Karin Milde-Langosch

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Expression pattern of the CCAAT/enhancer-binding proteins C/EBP-alpha, C/EBP-beta and C/EBP-delta in the human placenta
    Ana Maria Bamberger
    Department of Gynecopathology, Institute of Pathology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Virchows Arch 444:149-52. 2004
  2. ncbi request reprint The role of the AP-1 transcription factors c-Fos, FosB, Fra-1 and Fra-2 in the invasion process of mammary carcinomas
    Karin Milde-Langosch
    Department of Gynecopathology, Institute of Pathology, University Clinics Hamburg Eppendorf UKE, Hamburg, Germany
    Breast Cancer Res Treat 86:139-52. 2004
  3. pmc Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates
    Richard Ivell
    Institute for Hormone and Fertility Research at the University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Reprod Biol Endocrinol 1:114. 2003
  4. pmc Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer
    Linn Woelber
    Department of Gynecology and Gynecologic Oncology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    BMC Cancer 11:12. 2011
  5. pmc Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer
    K Milde-Langosch
    Institute of Gynecopathology, University Clinics Hamburg Eppendorf UKE, Martinistr 52, Hamburg D 20246, Germany
    Br J Cancer 92:2206-15. 2005
  6. ncbi request reprint The Fos family of transcription factors and their role in tumourigenesis
    Karin Milde-Langosch
    Institute of Pathology, University Clinics Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cancer 41:2449-61. 2005
  7. ncbi request reprint Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins
    Karin Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Hospital Hamburg Eppendorf UKE, Hamburg, Germany
    Breast Cancer Res Treat 79:175-85. 2003
  8. ncbi request reprint Role of cell-cycle regulatory proteins in gynecological cancer
    Karin Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Clinics Hamburg Eppendorf, Hamburg, Germany
    J Cell Physiol 196:224-44. 2003
  9. ncbi request reprint Role of Fra-2 in breast cancer: influence on tumor cell invasion and motility
    Karin Milde-Langosch
    Clinic of Gynecology, University Clinics Hamburg Eppendorf UKE, Martinistr 52, Hamburg 20246, Germany
    Breast Cancer Res Treat 107:337-47. 2008
  10. ncbi request reprint FosB is highly expressed in normal mammary epithelia, but down-regulated in poorly differentiated breast carcinomas
    Karin Milde-Langosch
    Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
    Breast Cancer Res Treat 77:265-75. 2003

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Expression pattern of the CCAAT/enhancer-binding proteins C/EBP-alpha, C/EBP-beta and C/EBP-delta in the human placenta
    Ana Maria Bamberger
    Department of Gynecopathology, Institute of Pathology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Virchows Arch 444:149-52. 2004
    ....
  2. ncbi request reprint The role of the AP-1 transcription factors c-Fos, FosB, Fra-1 and Fra-2 in the invasion process of mammary carcinomas
    Karin Milde-Langosch
    Department of Gynecopathology, Institute of Pathology, University Clinics Hamburg Eppendorf UKE, Hamburg, Germany
    Breast Cancer Res Treat 86:139-52. 2004
    ..These data indicate that Fos proteins, especially Fra-1, c-Fos and Fra-2, might be involved in invasion of breast cancer cells...
  3. pmc Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates
    Richard Ivell
    Institute for Hormone and Fertility Research at the University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Reprod Biol Endocrinol 1:114. 2003
    ....
  4. pmc Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer
    Linn Woelber
    Department of Gynecology and Gynecologic Oncology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    BMC Cancer 11:12. 2011
    ..The protein is overexpressed in a variety of tumors and potentially associated with negative outcome. This study was designed to investigate the prognostic role of CAIX in serum and tumor tissue of patients with primary cervical cancer...
  5. pmc Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer
    K Milde-Langosch
    Institute of Gynecopathology, University Clinics Hamburg Eppendorf UKE, Martinistr 52, Hamburg D 20246, Germany
    Br J Cancer 92:2206-15. 2005
    ....
  6. ncbi request reprint The Fos family of transcription factors and their role in tumourigenesis
    Karin Milde-Langosch
    Institute of Pathology, University Clinics Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cancer 41:2449-61. 2005
    ..Knowledge about regulation of invasion and metastasis in different malignant tumours in vivo might open promising perspectives to targeted therapeutic approaches...
  7. ncbi request reprint Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins
    Karin Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Hospital Hamburg Eppendorf UKE, Hamburg, Germany
    Breast Cancer Res Treat 79:175-85. 2003
    ..These results suggest that high C/EBPbeta expression might be involved in tumor progression and indicative of an unfavorable prognosis...
  8. ncbi request reprint Role of cell-cycle regulatory proteins in gynecological cancer
    Karin Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Clinics Hamburg Eppendorf, Hamburg, Germany
    J Cell Physiol 196:224-44. 2003
    ..For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described...
  9. ncbi request reprint Role of Fra-2 in breast cancer: influence on tumor cell invasion and motility
    Karin Milde-Langosch
    Clinic of Gynecology, University Clinics Hamburg Eppendorf UKE, Martinistr 52, Hamburg 20246, Germany
    Breast Cancer Res Treat 107:337-47. 2008
    ..e., members of the MAGE family, S100P, TIMP2, IL24 etc. These results show that Fra-2 overexpression is associated with a more aggressive tumor phenotype and is probably involved in breast cancer progression in vivo...
  10. ncbi request reprint FosB is highly expressed in normal mammary epithelia, but down-regulated in poorly differentiated breast carcinomas
    Karin Milde-Langosch
    Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
    Breast Cancer Res Treat 77:265-75. 2003
    ....
  11. ncbi request reprint Expression of cell-cycle regulatory proteins in endometrial carcinomas: correlations with hormone receptor status and clinicopathologic parameters
    K Milde-Langosch
    Department of Gynecopathology, Institute of Pathology, University Hospital Hamburg Eppendorf, Germany
    J Cancer Res Clin Oncol 127:537-44. 2001
    ..As this tightly controlled system is disturbed in endometrial carcinomas, we analyzed which cell-cycle regulators are involved in endometrial carcinogenesis...
  12. ncbi request reprint Expression of cell cycle-regulatory proteins rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: correlations with expression of activating protein-1 family members
    K Milde-Langosch
    Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
    Int J Cancer 87:468-72. 2000
    ..In addition, our data suggest differential regulation of cell cycle-stimulating and -inhibiting factors depending on the abundance of single AP-1 family members...
  13. ncbi request reprint Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas
    K Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Hospital Eppendorf, Hamburg, Germany
    Virchows Arch 439:55-61. 2001
    ..In contrast, absent or low p16, p21, and p27 immunostaining was observed in most HPV-negative cervical adenocarcinomas and might contribute to carcinogenesis in these tumors...
  14. ncbi request reprint Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype
    K Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Hospital Eppendorf, Hamburg, Germany
    Breast Cancer Res Treat 67:61-70. 2001
    ..We conclude that high p16 reactivity (both nuclear andcytoplasmic) is indicative of a more undifferentiated, malignant phenotype in mammary carcinomas...
  15. ncbi request reprint Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue
    Sibyll Hein
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Breast Cancer Res Treat 129:347-60. 2011
    ..048) and overall survival (OAS, P=0.003). Our results indicate that the biologic role of ALCAM in breast cancer is complex, but overexpression might be relevant for outcome in ductal carcinomas...
  16. ncbi request reprint Expression and prognostic value of L1-CAM in breast cancer
    Christine Schröder
    Department of Gynecology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Oncol Rep 22:1109-17. 2009
    ..Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well...
  17. ncbi request reprint Expression and prognostic value of the cell-cycle regulatory proteins, Rb, p16MTS1, p21WAF1, p27KIP1, cyclin E, and cyclin D2, in ovarian cancer
    Karin Milde-Langosch
    Institute of Pathology, Department of Gynecopathology, University Hospital Hamburg Eppendorf UKE, Hamburg, Germany
    Int J Gynecol Pathol 22:168-74. 2003
    ..In addition, trends pointing to an association of higher age (p=0.067) and positive cyclin E immunoreactivity (p=0.093) with an unfavorable prognosis were observed...
  18. doi request reprint Prognostic value of intercellular adhesion molecule (ICAM)-1 expression in breast cancer
    Christine Schröder
    Department of Anatomy, University Medical Centre Hamburg Eppendorf UKE, Martinistr 52, 20246 Hamburg, Germany
    J Cancer Res Clin Oncol 137:1193-201. 2011
    ..Yet, little is known about the role of ICAM-1 expression during malignant progression in breast cancer patients...
  19. doi request reprint Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients
    Christine Schröder
    Department of Gynaecology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Cancer Res Clin Oncol 139:1745-55. 2013
    ..However, only limited information about its role in breast cancer is available. The aim of this study was to examine the UCH-L1 expression in primary breast cancer and to determine its relevance as a potential prognostic marker...
  20. doi request reprint Relevance of cellular and serum carbonic anhydrase IX in primary breast cancer
    Dina Schütze
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Cancer Res Clin Oncol 139:747-54. 2013
    ..The aim of this study was to examine the relationships of CAIX mRNA expression and s-CAIX levels with clinicopathological parameters and survival of patients with primary breast cancer...
  21. doi request reprint Influence of L1-CAM expression of breast cancer cells on adhesion to endothelial cells
    Virginia Dippel
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, Bldg N27, 20246 Hamburg, Germany
    J Cancer Res Clin Oncol 139:107-21. 2013
    ..Here, we investigated whether L1-CAM expression of breast cancer cells might influence adherence to human pulmonary microvascular endothelial cells (HPMEC) and thus promote metastasis...
  22. doi request reprint Serum carbonic anhydrase IX during first-line therapy of ovarian cancer
    Linn Woelber
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Gynecol Oncol 117:183-8. 2010
    ..It is overexpressed in a variety of tumors including ovarian cancer. To evaluate the potential prognostic and predictive role of serum CAIX for therapy response in ovarian cancer, we analyzed longitudinal serum samples...
  23. doi request reprint The prognostic significance of Jun transcription factors in ovarian cancer
    Kerstin Eckhoff
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, Bldg N27, 20246, Hamburg, Germany
    J Cancer Res Clin Oncol 139:1673-80. 2013
    ..However, little is known about the prognostic significance of Jun proteins in patients with invasive epithelial ovarian carcinoma...
  24. doi request reprint Androgen receptor expression is a predictive marker in chemotherapy-treated patients with endocrine receptor-positive primary breast cancers
    Isabell Witzel
    Department of Gynecology, University Medical Center, Martinistrasse 52, 20246 Hamburg, Germany
    J Cancer Res Clin Oncol 139:809-16. 2013
    ..The androgen receptor (AR) is intensively discussed as a prognostic and/or predictive marker in breast cancer patients...
  25. doi request reprint Detection of activated leukocyte cell adhesion molecule in the serum of breast cancer patients and implications for prognosis
    Isabell Witzel
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncology 82:305-12. 2012
    ..Conflicting results have been reported about activated leukocyte cell adhesion molecule (ALCAM) expression in breast cancer and its prognostic value. Little is known about the role of ALCAM levels in the serum of breast cancer patients...
  26. pmc Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients
    Maike Ihnen
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BMC Cancer 12:140. 2012
    ..In some cancers ALCAM has a prognostic value or is predictive for the benefit of therapeutic interventions. To date there are no data on the role of ALCAM in cervical cancer available...
  27. ncbi request reprint Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines
    Sibyll Hein
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncol Rep 22:177-83. 2009
    ..No correlation with the proliferative and invasive potential of ovarian cancer cell lines could be found...
  28. ncbi request reprint Expression and prognostic value of activating transcription factor 2 (ATF2) and its phosphorylated form in mammary carcinomas
    Stefan Knippen
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anticancer Res 29:183-9. 2009
    ..The transcription factor ATF2 is overexpressed in various tumors, but its role in breast cancer is still not understood...
  29. ncbi request reprint Expression of the adhesion molecule CEACAM1 (CD66a, BGP, C-CAM) in breast cancer is associated with the expression of the tumor-suppressor genes Rb, Rb2, and p27
    Ana Maria Bamberger
    Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
    Virchows Arch 440:139-44. 2002
    ..These results indicate the possibility of a functional link between cell-adhesion molecules and cell-cycle regulation that might play an important role in the development of mammary carcinomas...
  30. doi request reprint Validity of the proliferation markers Ki67, TOP2A, and RacGAP1 in molecular subgroups of breast cancer
    Karin Milde-Langosch
    Department of Gynecology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res Treat 137:57-67. 2013
    ..These data point to subtype-specific differences in the relevance of proliferation-associated genes, and RacGAP1 might be a strong prognostic and predictive marker in the luminal subgroup...
  31. doi request reprint Serum carbonic anhydrase IX and its prognostic relevance in vulvar cancer
    Lilli Kock
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Gynecol Cancer 21:141-8. 2011
    ..We therefore determined CAIX serum concentration and its prognostic relevance in correlation to intratumoral CAIX expression in patients with primary vulvar cancer...
  32. ncbi request reprint Prognostic relevance of glycosylation-associated genes in breast cancer
    Karin Milde-Langosch
    Department of Gynecology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res Treat 145:295-305. 2014
    ..Our results indicate that various glycosylation reactions influence progression and metastasis of breast cancer and might thus represent potential therapeutic targets. ..
  33. doi request reprint Platelet-derived growth factor receptor beta serum concentrations during first-line therapy in ovarian cancer
    Sabrina Mathey
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncology 85:69-77. 2013
    ..The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease...
  34. ncbi request reprint Expression pattern of the activating protein-1 family of transcription factors in the human placenta
    Ana Maria Bamberger
    Institute of Pathology, Department of Gynaecopathology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Mol Hum Reprod 10:223-8. 2004
    ....
  35. ncbi request reprint Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, Transplant Center, Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 12:159-68. 2006
    ..To analyze prognostic and predictive effects of immunohistochemical factors within a randomized study of high-dose versus standard-dose chemotherapy in high-risk breast cancer with >10 involved lymph nodes...
  36. ncbi request reprint The transcription factor Fra-2 promotes mammary tumour progression by changing the adhesive properties of breast cancer cells
    Christine Schröder
    Department of Gynecology, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cancer 46:1650-60. 2010
    ....
  37. ncbi request reprint Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators
    A M Bamberger
    Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
    J Cancer Res Clin Oncol 127:545-50. 2001
    ..To study the expression pattern and the role of the AP-1 (activating protein-1) family of transcription factors in endometrial carcinogenesis...
  38. doi request reprint Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas
    Juliane Briese
    Section on Endocrinology and Metabolism of Ageing, University Clinic Hamburg Eppendorf, Hamburg, Germany
    Virchows Arch 453:89-96. 2008
    ..In conclusion, KAI-1 and p53 show inverse expression. The reduced KAI-1 expression may be the result of dysregulated p53 function and could be an important step in the endometrial carcinogenesis...
  39. pmc Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastases
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 7:e47537. 2012
    ..In conclusion, we found loss at 11p15 to be a marker for TNBC primary tumors and BCBM and PRKCDBP to be a potential target gene in this locus...
  40. ncbi request reprint Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasia
    A M Bamberger
    Institute of Pathology, Department for Gynaecopathology, University Hospital Eppendorf, Hamburg, Germany
    Virchows Arch 434:423-8. 1999
    ..It thus seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis...
  41. doi request reprint Predictive impact of activated leukocyte cell adhesion molecule (ALCAM/CD166) in breast cancer
    M Ihnen
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res Treat 112:419-27. 2008
    ..001 for OAS). Our overall results reveal that high ALCAM expression levels in primary tumors might be a suitable marker for prediction of the response to adjuvant chemotherapy in breast cancer...
  42. doi request reprint Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin
    Maike Ihnen
    Department of Gynaecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Pathol 64:146-52. 2011
    ..Therefore this study focuses on analysing the distribution of ALCAM and CEACAM6 protein expression in breast cancer metastases from different sites...
  43. ncbi request reprint Expression pattern of the cell cycle promoter cyclin e in benign extravillous trophoblast and gestational trophoblastic lesions: correlation with expression of Ki-67
    Ana Maria Bamberger
    Department of Gynecopathology, Institute of Pathology, University Hospital Eppendorf, Hamburg, Germany
    Int J Gynecol Pathol 22:156-61. 2003
    ....
  44. doi request reprint Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients
    Heidi Schwarzenbach
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    Breast Cancer Res Treat 134:933-41. 2012
    ..Since PTEN is an important target gene of miR-214, this finding could also have potential implications for therapeutic approaches...
  45. ncbi request reprint Clinical significance of p53 alterations in surgically treated prostate cancers
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Mod Pathol 21:1371-8. 2008
    ..The rate of p53 alterations increases with prostate cancer progression...
  46. pmc Expression levels of Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) in primary breast carcinoma and distant breast cancer metastases
    M Ihnen
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Dis Markers 28:71-8. 2010
    ....
  47. ncbi request reprint Frequent p16/MTS1 inactivation in early stages of urothelial carcinoma of the bladder is not associated with tumor recurrence
    M G Friedrich
    Department of Urology, University of Hamburg, University Hospital Eppendorf, Germany
    Eur Urol 40:518-24. 2001
    ..We investigated 40 patients with Ta, T1 TCC of the bladder for p16 alterations (mutations, homozygote deletions, allelic loss) or reduced p16 immunoreaction...
  48. pmc Combination of osteopontin and activated leukocyte cell adhesion molecule as potent prognostic discriminators in HER2- and ER-negative breast cancer
    M Ihnen
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, Hamburg D 20246, Germany
    Br J Cancer 103:1048-56. 2010
    ..To analyse the discriminative impact of osteopontin (OPN) and activated leukocyte cell adhesion molecule (ALCAM), combined with human epidermal growth factor 2 (HER2) and oestrogen receptor (ER) in breast cancer...
  49. pmc C-Fos expression is a molecular predictor of progression and survival in epithelial ovarian carcinoma
    S Mahner
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Br J Cancer 99:1269-75. 2008
    ..These results are in contrast to the classic concept of c-Fos as an oncogene, but are supported by the recently discovered tumour-suppressing and proapoptotic function of c-Fos in various cancer types...
  50. ncbi request reprint Vitamin B6 modulates glucocorticoid-dependent gene transcription in a promoter- and cell type-specific manner
    C M Bamberger
    Department of Medicine I, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Exp Clin Endocrinol Diabetes 112:595-600. 2004
    ....
  51. doi request reprint AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice
    Nicole Grabinski
    Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Cell Signal 26:1021-9. 2014
    ..Therefore, AKT3 targeting might be a new promising strategy for therapy of ErbB2(+)/ERα(-) breast cancer and might further increase the responsiveness to an endocrine therapy approach. ..
  52. pmc TIMP-1 and VEGF-165 serum concentration during first-line therapy of ovarian cancer patients
    Sven Mahner
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BMC Cancer 10:139. 2010
    ..The application of serum TIMP-1 and VEGF to monitor primary therapy and predict clinical outcome of patients with ovarian cancer is unclear...
  53. doi request reprint Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease
    Heidi Schwarzenbach
    Department of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, Hamburg, Germany
    Mol Biosyst 7:2848-54. 2011
    ..In conclusion, the quantification of cell-free tumour DNA had diagnostic and prognostic values in breast cancer patients, and DNA loss at the region 13q31-33 may be an indication of lymphatic tumour cell spread...
  54. pmc Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients
    J Panse
    Department of Oncology Hematology, Center of Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
    Br J Cancer 99:930-8. 2008
    ....
  55. doi request reprint Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients
    Nadia Harbeck
    Department of Obstetrics and Gynecology and Pathology, Technical University of Munich, Munich, Germany
    J Clin Oncol 26:5036-42. 2008
    ....
  56. ncbi request reprint Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells
    Jasmin Fahnenstich
    IHF Institute for Hormone and Fertility Research, University of Hamburg, 20251 Hamburg, Germany
    Mol Hum Reprod 9:611-23. 2003
    ..In contrast, co-transfection of c-jun and c-fos expression vectors resulted in stimulation of reporter gene activity, indicating an involvement of AP-1 transcription factors in PLZF expression...
  57. ncbi request reprint Ulex europeus agglutinin-I binding as a potential prognostic marker in ovarian cancer
    Katharina Blonski
    Department of Anatomy II Experimental Morphology, University Medical Center Hamburg Eppendorf 20246 Hamburg, Germany
    Anticancer Res 27:2785-90. 2007
    ..Changes in the glycosylation of the cell membrane, as detected by lectin histochemistry, are sometimes associated with a poor prognosis...
  58. ncbi request reprint Wild-type p53 protein is up-regulated upon cyclic adenosine monophosphate-induced differentiation of human endometrial stromal cells
    Yvonne Pohnke
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    J Clin Endocrinol Metab 89:5233-44. 2004
    ..The observation that p53 protein expression is closely associated with decidual transformation indicates a novel role for this tumor suppressor in regulating human endometrial function...