K Messmer

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Professor Dr. med. Dr. med. h. c. Walter Brendel 1922-1989
    K Messmer
    Klinikum der Universitat Munchen, Grosshadern VI KU 1 953, Marchioninistrasse 15, 81366 Munich, Germany
    Langenbecks Arch Surg 389:155-6. 2004
  2. ncbi request reprint Perspectives of surgical research
    K Messmer
    Institute for Surgical Research, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    Inflamm Res 53:S194-6. 2004
  3. ncbi request reprint Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C mice
    D Nolte
    Institute for Surgical Research, University of Munich, Germany
    Am J Physiol 267:H1320-8. 1994
  4. ncbi request reprint Differential function of nitric oxide in murine antigen-induced arthritis
    A Veihelmann
    Department of Orthopaedics, Ludwig Maximilians University of Munich, Munich, Germany
    Rheumatology (Oxford) 41:509-17. 2002
  5. ncbi request reprint Validity of fluorescent microspheres method for bone blood flow measurement during intentional arterial hypotension
    H Anetzberger
    Department of Orthopaedics, Ludwig Maximilians University, 81377 Munich, Germany
    J Appl Physiol 95:1153-8. 2003
  6. ncbi request reprint Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit
    F G Meisner
    Institute for Surgical Research, Klinikum Grobetahadern, Ludwig-Maximilians-University Munich, Germany
    Crit Care Med 29:829-38. 2001
  7. ncbi request reprint In vivo assessment of synovial microcirculation and leukocyte-endothelial cell interaction in mouse antigen-induced arthritis
    A Veihelmann
    Institute for Surgical Research, Department for Orthopedics, Ludwig Maximilians University of Munich, Germany
    Microcirculation 6:281-90. 1999
  8. pmc Orthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study
    S Pahernik
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Br J Cancer 86:1622-7. 2002
  9. ncbi request reprint The effects of Celecoxib on inflammation and synovial microcirculation in murine antigen-induced arthritis
    H H Gebhard
    Institute for Surgical Research, Ludwig Maximilians University of Munich, Germany
    Clin Exp Rheumatol 23:63-70. 2005
  10. ncbi request reprint Heparin protects local skin microcirculation in 210 minutes-long intravital microscopy observations under general anaesthesia
    G Szczesny
    Institute of Surgical Research, Klinikum Grosshadern, Munich, Germany
    Eur J Med Res 6:175-80. 2001

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Professor Dr. med. Dr. med. h. c. Walter Brendel 1922-1989
    K Messmer
    Klinikum der Universitat Munchen, Grosshadern VI KU 1 953, Marchioninistrasse 15, 81366 Munich, Germany
    Langenbecks Arch Surg 389:155-6. 2004
  2. ncbi request reprint Perspectives of surgical research
    K Messmer
    Institute for Surgical Research, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    Inflamm Res 53:S194-6. 2004
  3. ncbi request reprint Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C mice
    D Nolte
    Institute for Surgical Research, University of Munich, Germany
    Am J Physiol 267:H1320-8. 1994
    ..Postischemic capillary perfusion was efficiently preserved in animals treated with anti-Mac-1 and anti-ICAM-1 MAb compared with animals receiving the isotype-matched control antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)..
  4. ncbi request reprint Differential function of nitric oxide in murine antigen-induced arthritis
    A Veihelmann
    Department of Orthopaedics, Ludwig Maximilians University of Munich, Munich, Germany
    Rheumatology (Oxford) 41:509-17. 2002
    ..The aim of our study was to investigate the role of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) production in different stages of murine antigen-induced arthritis (AiA)...
  5. ncbi request reprint Validity of fluorescent microspheres method for bone blood flow measurement during intentional arterial hypotension
    H Anetzberger
    Department of Orthopaedics, Ludwig Maximilians University, 81377 Munich, Germany
    J Appl Physiol 95:1153-8. 2003
    ..In addition, changes in bone blood flow during hypotension indicate that vasomotor control mechanisms, as well as cardiac output, play a role in setting bone blood flow...
  6. ncbi request reprint Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit
    F G Meisner
    Institute for Surgical Research, Klinikum Grobetahadern, Ludwig-Maximilians-University Munich, Germany
    Crit Care Med 29:829-38. 2001
    ..This discrepancy in regional oxygenation might be caused by a redistribution of blood flow favoring the heart, which is related to a disproportionate decrease of coronary vascular resistance index during hemodilution with DCLHb...
  7. ncbi request reprint In vivo assessment of synovial microcirculation and leukocyte-endothelial cell interaction in mouse antigen-induced arthritis
    A Veihelmann
    Institute for Surgical Research, Department for Orthopedics, Ludwig Maximilians University of Munich, Germany
    Microcirculation 6:281-90. 1999
    ..The expression of E- and P-selectin and ICAM-1 were also studied using immunohistochemistry...
  8. pmc Orthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study
    S Pahernik
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Br J Cancer 86:1622-7. 2002
    ..Thus, quantification of tumour angiogenesis can be used to more accurately classify and monitor tumour biologic characteristics, and to explore aggressiveness of tumours...
  9. ncbi request reprint The effects of Celecoxib on inflammation and synovial microcirculation in murine antigen-induced arthritis
    H H Gebhard
    Institute for Surgical Research, Ludwig Maximilians University of Munich, Germany
    Clin Exp Rheumatol 23:63-70. 2005
    ....
  10. ncbi request reprint Heparin protects local skin microcirculation in 210 minutes-long intravital microscopy observations under general anaesthesia
    G Szczesny
    Institute of Surgical Research, Klinikum Grosshadern, Munich, Germany
    Eur J Med Res 6:175-80. 2001
    ..The aim of our study was to investigate the influence of heparin and buflomedil, drugs improving the microcirculation, on local skin blood perfusion using intravital fluorescent microscopy (IVM) technique...
  11. doi request reprint Involvement of nitric oxide in microcirculatory reactions after ischemia-reperfusion of the rat urinary bladder
    Z Bajory
    Institute for Surgical Research, University of Munich, Munich, Germany
    Eur Surg Res 42:28-34. 2009
    ..Nitric oxide (NO) plays a role in inflammation. Our aim was to investigate the role of NO in the microcirculatory changes after ischemia-reperfusion (I/R) of the bladder using intravital videomicroscopy (IVM)...
  12. ncbi request reprint Characterization and prevention of phototoxic effects in intravital fluorescence microscopy in the hamster dorsal skinfold model
    M Steinbauer
    Institute for Surgical Research, University of Munich, Germany
    Langenbecks Arch Surg 385:290-8. 2000
    ..Nevertheless every laboratory using epiillumination and fluorescent dyes should take precautions to avoid these effects by the use of sensitive cameras to lower the light dose...
  13. ncbi request reprint Use of selective and nonselective nitric oxide synthase inhibitors in rat endotoxemia: effects on hepatic morphology and function
    Y Gundersen
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Germany
    Shock 8:368-72. 1997
    ..Even with the iNOS selective inhibitor AE-ITU no benefit was noted. We conclude that during the early phases of endotoxemia therapeutic reduction of NO production has no positive effects on liver function or morphology...
  14. ncbi request reprint Effect of diaspirin cross-linked hemoglobin on normal and postischemic microcirculation of the rat pancreas
    E von Dobschuetz
    Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilians University, D 81366 Munich, Germany
    Am J Physiol 276:G1507-14. 1999
    ..Thus our data provide no evidence for a detrimental effect on the pancreatic microcirculation or an enhanced risk of postischemic pancreatitis by DCLHb...
  15. ncbi request reprint A novel model for the study of synovial microcirculation in the mouse knee joint in vivo
    A Veihelmann
    Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Res Exp Med (Berl) 198:43-54. 1998
    ..It provides insight into the dynamics of synovial microcirculation and leukocyte-endothelial cell interaction in acute or chronic joint inflammation...
  16. ncbi request reprint Orthogonal polarization spectral imaging versus intravital fluorescent microscopy for microvascular studies in wounds
    S Langer
    Institute for Surgical Research, Department of Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Ann Plast Surg 48:646-53. 2002
    ..Such a device should now help to study the role of microcirculation in physiology and pathophysiology during wound healing in patients. First clinical investigations are promising...
  17. ncbi request reprint A new chamber technique for intravital microscopic observations in the different soft tissue layers of mouse hindleg
    G Szczesny
    Institute for Surgical Research, Ludwig Maximilians University of Munich, Germany
    J Trauma 49:1108-15. 2000
    ....
  18. ncbi request reprint Simulated microgravity, psychic stress, and immune cells in men: observations during 120-day 6 degrees HDT
    A Chouker
    Clinic of Anaesthesiology, University of Munich, 81366 Munich, Germany
    J Appl Physiol 90:1736-43. 2001
    ..Thus 6 degrees HDT appears to be a valid model to induce psychic stress and neuroendocrine-related changes in the immune system, changes that might also be encountered by astronauts and cosmonauts during long-duration spaceflights...
  19. ncbi request reprint Prevention of hepatic ischemia-reperfusion injury by SOD-DIVEMA conjugate
    T Kondo
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Munich, D 81377, Germany
    J Surg Res 85:26-36. 1999
    ..0 +/- 5.9; SOD, 8.6 +/- 3.1 U/ml). The beneficial effect of SOD-DIVEMA was most prominent after 120 min of reperfusion, indicating a longer intravascular half-life of SOD-DIVEMA...
  20. ncbi request reprint Expression of adhesion molecules on circulating polymorphonuclear leukocytes during orthotopic liver transplantation
    M Thiel
    Department of Anaesthesiology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Hepatology 28:1538-50. 1998
    ....
  21. ncbi request reprint Fluorescent microsphere method is suitable for chronic bone blood flow measurement: a long-term study after meniscectomy in rabbits
    H Anetzberger
    Department of Orthopaedics, Klinikum Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany
    J Appl Physiol 96:1928-36. 2004
    ..In addition, we were able to demonstrate that meniscectomy leads to an increase in RBBF in the tibial condyles at a very early stage. This increase might be caused by stress-induced alterations of the subchondral bone...
  22. ncbi request reprint Stimulation of leukocyte/endothelium interaction by oxidized low-density lipoprotein in hairless mice. Involvement of CD11b/CD18 adhesion receptor complex
    H A Lehr
    Institute for Surgical Research, University of Munich, Germany
    Lab Invest 68:388-95. 1993
    ..Using a skinfold chamber model in hamsters for intravital microscopy, we have recently demonstrated the chemotactic and adhesion-promoting action of oxidatively modified low density lipoprotein (oxLDL) in vivo...
  23. ncbi request reprint Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man
    A Chouker
    Clinic of Anesthesiology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Eur Surg Res 37:144-52. 2005
    ....
  24. ncbi request reprint Effects of hypertonic saline on expression of human polymorphonuclear leukocyte adhesion molecules
    M Thiel
    Department of Anesthesiology and the Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    J Leukoc Biol 70:261-73. 2001
    ....
  25. ncbi request reprint Can we continue research in splenectomized dogs? Mycoplasma haemocanis: old problem--new insight
    G Kemming
    Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilian University Munich, Munich, Germany
    Eur Surg Res 36:198-205. 2004
    ..We, therefore, had to abandon the intended shock study. In the absence of effective surveillance and screening for M. haemocanis, the question arises whether it is prudent to continue shock research in splenectomized dogs...
  26. ncbi request reprint Changes in p(i)CO(2) reflect splanchnic mucosal ischaemia more reliably than changes in pH(i) during haemorrhagic shock
    F G Meisner
    Institute for Surgical Research, Clinic of the Ludwig Maximilians University Munich, Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Langenbecks Arch Surg 386:333-8. 2001
    ....
  27. ncbi request reprint The influence of organ temperature on hepatic ischemia-reperfusion injury: a systematic analysis
    P Biberthaler
    Institute for Surgical Research, University of Munich, Germany
    Transplantation 72:1486-90. 2001
    ..The aim of this study was to systematically investigate the impact of defined temperatures of the ischemic liver tissue on microvascular I/R injury...
  28. ncbi request reprint Changes in microvascular fluid filtration capacity during 120 days of 6 degrees head-down tilt
    F Christ
    Clinic of Anaesthesiology, Ludwig Maximillians University of Munich, 81366 Munich, Germany
    J Appl Physiol 91:2517-22. 2001
    ..We believe that the increased K(f) is caused by a higher microvascular water permeability. Because this may result in edema formation, it could contribute to the alterations in fluid homeostasis after exposure to microgravity...
  29. ncbi request reprint Microcirculatory failure after rat liver transplantation is related to Kupffer cell-derived oxidant stress but not involved in early graft dysfunction
    R J Schauer
    Department of Surgery, Klinikum Grosshadern, University of Munich, Germany
    Transplantation 72:1692-9. 2001
    ..We therefore investigated whether KC induce microcirculatory disturbances through ROS release and whether microcirculatory failure contributes to early graft function after liver transplantation...
  30. ncbi request reprint Comparison of regional blood flow values measured by radioactive and fluorescent microspheres
    Eckart Thein
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 27, D 81366 Munich, Germany
    Eur Surg Res 34:215-23. 2002
    ..95 +/- 0.03 to 0.97 +/- 0.02) and excellent agreement (bias 5.4-6.7%, precision 9.9- 16.5%) of both methods. Our results indicate the validity of MS and of the automated tissue processing technique by means of the SPU...
  31. ncbi request reprint Evaluation of murine liver transmission electron micrographs by an innovative object-based quantitative image analysis system (Cellenger)
    P Biberthaler
    Institute for Surgical Research, Klinikum der Ludwig Maximilians Universität Grosshadern, Munich, Germany
    Eur J Med Res 8:275-82. 2003
    ..The results were compared with those obtained by conventional qualitative classification. -..
  32. ncbi request reprint In vivo assessment of colon microcirculation: comparison of the new OPS imaging technique with intravital microscopy
    P Biberthaler
    Institut für Chirurgische Forschung, Klinikum Grosshadern, Marchioninistr 15, D 81366 Munich, Germany
    Eur J Med Res 6:525-34. 2001
    ..Therefore, the aim of this study was to validate the new technique against intravital fluorescence microscopy (IFM) for the visualization of colon microcirculation in a murine model of inflammatory bowel disease (IBD)...
  33. ncbi request reprint Effects of confinement (110 and 240 days) on neuroendocrine stress response and changes of immune cells in men
    A Chouker
    Clinic of Anaesthesiology, University of Munich, 81366 Munich, Germany
    J Appl Physiol 92:1619-27. 2002
    ....
  34. ncbi request reprint Direct assessment and distribution of regional portal blood flow in the pig by means of fluorescent microspheres
    E Thein
    Institute for Surgical Research, University of Munich, 81377 Munich, Germany
    J Appl Physiol 95:1808-16. 2003
    ..01) in the left liver lobe compared with the median and right lobes. The results show that the model presented makes it possible to measure RPBF by means of FM reliably and that RPBF is distributed heterogeneously in the porcine liver...
  35. ncbi request reprint Intravital fluorescence microscopy and phototocicity: effects on leukocytes
    Anthony G Harris
    Institute for Surgical Research, Klinikum Grosshadern, Marchioninistr 15, D 81366 Munich, Germany
    Eur J Med Res 7:117-24. 2002
    ....
  36. ncbi request reprint Effects of ibandronate on inflammation in mouse antigen-induced arthritis
    S P Zysk
    Department of Orthopaedics, Ludwig Maximilians University of Munich, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Inflamm Res 52:221-6. 2003
    ..To investigate the effects of ibandronate, a novel aminobisphosphonate, on inflammation as well as leukocyte-endothelial cell interaction in mouse antigen-induced arthritis (AiA)...
  37. ncbi request reprint Determination of regional bone blood flow by means of fluorescent microspheres using an automated sample-processing procedure
    H Anetzberger
    Department of Orthopedics, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Eur Surg Res 35:337-45. 2003
    ..96, slope = 1.06, intercept = 0.05), the mean difference was 0.39 +/- 1.11 ml/min/100 g. Our data demonstrate that the measurement of RBBF by means of FM allows a valid determination of RBBF...
  38. ncbi request reprint Small-volume resuscitation: from experimental evidence to clinical routine. Advantages and disadvantages of hypertonic solutions
    Uwe Kreimeier
    Department of Anesthesiology, Ludwig Maximilian University Munich, Munich, Germany
    Acta Anaesthesiol Scand 46:625-38. 2002
    ..e. approximately 250 ml in an adult patient) of 7.2-7.5% NaCl/colloid solution. Originally, SVR was aimed for initial therapy of severe hypovolemia and shock associated with trauma...
  39. ncbi request reprint Oxaceprol, an atypical inhibitor of inflammation, reduces leukocyte adherence in mouse antigen-induced arthritis
    A Veihelmann
    Department of Orthopedics, Ludwig Maximilians University of Munich, Germany
    Acta Orthop Scand 72:293-8. 2001
    ..Thus, oxaceprol reduces leukocyte adherence in vivo and leukocyte infiltration in mouse AiA, indicating an effect on synovial microcirculation...
  40. ncbi request reprint Quantitative assessment of angiogenesis in murine antigen-induced arthritis by intravital fluorescence microscopy
    M Schmitt-Sody
    Department of Orthopedics, Ludwig Maximilians University of Munich, Munich, Germany
    J Vasc Res 40:460-6. 2003
    ..133 +/- 16 mm(-2) in control). These findings demonstrate that angiogenesis in murine AIA can be assessed quantitatively using intravital microscopy. Further studies will address antiangiogenic strategies in AIA...
  41. ncbi request reprint Non-invasive temperature mapping using MRI: comparison of two methods based on chemical shift and T1-relaxation
    F Bertsch
    Institut fur Radiologische Diagnostik, Ludwig Maximilians Universitat, Munchen, Germany
    Magn Reson Imaging 16:393-404. 1998
    ..To implement and evaluate the accuracy of non-invasive temperature mapping using MRI methods based on the chemical shift (CS) and T1 relaxation in media of various heterogeneity during focal (laser) and external thermal energy deposition...
  42. ncbi request reprint Efficacy of myocardial initial reperfusion with 2,3 butanedione monoxime after cardioplegic arrest is time-dependent
    H Habazettl
    Institute for Surgical Research, University of Munich, Germany
    Cardiovasc Res 37:684-90. 1998
    ..However, left ventricular contractility was only marginally enhanced. The goal of the present study was to test, wether the efficacy of BDM reperfusion can be enhanced by prolonging the application period...
  43. ncbi request reprint Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectin
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 92:507-15. 1998
    ..Platelet recruitment and subsequent activation might play an important role in the pathogenesis of I/R injury...
  44. ncbi request reprint IV perflubron emulsion versus autologous transfusion in severe normovolemic anemia: effects on left ventricular perfusion and function
    O Habler
    Institute for Surgical Research, Ludwig Maximilians University, Munich, Germany
    Res Exp Med (Berl) 197:301-18. 1998
    ..After profound normovolemic hemodilution (Hct 9%) superiority of LV MC and LV diastolic properties was found, when myocardial oxygenation was supported by i.v. perflubron emulsion, a temporary O2 carrier...
  45. ncbi request reprint Changes in the arteriolar volume pulse of the finger during various degrees of tilt using near infra-red and red photoplethysmography
    F Christ
    Institut für Anaesthesiologie, Ludwig Maximillians University Munich, Klinikum Grosshadern, Marchioninistr 15, D 82362 Munich, Germany
    Eur J Med Res 3:249-55. 1998
    ..Time discrete parameters however did not depict these changes and appear unsuitable for data analysis when using this specific hardware applied in the current study...
  46. ncbi request reprint Effects of Daflon 500mg on postischemic macromolecular leak syndrome in striated skin muscle of the hamster
    D Nolte
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Germany
    Int J Microcirc Clin Exp 17:6-10. 1997
    ....
  47. ncbi request reprint Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis
    M Kleen
    Institute for Surgical Research, University of Munich, 81366 Munich, Germany
    J Appl Physiol 83:1832-41. 1997
    ..18 +/- 0.02). We conclude that hemorrhagic shock homogenized regional myocardial perfusion in coronary stenosis and that fluid therapy failed to restore this...
  48. ncbi request reprint Effects of hemodilution on splanchnic perfusion and hepatorenal function. II. Renal perfusion and hepatorenal function
    O Habler
    Institute for Surgical Research and Institute of Anesthesiology Marchioninistr 15 Munich, D 81366 Germany 49 89 7095 4357 49 89 7095 8897
    Eur J Med Res 2:419-24. 1997
    ..Increased urinary output points out the necessity for proper adjustment of crystalloid infusion to maintain normal intravascular volume and avoid hypovolemia and the associated risk of tissue hypoxia...
  49. ncbi request reprint Effects of hemodilution on splanchnic perfusion and hepatorenal function. I. Splanchnic perfusion
    M Kleen
    Institute for Surgical Research, University of Munich Marchioninistr 15 Munich D 81366 Germany 49 89 7095 4403 49 89 7095 8897
    Eur J Med Res 2:413-8. 1997
    ..This redistribution of intestinal flow might be the basis for the preservation of tissue oxygenation during moderate isovolemic anemia...
  50. ncbi request reprint A tool for balancing activity from isotopes used for the radioactive microsphere method
    M Kleen
    Institute for Surgical Research, Klinikum Grosshadern Marchioininistr Munich, Germany
    Comput Methods Programs Biomed 53:81-6. 1997
    ..3 +/- 6.9 85Sr, 18.9 +/- 6.8 141Ce, 10.7 +/- 6.2 51Cr, 23.9 +/- 6.7 95Nb, 16.9 +/- 7.2 46Sc, and 7.3 +/- 2.7% 114mIn radiation, respectively...
  51. pmc Dorsal skinfold chamber technique for intravital microscopy in nude mice
    H A Lehr
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Germany
    Am J Pathol 143:1055-62. 1993
    ....
  52. ncbi request reprint Microvascular phenomena during pancreatic islet graft rejection
    M D Menger
    Institute of Surgical Research, Ludwig Maximilians University, Munich, FRG
    Langenbecks Arch Chir 376:214-21. 1991
    ..Treatment with 2.5 mg/kg/d (+/-)-15-deoxyspergualin could not completely alleviate these microvascular rejection phenomena.(ABSTRACT TRUNCATED AT 250 WORDS)..
  53. ncbi request reprint Impact of ischemia-reperfusion injury on dimensional changes of hepatic microvessels
    T Kondo
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Germany
    Res Exp Med (Berl) 198:63-72. 1998
    ..It has been suggested that postischemic dimensional microvascular changes are involved in postischemic liver dysfunction...
  54. ncbi request reprint [Acute normovolemic hemodilutin (ANH). Effects of ANH on the diastolic function of the left ventricle]
    O Habler
    Klinik fur Anasthesiologie, Ludwig Maximilians Universitat, Munchen
    Anaesthesist 49:939-48. 2000
    ..Moreover neither myocardial perfusion and oxygenation nor myocardial function are endangered by this degree of dilutional anemia...
  55. ncbi request reprint The Cytoscan Model E-II, a new reflectance microscope for intravital microscopy: comparison with the standard fluorescence method
    A G Harris
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Munich, Germany
    J Vasc Res 37:469-76. 2000
    ..Thus, OPS imaging can be used to make valid measurements of microvascular diameter and red blood cell velocity in tissues...
  56. ncbi request reprint Acceleration of wound healing by topical drug delivery via liposomes
    F Roesken
    Institute for Surgical Research, Ludwig Maximilians University, Munich, Germany
    Langenbecks Arch Surg 385:42-9. 2000
    ..Therefore, topically applied liposome-encapsulated buflomedil hydrochloride was investigated for its ability to improve wound repair in normal (n=16) and ischemic (n=16) skin tissue...
  57. ncbi request reprint Effects of primary resuscitation from shock on distribution of myocardial blood flow
    M Kleen
    Institute for Surgical Research, University of Munich, 81366 Munich, Germany
    J Appl Physiol 88:373-85. 2000
    ..Administration of HSA left animals hypotensive (69 mmHg) and increased CI to 122% of the average baseline value. Shock-induced disturbances of the distribution of RMP were improved by administration of DCLHb but not by HSA...
  58. ncbi request reprint Diaspirin cross-linked hemoglobin effectively restores pancreatic microcirculatory failure in hemorrhagic shock
    E von Dobschuetz
    Institute for Surgical Research, Klinikum Grosshadern Ludwig Maximilians University, Munich, Germany
    Anesthesiology 91:1754-62. 1999
    ....
  59. ncbi request reprint Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 94:3829-38. 1999
    ..Since platelets are demonstrated here to induce tyrosine phosphorylation in endothelial cells, platelet recruitment might contribute to the development of an inflammatory reaction during I/R...
  60. ncbi request reprint Microvascular fluid filtration capacity (Kf) assessed with cumulative small venous pressure steps and with various degrees of tilt
    F Christ
    Institute of Anaesthesiology, Ludwig Maximilians University Munich, D 81366 Munich, Germany
    Eur J Med Res 4:264-70. 1999
    ....
  61. ncbi request reprint Selectins and beta 2-integrins mediate post-ischaemic venular adhesion of polymorphonuclear leukocytes, but not capillary plugging, in isolated hearts
    H Habazettl
    Institute for Surgical Research, University of Munich, Germany
    Pflugers Arch 438:479-85. 1999
    ..On the other hand, neither integrins nor selectins seem to be involved in post-ischaemic capillary plugging by PMN in our perfused heart model...
  62. ncbi request reprint Evaluation of a system for the perfusion of isolated, rodent organs
    E Thein
    Institute for Surgical Research, University of Munich, Marchionini Str 15, 81366 Munich, Germany
    Xenotransplantation 8:94-9. 2001
    ..Thus, the perfusion system does not have a negative influence on the blood and its individual components, and is therefore a reliable tool for perfusion experiments...
  63. ncbi request reprint [Direct visualization of microcirculation in burn wounds with OPS imaging--is determination of depth of burns possible?]
    S Langer
    Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Marchioninistrasse 15, 81377 Munchen
    Kongressbd Dtsch Ges Chir Kongr 119:756-8. 2002
    ....
  64. ncbi request reprint Characterization of microcirculatory disturbance in a novel model of pancreatic ischemia-reperfusion using intravital fluorescence-microscopy
    R Obermaier
    Department of Surgery, University of Freiburg, Germany
    Pancreas 25:142-8. 2002
    ..Microcirculatory disturbances caused by ischemia-reperfusion injury (IRI) are the crucial hallmarks of pancreatitis following pancreas transplantation...
  65. ncbi request reprint Soluble complement receptor 1 preserves endothelial barrier function and microcirculation in postischemic pancreatitis in the rat
    E von Dobschuetz
    Dept of General and Visceral Surgery, Albert Ludwigs Univ, Hugstetter Str 55, 79106 Freiburg, Germany
    Am J Physiol Gastrointest Liver Physiol 286:G791-6. 2004
    ..Complement inhibition by sCR1 effectively ameliorates pancreatic ischemia-reperfusion-induced microcirculatory disturbances and might be considered for treatment of postischemic pancreatitis...
  66. ncbi request reprint Exacerbation of antigen-induced arthritis in inducible nitric oxide synthase-deficient mice
    A Veihelmann
    Department of Orthopedics, Ludwig-Maximilians-University of Munich, Germany
    Arthritis Rheum 44:1420-7. 2001
    ..CONCLUSION: These data suggest that NO production by iNOS in vivo has antiinflammatory effects in experimental arthritis, by mediating a reduction in leukocyte adhesion and infiltration...
  67. ncbi request reprint Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia
    D Nolte
    Department of Oral and Maxillofacial Surgery Regional Plastic Surgery, Knappschaftskrankenhaus Bochum Langendreer, University of Bochum, Bochum, Germany
    Eur Surg Res 36:331-7. 2004
    ..This in vivo study investigates the biological role of murine PECAM-1 and VCAM-1 for leukocyte sequestration into the lung, liver and striated skin muscle...
  68. ncbi request reprint Noninvasive in vivo assessment of the pancreatic microcirculation: orthogonal polarization spectral imaging
    E von Dobschuetz
    Department of General and Visceral Surgery, Albert Ludwigs University, Freiburg, Germany
    Pancreas 26:139-43. 2003
    ..Up to now, no logistic suitable method for analyzing pancreatic capillary perfusion during operations in humans has been established without the use of fluorescent dyes...
  69. ncbi request reprint Validation of OPS imaging for microvascular measurements during isovolumic hemodilution and low hematocrits
    A G Harris
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, 81366 Munich, Germany
    Am J Physiol Heart Circ Physiol 282:H1502-9. 2002
    ..In conclusion, OPS imaging can be used to measure diameter and FCD at a wide range of Hcts...
  70. ncbi request reprint Effect of C-peptide on wound healing and microcirculation in diabetic mice
    S Langer
    Clinic for Plastic and Hand Surgery, Burn Center, Ruhr University Bochum, Germany
    Eur J Med Res 7:502-8. 2002
    ..The aim of this study was to investigate the effects of systemically given C-peptide on dermal wound healing in diabetic mice...
  71. ncbi request reprint [Inflammatory responses to wear particles in vivo: a novel model in the murine knee joint]
    S P Zysk
    Orthopädische Klinik und Poliklinik, Ludwig Maximilians Universitat, Klinikum Grosshadern, Munich
    Orthopade 32:305-11. 2003
    ..This model seems to be suitable for further investigations, e.g., dealing with the biocompatibility of different particle materials...
  72. ncbi request reprint Differential responses of rat alveolar and peritoneal macrophages to man-made vitreous fibers in vitro
    M Dorger
    Institute for Surgical Research, Klinikum der Universitat Munchen, Munich, D 81366, Germany
    Environ Res 85:207-14. 2001
    ..The data support the idea that the durability and biopersistence of mineral fibers are higher in the peritoneal cavity than in the lung...
  73. ncbi request reprint Phenotypic and functional differences between rat alveolar, pleural, and peritoneal macrophages
    M Dorger
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Munich, Germany
    Exp Lung Res 27:65-76. 2001
    ..Taken together, the findings of this study demonstrate that rat PLM resemble PM more than AM in terms of production of key inflammatory mediators...
  74. pmc Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo
    M A Buerkle
    Institute for Surgical Research, Klinikum Grosshadern, Marchioninistrasse 15, Ludwig Maximilians University, 81377 Munich, Germany
    Br J Cancer 86:788-95. 2002
    ..Taken together, these results implicate RGD-peptides as agents which have anti-tumour and anti-metastatic activity in vivo...
  75. ncbi request reprint Inhaled nitric oxide induces cerebrovascular effects in anesthetized pigs
    W M Kuebler
    Institute for Surgical Research, University of Munich, Munich, Germany
    Neurosci Lett 348:85-8. 2003
    ..Simultaneously, cerebral transit time increased while cerebral blood flow remained unchanged. These data demonstrate a vasodilatory action of NO(i) in the cerebral vasculature, which may occur preferentially in the venous compartment...
  76. ncbi request reprint New mathematical model for the correct prediction of the exchangeable blood volume during acute normovolemic hemodilution
    J Meier
    Institute for Surgical Research, Klinikum Grosshadern, Ludwig Maximilians University Munich, Germany
    Acta Anaesthesiol Scand 47:37-45. 2003
    ..Our objective was to develop a more accurate mathematical model of hemodilution kinetics and to validate this new model in animals and in patients undergoing ANH...
  77. pmc Influence of hypertonic-hyperoncotic solution and furosemide on canine hydrostatic pulmonary oedema resorption
    C J Wickerts
    Institution of Clinical Physiology, University Hospital of Uppsala, Sweden
    J Physiol 458:425-38. 1992
    ..0 +/- 5.7; B, 9.7 +/- 3.3; C, 10.5 +/- 3.1 and D, 10.6 +/- 1.8 g kg-1. 8. We speculate that mechanisms other than effective Starling gradients and enhanced diuresis might define a maximal rate of pulmonary oedema clearance...