Patrick Meybohm

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. pmc The impact of response time reliability on CPR incidence and resuscitation success: a benchmark study from the German Resuscitation Registry
    Jürgen Neukamm
    Department of Anesthesiology and Intensive Care, Klinik am Eichert, Eichertstrasse 3, D 73035 Göppingen, Germany
    Crit Care 15:R282. 2011
  2. pmc Pharmacological postconditioning with sevoflurane after cardiopulmonary resuscitation reduces myocardial dysfunction
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, Schleswig Holstein University Hospital, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    Crit Care 15:R241. 2011
  3. pmc Vital organ blood flow during high-frequency ventilation
    Patrick Meybohm
    Crit Care 10:426. 2006
  4. ncbi request reprint Impact of norepinephrine and fluid on cerebral oxygenation in experimental hemorrhagic shock
    Patrick Meybohm
    Department of Anesthesiology and Intensive Care Medicine, Pediatric Anesthesia Research Unit, University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    Pediatr Res 62:440-4. 2007
  5. doi request reprint Measurement of blood flow index during antegrade selective cerebral perfusion with near-infrared spectroscopy in newborn piglets
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Anesth Analg 106:795-803, table of contents. 2008
  6. doi request reprint Correlation and agreement between the bispectral index vs. state entropy during hypothermic cardio-pulmonary bypass
    P Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Acta Anaesthesiol Scand 54:169-75. 2010
  7. ncbi request reprint Release of protein S100B in haemorrhagic shock: effects of small volume resuscitation combined with arginine vasopressin
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Resuscitation 76:449-56. 2008
  8. pmc Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 4:e7588. 2009
  9. ncbi request reprint Neurochemical monitoring using intracerebral microdialysis during systemic haemorrhage
    P Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Acta Neurochir (Wien) 149:691-8. 2007
  10. ncbi request reprint Revised resuscitation guidelines: adrenaline versus adrenaline/vasopressin in a pig model of cardiopulmonary resuscitation--a randomised, controlled trial
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Resuscitation 75:380-8. 2007

Collaborators

Detail Information

Publications62

  1. pmc The impact of response time reliability on CPR incidence and resuscitation success: a benchmark study from the German Resuscitation Registry
    Jürgen Neukamm
    Department of Anesthesiology and Intensive Care, Klinik am Eichert, Eichertstrasse 3, D 73035 Göppingen, Germany
    Crit Care 15:R282. 2011
    ....
  2. pmc Pharmacological postconditioning with sevoflurane after cardiopulmonary resuscitation reduces myocardial dysfunction
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, Schleswig Holstein University Hospital, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    Crit Care 15:R241. 2011
    ..In this study, we sought to examine whether pharmacological postconditioning with sevoflurane (SEVO) is neuro- and cardioprotective in a pig model of cardiopulmonary resuscitation...
  3. pmc Vital organ blood flow during high-frequency ventilation
    Patrick Meybohm
    Crit Care 10:426. 2006
  4. ncbi request reprint Impact of norepinephrine and fluid on cerebral oxygenation in experimental hemorrhagic shock
    Patrick Meybohm
    Department of Anesthesiology and Intensive Care Medicine, Pediatric Anesthesia Research Unit, University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    Pediatr Res 62:440-4. 2007
    ..In conclusion, while norepinephrine increased CPP immediately, cerebral oxygenation as reflected by TOI and Ptio2 could not be improved by norepinephrine, but only by retransfusion...
  5. doi request reprint Measurement of blood flow index during antegrade selective cerebral perfusion with near-infrared spectroscopy in newborn piglets
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Anesth Analg 106:795-803, table of contents. 2008
    ..We investigated SCP with different flow rates compared with HCA with respect to cerebral perfusion and tissue oxygenation as assessed by near-infrared spectroscopy...
  6. doi request reprint Correlation and agreement between the bispectral index vs. state entropy during hypothermic cardio-pulmonary bypass
    P Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Acta Anaesthesiol Scand 54:169-75. 2010
    ..The purpose of this study was to investigate the effect of hypothermia during a cardio-pulmonary bypass on the correlation and agreement between the BIS and entropy variables compared with normothermic conditions...
  7. ncbi request reprint Release of protein S100B in haemorrhagic shock: effects of small volume resuscitation combined with arginine vasopressin
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Resuscitation 76:449-56. 2008
    ....
  8. pmc Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 4:e7588. 2009
    ..This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postconditioning are cardioprotective in a model of cardiopulmonary resuscitation following acute myocardial ischemia...
  9. ncbi request reprint Neurochemical monitoring using intracerebral microdialysis during systemic haemorrhage
    P Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Acta Neurochir (Wien) 149:691-8. 2007
    ..The present study was designed to assess changes of intracerebral microdialysis parameters both during systemic haemorrhage and after initiation of therapy...
  10. ncbi request reprint Revised resuscitation guidelines: adrenaline versus adrenaline/vasopressin in a pig model of cardiopulmonary resuscitation--a randomised, controlled trial
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Resuscitation 75:380-8. 2007
    ....
  11. ncbi request reprint Cerebral metabolism assessed with microdialysis in uncontrolled hemorrhagic shock after penetrating liver trauma
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Anesth Analg 103:948-54. 2006
    ..In conclusion, AVP/HHS proved to be superior to fluid in the initial phase of therapy with respect to CPP and cerebral oxygenation, but was comparable to fluid regarding cerebral metabolism and secondary cell damage in surviving animals...
  12. pmc Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, Kiel, 24105, Germany
    Crit Care 14:R21. 2010
    ..This study sought to examine whether hypothermia or the combination of hypothermia with anesthetic post-conditioning with sevoflurane affect cerebral inflammatory response after cardiopulmonary resuscitation...
  13. ncbi request reprint [Comparison of premedication regimes. A randomized, controlled trial]
    P Meybohm
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel
    Anaesthesist 56:890-2, 894-6. 2007
    ..The effect of two premedication regimes with different benzodiazepines on anxiety, hemodynamic data, sympatho-adrenal activity, and bispectral index (BIS) was evaluated during the variable time period prior to induction of anesthesia...
  14. ncbi request reprint Assessment of left ventricular systolic function during acute myocardial ischemia: a comparison of transpulmonary thermodilution and transesophageal echocardiography
    P Meybohm
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Minerva Anestesiol 77:132-41. 2011
    ..The purpose of this study was to investigate the ability of these variables to predict impaired left ventricular ejection fraction (LVEF) derived by transesophageal echocardiography during acute myocardial ischemia...
  15. ncbi request reprint Small volume resuscitation: a randomized controlled trial with either norepinephrine or vasopressin during severe hemorrhage
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Trauma 62:640-6. 2007
    ....
  16. doi request reprint Effects of cerebral hypoperfusion on bispectral index: a randomised, controlled animal experiment during haemorrhagic shock
    Erol Cavus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Resuscitation 81:1183-9. 2010
    ..The aim of this porcine haemorrhagic shock model was to investigate the changes of bispectral index (BIS) after slow and fast recovery of cerebral perfusion, and its correlation with plasma propofol concentrations...
  17. doi request reprint Cerebral effects of three resuscitation protocols in uncontrolled haemorrhagic shock: a randomised controlled experimental study
    Erol Cavus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Resuscitation 80:567-72. 2009
    ..administration of a hypertonic starch solution (HS) combined with either noradrenaline [norepinephrine] or arginine vasopressin in an animal model of uncontrolled haemorrhagic shock...
  18. doi request reprint Regional and local brain oxygenation during hemorrhagic shock: a prospective experimental study on the effects of small-volume resuscitation with norepinephrine
    Erol Cavus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Trauma 64:641-8; discussion 648-9. 2008
    ....
  19. doi request reprint Dynamic and volumetric variables of fluid responsiveness fail during immediate postresuscitation period
    Matthias Gruenewald
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Crit Care Med 39:1953-9. 2011
    ....
  20. doi request reprint Impact of different compression-ventilation ratios during basic life support cardiopulmonary resuscitation
    Erol Cavus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Resuscitation 79:118-24. 2008
    ..The 2005 revised guidelines for cardiopulmonary resuscitation (CPR) suggest a universal compression-to-ventilation (C:V) ratio of 30:2. The effects of this ratio in a realistic CPR scenario have not been investigated completely...
  21. doi request reprint Cerebral metabolism during deep hypothermic circulatory arrest vs moderate hypothermic selective cerebral perfusion in a piglet model: a microdialysis study
    Erol Cavus
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, Kiel 24105, Germany
    Paediatr Anaesth 19:770-8. 2009
    ..Clinical data suggest ASCP alone to be superior to deep hypothermic circulatory arrest (DHCA); however, the effects of moderate hypothermia during ASCP on cerebral metabolism in this patient population are still unclear...
  22. pmc Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion
    Ole Broch
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schleswig Holstein, Germany
    PLoS ONE 8:e56267. 2013
    ..The aim of the present study was to challenge the ability of SVV, PPV and GEDV to predict fluid responsiveness in a porcine model with pleural effusions...
  23. doi request reprint Remote ischemic preconditioning regulates HIF-1α levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: a pilot experimental study
    Martin Albrecht
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Schwanenweg 21, 24105 Kiel, Germany
    Basic Res Cardiol 108:314. 2013
    ..05 vs. control before CPB). In summary, RIPC regulates HIF-1α levels, apoptosis and inflammation in the myocardium of cardiosurgical patients and leads to increased concentrations of circulating cytokines...
  24. doi request reprint Variation of left ventricular outflow tract velocity and global end-diastolic volume index reliably predict fluid responsiveness in cardiac surgery patients
    Ole Broch
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Crit Care 27:325.e7-13. 2012
    ..The aim of the present study was to challenge the predictive power of GEDVI and ΔVTI(LVOT) compared with pulse pressure variation (PPV) and stroke volume variation (SVV) in a large patient population...
  25. doi request reprint Effect of elevated PEEP on dynamic variables of fluid responsiveness in a pediatric animal model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Paediatr Anaesth 18:1170-7. 2008
    ..The aim of our study was to assess the effect of increasing PEEP levels on the predictive value of SVV, PPV and GEDV with respect to fluid responsiveness...
  26. doi request reprint Salicylic acid induces apoptosis in colon carcinoma cells grown in-vitro: influence of oxygen and salicylic acid concentration
    Karina Zitta
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Exp Cell Res 318:828-34. 2012
    ..We conclude that in colon carcinoma cells effects of SA on apoptosis and cellular signaling are dependent on the availability of oxygen...
  27. doi request reprint Visual evaluation of left ventricular performance predicts volume responsiveness early after resuscitation from cardiac arrest
    Matthias Gruenewald
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, D 24119 Kiel, Germany
    Resuscitation 82:1553-7. 2011
    ..The aim of the present study was to evaluate the performance of visual evaluation (eyeballing) of standardised TEE-loops to predict volume responsiveness during post-cardiac arrest period...
  28. ncbi request reprint The reliability of pulse contour-derived cardiac output during hemorrhage and after vasopressor administration
    Berthold Bein
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Anesth Analg 105:107-13. 2007
    ..We compared PCCO measurements of CO with TPCO and continuous and bolus pulmonary artery CO (CCO and BCO, respectively) during conditions of uncontrolled hemorrhage and resuscitation with norepinephrine...
  29. pmc Uncalibrated pulse power analysis fails to reliably measure cardiac output in patients undergoing coronary artery bypass surgery
    Ole Broch
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Crit Care 15:R76. 2011
    ..The aim of the present study was to compare the accuracy of arterial pulse power analysis with intermittent transpulmonary thermodilution (TPTD) before and after cardiopulmonary bypass (CPB)...
  30. doi request reprint Effects of norepinephrine on dynamic variables of fluid responsiveness during hemorrhage and after resuscitation in a pediatric porcine model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Paediatr Anaesth 19:688-94. 2009
    ..The aim of our study was to investigate the effect of norepinephrine (NE) on PPV, SVV and GEDV in a pediatric animal model of hemorrhage and resuscitation...
  31. doi request reprint Cytoprotective effects of the volatile anesthetic sevoflurane are highly dependent on timing and duration of sevoflurane conditioning: findings from a human, in-vitro hypoxia model
    Karina Zitta
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Eur J Pharmacol 645:39-46. 2010
    ..Our results suggest short pre- and intraconditioning with sevoflurane as most potent strategies to reduce hypoxia induced neuronal cell damage...
  32. pmc Effect of norepinephrine dosage and calibration frequency on accuracy of pulse contour-derived cardiac output
    Matthias Gruenewald
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    Crit Care 15:R22. 2011
    ....
  33. doi request reprint Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Crit Care Med 37:650-8. 2009
    ..Therefore, the present study was designed to evaluate whether PPV and SVV are suitable for predicting fluid responsiveness during elevated IAP...
  34. doi request reprint ROSC after cardiac arrest--the RACA score to predict outcome after out-of-hospital cardiac arrest
    Jan Thorsten Gräsner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Schwanenweg 21, Campus Kiel, Kiel, Germany
    Eur Heart J 32:1649-56. 2011
    ..The aim of this study was to develop a score to predict the initial resuscitation outcome-the RACA (ROSC after cardiac arrest) score...
  35. pmc Cardiopulmonary resuscitation traumatic cardiac arrest--there are survivors. An analysis of two national emergency registries
    Jan Thorsten Gräsner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, Kiel, 24105, Germany
    Crit Care 15:R276. 2011
    ..The aim of the present study was to analyze the outcome of cardiopulmonary resuscitation (CPR) after traumatic cardiac arrest by combining data from two different large national registries in Germany...
  36. doi request reprint Hypothermia and anesthetic postconditioning influence the expression and activity of small intestinal proteins possibly involved in ischemia/reperfusion-mediated events following cardiopulmonary resuscitation
    Martin Albrecht
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Resuscitation 83:113-8. 2012
    ..Crit Care, 2010]. As the intestine is also highly susceptible to I/R-injury, we investigated the influence of HT and SEV on intestinal I/R-mediated events induced by cardiac arrest and successful resuscitation...
  37. pmc Reliability of continuous cardiac output measurement during intra-abdominal hypertension relies on repeated calibrations: an experimental animal study
    Matthias Gruenewald
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    Crit Care 12:R132. 2008
    ..The aim of the present study was to compare the agreement between three CCO methods and a bolus thermodilution CO technique during acute IAH and volume loading...
  38. ncbi request reprint Postoperative neurocognitive function and microembolus detection in patients undergoing neck dissection: a pilot study
    Jörn Leiendecker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Eur J Anaesthesiol 27:417-24. 2010
    ..The present study was designed to investigate development of postoperative neurocognitive dysfunction in these patients...
  39. ncbi request reprint Global end-diastolic volume during different loading conditions in a pediatric animal model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Anesth Analg 105:1243-9, table of contents. 2007
    ..Therefore, we designed the present study to evaluate whether GEDV and PPV are suitable variables of preload and fluid responsiveness during rapidly changing loading conditions in a pediatric animal model...
  40. doi request reprint Propofol sedation is reduced by delta9-tetrahydrocannabinol in mice
    Philipp Alexander Brand
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Anesth Analg 107:102-6. 2008
    ..Our aim was to characterize the interaction between Delta9-THC and propofol in terms of sedation and analgesia...
  41. pmc Postoperative neurocognitive dysfunction in patients undergoing cardiac surgery after remote ischemic preconditioning: a double-blind randomized controlled pilot study
    Patrick Meybohm
    Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 8:e64743. 2013
    ..We hypothesized that RIPC reduces postoperative neurocognitive dysfunction (POCD) in patients undergoing complex cardiac surgery...
  42. pmc A comparison of third-generation semi-invasive arterial waveform analysis with thermodilution in patients undergoing coronary surgery
    Ole Broch
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    ScientificWorldJournal 2012:451081. 2012
    ..Furthermore, the semi-invasive monitoring device was able to track haemodynamic changes and trends...
  43. pmc Serum from patients undergoing remote ischemic preconditioning protects cultured human intestinal cells from hypoxia-induced damage: involvement of matrixmetalloproteinase-2 and -9
    Karina Zitta
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Mol Med 18:29-37. 2012
    ..Our results suggest MMP-2 and MMP-9 as currently unknown humoral factors that may be involved in RIPC-mediated cytoprotection in the intestine...
  44. pmc Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis
    Jan Thorsten Gräsner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, Kiel 24105, Germany
    Crit Care 15:R61. 2011
    ..Percutaneous coronary intervention (PCI) may also be beneficial in patients after out-of-hospital cardiac arrest (OHCA)...
  45. pmc A comparison of transcranial Doppler with near infrared spectroscopy and indocyanine green during hemorrhagic shock: a prospective experimental study
    Berthold Bein
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Crit Care 10:R18. 2006
    ....
  46. doi request reprint Nefopam but not physostigmine affects the thermoregulatory response in mice via alpha(2)-adrenoceptors
    Jan Höcker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Neuropharmacology 58:495-500. 2010
    ..Our results indicate an important role of the alpha(2A)-adrenoceptor in the thermoregulatory response induced by nefopam but not by physostigmine in mice...
  47. doi request reprint Postoperative neurocognitive dysfunction in elderly patients after xenon versus propofol anesthesia for major noncardiac surgery: a double-blinded randomized controlled pilot study
    Jan Höcker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Anesthesiology 110:1068-76. 2009
    ..Therefore, this study was designed to assess POCD after xenon anesthesia in comparison to propofol in elderly patients undergoing major noncardiac surgery...
  48. doi request reprint Hypoxia-induced cell damage is reduced by mild hypothermia and postconditioning with catalase in-vitro: application of an enzyme based oxygen deficiency system
    Karina Zitta
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Eur J Pharmacol 628:11-8. 2010
    ..Moreover, our in-vitro results imply that catalase postconditioning may be a promising approach to attenuate hypoxia-induced and hydrogen peroxide-mediated cell and tissue damage...
  49. doi request reprint Interleukin-1beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in cultured primary pig heart cells
    Karina Zitta
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Biochem Biophys Res Commun 399:542-7. 2010
    ..Combined with our recently published in vivo data (Meybohm et al., PLoS One, 2009), the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction...
  50. doi request reprint A national resuscitation registry of out-of-hospital cardiac arrest in Germany-a pilot study
    Jan Thorsten Gräsner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Resuscitation 80:199-203. 2009
    ..A uniform resuscitation registry may be advantageous for quality management of cardiopulmonary resuscitation (CPR). This study was conducted to evaluate the establishment of a national CPR registry in Germany...
  51. doi request reprint Additive interaction of the cannabinoid receptor I agonist arachidonyl-2-chloroethylamide with etomidate in a sedation model in mice
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Anesthesiology 108:669-74. 2008
    ..The purpose of this study was to evaluate the effect of selective agonists for cannabinoid receptor types 1 and 2 on etomidate-induced sedation...
  52. pmc Postoperative cognitive deficit after cardiopulmonary bypass with preserved cerebral oxygenation: a prospective observational pilot study
    Axel Fudickar
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    BMC Anesthesiol 11:7. 2011
    ..abstract:..
  53. doi request reprint Interaction of morphine but not fentanyl with cerebral alpha2-adrenoceptors in alpha2-adrenoceptor knockout mice
    Jan Höcker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Pharm Pharmacol 61:901-10. 2009
    ..To evaluate underlying mechanisms, we have studied whether morphine and fentanyl interacted with alpha(2)-adrenoceptor-subtypes in mice lacking one individual alpha(2)-adrenoceptor-subtype (alpha(2)-adrenoceptor knockout)...
  54. doi request reprint Evaluation of the pediatric Bonfils fiberscope for elective endotracheal intubation
    Berthold Bein
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Paediatr Anaesth 18:1040-4. 2008
    ..This study was designed to evaluate the performance of the recently developed pediatric versions of the Bonfils fiberscope for elective endotracheal intubation during routine surgical procedures...
  55. doi request reprint Pulse pressure variation and stroke volume variation during different loading conditions in a paediatric animal model
    J Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Acta Anaesthesiol Scand 52:374-80. 2008
    ..The aim of our study was to assess whether PPV and SVV can predict fluid responsiveness in an animal model and to investigate the influence of different tidal volumes applied...
  56. pmc Hands-on defibrillation has the potential to improve the quality of cardiopulmonary resuscitation and is safe for rescuers-a preclinical study
    Tobias Neumann
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    J Am Heart Assoc 1:e001313. 2012
    ....
  57. doi request reprint [Organ protection by conditioning]
    Berthold Bein
    Anasthesiol Intensivmed Notfallmed Schmerzther 45:254-61; quiz 262. 2010
    ..Clinical trials in patients undergoing cardiac surgery have provided evidence for organ protection by conditioning. Large scale multicenter randomised trials, however, are still needed...
  58. ncbi request reprint M-Entropy guidance vs standard practice during propofol-remifentanil anaesthesia: a randomised controlled trial
    M Gruenewald
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    Anaesthesia 62:1224-9. 2007
    ..01). Both regimens resulted in fast recovery with no clinical advantage for either one. There were no significant differences in haemodynamic parameters, postoperative nausea and vomiting or satisfaction with the procedure...
  59. doi request reprint Influence of different remifentanil concentrations on the performance of the surgical stress index to detect a standardized painful stimulus during sevoflurane anaesthesia
    M Gruenewald
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    Br J Anaesth 103:586-93. 2009
    ..The present study aimed to examine the influence of increasing remifentanil concentrations on the ability of SSI to detect a standardized painful stimulus during sevoflurane anaesthesia...
  60. doi request reprint Differences between bispectral index and spectral entropy during xenon anaesthesia: a comparison with propofol anaesthesia
    J Hocker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Anaesthesia 65:595-600. 2010
    ..We therefore conclude that these measures are not interchangeable for the assessment of depth of hypnosis and that bispectral index is likely to reflect actual depth of anaesthesia more precisely compared with spectral entropy...
  61. ncbi request reprint Stroke volume variation during hemorrhage and after fluid loading: impact of different tidal volumes
    J Renner
    Departments of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, D 24105 Kiel, Germany
    Acta Anaesthesiol Scand 51:538-44. 2007
    ..This study was designed to evaluate whether the predictive value of SVV depends on the tidal volume applied particularly during acute changes of preload...
  62. ncbi request reprint Gas exchange of lung-protective ventilation strategies in pigs with normal lungs
    Patrick Meybohm
    Crit Care Med 35:1447; author reply 1448. 2007