamine-synthesizing enzymes by ICA cells exposed to irregular pacing...
  29. doi request reprint Chronic electrical neuronal stimulation increases cardiac parasympathetic tone by eliciting neurotrophic effects
    Obaida R Rana
    Department of Cardiology, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    Circ Res 108:1209-19. 2011
    ..In these experiments, we observed a decrease of the intrinsic ventricular rate during the first 4 to 5 months when HFES was intermittently shut off...
  30. doi request reprint Video-assisted pericardioscopic surgery for epimyocardial lead implantation
    Nima Hatam
    Department of Cardiovascular and Thoracic Surgery, University Hospital, Medical Faculty RWTH Aachen, Aachen, Germany
    Ann Thorac Surg 96:293-6. 2013
    ..We evaluated the employment of a newly developed trocar for pericardioscopy with regard to long-term effects and feasibility of reoperation...
  31. doi request reprint Integration of automatic intrathoracic fluid content measurement into clinical decision making in patients with congestive heart failure
    Christian Knackstedt
    Medical Clinic I, RWTH Aachen University, Aachen, Germany
    Pacing Clin Electrophysiol 31:961-7. 2008
    ..An acoustic alert might allow an earlier treatment of impending decompensation. An algorithm that implemented impedance measurement into clinical decision making in treating CHF patients was evaluated...
  32. doi request reprint Imaging of the coronary venous system in patients with congestive heart failure: comparison of 16 slice MSCT and retrograde coronary sinus venography: comparative imaging of coronary venous system
    Christian Knackstedt
    Department of Cardiology, Pneumology, Vascular Medicine, University Hospital, RWTH Aachen University, Aachen, Germany
    Int J Cardiovasc Imaging 24:783-91. 2008
    ..Thus, a comparison of retrograde CSA and ECG-gated MSCT for the visualization of the CVS in patients with congestive heart failure (CHF) was performed...
  33. ncbi request reprint Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation
    Felix Gramley
    Department of Cardiology, Technical University Aachen, Aachen, Germany
    J Cardiovasc Electrophysiol 18:1076-82. 2007
    ..Besides the angiotensin system, the matrix metalloproteinases (MMP) play a major role in the pathogenesis of fibrosis. Thus, the present study investigated changes of the MMP system during the development of human AF...
  34. ncbi request reprint Comparison of left ventricular lead placement via the coronary venous approach versus lateral thoracotomy in patients receiving cardiac resynchronization therapy
    Ralf Koos
    Department of Cardiology, University of Technology, Aachen, Germany
    Am J Cardiol 94:59-63. 2004
    ..Hospitalization was longer, increase in functional capacity smaller, and mortality at 1-year follow-up higher, which were potentially related to a more anterior lead position. Therefore, CV leads are preferable to LLT leads...
  35. doi request reprint Super-selective electrical stimulation of the left ventricle via a miniaturized magnetized stimulation wire: proof of concept study
    Christian Knackstedt
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    Biomed Tech (Berl) 55:285-90. 2010
    ..75±0.7 ms. The MSW could be navigated into small CVS branches with reasonable MN properties. This could allow stimulation at CVS sites currently not accessible for conventional stimulation catheters or electrodes...
  36. doi request reprint The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytes
    Erol Saygili
    Dept of Cardiology, Medical Clinic I, University Hospital Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Basic Res Cardiol 104:435-48. 2009
    ....
  37. ncbi request reprint A simple device to apply equibiaxial strain to cells cultured on flexible membranes
    Obaida R Rana
    Univ Hospital RWTH Aachen, Dept I of Internal Medicine, Division of Cardiology, Pulmonary and Vascular Diseases, Pauwelsstrasse 30, Aachen, Germany
    Am J Physiol Heart Circ Physiol 294:H532-40. 2008
    ..The simple and low-cost device presented here might be applied to a wide range of experimental settings in different fields of research...
  38. doi request reprint Video-assisted pericardioscopic surgery: refinement of a new technique for implanting epimyocardial pacemaker leads
    Nima Hatam
    Department of Cardiovascular and Thoracic Surgery, Medical Faculty RWTH Aachen, Aachen, Germany
    Eur J Cardiothorac Surg 39:335-41. 2011
    ..Our main goal was to compare rigid and flexible endoscopy and to establish a standardised protocol for the implementation of a closed-chest subxiphoid approach for epimyocardial lead implantation...
  39. doi request reprint Development of an item bank for the assessment of depression in persons with mental illnesses and physical diseases using Rasch analysis
    Thomas Forkmann
    Institute of Medical Psychology and Medical Sociology, University Hospital of RWTH Aachen Germany
    Rehabil Psychol 54:186-97. 2009
    ..The present study aimed at developing a new item bank that allows for assessing depression in persons with mental and persons with somatic diseases...
  40. ncbi request reprint The role of intracardiac echocardiography in interventional electrophysiology
    C Knackstedt
    Department of Cardiology, RWTH University Aachen, Aachen, Germany
    Minerva Cardioangiol 55:755-70. 2007
    ..Even more, new therapy strategies have been evaluated based on ICE and it has also been used in the setting of three- dimensional imaging and image integration...
  41. doi request reprint Development and validation of the Rasch-based Depression Screening (DESC) using Rasch analysis and structural equation modelling
    Thomas Forkmann
    Institute of Medical Psychology and Medical Sociology, University Hospital of the RWTH Aachen University, Aachen, Germany
    J Behav Ther Exp Psychiatry 40:468-78. 2009
    ..Cut-off scores with good sensitivity and specificity were developed using ROC analyses. Results suggest that DESC may be appropriately used to screen for depression and may be beneficial for repeated measurements...
  42. ncbi request reprint Evidence of sinoatrial block as a curative mechanism in radiofrequency current ablation of inappropriate sinus tachycardia
    K Mischke
    Department of Cardiology and Internal Medicine, University of Technology, Aachen, Germany
    J Cardiovasc Electrophysiol 12:264-7. 2001
    ..We report a case of a patient with drug-resistant inappropriate sinus tachycardia in whom successful treatment of the arrhythmia was achieved by documented sinoatrial exit block induced by radiofrequency current applications...
  43. ncbi request reprint Spatial features in body surface potential maps of patients with ventricular tachyarrhythmias with or without coronary artery disease
    C Stellbrink
    Department of Cardiology, University of Technology, Aachen, Germany
    Int J Cardiol 70:109-18. 1999
    ..However, our results do not suggest a major impact of QT/QTc dispersion or QRST integral mapping for identification of ventricular fibrillation patients with coronary artery disease...
  44. ncbi request reprint Catheter stimulation of cardiac parasympathetic nerves in humans: a novel approach to the cardiac autonomic nervous system
    P Schauerte
    Technical University RWTH Aachen, Department of Cardiology, Aachen, Germany
    Circulation 104:2430-5. 2001
    ..Using this technique, we investigated for the first time whether neurophysiological effects similar to those in animals can be obtained in humans...
  45. ncbi request reprint Single-step atrial thrombus exclusion and internal cardioversion of atrial fibrillation via a transesophageal echocardiography probe
    Thomas Schimpf
    J Am Coll Cardiol 46:560-1. 2005
  46. ncbi request reprint Ventricular fibrillation due to severe mitral valve prolapse
    Christian Knackstedt
    Int J Cardiol 116:e101-2. 2007
    ..This case presents a patient who was admitted after cardiac resuscitation due to ventricular fibrillation. A severe mitral valve prolapse was the only pathology found...
  47. ncbi request reprint Paired ventricular stimulation: an approach for hemodynamic stabilization during ventricular tachycardia
    Karl Mischke
    J Am Coll Cardiol 47:2337-9. 2006
  48. ncbi request reprint Pacemaker with 2:1 hyperkalemic ventricular exit block
    Karl Mischke
    Int J Cardiol 116:117-9. 2007