Research Topics
Genomes and Genes | Martha MerrowSummaryAffiliation: University of Munich Country: Germany Publications
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Publications
Assignment of circadian function for the Neurospora clock gene frequencyM Merrow
Institute for Medical Psychology, Ludwig Maximilians University, Munchen, Germany
Nature 399:584-6. 1999..To distinguish between these two possibilities, we used traditional circadian entrainment protocols on a genetic model system, Neurospora crassa...- The circadian cycle: is the whole greater than the sum of its parts?M Merrow
Institute for Medical Psychology, Goethestrasse 31, 80336 Munich, Germany
Trends Genet 17:4-7. 2001..In combining molecular analyses and physiological experiments, those features that are crucial for structuring a circadian day could be uncovered... - Cellular clocks: coupled circadian and cell division cyclesMartha Merrow
Institute for Medical Psychology, University of Munich, Munich, Germany
Curr Biol 14:R25-6. 2004..Gating of cell division by the circadian clock is well known, yet its mechanism is little understood. Genetically tractable model systems have led to new hypotheses and questions concerning the coupling of these two cellular cycles... - Novel strategies for identification of clock genes in Neurospora with insertional mutagenesisKruno Sveric
Institute for Medical Psychology, University of Munich, Germany
Methods Mol Biol 362:173-85. 2007..g., those with alternative selection markers or that facilitate overexpression) or combined with strains carrying clock-regulated reporter genes... - Combining theoretical and experimental approaches to understand the circadian clockMartha Merrow
Institut fur Medizinische Psychologie, Munich, Germany
Chronobiol Int 20:559-75. 2003..The models introduce the "zeitnehmer," i.e., a clock-regulated input pathway, to the conceptual framework of circadian systems, and proposes networks of individual feedbacks as the basis for circadian rhythmicity... 
Demasking biological oscillators: properties and principles of entrainment exemplified by the Neurospora circadian clockTill Roenneberg
Centre for Chronobiology, Institute of Medical Psychology, Medical Faculty, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
Proc Natl Acad Sci U S A 102:7742-7. 2005..By comparing data sets from independent studies, we develop a template for analyzing, modeling, and dissecting the interactions of entrained and masked components. These insights can be applied to oscillators of all periodicities...- Photoperiodism in Neurospora crassaYing Tan
Institute for Medical Psychology, University of Munich, Munich, Germany
J Biol Rhythms 19:135-43. 2004..Night break experiments show that measuring night length is one of the mechanisms used for photoperiod assessment. This represents the first formal report of photoperiodism in the fungi... - The human circadian clock's seasonal adjustment is disrupted by daylight saving timeThomas Kantermann
Ludwig Maximilian University, Goethestrasse 31, D 80336 Munich, Germany
Curr Biol 17:1996-2000. 2007..This disruption may extend to other aspects of seasonal biology in humans... - Entrainment dissociates transcription and translation of a circadian clock gene in neurosporaYing Tan
Institute for Medical Psychology, University of Munich, Munich D-80336, Germany
Curr Biol 14:433-8. 2004..The regulators mediating the dissociation between RNA and protein levels are still unknown and will be the key to understanding both circadian timing at the molecular level and how the clock exerts control over many cellular processes... 
Modeling a circadian surfaceTill Roenneberg
Institute for Medical Psychology, University of Munich, Munich, Germany
J Biol Rhythms 25:340-9. 2010..Experiments measuring aftereffects support the prediction that τ(E) plays an important role in entrainment...- A circadian surface of entrainment: varying T, τ, and photoperiod in Neurospora crassaJan Rémi
Institute for Medical Psychology, University of Munich, Munich, Germany
J Biol Rhythms 25:318-28. 2010..These combinations produce a circadian surface with highly systematic phases of entrainment. The results suggest that the traditional entrainment paradigms using the PRC and τ(DD) have to be reevaluated... - Epidemiology of the human circadian clockTill Roenneberg
Centre for Chronobiology, Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
Sleep Med Rev 11:429-38. 2007..The timing and duration of sleep are generally independent. However, when the two are analysed separately for work and free days, sleep duration strongly depends on chronotype. In addition, chronotype is both age- and sex-dependent... - CLOCK gene variants associate with sleep duration in two independent populationsKarla V Allebrandt
Centre for Chronobiology, Ludwig Maximilians University of Munich, Munich, Germany
Biol Psychiatry 67:1040-7. 2010..Clock genes are associated with dysfunctional timing of sleep, mood, and obesity disorders, which are commonly associated with sleep duration... - Light reception and circadian behavior in 'blind' and 'clock-less' mutants of Neurospora crassaZdravko Dragovic
Institute for Medical Psychology, Division of Chronobiology, Goethestrasse 31, D-80336 Munich, Germany
EMBO J 21:3643-51. 2002..Furthermore, the extant circadian clock machinery in these mutant strains supports the notion that the circadian system in Neurospora involves components outside the WC-FRQ loop... - Entrainment concepts revisitedTill Roenneberg
Institute for Medical Psychology, University of Munich, Munich, Germany
J Biol Rhythms 25:329-39. 2010..Unlike the PRC and the velocity response curve, the CIRC can be assessed on the basis of entrained steady states, by modeling experimental results. The CIRC approach makes several predictions that can be tested experimentally... - The art of entrainmentTill Roenneberg
Institute for Medical Psychology, University of Munich, Germany
J Biol Rhythms 18:183-94. 2003..The results of this basic research will help us to understand temporal ecology and will allow us to improve conditions for humans in industrialized societies... - Social jetlag and obesityTill Roenneberg
Institute for Medical Psychology, University of Munich, Munich, Germany
Curr Biol 22:939-43. 2012..Our data suggest that improving the correspondence between biological and social clocks will contribute to the management of obesity... - Circadian clocks - the fall and rise of physiologyTill Roenneberg
Centre for Chronobiology, Institute of Medical Psychology, Medical Faculty, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
Nat Rev Mol Cell Biol 6:965-71. 2005..Insights from this research will help to optimize medical diagnostics and therapy, as well as adjust social and biological timing on the individual level... - Circadian clocks: translationTill Roenneberg
Centre for Chronobiology, Institute of Medical Psychology, Medical Faculty, University of Munich, Goethestr 31, D 80336 Munich, Germany
Curr Biol 15:R470-3. 2005..While increasing complexity seemed to be the key, a recent report suggests that circa-24 hour rhythms can be generated by just four molecules incubated in a test tube... - Cellular clocks: circadian rhythms in primary human fibroblastsMartha Merrow
Biologisch Centrum, University of Groningen, Postbus 14, 9750AA Haren the Netherlands, University of Munich, Goethestrasse 31, Germany
J Biosci 30:553-5. 2005 - "What watch?...such much!" Complexity and evolution of circadian clocksTill Roenneberg
Institute for Medical Psychology, Chronobiology Division, Ludwig Maximilians Universitat Munchen, Goethestr 31, 80336 Munich, Germany
Cell Tissue Res 309:3-9. 2002..The second example looks at the role of clocks in tissues and cells within a complex organism, and the third speculates on how the circadian system may have evolved... - Life before the clock: modeling circadian evolutionTill Roenneberg
Institute for Medical Psychology, Chronobiology Division, Ludwig Maximilians Universitat Munchen, D 80336 Munich, Germany
J Biol Rhythms 17:495-505. 2002.... - Life between clocks: daily temporal patterns of human chronotypesTill Roenneberg
Center for Chronobiology, Institute for Medical Psychology, Munich, Germany
J Biol Rhythms 18:80-90. 2003..The implications are far ranging concerning learning, memory, vigilance, performance, and quality of life... - Light reception: discovering the clock-eye in mammalsTill Roenneberg
Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336, Munich, Germany
Curr Biol 12:R163-5. 2002..Mammals receive this signal exclusively through the eyes, but not just via rods and cones. New evidence has been uncovered for a novel photoreceptor that may be responsible for more than just adjusting the clock... - The network of time: understanding the molecular circadian systemTill Roenneberg
Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
Curr Biol 13:R198-207. 2003.... - Circadian clock: time for a phase shift of ideas?Martha Merrow
Biological Center, University of Groningen, Postbus 14, 9750AA, Haren, Netherlands
Curr Biol 17:R636-8. 2007..A recent study shows that cycling of cryptochrome proteins is dispensable for circadian clock function in mammalian cells. Is it time for a paradigm shift in how we think about the circadian clock mechanism?.. - The circadian cycle: daily rhythms from behaviour to genesMartha Merrow
Biologisch Centrum, University of Groningen, PO Box 14, 9750AA Haren, The Netherlands
EMBO Rep 6:930-5. 2005..These behavioural oscillations are mirrored in the levels of physiology and gene expression. Deciphering the underlying mechanisms will provide important insights into how the circadian clock affects health and disease... - The human circadian clock entrains to sun timeTill Roenneberg
Curr Biol 17:R44-5. 2007 - Entrainment of the Neurospora circadian clockMartha Merrow
Biologisch Centrum, University of Groningen, Haren, The Netherlands
Chronobiol Int 23:71-80. 2006..Clock gene expression during entrainment and entrainment without clock genes suggest that the known transcription/translation feedback loop is not alone responsible for entrainment in Neurospora... - External time--internal timeSerge Daan
J Biol Rhythms 17:107-9. 2002 - Social jetlag: misalignment of biological and social timeMarc Wittmann
Generation Research Program, Human Science Center, Ludwig-Maximilian University Munich, Germany
Chronobiol Int 23:497-509. 2006..e., the discrepancies between social and biological timing rather than a simple association to different chronotypes. Our results strongly suggest that work (and school) schedules should be adapted to chronotype whenever possible... - The right place at the right time: regulation of daily timing by phosphorylationMartha Merrow
University of Groningen, Haren 9750 AA, The Netherlands
Genes Dev 20:2629-3. 2006 - Lego clocks: building a clock from partsMichael Brunner
University of Heidelberg Biochemistry Center, 69120 Heidelberg, Germany
Genes Dev 22:1422-6. 2008..However, an alternative intepretation is that the pacemaker mechanism-as previously suggested-lies primarily in the rate of ATP hydrolysis by the clock protein KaiC... - The green yeast uses its plant-like clock to regulate its animal-like tailMichael Brunner
University of Heidelberg Biochemistry Center, 69120 Heidelberg, Germany
Genes Dev 22:825-31. 2008 - New findings of Neurospora in Europe and comparisons of diversity in temperate climates on continental scalesDavid J Jacobson
Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
Mycologia 98:550-9. 2006..The differences in regional diversity, reported here, can form the basis of testable hypotheses. Questions of phylogeography and adaptations can be addressed specifically by studying Neurospora in nature... - A marker for the end of adolescenceTill Roenneberg
Curr Biol 14:R1038-9. 2004