D Meyer zu Heringdorf

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1)
    Dagmar Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Cell Signal 15:677-87. 2003
  2. ncbi request reprint Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors
    Dagmar Meyer Zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    FEBS Lett 554:443-9. 2003
  3. ncbi request reprint Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine
    D Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Eur J Pharmacol 354:113-22. 1998
  4. ncbi request reprint Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor
    D Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122, Essen, Germany
    FEBS Lett 461:217-22. 1999
  5. ncbi request reprint Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors
    D Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Eur J Pharmacol 414:145-54. 2001
  6. ncbi request reprint Lysophospholipid receptor-dependent and -independent calcium signaling
    Dagmar Meyer Zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, 45122 Essen, Germany
    J Cell Biochem 92:937-48. 2004
  7. ncbi request reprint Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
    Dagmar Meyer Zu Heringdorf
    Institut für Pharmakologie Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Biochim Biophys Acta 1768:923-40. 2007
  8. ncbi request reprint Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility
    U Rümenapp
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 361:1-11. 2000
  9. pmc Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro
    A Bischoff
    Department of Medicine, University of Essen, 45122 Essen, Germany
    Br J Pharmacol 130:1871-7. 2000
  10. ncbi request reprint Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors
    C J van Koppen
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Life Sci 68:2535-40. 2001

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1)
    Dagmar Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Cell Signal 15:677-87. 2003
    ..Co-expression of S1P(1) with S1P(3), but not S1P(2), reversed the inhibitory effect of S1P(1), furthermore suggesting a specific interplay of S1P receptor subtypes usually found within a single cell type...
  2. ncbi request reprint Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors
    Dagmar Meyer Zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    FEBS Lett 554:443-9. 2003
    ..Ca(2+) transients induced by photolysis of caged S1P were caused by Ca(2+) mobilization from thapsigargin-sensitive stores. These results provide direct evidence for a true intracellular action of S1P...
  3. ncbi request reprint Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine
    D Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Eur J Pharmacol 354:113-22. 1998
    ..Thus, SPPC can regulate Ca2+ homeostasis by acting apparently at two cellular targets, which exhibit clearly distinct recognition patterns...
  4. ncbi request reprint Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor
    D Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122, Essen, Germany
    FEBS Lett 461:217-22. 1999
    ..In HEK2 cells, EGF similarly stimulated PLC, but did not increase [Ca(2+)](i) or stimulate SPK, suggesting that intracellular SPP production plays a major role for Ca(2+) signalling by EGF in HEK-293 cells...
  5. ncbi request reprint Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors
    D Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Eur J Pharmacol 414:145-54. 2001
    ....
  6. ncbi request reprint Lysophospholipid receptor-dependent and -independent calcium signaling
    Dagmar Meyer Zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, 45122 Essen, Germany
    J Cell Biochem 92:937-48. 2004
    ..Of the many open questions, identification of the intracellular S1P target site(s) appears to be of particular importance...
  7. ncbi request reprint Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
    Dagmar Meyer Zu Heringdorf
    Institut für Pharmakologie Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Biochim Biophys Acta 1768:923-40. 2007
    ....
  8. ncbi request reprint Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility
    U Rümenapp
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 361:1-11. 2000
    ....
  9. pmc Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro
    A Bischoff
    Department of Medicine, University of Essen, 45122 Essen, Germany
    Br J Pharmacol 130:1871-7. 2000
    ..This is the first demonstration of effects of SPP and SPPC on vascular tone and suggests that sphingolipids may be an hitherto unrecognized class of endogenous regulators of vascular tone...
  10. ncbi request reprint Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors
    C J van Koppen
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Life Sci 68:2535-40. 2001
    ..Thus, sphingosine kinase activation most likely represents an amplification system for calcium signaling by mAChRs and other GPCRs...
  11. ncbi request reprint Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate
    R Alemany
    , , Hufelandstrasse 55, D-45122 Essen, Germany
    FEBS Lett 509:239-44. 2001
    ..Studies with sphingosine kinase inhibitors and overexpression of sphingosine kinase revealed a partial contribution of this pathway to depolarisation-induced noradrenaline release and Ca(2+) increase...
  12. pmc Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats
    A Bischoff
    Department of Medicine, University of Essen, 45122 Essen, Germany
    Br J Pharmacol 132:1925-33. 2001
    ..SPP affects renovascular tone and tubular function via receptors coupled to G(i)-type G-proteins. SPPC, sphingosine and glucopsychosine mimic only the tubular effects of SPP, and hence may act on distinct sites...
  13. ncbi request reprint A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils
    C J van Koppen
    Institut fur Pharmakologie, Universität GH Essen, Germany
    Mol Pharmacol 49:956-61. 1996
    ..On the basis of these results, we conclude that there apparently is a heterogeneity of G protein-coupled receptors for sphingolipids in mammalian cells...
  14. doi request reprint Lysophospholipid receptor-mediated calcium signaling in human keratinocytes
    Karin Lichte
    Institut fur Pharmakologie, Universitat Duisburg Essen, Essen, Germany
    J Invest Dermatol 128:1487-98. 2008
    ..The S1P(1) receptor, without stimulating [Ca(2+)](i) increases, mediates chemotaxis of keratinocytes...
  15. ncbi request reprint Sphingosylphosphorylcholine-biological functions and mechanisms of action
    Dagmar Meyer Zu Heringdorf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
    Biochim Biophys Acta 1582:178-89. 2002
    ..This concept was corroborated by the recent discovery of specific high-affinity G-protein-coupled SPC receptors. In this article, our present knowledge on cellular actions and biological functions of SPC will be reviewed...
  16. pmc Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function
    Christoph Altmann
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Br J Pharmacol 138:435-44. 2003
    ..7 These results indicate that the lysophospholipid SPC is an effective inhibitor of human platelet activation, apparently primarily by uncoupling agonist-activated receptors from their effectors...
  17. pmc Renal mesangial cells: moving on sphingosine kinase-1
    D Meyer zu Heringdorf
    Institut fur Pharmakologie, Universitat Duisburg Essen, Essen, Germany
    Br J Pharmacol 150:255-7. 2007
    ..raise exciting questions: by which mechanism does SphK1 regulate migration in mesangial cells, how is the interplay of purinoceptors and S1P receptors organized in these cells, and how would SphK1-deficient mice respond to kidney damage?..
  18. ncbi request reprint Regulation and functional roles of sphingosine kinases
    Regina Alemany
    Institut fur Pharmakologie, Universitat Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:413-28. 2007
    ..In this review, our understanding of structure, regulation, and functional roles of SphKs is updated and discussed with regard to their implication in pathophysiological and disease states...
  19. pmc Transient relaxation of rat mesenteric microvessels by ceramides
    Peter Czyborra
    Department of Medicine, University of Essen, Essen, Germany
    Br J Pharmacol 135:417-26. 2002
    ..The vasodilation abates with time partly due to desensitization of the ceramide response and partly due to metabolism of C2-ceramide to an inactive metabolite...
  20. ncbi request reprint Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors
    Michael Ter Braak
    Institut fur Pharmakologie, Universitatsklinikum Essen, Essen, Germany
    Biochim Biophys Acta 1791:357-70. 2009
    ..It is concluded that SphK1 is an important effector of Gq-coupled receptors, linking them via cross-activation of S1P receptors to G(i) and G12/13 signalling pathways...