M P Mayer

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi The unfolding story of a redox chaperone
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Heidelberg, Germany
    Cell 148:843-4. 2012
  2. ncbi Gymnastics of molecular chaperones
    Matthias P Mayer
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Allianz, Heidelberg, Germany
    Mol Cell 39:321-31. 2010
  3. ncbi Phosphotyrosine confers client specificity to Hsp90
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Heidelberg 69120, Germany
    Mol Cell 37:295-6. 2010
  4. ncbi Hsp70 chaperones: cellular functions and molecular mechanism
    M P Mayer
    Zentrum für Molekulare Biologie ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Cell Mol Life Sci 62:670-84. 2005
  5. ncbi Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies
    M P Mayer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Rev Physiol Biochem Pharmacol 153:1-46. 2005
  6. ncbi Mechanism of substrate recognition by Hsp70 chaperones
    A Erbse
    , , Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany
    Biochem Soc Trans 32:617-21. 2004
  7. ncbi Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis
    F Prols
    Institute of Anatomy II, Albert Ludwigs University, Freiburg, 79104, Germany
    Exp Cell Res 269:42-53. 2001
  8. ncbi Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor
    C S Gassler
    , , 79104 Freiburg, Germany
    J Biol Chem 276:32538-44. 2001
  9. ncbi Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange
    D Brehmer
    Institut fur Biochemie und Molekularbiologie, Albert Ludwigs Universitat Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Nat Struct Biol 8:427-32. 2001
  10. ncbi Pseudo-T-even bacteriophage RB49 encodes CocO, a cochaperonin for GroEL, which can substitute for Escherichia coli's GroES and bacteriophage T4's Gp31
    D Ang
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    J Biol Chem 276:8720-6. 2001

Collaborators

  • B Bukau
  • D Brehmer
  • C S Gassler
  • S Rudiger
  • A Erbse
  • F Prols
  • D Ang
  • C Georgopoulos
  • D Missiakas
  • F Keppel
  • J Reinstein
  • J Wilting
  • B Christ
  • T Wiederkehr
  • H Kurz
  • L Packschies
  • M Ast
  • D Klostermeier
  • C Gassler
  • O Renner
  • A Richardson
  • H Krisch
  • P G Czarnecki
  • J Schneider-Mergener
  • S Raina
  • M Lemaire

Detail Information

Publications12

  1. ncbi The unfolding story of a redox chaperone
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Heidelberg, Germany
    Cell 148:843-4. 2012
    ..In this issue, Reichmann et al. demonstrate how a destabilized linker region of the bacterial chaperone Hsp33 prevents aggregation of a denatured protein by stabilizing structural elements...
  2. ncbi Gymnastics of molecular chaperones
    Matthias P Mayer
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Allianz, Heidelberg, Germany
    Mol Cell 39:321-31. 2010
    ..In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families...
  3. ncbi Phosphotyrosine confers client specificity to Hsp90
    Matthias P Mayer
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Heidelberg 69120, Germany
    Mol Cell 37:295-6. 2010
    ..In this issue of Molecular Cell, Mollapour et al. (2010) report a new tyrosine phosphorylation site in Hsp90, which is essential for Hsp90's interaction with a subset of its client proteins, notably protein kinases...
  4. ncbi Hsp70 chaperones: cellular functions and molecular mechanism
    M P Mayer
    Zentrum für Molekulare Biologie ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Cell Mol Life Sci 62:670-84. 2005
    ..Additional co-chaperones fine-tune this chaperone cycle. For specific tasks the Hsp70 cycle is coupled to the action of other chaperones, such as Hsp90 and Hsp100...
  5. ncbi Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies
    M P Mayer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Rev Physiol Biochem Pharmacol 153:1-46. 2005
    ..This review focuses on the function of Hsp70 chaperones at the different stages of the viral life cycle emphasizing mechanistic aspects...
  6. ncbi Mechanism of substrate recognition by Hsp70 chaperones
    A Erbse
    , , Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany
    Biochem Soc Trans 32:617-21. 2004
    ..In the present study, we review the molecular details of the mechanism behind substrate recognition by Hsp70 proteins...
  7. ncbi Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis
    F Prols
    Institute of Anatomy II, Albert Ludwigs University, Freiburg, 79104, Germany
    Exp Cell Res 269:42-53. 2001
    ..These data suggest that Mdg1 is involved in the control of cell cycle arrest taking place during terminal cell differentiation and under stress conditions...
  8. ncbi Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor
    C S Gassler
    , , 79104 Freiburg, Germany
    J Biol Chem 276:32538-44. 2001
    ..Bag-1M accelerated ATP-triggered substrate release by Hsc70/Hsp70. We propose that Bag-1M acts as substrate discharging factor for Hsc70 and Hsp70...
  9. ncbi Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange
    D Brehmer
    Institut fur Biochemie und Molekularbiologie, Albert Ludwigs Universitat Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Nat Struct Biol 8:427-32. 2001
    ..These subfamilies show strong differences in nucleotide dissociation and interaction with the exchange factors GrpE and Bag-1...
  10. ncbi Pseudo-T-even bacteriophage RB49 encodes CocO, a cochaperonin for GroEL, which can substitute for Escherichia coli's GroES and bacteriophage T4's Gp31
    D Ang
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    J Biol Chem 276:8720-6. 2001
    ..Both the CocO wild type and epsilon22 proteins have been purified and shown in vitro to assist GroEL in the refolding of denatured citrate synthase...
  11. ncbi Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch
    S Rudiger
    Institut fur Biochemie und Molekularbiologie, Hermann Herder Str 7, Universitat Freiburg, D 79104, Germany
    J Mol Biol 304:245-51. 2000
    ..This finding is of particular interest, since of all the residues of the substrate-binding cavity that contact bound substrate, only the arch-forming residues show significant variation within the Hsp70 family...
  12. ncbi Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins
    D Missiakas
    Centre National de Recherche Scientifique, LIDSM, Marseille, France
    Mol Microbiol 24:355-71. 1997
    ..In contrast, RseC is an inner membrane protein that positively modulates sigma(E) activity. Most of these protein-protein interactions were verified in vivo using the yeast two-hybrid system...