Research Topics
Species | D Meyer zu HeringdorfSummaryAffiliation: University of Essen Country: Germany Publications
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Publications
Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1)Dagmar Meyer zu Heringdorf
Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Cell Signal 15:677-87. 2003..Co-expression of S1P(1) with S1P(3), but not S1P(2), reversed the inhibitory effect of S1P(1), furthermore suggesting a specific interplay of S1P receptor subtypes usually found within a single cell type...- Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptorsDagmar Meyer Zu Heringdorf
Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
FEBS Lett 554:443-9. 2003..Ca(2+) transients induced by photolysis of caged S1P were caused by Ca(2+) mobilization from thapsigargin-sensitive stores. These results provide direct evidence for a true intracellular action of S1P... - Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholineD Meyer zu Heringdorf
Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
Eur J Pharmacol 354:113-22. 1998..Thus, SPPC can regulate Ca2+ homeostasis by acting apparently at two cellular targets, which exhibit clearly distinct recognition patterns... - Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptorD Meyer zu Heringdorf
Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122, Essen, Germany
FEBS Lett 461:217-22. 1999..In HEK2 cells, EGF similarly stimulated PLC, but did not increase [Ca(2+)](i) or stimulate SPK, suggesting that intracellular SPP production plays a major role for Ca(2+) signalling by EGF in HEK-293 cells... - Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptorsD Meyer zu Heringdorf
Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Eur J Pharmacol 414:145-54. 2001.... - Lysophospholipid receptor-dependent and -independent calcium signalingDagmar Meyer Zu Heringdorf
Institut fur Pharmakologie, Universitatsklinikum Essen, 45122 Essen, Germany
J Cell Biochem 92:937-48. 2004..Of the many open questions, identification of the intracellular S1P target site(s) appears to be of particular importance... - Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolismDagmar Meyer Zu Heringdorf
Institut für Pharmakologie Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
Biochim Biophys Acta 1768:923-40. 2007.... - Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motilityU Rümenapp
Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
Naunyn Schmiedebergs Arch Pharmacol 361:1-11. 2000.... 
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitroA Bischoff
Department of Medicine, University of Essen, 45122 Essen, Germany
Br J Pharmacol 130:1871-7. 2000..This is the first demonstration of effects of SPP and SPPC on vascular tone and suggests that sphingolipids may be an hitherto unrecognized class of endogenous regulators of vascular tone...- Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptorsC J van Koppen
Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
Life Sci 68:2535-40. 2001..Thus, sphingosine kinase activation most likely represents an amplification system for calcium signaling by mAChRs and other GPCRs... - Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphateR Alemany
, , Hufelandstrasse 55, D-45122 Essen, Germany
FEBS Lett 509:239-44. 2001..Studies with sphingosine kinase inhibitors and overexpression of sphingosine kinase revealed a partial contribution of this pathway to depolarisation-induced noradrenaline release and Ca(2+) increase... - Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized ratsA Bischoff
Department of Medicine, University of Essen, 45122 Essen, Germany
Br J Pharmacol 132:1925-33. 2001..SPP affects renovascular tone and tubular function via receptors coupled to G(i)-type G-proteins. SPPC, sphingosine and glucopsychosine mimic only the tubular effects of SPP, and hence may act on distinct sites... - A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophilsC J van Koppen
Institut fur Pharmakologie, Universität GH Essen, Germany
Mol Pharmacol 49:956-61. 1996..On the basis of these results, we conclude that there apparently is a heterogeneity of G protein-coupled receptors for sphingolipids in mammalian cells... 
Lysophospholipid receptor-mediated calcium signaling in human keratinocytesKarin Lichte
Institut fur Pharmakologie, Universitat Duisburg Essen, Essen, Germany
J Invest Dermatol 128:1487-98. 2008..The S1P(1) receptor, without stimulating [Ca(2+)](i) increases, mediates chemotaxis of keratinocytes...- Sphingosylphosphorylcholine-biological functions and mechanisms of actionDagmar Meyer Zu Heringdorf
Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
Biochim Biophys Acta 1582:178-89. 2002..This concept was corroborated by the recent discovery of specific high-affinity G-protein-coupled SPC receptors. In this article, our present knowledge on cellular actions and biological functions of SPC will be reviewed... - Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet functionChristoph Altmann
, , Germany
Br J Pharmacol 138:435-44. 2003..7 These results indicate that the lysophospholipid SPC is an effective inhibitor of human platelet activation, apparently primarily by uncoupling agonist-activated receptors from their effectors... - Renal mesangial cells: moving on sphingosine kinase-1D Meyer zu Heringdorf
Institut fur Pharmakologie, Universitat Duisburg Essen, Essen, Germany
Br J Pharmacol 150:255-7. 2007..raise exciting questions: by which mechanism does SphK1 regulate migration in mesangial cells, how is the interplay of purinoceptors and S1P receptors organized in these cells, and how would SphK1-deficient mice respond to kidney damage?.. - Regulation and functional roles of sphingosine kinasesRegina Alemany
Institut fur Pharmakologie, Universitat Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Naunyn Schmiedebergs Arch Pharmacol 374:413-28. 2007..In this review, our understanding of structure, regulation, and functional roles of SphKs is updated and discussed with regard to their implication in pathophysiological and disease states... - Transient relaxation of rat mesenteric microvessels by ceramidesPeter Czyborra
Department of Medicine, University of Essen, Essen, Germany
Br J Pharmacol 135:417-26. 2002..The vasodilation abates with time partly due to desensitization of the ceramide response and partly due to metabolism of C2-ceramide to an inactive metabolite... - Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptorsMichael Ter Braak
Institut fur Pharmakologie, Universitatsklinikum Essen, Essen, Germany
Biochim Biophys Acta 1791:357-70. 2009..It is concluded that SphK1 is an important effector of Gq-coupled receptors, linking them via cross-activation of S1P receptors to G(i) and G12/13 signalling pathways...