Research Topics
Genomes and Genes | Karin Milde-LangoschSummaryAffiliation: University of Hamburg Country: Germany Publications
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Publications
Expression pattern of the CCAAT/enhancer-binding proteins C/EBP-alpha, C/EBP-beta and C/EBP-delta in the human placentaAna Maria Bamberger
Department of Gynecopathology, Institute of Pathology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
Virchows Arch 444:149-52. 2004....
Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primatesRichard Ivell
Institute for Hormone and Fertility Research at the University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
Reprod Biol Endocrinol 1:114. 2003....
Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancerLinn Woelber
Department of Gynecology and Gynecologic Oncology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
BMC Cancer 11:12. 2011..The protein is overexpressed in a variety of tumors and potentially associated with negative outcome. This study was designed to investigate the prognostic role of CAIX in serum and tumor tissue of patients with primary cervical cancer...- Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancerK Milde-Langosch
Institute of Gynecopathology, University Clinics Hamburg Eppendorf UKE, Martinistr 52, Hamburg D 20246, Germany
Br J Cancer 92:2206-15. 2005.... - The Fos family of transcription factors and their role in tumourigenesisKarin Milde-Langosch
Institute of Pathology, University Clinics Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
Eur J Cancer 41:2449-61. 2005..Knowledge about regulation of invasion and metastasis in different malignant tumours in vivo might open promising perspectives to targeted therapeutic approaches... - Role of Fra-2 in breast cancer: influence on tumor cell invasion and motilityKarin Milde-Langosch
Clinic of Gynecology, University Clinics Hamburg Eppendorf UKE, Martinistr 52, Hamburg 20246, Germany
Breast Cancer Res Treat 107:337-47. 2008..e., members of the MAGE family, S100P, TIMP2, IL24 etc. These results show that Fra-2 overexpression is associated with a more aggressive tumor phenotype and is probably involved in breast cancer progression in vivo... - Role of cell-cycle regulatory proteins in gynecological cancerKarin Milde-Langosch
Institute of Pathology, Department of Gynecopathology, University Clinics Hamburg Eppendorf, Hamburg, Germany
J Cell Physiol 196:224-44. 2003..For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described... - Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteinsKarin Milde-Langosch
Institute of Pathology, Department of Gynecopathology, University Hospital Hamburg Eppendorf UKE, Hamburg, Germany
Breast Cancer Res Treat 79:175-85. 2003..These results suggest that high C/EBPbeta expression might be involved in tumor progression and indicative of an unfavorable prognosis... - FosB is highly expressed in normal mammary epithelia, but down-regulated in poorly differentiated breast carcinomasKarin Milde-Langosch
Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
Breast Cancer Res Treat 77:265-75. 2003.... - The role of the AP-1 transcription factors c-Fos, FosB, Fra-1 and Fra-2 in the invasion process of mammary carcinomasKarin Milde-Langosch
Department of Gynecopathology, Institute of Pathology, University Clinics Hamburg Eppendorf UKE, Hamburg, Germany
Breast Cancer Res Treat 86:139-52. 2004..These data indicate that Fos proteins, especially Fra-1, c-Fos and Fra-2, might be involved in invasion of breast cancer cells... - Expression of cell cycle-regulatory proteins rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: correlations with expression of activating protein-1 family membersK Milde-Langosch
Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
Int J Cancer 87:468-72. 2000..In addition, our data suggest differential regulation of cell cycle-stimulating and -inhibiting factors depending on the abundance of single AP-1 family members... - Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomasK Milde-Langosch
Institute of Pathology, Department of Gynecopathology, University Hospital Eppendorf, Hamburg, Germany
Virchows Arch 439:55-61. 2001..In contrast, absent or low p16, p21, and p27 immunostaining was observed in most HPV-negative cervical adenocarcinomas and might contribute to carcinogenesis in these tumors... - Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotypeK Milde-Langosch
Institute of Pathology, Department of Gynecopathology, University Hospital Eppendorf, Hamburg, Germany
Breast Cancer Res Treat 67:61-70. 2001..We conclude that high p16 reactivity (both nuclear andcytoplasmic) is indicative of a more undifferentiated, malignant phenotype in mammary carcinomas... - Expression of cell-cycle regulatory proteins in endometrial carcinomas: correlations with hormone receptor status and clinicopathologic parametersK Milde-Langosch
Department of Gynecopathology, Institute of Pathology, University Hospital Hamburg Eppendorf, Germany
J Cancer Res Clin Oncol 127:537-44. 2001..As this tightly controlled system is disturbed in endometrial carcinomas, we analyzed which cell-cycle regulators are involved in endometrial carcinogenesis... 
Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissueSibyll Hein
Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Breast Cancer Res Treat 129:347-60. 2011..048) and overall survival (OAS, P=0.003). Our results indicate that the biologic role of ALCAM in breast cancer is complex, but overexpression might be relevant for outcome in ductal carcinomas...- Expression and prognostic value of L1-CAM in breast cancerChristine Schröder
Department of Gynecology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
Oncol Rep 22:1109-17. 2009..Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well... - Expression and prognostic value of the cell-cycle regulatory proteins, Rb, p16MTS1, p21WAF1, p27KIP1, cyclin E, and cyclin D2, in ovarian cancerKarin Milde-Langosch
Institute of Pathology, Department of Gynecopathology, University-Hospital Hamburg-Eppendorf (UKE, Hamburg, Germany
Int J Gynecol Pathol 22:168-74. 2003..In addition, trends pointing to an association of higher age (p=0.067) and positive cyclin E immunoreactivity (p=0.093) with an unfavorable prognosis were observed... - Prognostic value of intercellular adhesion molecule (ICAM)-1 expression in breast cancerChristine Schröder
Department of Anatomy, University Medical Centre Hamburg Eppendorf UKE, Martinistr 52, 20246 Hamburg, Germany
J Cancer Res Clin Oncol 137:1193-201. 2011..Yet, little is known about the role of ICAM-1 expression during malignant progression in breast cancer patients... - Serum carbonic anhydrase IX during first-line therapy of ovarian cancerLinn Woelber
Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Gynecol Oncol 117:183-8. 2010..It is overexpressed in a variety of tumors including ovarian cancer. To evaluate the potential prognostic and predictive role of serum CAIX for therapy response in ovarian cancer, we analyzed longitudinal serum samples... - Influence of L1-CAM expression of breast cancer cells on adhesion to endothelial cellsVirginia Dippel
Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, Bldg N27, 20246 Hamburg, Germany
J Cancer Res Clin Oncol 139:107-21. 2013..Here, we investigated whether L1-CAM expression of breast cancer cells might influence adherence to human pulmonary microvascular endothelial cells (HPMEC) and thus promote metastasis... - Detection of activated leukocyte cell adhesion molecule in the serum of breast cancer patients and implications for prognosisIsabell Witzel
Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Oncology 82:305-12. 2012..Conflicting results have been reported about activated leukocyte cell adhesion molecule (ALCAM) expression in breast cancer and its prognostic value. Little is known about the role of ALCAM levels in the serum of breast cancer patients... - Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patientsMaike Ihnen
Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
BMC Cancer 12:140. 2012..In some cancers ALCAM has a prognostic value or is predictive for the benefit of therapeutic interventions. To date there are no data on the role of ALCAM in cervical cancer available... - Expression of the adhesion molecule CEACAM1 (CD66a, BGP, C-CAM) in breast cancer is associated with the expression of the tumor-suppressor genes Rb, Rb2, and p27Ana Maria Bamberger
Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
Virchows Arch 440:139-44. 2002..These results indicate the possibility of a functional link between cell-adhesion molecules and cell-cycle regulation that might play an important role in the development of mammary carcinomas... - Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell linesSibyll Hein
Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Oncol Rep 22:177-83. 2009..No correlation with the proliferative and invasive potential of ovarian cancer cell lines could be found... - Expression and prognostic value of activating transcription factor 2 (ATF2) and its phosphorylated form in mammary carcinomasStefan Knippen
Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Anticancer Res 29:183-9. 2009..The transcription factor ATF2 is overexpressed in various tumors, but its role in breast cancer is still not understood... - Expression pattern of the activating protein-1 family of transcription factors in the human placentaAna Maria Bamberger
Institute of Pathology, Department of Gynaecopathology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Mol Hum Reprod 10:223-8. 2004.... - Serum carbonic anhydrase IX and its prognostic relevance in vulvar cancerLilli Kock
Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int J Gynecol Cancer 21:141-8. 2011..We therefore determined CAIX serum concentration and its prognostic relevance in correlation to intratumoral CAIX expression in patients with primary vulvar cancer... - Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patientsNicolaus Kroger
Department of Bone Marrow Transplantation, Transplant Center, Hamburg Eppendorf, Hamburg, Germany
Clin Cancer Res 12:159-68. 2006..To analyze prognostic and predictive effects of immunohistochemical factors within a randomized study of high-dose versus standard-dose chemotherapy in high-risk breast cancer with >10 involved lymph nodes... - Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomasJuliane Briese
Section on Endocrinology and Metabolism of Ageing, University Clinic Hamburg Eppendorf, Hamburg, Germany
Virchows Arch 453:89-96. 2008..In conclusion, KAI-1 and p53 show inverse expression. The reduced KAI-1 expression may be the result of dysregulated p53 function and could be an important step in the endometrial carcinogenesis... - The transcription factor Fra-2 promotes mammary tumour progression by changing the adhesive properties of breast cancer cellsChristine Schröder
Department of Gynecology, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
Eur J Cancer 46:1650-60. 2010.... - Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulatorsA M Bamberger
Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
J Cancer Res Clin Oncol 127:545-50. 2001..To study the expression pattern and the role of the AP-1 (activating protein-1) family of transcription factors in endometrial carcinogenesis... - Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasiaA M Bamberger
Institute of Pathology, Department for Gynaecopathology, University Hospital Eppendorf, Hamburg, Germany
Virchows Arch 434:423-8. 1999..It thus seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis... - Predictive impact of activated leukocyte cell adhesion molecule (ALCAM/CD166) in breast cancerM Ihnen
Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Breast Cancer Res Treat 112:419-27. 2008..001 for OAS). Our overall results reveal that high ALCAM expression levels in primary tumors might be a suitable marker for prediction of the response to adjuvant chemotherapy in breast cancer... - Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skinMaike Ihnen
Department of Gynaecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Clin Pathol 64:146-52. 2011..Therefore this study focuses on analysing the distribution of ALCAM and CEACAM6 protein expression in breast cancer metastases from different sites... - Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patientsHeidi Schwarzenbach
Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
Breast Cancer Res Treat 134:933-41. 2012..Since PTEN is an important target gene of miR-214, this finding could also have potential implications for therapeutic approaches... - Clinical significance of p53 alterations in surgically treated prostate cancersThorsten Schlomm
Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
Mod Pathol 21:1371-8. 2008..The rate of p53 alterations increases with prostate cancer progression... - Frequent p16/MTS1 inactivation in early stages of urothelial carcinoma of the bladder is not associated with tumor recurrenceM G Friedrich
Department of Urology, University of Hamburg, University Hospital Eppendorf, Germany
Eur Urol 40:518-24. 2001..We investigated 40 patients with Ta, T1 TCC of the bladder for p16 alterations (mutations, homozygote deletions, allelic loss) or reduced p16 immunoreaction... - Vitamin B6 modulates glucocorticoid-dependent gene transcription in a promoter- and cell type-specific mannerC M Bamberger
Department of Medicine I, University Hospital Hamburg Eppendorf, Hamburg, Germany
Exp Clin Endocrinol Diabetes 112:595-600. 2004.... - Combination of osteopontin and activated leukocyte cell adhesion molecule as potent prognostic discriminators in HER2- and ER-negative breast cancerM Ihnen
Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, Hamburg D 20246, Germany
Br J Cancer 103:1048-56. 2010..To analyse the discriminative impact of osteopontin (OPN) and activated leukocyte cell adhesion molecule (ALCAM), combined with human epidermal growth factor 2 (HER2) and oestrogen receptor (ER) in breast cancer... - Expression levels of Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) in primary breast carcinoma and distant breast cancer metastasesM Ihnen
Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
Dis Markers 28:71-8. 2010.... - C-Fos expression is a molecular predictor of progression and survival in epithelial ovarian carcinomaS Mahner
Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Br J Cancer 99:1269-75. 2008..These results are in contrast to the classic concept of c-Fos as an oncogene, but are supported by the recently discovered tumour-suppressing and proapoptotic function of c-Fos in various cancer types... - Validity of the proliferation markers Ki67, TOP2A, and RacGAP1 in molecular subgroups of breast cancerKarin Milde-Langosch
Department of Gynecology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Breast Cancer Res Treat 137:57-67. 2013..These data point to subtype-specific differences in the relevance of proliferation-associated genes, and RacGAP1 might be a strong prognostic and predictive marker in the luminal subgroup... - Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastasesHarriet Wikman
Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
PLoS ONE 7:e47537. 2012..In conclusion, we found loss at 11p15 to be a marker for TNBC primary tumors and BCBM and PRKCDBP to be a potential target gene in this locus... - TIMP-1 and VEGF-165 serum concentration during first-line therapy of ovarian cancer patientsSven Mahner
Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
BMC Cancer 10:139. 2010..The application of serum TIMP-1 and VEGF to monitor primary therapy and predict clinical outcome of patients with ovarian cancer is unclear... - Expression pattern of the cell cycle promoter cyclin e in benign extravillous trophoblast and gestational trophoblastic lesions: correlation with expression of Ki-67Ana-Maria Bamberger
Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
Int J Gynecol Pathol 22:156-61. 2003.... - Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast diseaseHeidi Schwarzenbach
Department of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, Hamburg, Germany
Mol Biosyst 7:2848-54. 2011..In conclusion, the quantification of cell-free tumour DNA had diagnostic and prognostic values in breast cancer patients, and DNA loss at the region 13q31-33 may be an indication of lymphatic tumour cell spread... - Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patientsJ Panse
Department of Oncology Hematology, Center of Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
Br J Cancer 99:930-8. 2008.... - Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patientsNadia Harbeck
Department of Obstetrics and Gynecology and Pathology, Technical University of Munich, Munich, Germany
J Clin Oncol 26:5036-42. 2008.... - Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cellsJasmin Fahnenstich
IHF Institute for Hormone and Fertility Research, University of Hamburg, 20251 Hamburg, Germany
Mol Hum Reprod 9:611-23. 2003..In contrast, co-transfection of c-jun and c-fos expression vectors resulted in stimulation of reporter gene activity, indicating an involvement of AP-1 transcription factors in PLZF expression... - Wild-type p53 protein is up-regulated upon cyclic adenosine monophosphate-induced differentiation of human endometrial stromal cellsYvonne Pohnke
Institute for Hormone and Fertility Research, University of Hamburg, Germany
J Clin Endocrinol Metab 89:5233-44. 2004..The observation that p53 protein expression is closely associated with decidual transformation indicates a novel role for this tumor suppressor in regulating human endometrial function... - Ulex europeus agglutinin-I binding as a potential prognostic marker in ovarian cancerKatharina Blonski
Department of Anatomy II Experimental Morphology, University Medical Center Hamburg Eppendorf 20246 Hamburg, Germany
Anticancer Res 27:2785-90. 2007..Changes in the glycosylation of the cell membrane, as detected by lectin histochemistry, are sometimes associated with a poor prognosis...