S Mazurek

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint The tumor metabolome
    Sybille Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, Justus Liebig University of Giessen, Frankfurter Strasse 100, 35392 Giessen, Germany
    Anticancer Res 23:1149-54. 2003
  2. ncbi request reprint Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism
    Sybille Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, Justus Liebig University, Giessen, Germany
    Anticancer Res 27:3963-71. 2007
  3. doi request reprint Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells
    Sybille Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Medicine, University of Giessen, Giessen, Germany
    Int J Biochem Cell Biol 43:969-80. 2011
  4. ncbi request reprint Pyruvate kinase type M2 and its role in tumor growth and spreading
    Sybille Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, 35392 Giessen, Germany
    Semin Cancer Biol 15:300-8. 2005
  5. ncbi request reprint Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, 35392 Giessen, Germany
    Oncogene 20:6891-8. 2001
  6. pmc Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, D 35392 Giessen, Germany
    Biochem J 356:247-56. 2001
  7. ncbi request reprint Energy metabolism in the involuting mammary gland
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Germany
    In Vivo 13:467-77. 1999
  8. ncbi request reprint Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Giessen, Germany
    J Cell Physiol 181:136-46. 1999
  9. ncbi request reprint Metabolic characteristics of different malignant cancer cell lines
    S Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Germany
    Anticancer Res 18:3275-82. 1998
  10. ncbi request reprint Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors
    E Eigenbrodt
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Germany
    Anticancer Res 18:3267-74. 1998

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The tumor metabolome
    Sybille Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, Justus Liebig University of Giessen, Frankfurter Strasse 100, 35392 Giessen, Germany
    Anticancer Res 23:1149-54. 2003
    ..The metabolic Achilles' heel of the tumor metabolome is its sensitivity to a reduction of NAD levels caused by activation of poly(ADP-ribose) polymerase after DNA damage...
  2. ncbi request reprint Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism
    Sybille Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, Justus Liebig University, Giessen, Germany
    Anticancer Res 27:3963-71. 2007
    ..High serine levels thus may be responsible for the activation of M2-PK in A-Raf transformed NIH3T3 cells...
  3. doi request reprint Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells
    Sybille Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Medicine, University of Giessen, Giessen, Germany
    Int J Biochem Cell Biol 43:969-80. 2011
    ..The role of pyruvate kinase M2 in the nucleus is complex as witnessed by evidence of its effect both as pro-proliferative as well as pro-apoptotic stimuli...
  4. ncbi request reprint Pyruvate kinase type M2 and its role in tumor growth and spreading
    Sybille Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, 35392 Giessen, Germany
    Semin Cancer Biol 15:300-8. 2005
    ..The dimerization is caused by direct interaction of M2-PK with certain oncoproteins. The switch between the tetrameric and dimeric form of M2-PK allows tumor cells to survive in environments with varying oxygen und nutrient supply...
  5. ncbi request reprint Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, 35392 Giessen, Germany
    Oncogene 20:6891-8. 2001
    ..Apparently, the combination of the different metabolic effects of ras and E7 constructs the perfect tumor metabolome as generally found in tumor cells...
  6. pmc Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, D 35392 Giessen, Germany
    Biochem J 356:247-56. 2001
    ..In both NIH 3T3 cell lines, transformation increased glutaminolysis and the positive correlation between alanine and lactate production...
  7. ncbi request reprint Energy metabolism in the involuting mammary gland
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Germany
    In Vivo 13:467-77. 1999
    ..AMP was found in the milk, not in the epithelial cells. The inactivation of the enzymes was caused by partial proteolysis or by a loss of the intact proteins from the cytosol without signs of proteolysis...
  8. ncbi request reprint Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Giessen, Germany
    J Cell Physiol 181:136-46. 1999
    ....
  9. ncbi request reprint Metabolic characteristics of different malignant cancer cell lines
    S Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Germany
    Anticancer Res 18:3275-82. 1998
    ..MCF-7 and Novikoff cells contain the pI 7.8 form of malate dehydrogenase which couples glycolysis with glutaminolysis...
  10. ncbi request reprint Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors
    E Eigenbrodt
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Germany
    Anticancer Res 18:3267-74. 1998
    ..The shift from glutamate consumption to glutamate production is correlated with an increase in glutamate dehydrogenase and glutamate oxaloacetate transaminase activity...
  11. ncbi request reprint Pyruvate kinase type M2: a crossroad in the tumor metabolome
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Germany
    Br J Nutr 87:S23-9. 2002
    ..Pyruvate produced in glycolysis and glutaminolysis is used for the synthesis of lactate, glutamate and fatty acids thereby releasing the hydrogen produced in the glycolytic glyceraldehyde 3-phosphate dehydrogenase reaction...
  12. pmc Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer
    P D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Justus Liebig University of Giessen, Rodthohl 6, Giessen 35392, Germany
    Br J Cancer 91:980-4. 2004
    ..TNM and Dukes' classification of the tumours revealed a strong correlation between faecal Tumour M2-PK levels and staging. The determination of Tumour M2-PK in faeces provides a new promising screening tool for colorectal tumours...
  13. ncbi request reprint Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas
    E Eigenbrodt
    Institute for Biochemistry and Endocrinology, University of Giessen, Germany
    Anticancer Res 17:3153-6. 1997
    ..001). The values for the 50%-percentiles (median) of blood donors were 10.8 U/ml and 55.0 U/ml for colon carcinoma...
  14. pmc Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
    Werner Zwerschke
    Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, A 6020 Innsbruck, Austria
    Biochem J 376:403-11. 2003
    ..These results suggest that metabolic regulation plays an important role during cellular senescence and hence tumour suppression...
  15. doi request reprint Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
    Gilles A Spoden
    Cell Metabolism and Differentiation Research Group, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria
    Int J Cancer 123:312-21. 2008
    ..In the present study, we developed the first specific inhibitors of the pyruvate kinase isoenzyme type M2 and present evidence that these inhibitors moderately decelerate tumor cell proliferation...
  16. ncbi request reprint Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines
    Matthias Engel
    Department of Human Genetics, Medical School, University of Saarland, Building 60, D 66421 Homburg, Germany
    J Biol Chem 279:35803-12. 2004
    ..The data presented here provide evidence that inhibition of PGM activity can be achieved by exogenous addition of a polypeptide, resulting in inhibition of glycolysis and cell growth arrest in cell culture...
  17. ncbi request reprint Regulation of glycolysis by Raf protein serine/threonine kinases
    Véronique Le Mellay
    Institut für Medizinische, Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Str 5, Germany
    Adv Enzyme Regul 42:317-32. 2002
  18. doi request reprint Premature senescence of human endothelial cells induced by inhibition of glutaminase
    Hermann Unterluggauer
    Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, Innsbruck, 6020, Austria
    Biogerontology 9:247-59. 2008
    ..Together, the data indicate that glutaminolysis is an important energy source in endothelial cells and that alterations in this pathway play a role in endothelial cell senescence...
  19. ncbi request reprint Interaction between HERC1 and M2-type pyruvate kinase
    Francesc R Garcia-Gonzalo
    Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, c Feixa Llarga s n, L Hospitalet de Llobregat, E 08907 Barcelona, Spain
    FEBS Lett 539:78-84. 2003
    ..This interaction neither induced M2-PK ubiquitination nor affected its enzymatic activity. The putative significance of the association is discussed...