Karin J Metzner

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Deltanef increases viral replication
    Lisa A Chakrabarti
    Viral Immunology Unit, Pasteur Institute, Paris, France
    J Virol 77:1245-56. 2003
  2. ncbi request reprint Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions
    Karin J Metzner
    Aaron Diamond AIDS Research Center, Columbia University, New York, New York, USA
    J Infect Dis 188:1433-43. 2003
  3. ncbi request reprint Detection and significance of minority quasispecies of drug-resistant HIV-1
    Karin J Metzner
    Institute of Clinical and Molecular Virology, University of Erlangen Nuremberg, Schlossgarten, Erlangen, Germany
    J HIV Ther 11:74-81. 2006
  4. ncbi request reprint Rapid selection of drug-resistant HIV-1 during the first months of suppressive ART in treatment-naive patients
    Karin J Metzner
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Erlangen, Germany
    AIDS 21:703-11. 2007
  5. pmc Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques
    Karin J Metzner
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    Retrovirology 3:97. 2006
  6. ncbi request reprint Detection of minor populations of drug-resistant HIV-1 in acute seroconverters
    Karin J Metzner
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Germany
    AIDS 19:1819-25. 2005
  7. doi request reprint Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients
    Karin J Metzner
    Institute of Clinical and Molecular Virology, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Infect Dis 48:239-47. 2009
  8. ncbi request reprint Persistence of lamivudine-sensitive HIV-1 quasispecies in the presence of lamivudine in vitro and in vivo
    Kristina Allers
    Institute of Clinical and Moleculr Virology, University of Erlangen Nuremburg, Erlangen, Germany
    J Acquir Immune Defic Syndr 44:377-85. 2007
  9. doi request reprint The antiretroviral potency of emtricitabine is approximately 3-fold higher compared to lamivudine in dual human immunodeficiency virus type 1 infection/competition experiments in vitro
    Daniel Drogan
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Erlangen, Germany
    Antiviral Res 86:312-5. 2010
  10. ncbi request reprint Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus
    Karin J Metzner
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    J Gen Virol 86:3375-84. 2005

Collaborators

Detail Information

Publications16

  1. pmc A truncated form of Nef selected during pathogenic reversion of simian immunodeficiency virus SIVmac239Deltanef increases viral replication
    Lisa A Chakrabarti
    Viral Immunology Unit, Pasteur Institute, Paris, France
    J Virol 77:1245-56. 2003
    ..Taken together, these results show that SIV with a deletion in the nef gene can revert to virulence and that expression of a form of nef with multiple deletions may contribute to this process by increasing viral replication...
  2. ncbi request reprint Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions
    Karin J Metzner
    Aaron Diamond AIDS Research Center, Columbia University, New York, New York, USA
    J Infect Dis 188:1433-43. 2003
    ..Overall, these results indicate that, in subjects undergoing multiple STIs, HIV-1 variants carrying drug-resistance mutations can emerge during periods of increased HIV-1 replication...
  3. ncbi request reprint Detection and significance of minority quasispecies of drug-resistant HIV-1
    Karin J Metzner
    Institute of Clinical and Molecular Virology, University of Erlangen Nuremberg, Schlossgarten, Erlangen, Germany
    J HIV Ther 11:74-81. 2006
  4. ncbi request reprint Rapid selection of drug-resistant HIV-1 during the first months of suppressive ART in treatment-naive patients
    Karin J Metzner
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Erlangen, Germany
    AIDS 21:703-11. 2007
    ..In this study, we wanted to determine whether drug-resistant viruses are already selected during viral decline within the first months of ART...
  5. pmc Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques
    Karin J Metzner
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    Retrovirology 3:97. 2006
    ....
  6. ncbi request reprint Detection of minor populations of drug-resistant HIV-1 in acute seroconverters
    Karin J Metzner
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Germany
    AIDS 19:1819-25. 2005
    ..As minor populations of drug-resistant HIV-1 could impact the efficiency of antiretroviral therapy, this study was performed to determine the prevalence of minor populations of drug-resistant HIV-1 in acute seroconverters...
  7. doi request reprint Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients
    Karin J Metzner
    Institute of Clinical and Molecular Virology, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Infect Dis 48:239-47. 2009
    ..Therefore, we evaluated the possible role of minority quasispecies of drug-resistant human immunodeficiency virus type 1, which are undetectable at baseline by population sequencing, with regard to early virological failure...
  8. ncbi request reprint Persistence of lamivudine-sensitive HIV-1 quasispecies in the presence of lamivudine in vitro and in vivo
    Kristina Allers
    Institute of Clinical and Moleculr Virology, University of Erlangen Nuremburg, Erlangen, Germany
    J Acquir Immune Defic Syndr 44:377-85. 2007
    ....
  9. doi request reprint The antiretroviral potency of emtricitabine is approximately 3-fold higher compared to lamivudine in dual human immunodeficiency virus type 1 infection/competition experiments in vitro
    Daniel Drogan
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Erlangen, Germany
    Antiviral Res 86:312-5. 2010
    ..Mathematical modeling of the distinct rates of suppression of drug-sensitive viruses revealed an approximately 3-fold higher antiretroviral potency for FTC compared to 3TC...
  10. ncbi request reprint Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus
    Karin J Metzner
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    J Gen Virol 86:3375-84. 2005
    ....
  11. ncbi request reprint Inhibition of drug-resistant HIV-1 by RNA interference
    Peter M Huelsmann
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Schlossgarten 4, D 91054 Erlangen, Germany
    Antiviral Res 69:1-8. 2006
    ..Taken together, these results demonstrate that RNA interference might be useful in the treatment of drug-resistant HIV-1 infection...
  12. doi request reprint Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naïve patients
    Karin J Metzner
    Institute of Clinical and Molecular Virology, University of Erlangen Nuremberg, Germany
    J Clin Virol 50:156-61. 2011
    ....
  13. pmc A suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replication
    Peter M Huelsmann
    University of Erlangen Nuremberg, Institute of Clinical and Molecular Virology, Erlangen, Germany
    BMC Biotechnol 11:4. 2011
    ..We tested truncated Bid (tBid), a human pro-apoptotic protein that induces apoptosis very rapidly and efficiently, as suicide gene for gene therapy against HIV-1 infection...
  14. doi request reprint Generation of HIV-1-specific T cells by electroporation of T-cell receptor RNA
    Christian Hofmann
    Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    AIDS 22:1577-82. 2008
    ..Antigen-specific cytotoxic T lymphocytes can be generated by T-cell receptor transfer. This is commonly done by retroviral transduction, which is complicated and poses the threat of stable genetic alteration of autologous cells...
  15. doi request reprint In-depth analysis of G-to-A hypermutation rate in HIV-1 env DNA induced by endogenous APOBEC3 proteins using massively parallel sequencing
    Stefanie A Knoepfel
    Institute of Clinical and Molecular Virology, University of Erlangen Nuremberg, Germany
    J Virol Methods 171:329-38. 2011
    ..6%). Single hypermutated sequences contained up to 24 G-to-A mutations. Overall, massively parallel sequencing is a very useful tool for in-depth analysis of G-to-A hypermutation in HIV-1 DNA induced by APOBEC3 proteins...
  16. pmc Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency
    Elias K Halvas
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, S818 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, and Children s Hospital of Los Angeles, CA, USA
    J Clin Microbiol 44:2612-4. 2006
    ..1 to 0.4%. These technologies should help define the impact of low-frequency drug-resistant mutants on response to antiretroviral therapy...