Martha Merrow

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Assignment of circadian function for the Neurospora clock gene frequency
    M Merrow
    Institute for Medical Psychology, Ludwig Maximilians University, Munchen, Germany
    Nature 399:584-6. 1999
  2. ncbi request reprint The circadian cycle: is the whole greater than the sum of its parts?
    M Merrow
    Institute for Medical Psychology, Goethestrasse 31, 80336 Munich, Germany
    Trends Genet 17:4-7. 2001
  3. ncbi request reprint Cellular clocks: coupled circadian and cell division cycles
    Martha Merrow
    Institute for Medical Psychology, University of Munich, Munich, Germany
    Curr Biol 14:R25-6. 2004
  4. ncbi request reprint Novel strategies for identification of clock genes in Neurospora with insertional mutagenesis
    Kruno Sveric
    Institute for Medical Psychology, University of Munich, Germany
    Methods Mol Biol 362:173-85. 2007
  5. ncbi request reprint Combining theoretical and experimental approaches to understand the circadian clock
    Martha Merrow
    Institut fur Medizinische Psychologie, Munich, Germany
    Chronobiol Int 20:559-75. 2003
  6. pmc Demasking biological oscillators: properties and principles of entrainment exemplified by the Neurospora circadian clock
    Till Roenneberg
    Centre for Chronobiology, Institute of Medical Psychology, Medical Faculty, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
    Proc Natl Acad Sci U S A 102:7742-7. 2005
  7. ncbi request reprint Photoperiodism in Neurospora crassa
    Ying Tan
    Institute for Medical Psychology, University of Munich, Munich, Germany
    J Biol Rhythms 19:135-43. 2004
  8. ncbi request reprint The human circadian clock's seasonal adjustment is disrupted by daylight saving time
    Thomas Kantermann
    Ludwig Maximilian University, Goethestrasse 31, D 80336 Munich, Germany
    Curr Biol 17:1996-2000. 2007
  9. ncbi request reprint Entrainment dissociates transcription and translation of a circadian clock gene in neurospora
    Ying Tan
    Institute for Medical Psychology, University of Munich, Munich D 80336, Germany
    Curr Biol 14:433-8. 2004
  10. doi request reprint Modeling a circadian surface
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Munich, Germany
    J Biol Rhythms 25:340-9. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Assignment of circadian function for the Neurospora clock gene frequency
    M Merrow
    Institute for Medical Psychology, Ludwig Maximilians University, Munchen, Germany
    Nature 399:584-6. 1999
    ..To distinguish between these two possibilities, we used traditional circadian entrainment protocols on a genetic model system, Neurospora crassa...
  2. ncbi request reprint The circadian cycle: is the whole greater than the sum of its parts?
    M Merrow
    Institute for Medical Psychology, Goethestrasse 31, 80336 Munich, Germany
    Trends Genet 17:4-7. 2001
    ..In combining molecular analyses and physiological experiments, those features that are crucial for structuring a circadian day could be uncovered...
  3. ncbi request reprint Cellular clocks: coupled circadian and cell division cycles
    Martha Merrow
    Institute for Medical Psychology, University of Munich, Munich, Germany
    Curr Biol 14:R25-6. 2004
    ..Gating of cell division by the circadian clock is well known, yet its mechanism is little understood. Genetically tractable model systems have led to new hypotheses and questions concerning the coupling of these two cellular cycles...
  4. ncbi request reprint Novel strategies for identification of clock genes in Neurospora with insertional mutagenesis
    Kruno Sveric
    Institute for Medical Psychology, University of Munich, Germany
    Methods Mol Biol 362:173-85. 2007
    ..g., those with alternative selection markers or that facilitate overexpression) or combined with strains carrying clock-regulated reporter genes...
  5. ncbi request reprint Combining theoretical and experimental approaches to understand the circadian clock
    Martha Merrow
    Institut fur Medizinische Psychologie, Munich, Germany
    Chronobiol Int 20:559-75. 2003
    ..The models introduce the "zeitnehmer," i.e., a clock-regulated input pathway, to the conceptual framework of circadian systems, and proposes networks of individual feedbacks as the basis for circadian rhythmicity...
  6. pmc Demasking biological oscillators: properties and principles of entrainment exemplified by the Neurospora circadian clock
    Till Roenneberg
    Centre for Chronobiology, Institute of Medical Psychology, Medical Faculty, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
    Proc Natl Acad Sci U S A 102:7742-7. 2005
    ..By comparing data sets from independent studies, we develop a template for analyzing, modeling, and dissecting the interactions of entrained and masked components. These insights can be applied to oscillators of all periodicities...
  7. ncbi request reprint Photoperiodism in Neurospora crassa
    Ying Tan
    Institute for Medical Psychology, University of Munich, Munich, Germany
    J Biol Rhythms 19:135-43. 2004
    ..Night break experiments show that measuring night length is one of the mechanisms used for photoperiod assessment. This represents the first formal report of photoperiodism in the fungi...
  8. ncbi request reprint The human circadian clock's seasonal adjustment is disrupted by daylight saving time
    Thomas Kantermann
    Ludwig Maximilian University, Goethestrasse 31, D 80336 Munich, Germany
    Curr Biol 17:1996-2000. 2007
    ..This disruption may extend to other aspects of seasonal biology in humans...
  9. ncbi request reprint Entrainment dissociates transcription and translation of a circadian clock gene in neurospora
    Ying Tan
    Institute for Medical Psychology, University of Munich, Munich D 80336, Germany
    Curr Biol 14:433-8. 2004
    ..The regulators mediating the dissociation between RNA and protein levels are still unknown and will be the key to understanding both circadian timing at the molecular level and how the clock exerts control over many cellular processes...
  10. doi request reprint Modeling a circadian surface
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Munich, Germany
    J Biol Rhythms 25:340-9. 2010
    ..Experiments measuring aftereffects support the prediction that τ(E) plays an important role in entrainment...
  11. doi request reprint A circadian surface of entrainment: varying T, τ, and photoperiod in Neurospora crassa
    Jan Rémi
    Institute for Medical Psychology, University of Munich, Munich, Germany
    J Biol Rhythms 25:318-28. 2010
    ..These combinations produce a circadian surface with highly systematic phases of entrainment. The results suggest that the traditional entrainment paradigms using the PRC and τ(DD) have to be reevaluated...
  12. ncbi request reprint Epidemiology of the human circadian clock
    Till Roenneberg
    Centre for Chronobiology, Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
    Sleep Med Rev 11:429-38. 2007
    ..The timing and duration of sleep are generally independent. However, when the two are analysed separately for work and free days, sleep duration strongly depends on chronotype. In addition, chronotype is both age- and sex-dependent...
  13. doi request reprint CLOCK gene variants associate with sleep duration in two independent populations
    Karla V Allebrandt
    Centre for Chronobiology, Ludwig Maximilians University of Munich, Munich, Germany
    Biol Psychiatry 67:1040-7. 2010
    ..Clock genes are associated with dysfunctional timing of sleep, mood, and obesity disorders, which are commonly associated with sleep duration...
  14. pmc Light reception and circadian behavior in 'blind' and 'clock-less' mutants of Neurospora crassa
    Zdravko Dragovic
    Institute for Medical Psychology, Division of Chronobiology, Goethestrasse 31, D 80336 Munich, Germany
    EMBO J 21:3643-51. 2002
    ..Furthermore, the extant circadian clock machinery in these mutant strains supports the notion that the circadian system in Neurospora involves components outside the WC-FRQ loop...
  15. doi request reprint Entrainment concepts revisited
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Munich, Germany
    J Biol Rhythms 25:329-39. 2010
    ..Unlike the PRC and the velocity response curve, the CIRC can be assessed on the basis of entrained steady states, by modeling experimental results. The CIRC approach makes several predictions that can be tested experimentally...
  16. ncbi request reprint The art of entrainment
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Germany
    J Biol Rhythms 18:183-94. 2003
    ..The results of this basic research will help us to understand temporal ecology and will allow us to improve conditions for humans in industrialized societies...
  17. doi request reprint Social jetlag and obesity
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Munich, Germany
    Curr Biol 22:939-43. 2012
    ..Our data suggest that improving the correspondence between biological and social clocks will contribute to the management of obesity...
  18. ncbi request reprint Circadian clocks - the fall and rise of physiology
    Till Roenneberg
    Centre for Chronobiology, Institute of Medical Psychology, Medical Faculty, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
    Nat Rev Mol Cell Biol 6:965-71. 2005
    ..Insights from this research will help to optimize medical diagnostics and therapy, as well as adjust social and biological timing on the individual level...
  19. ncbi request reprint Circadian clocks: translation
    Till Roenneberg
    Centre for Chronobiology, Institute of Medical Psychology, Medical Faculty, University of Munich, Goethestr 31, D 80336 Munich, Germany
    Curr Biol 15:R470-3. 2005
    ..While increasing complexity seemed to be the key, a recent report suggests that circa-24 hour rhythms can be generated by just four molecules incubated in a test tube...
  20. ncbi request reprint Cellular clocks: circadian rhythms in primary human fibroblasts
    Martha Merrow
    Biologisch Centrum, University of Groningen, Postbus 14, 9750AA Haren the Netherlands, University of Munich, Goethestrasse 31, Germany
    J Biosci 30:553-5. 2005
  21. ncbi request reprint "What watch?...such much!" Complexity and evolution of circadian clocks
    Till Roenneberg
    Institute for Medical Psychology, Chronobiology Division, Ludwig Maximilians Universitat Munchen, Goethestr 31, 80336 Munich, Germany
    Cell Tissue Res 309:3-9. 2002
    ..The second example looks at the role of clocks in tissues and cells within a complex organism, and the third speculates on how the circadian system may have evolved...
  22. ncbi request reprint Life before the clock: modeling circadian evolution
    Till Roenneberg
    Institute for Medical Psychology, Chronobiology Division, Ludwig Maximilians Universitat Munchen, D 80336 Munich, Germany
    J Biol Rhythms 17:495-505. 2002
    ....
  23. ncbi request reprint Life between clocks: daily temporal patterns of human chronotypes
    Till Roenneberg
    Center for Chronobiology, Institute for Medical Psychology, Munich, Germany
    J Biol Rhythms 18:80-90. 2003
    ..The implications are far ranging concerning learning, memory, vigilance, performance, and quality of life...
  24. ncbi request reprint Light reception: discovering the clock-eye in mammals
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336, Munich, Germany
    Curr Biol 12:R163-5. 2002
    ..Mammals receive this signal exclusively through the eyes, but not just via rods and cones. New evidence has been uncovered for a novel photoreceptor that may be responsible for more than just adjusting the clock...
  25. ncbi request reprint The network of time: understanding the molecular circadian system
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
    Curr Biol 13:R198-207. 2003
    ....
  26. ncbi request reprint Circadian clock: time for a phase shift of ideas?
    Martha Merrow
    Biological Center, University of Groningen, Postbus 14, 9750AA, Haren, Netherlands
    Curr Biol 17:R636-8. 2007
    ..A recent study shows that cycling of cryptochrome proteins is dispensable for circadian clock function in mammalian cells. Is it time for a paradigm shift in how we think about the circadian clock mechanism?..
  27. pmc The circadian cycle: daily rhythms from behaviour to genes
    Martha Merrow
    Biologisch Centrum, University of Groningen, PO Box 14, 9750AA Haren, The Netherlands
    EMBO Rep 6:930-5. 2005
    ..These behavioural oscillations are mirrored in the levels of physiology and gene expression. Deciphering the underlying mechanisms will provide important insights into how the circadian clock affects health and disease...
  28. ncbi request reprint The human circadian clock entrains to sun time
    Till Roenneberg
    Curr Biol 17:R44-5. 2007
  29. ncbi request reprint Entrainment of the Neurospora circadian clock
    Martha Merrow
    Biologisch Centrum, University of Groningen, Haren, The Netherlands
    Chronobiol Int 23:71-80. 2006
    ..Clock gene expression during entrainment and entrainment without clock genes suggest that the known transcription/translation feedback loop is not alone responsible for entrainment in Neurospora...
  30. ncbi request reprint External time--internal time
    Serge Daan
    J Biol Rhythms 17:107-9. 2002
  31. ncbi request reprint Social jetlag: misalignment of biological and social time
    Marc Wittmann
    Generation Research Program, Human Science Center, Ludwig Maximilian University Munich, Germany
    Chronobiol Int 23:497-509. 2006
    ..e., the discrepancies between social and biological timing rather than a simple association to different chronotypes. Our results strongly suggest that work (and school) schedules should be adapted to chronotype whenever possible...
  32. ncbi request reprint The right place at the right time: regulation of daily timing by phosphorylation
    Martha Merrow
    University of Groningen, Haren 9750 AA, The Netherlands
    Genes Dev 20:2629-3. 2006
  33. pmc Lego clocks: building a clock from parts
    Michael Brunner
    University of Heidelberg Biochemistry Center, 69120 Heidelberg, Germany
    Genes Dev 22:1422-6. 2008
    ..However, an alternative intepretation is that the pacemaker mechanism-as previously suggested-lies primarily in the rate of ATP hydrolysis by the clock protein KaiC...
  34. pmc The green yeast uses its plant-like clock to regulate its animal-like tail
    Michael Brunner
    University of Heidelberg Biochemistry Center, 69120 Heidelberg, Germany
    Genes Dev 22:825-31. 2008
  35. ncbi request reprint New findings of Neurospora in Europe and comparisons of diversity in temperate climates on continental scales
    David J Jacobson
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Mycologia 98:550-9. 2006
    ..The differences in regional diversity, reported here, can form the basis of testable hypotheses. Questions of phylogeography and adaptations can be addressed specifically by studying Neurospora in nature...
  36. ncbi request reprint A marker for the end of adolescence
    Till Roenneberg
    Curr Biol 14:R1038-9. 2004