M P Mayer

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Functional analysis of Hsp70 inhibitors
    Rainer Schlecht
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 8:e78443. 2013
  2. doi request reprint Hsp70 chaperone dynamics and molecular mechanism
    Matthias P Mayer
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany Electronic address
    Trends Biochem Sci 38:507-14. 2013
  3. ncbi request reprint The unfolding story of a redox chaperone
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Heidelberg, Germany
    Cell 148:843-4. 2012
  4. doi request reprint Gymnastics of molecular chaperones
    Matthias P Mayer
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Allianz, Heidelberg, Germany
    Mol Cell 39:321-31. 2010
  5. doi request reprint Phosphotyrosine confers client specificity to Hsp90
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Heidelberg 69120, Germany
    Mol Cell 37:295-6. 2010
  6. pmc Hsp70 chaperones: cellular functions and molecular mechanism
    M P Mayer
    Zentrum für Molekulare Biologie ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Cell Mol Life Sci 62:670-84. 2005
  7. ncbi request reprint Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies
    M P Mayer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Rev Physiol Biochem Pharmacol 153:1-46. 2005
  8. ncbi request reprint Mechanism of substrate recognition by Hsp70 chaperones
    A Erbse
    Zentrum für Molekulare Biologie Heidelberg, Universitat Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Biochem Soc Trans 32:617-21. 2004
  9. ncbi request reprint Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis
    F Prols
    Institute of Anatomy II, Albert Ludwigs University, Freiburg, 79104, Germany
    Exp Cell Res 269:42-53. 2001
  10. ncbi request reprint Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor
    C S Gassler
    , , 79104 Freiburg, Germany
    J Biol Chem 276:32538-44. 2001

Collaborators

  • Bernd Bukau
  • Rainer Schlecht
  • D Brehmer
  • C S Gassler
  • S Rudiger
  • A Erbse
  • Heike Dahmen
  • Ansgar Wegener
  • Hans Michael Eggenweiler
  • Sebastian R Scholz
  • Christian Sirrenberg
  • Joerg Bomke
  • Djordje Musil
  • F Prols
  • D Ang
  • C Georgopoulos
  • D Missiakas
  • O Renner
  • A Richardson
  • B Christ
  • H Krisch
  • M Ast
  • L Packschies
  • F Keppel
  • T Wiederkehr
  • D Klostermeier
  • C Gassler
  • P G Czarnecki
  • H Kurz
  • J Reinstein
  • J Wilting
  • J Schneider-Mergener
  • M Lemaire
  • S Raina

Detail Information

Publications14

  1. pmc Functional analysis of Hsp70 inhibitors
    Rainer Schlecht
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 8:e78443. 2013
    ..Compound PES interacts with the SBD of Hsp70 in an unspecific, detergent-like fashion, under the conditions tested. None of the two inhibitors investigated was isoform-specific. ..
  2. doi request reprint Hsp70 chaperone dynamics and molecular mechanism
    Matthias P Mayer
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany Electronic address
    Trends Biochem Sci 38:507-14. 2013
    ..In this review recent insights into the structure and mechanism of Hsp70s are discussed. ..
  3. ncbi request reprint The unfolding story of a redox chaperone
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Heidelberg, Germany
    Cell 148:843-4. 2012
    ..In this issue, Reichmann et al. demonstrate how a destabilized linker region of the bacterial chaperone Hsp33 prevents aggregation of a denatured protein by stabilizing structural elements...
  4. doi request reprint Gymnastics of molecular chaperones
    Matthias P Mayer
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Allianz, Heidelberg, Germany
    Mol Cell 39:321-31. 2010
    ..In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families...
  5. doi request reprint Phosphotyrosine confers client specificity to Hsp90
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Heidelberg 69120, Germany
    Mol Cell 37:295-6. 2010
    ..In this issue of Molecular Cell, Mollapour et al. (2010) report a new tyrosine phosphorylation site in Hsp90, which is essential for Hsp90's interaction with a subset of its client proteins, notably protein kinases...
  6. pmc Hsp70 chaperones: cellular functions and molecular mechanism
    M P Mayer
    Zentrum für Molekulare Biologie ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Cell Mol Life Sci 62:670-84. 2005
    ..Additional co-chaperones fine-tune this chaperone cycle. For specific tasks the Hsp70 cycle is coupled to the action of other chaperones, such as Hsp90 and Hsp100...
  7. ncbi request reprint Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies
    M P Mayer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Rev Physiol Biochem Pharmacol 153:1-46. 2005
    ..This review focuses on the function of Hsp70 chaperones at the different stages of the viral life cycle emphasizing mechanistic aspects...
  8. ncbi request reprint Mechanism of substrate recognition by Hsp70 chaperones
    A Erbse
    Zentrum für Molekulare Biologie Heidelberg, Universitat Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Biochem Soc Trans 32:617-21. 2004
    ..In the present study, we review the molecular details of the mechanism behind substrate recognition by Hsp70 proteins...
  9. ncbi request reprint Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis
    F Prols
    Institute of Anatomy II, Albert Ludwigs University, Freiburg, 79104, Germany
    Exp Cell Res 269:42-53. 2001
    ..These data suggest that Mdg1 is involved in the control of cell cycle arrest taking place during terminal cell differentiation and under stress conditions...
  10. ncbi request reprint Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor
    C S Gassler
    , , 79104 Freiburg, Germany
    J Biol Chem 276:32538-44. 2001
    ..Bag-1M accelerated ATP-triggered substrate release by Hsc70/Hsp70. We propose that Bag-1M acts as substrate discharging factor for Hsc70 and Hsp70...
  11. ncbi request reprint Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange
    D Brehmer
    Institut fur Biochemie und Molekularbiologie, Albert Ludwigs Universitat Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Nat Struct Biol 8:427-32. 2001
    ..These subfamilies show strong differences in nucleotide dissociation and interaction with the exchange factors GrpE and Bag-1...
  12. ncbi request reprint Pseudo-T-even bacteriophage RB49 encodes CocO, a cochaperonin for GroEL, which can substitute for Escherichia coli's GroES and bacteriophage T4's Gp31
    D Ang
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    J Biol Chem 276:8720-6. 2001
    ..Both the CocO wild type and epsilon22 proteins have been purified and shown in vitro to assist GroEL in the refolding of denatured citrate synthase...
  13. ncbi request reprint Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch
    S Rudiger
    Institut fur Biochemie und Molekularbiologie, Hermann Herder Str 7, Universitat Freiburg, D 79104, Germany
    J Mol Biol 304:245-51. 2000
    ..This finding is of particular interest, since of all the residues of the substrate-binding cavity that contact bound substrate, only the arch-forming residues show significant variation within the Hsp70 family...
  14. ncbi request reprint Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins
    D Missiakas
    Centre National de Recherche Scientifique, LIDSM, Marseille, France
    Mol Microbiol 24:355-71. 1997
    ..In contrast, RseC is an inner membrane protein that positively modulates sigma(E) activity. Most of these protein-protein interactions were verified in vivo using the yeast two-hybrid system...