R Metzger

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi Molecular biology of esophageal cancer
    R Metzger
    Klinik und Poliklinik für Visceral und Gefässchirurgie der Universität zu Köln, Germany
    Onkologie 27:200-6. 2004
  2. ncbi High volume centers for esophagectomy: what is the number needed to achieve low postoperative mortality?
    R Metzger
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Dis Esophagus 17:310-4. 2004
  3. ncbi [18F]-fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemotherapy in gastric cancer
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 102:135-40. 2010
  4. ncbi Histological type of esophageal cancer might affect response to neo-adjuvant radiochemotherapy and subsequent prognosis
    E Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
    Ann Oncol 20:231-8. 2009
  5. ncbi Clinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma: is there really a difference?
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 21:596-600. 2008
  6. ncbi High-volume centers--effect of case load on outcome in cancer surgery
    A H Holscher
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Onkologie 27:412-6. 2004
  7. ncbi Lack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer
    A C Hoffmann
    Department of General, Visceral and Tumor Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 100:414-7. 2009
  8. ncbi Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Oncol Rep 20:779-83. 2008
  9. ncbi Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer
    H Alakus
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Histol Histopathol 23:917-23. 2008
  10. ncbi Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact?
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpenerstrasse 62, Cologne, Germany
    Int J Colorectal Dis 27:1295-301. 2012

Collaborators

Detail Information

Publications27

  1. ncbi Molecular biology of esophageal cancer
    R Metzger
    Klinik und Poliklinik für Visceral und Gefässchirurgie der Universität zu Köln, Germany
    Onkologie 27:200-6. 2004
    ..Regarding the dysplasia-metaplasia-carcinoma sequence of Barrett's esophagus, inhibition of apoptosis by overexpression of bcl-2 proteins occurs as an early event...
  2. ncbi High volume centers for esophagectomy: what is the number needed to achieve low postoperative mortality?
    R Metzger
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Dis Esophagus 17:310-4. 2004
    ..9%, be achieved. Based on this survey, surgery of esophageal cancer is a task for high-volume hospitals because of decreased postoperative mortality and improved long-term prognosis compared with low volume hospitals...
  3. ncbi [18F]-fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemotherapy in gastric cancer
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 102:135-40. 2010
    ..We evaluated the potential of FDG-PET for the assessment of response and prognosis in the multimodality treatment of gastric cancer...
  4. ncbi Histological type of esophageal cancer might affect response to neo-adjuvant radiochemotherapy and subsequent prognosis
    E Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
    Ann Oncol 20:231-8. 2009
    ..This study investigates response and prognosis after neo-adjuvant chemoradiation (CTx/RTx) in patients with advanced esophageal carcinoma, according to histological type...
  5. ncbi Clinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma: is there really a difference?
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 21:596-600. 2008
    ..The better prognosis of young patients is mainly caused by less comorbidity and more frequent use of neoadjuvant therapy...
  6. ncbi High-volume centers--effect of case load on outcome in cancer surgery
    A H Holscher
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Onkologie 27:412-6. 2004
    ..Surgery of pancreatic and esophageal cancer is a task for high-volume hospitals because they have less postoperative mortality and improved long-term prognosis compared to low-volume hospitals...
  7. ncbi Lack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer
    A C Hoffmann
    Department of General, Visceral and Tumor Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 100:414-7. 2009
    ..Aim of this study was to investigate the potential of the DNA methylation of DAPK, MGMT, and GSTPI in serum of patients with NSCLC as a prognostic molecular marker in this disease...
  8. ncbi Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Oncol Rep 20:779-83. 2008
    ..Since our data are merely hypothesis-generating, serosal penetration should be evaluated in large prospective databases...
  9. ncbi Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer
    H Alakus
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Histol Histopathol 23:917-23. 2008
    ....
  10. ncbi Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact?
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpenerstrasse 62, Cologne, Germany
    Int J Colorectal Dis 27:1295-301. 2012
    ..However, currently no accepted comprehensive grading system for clinical use is available. Therefore, we studied the impact of four histological regression grading systems in the neoadjuvant therapy of rectal cancer...
  11. ncbi Differential SPARC mRNA expression in Barrett's oesophagus
    J Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, Cologne 50931, Germany
    Br J Cancer 89:1508-12. 2003
    ....
  12. ncbi Association of COX-2 expression with corresponding active and chronic inflammatory reactions in Barrett's metaplasia and progression to cancer
    F C Ling
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne corrected Germany
    Histopathology 50:203-9. 2007
    ....
  13. ncbi Comparative analysis of four histopathological classification systems to discriminate benign and malignant behaviour in gastrointestinal stromal tumors
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Anticancer Res 28:367-72. 2008
    ..The prognostic value of the four most common histopathological classification systems in gastrointestinal stromal tumors (GISTs) was evaluated retrospectively...
  14. ncbi Survivin mRNA in peripheral blood is frequently detected and significantly decreased following resection of gastrointestinal cancers
    A C Hoffmann
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 95:51-4. 2007
    ....
  15. ncbi Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer
    F Miyazono
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Br J Cancer 91:666-72. 2004
    ..This test could be used to prevent expensive, non effective and potentially harmful therapies in approximately one-fourth of our patients, and leads to a more individualised type of combined modality treatment...
  16. ncbi Multiple molecular marker testing (p53, C-Ki-ras, c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer
    P M Schneider
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Br J Cancer 83:473-9. 2000
    ..6%+/-7.9% 5-year survival) and high risk (40.2%+/-5.5% 5-year survival) groups for treatment failure in potentially curative (RO) resected NSCLC...
  17. ncbi Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses
    S Awerkiew
    Institute of Virology, University of Cologne, Germany
    Med Microbiol Immunol 192:137-40. 2003
    ..In contrast, 35% of squamous cell carcinomas and 36% of adenocarcinomas were shown to contain EBV DNA by nested polymerase chain reaction...
  18. ncbi Successful management of esophageal perforation due to an aortic arch aneurysm replacement
    P Grimminger
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 22:471-4. 2009
    ..The aortic prosthesis was covered by omentum. After a prolonged postoperative course, the patient was discharged from the hospital on a full oral diet. She is well after 1 year without signs of infection...
  19. ncbi [Regression of oesophageal carcinomas after neoadjuvant radiochemotherapy: criteria of the histopathological evaluation]
    S E Baldus
    Institut fur Pathologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Pathologe 25:421-7. 2004
    ..These results underline the importance of an exact examination and histomorphological evaluation of the response for the assessment of survival probability after neoadjuvant radiochemotherapy of oesophageal carcinomas...
  20. ncbi [Preoperative radiochemotherapy of esophageal carcinoma. Light at the end of the tunnel?]
    A H Holscher
    Klinik und Poliklinik für Viszeral und Gefässchirurgie, Universitat zu Koln
    Zentralbl Chir 125:319-25. 2000
    ..For future research, predictive response analyses based on molecular biologic and immuno-histochemic techniques are of great importance and first differentiations by biomarkers have been detected...
  21. ncbi Coincidence of nutritional habits and esophageal cancer in Germany
    E Wolfgarten
    , , Germany
    Onkologie 24:546-51. 2001
    ..Patients with cancer of the esophagus had a nutritonal deficit in fresh fruit, vegetables, dietary fiber, and carbohydrates. Compared with the other groups, patients with AC had a higher intake of protein, fat, and milk...
  22. ncbi Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival
    J Brabender
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, CA 90033, USA
    Oncogene 20:3528-32. 2001
    ..High APC promoter methylation is significantly associated with inferior survival, showing promise as a biomarker of biologically aggressive disease in NSCLC...
  23. ncbi Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology/Norris Comprehensive Cancer Research Center, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Gastrointest Surg 5:174-81; discussion 182. 2001
    ..early event in the development and progression of Barrett's-associated adenocarcinoma of the esophagus, and they suggest that high ODC mRNA expression levels may be a clinically useful biomarker for the detection of occult adenocarcinoma..
  24. ncbi Long gap esophageal atresia and arterial circle of Willis variant leading to ischemic stroke during gastric transposition
    R Metzger
    Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany
    Eur J Pediatr Surg 18:121-2. 2008
    ..Today, at the age of 14 months, almost no neurological deficits are evident. To the best of our knowledge, no description of vascular cerebral complications combined with esophageal atresia can be found in the literature...
  25. ncbi Randomized trial of tacrolimus plus mycophenolate mofetil or azathioprine versus cyclosporine oral solution (modified) plus mycophenolate mofetil after cadaveric kidney transplantation: results at 2 years
    N Ahsan
    Milton S. Hershey Medical Center, Hershey, PA 17104-1696, USA
    Transplantation 72:245-50. 2001
    ..The combination may provide particular benefit to kidney allograft recipients who develop delayed graft function/acute tubular necrosis. Renal function at 2 years was better in the tacrolimus treatment groups compared with the CsA group...
  26. ncbi [Psychiatric-psychotherapeutic inpatient treatment for depression. Process and outcome quality based on a model project in Baden-Wurttemberg]
    M Harter
    Abteilung für Psychiatrie und Psychotherapie, Universitatsklinikum, Freiburg
    Nervenarzt 75:1083-91. 2004
    ..The results show that the patients' satisfaction with the care received is very high and the pre-post effect sizes of inpatient treatment for depression are high...
  27. ncbi [After cat bite antibiotics are obligatory. Acute management of bite injuries]
    R Metzger
    Chirurgische Klinik und Poliklinik-Innenstadt,
    MMW Fortschr Med 144:46-9. 2002