A May

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Structural brain alterations following 5 days of intervention: dynamic aspects of neuroplasticity
    A May
    Department of Systems Neuroscience, University of Hamburg, Martinist 52, 20246 Hamburg, Germany
    Cereb Cortex 17:205-10. 2007
  2. ncbi request reprint EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias
    A May
    Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Eur J Neurol 13:1066-77. 2006
  3. ncbi request reprint Neuroimaging: visualising the brain in pain
    A May
    Department of Systems Neuroscience, Universitats Krankenhaus Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Neurol Sci 28:S101-7. 2007
  4. doi request reprint [The window into headache research : what have we learned from functional and structural neuroimaging]
    A May
    Institut für Systemische Neurowissenschaften, Universitäts Krankenhaus Eppendorf UKE, Martinistr 52, 20246, Hamburg, Deutschland
    Schmerz 24:130-6. 2010
  5. doi request reprint Pearls and pitfalls: neuroimaging in headache
    Arne May
    Department of Systems Neuroscience, University of Hamburg, Germany
    Cephalalgia 33:554-65. 2013
  6. doi request reprint Within-session sensitization and between-session habituation: a robust physiological response to repetitive painful heat stimulation
    A May
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Pain 16:401-9. 2012
  7. pmc Effectiveness of anodal transcranial direct current stimulation in patients with chronic low back pain: design, method and protocol for a randomised controlled trial
    Kerstin Luedtke
    Institute of Systems Neurosciences, University Hospital Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    BMC Musculoskelet Disord 12:290. 2011
  8. doi request reprint Morphing voxels: the hype around structural imaging of headache patients
    Arne May
    Department of Systems Neuroscience, Universitats Krankenhaus Eppendorf, Martinistrasse 52, Hamburg, Germany
    Brain 132:1419-25. 2009
  9. ncbi request reprint The contribution of functional neuroimaging to primary headaches
    A May
    Department of Neurology, Universitats Krankenhaus Eppendorf, Martinstr 52, D 20246 Hamburg, Germany
    Neurol Sci 25:S85-8. 2004
  10. pmc A review of diagnostic and functional imaging in headache
    Arne May
    Department of Systems Neuroscience, Universitats Krankenhaus Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    J Headache Pain 7:174-84. 2006

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Structural brain alterations following 5 days of intervention: dynamic aspects of neuroplasticity
    A May
    Department of Systems Neuroscience, University of Hamburg, Martinist 52, 20246 Hamburg, Germany
    Cereb Cortex 17:205-10. 2007
    ....
  2. ncbi request reprint EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias
    A May
    Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Eur J Neurol 13:1066-77. 2006
    ..Intravenous lidocaine may also be helpful as an acute therapy when patients are extremely distressed and disabled by frequent attacks...
  3. ncbi request reprint Neuroimaging: visualising the brain in pain
    A May
    Department of Systems Neuroscience, Universitats Krankenhaus Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Neurol Sci 28:S101-7. 2007
    ..However, modern neuroimaging suggests that the chronification of pain (and headaches) involves functional and structural plasticity of both the central and peripheral nervous system...
  4. doi request reprint [The window into headache research : what have we learned from functional and structural neuroimaging]
    A May
    Institut für Systemische Neurowissenschaften, Universitäts Krankenhaus Eppendorf UKE, Martinistr 52, 20246, Hamburg, Deutschland
    Schmerz 24:130-6. 2010
    ....
  5. doi request reprint Pearls and pitfalls: neuroimaging in headache
    Arne May
    Department of Systems Neuroscience, University of Hamburg, Germany
    Cephalalgia 33:554-65. 2013
    ....
  6. doi request reprint Within-session sensitization and between-session habituation: a robust physiological response to repetitive painful heat stimulation
    A May
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Pain 16:401-9. 2012
    ..This uniform pattern was equally present in all examined groups. Chronic pain and depression do not seem to interfere with short-term sensitization and long-term habituation in this model of repetitive phasic heat pain...
  7. pmc Effectiveness of anodal transcranial direct current stimulation in patients with chronic low back pain: design, method and protocol for a randomised controlled trial
    Kerstin Luedtke
    Institute of Systems Neurosciences, University Hospital Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    BMC Musculoskelet Disord 12:290. 2011
    ..Evidence indicates that the method is pain free, safe and inexpensive...
  8. doi request reprint Morphing voxels: the hype around structural imaging of headache patients
    Arne May
    Department of Systems Neuroscience, Universitats Krankenhaus Eppendorf, Martinistrasse 52, Hamburg, Germany
    Brain 132:1419-25. 2009
    ..One of the major future challenges is to understand the behavioural consequences and cellular mechanisms underlying neuroanatomic changes in pain and headache...
  9. ncbi request reprint The contribution of functional neuroimaging to primary headaches
    A May
    Department of Neurology, Universitats Krankenhaus Eppendorf, Martinstr 52, D 20246 Hamburg, Germany
    Neurol Sci 25:S85-8. 2004
    ..Functional imaging will undoubtedly provide further opportunities to study and compare metabolic, haemodynamic and structural parameters in headache sufferers' brains...
  10. pmc A review of diagnostic and functional imaging in headache
    Arne May
    Department of Systems Neuroscience, Universitats Krankenhaus Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    J Headache Pain 7:174-84. 2006
    ..Modern neuroimaging thus clearly suggests that most primary headache syndromes are predominantly driven from the brain, activating the trigeminovascular reflex and needing therapeutics that act on both sides: centrally and peripherally...
  11. ncbi request reprint [Treatment and prophylaxis for cluster headaches and other trigeminal autonomic headaches. Revised recommendations of the German Migraine and Headache Society]
    A May
    Neurologische Universitätsklinik Regensburg
    Schmerz 19:225-41. 2005
    ..This review covers the clinical picture and therapeutic options. Although studies following the criteria of evidence-based medicine (EBM) are rare, most patients can be treated sufficiently...
  12. ncbi request reprint The role of imaging in the pathophysiology and diagnosis of headache
    Arne May
    Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Curr Opin Neurol 18:293-7. 2005
    ..This review highlights new studies and recent advances in studying headache using neuroimaging...
  13. doi request reprint [Chronic pain alters the structure of the brain]
    A May
    Institut für Systemische Neurowissenschaften, Universitäts Krankenhaus Eppendorf UKE, Martinistr 52, 20246, Hamburg, Deutschland
    Schmerz 23:569-75. 2009
    ..The in vivo demonstration of a loss of brain gray matter in patients suffering from chronic pain compared to age and sex-matched healthy controls could represent the heavily discussed neuroanatomical substrate for pain memory...
  14. doi request reprint New insights into headache: an update on functional and structural imaging findings
    Arne May
    Department of Systems Neuroscience, Universitäts Krankenhaus Eppendorf UKE, Martinistrasse 52, Hamburg, Germany
    Nat Rev Neurol 5:199-209. 2009
    ....
  15. ncbi request reprint Hypothalamic deep brain stimulation in positron emission tomography
    Arne May
    Department of Systems Neuroscience, University of Hamburg, D 20246 Hamburg, Germany
    J Neurosci 26:3589-93. 2006
    ..Instead, the data suggest a hitherto unrecognized functional modulation of the pain processing network as the mode of action of hypothalamic deep brain stimulation in cluster headache...
  16. ncbi request reprint Cluster headache: pathogenesis, diagnosis, and management
    Arne May
    Department of Systems Neuroscience, Universitats Krankenhaus Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Lancet 366:843-55. 2005
    ..This is probably the result of a better understanding of the pathophysiology in combination with efficient treatment strategies, leading to a broader acceptance of the syndrome by doctors...
  17. doi request reprint [Therapeutic neuromodulation in primary headaches]
    A May
    Institut für Systemische Neurowissenschaften und Kopfschmerzambulanz der Neurologischen Klinik, Universitätsklinikum Hamburg Eppendorf UKE, Hamburg
    Nervenarzt 82:743-52. 2011
    ..It is crucial to ensure a competent postoperative follow-up with optimization of stimulation parameters and adjustment of medication...
  18. ncbi request reprint [Hypothalamic deep brain stimulation in patients with chronic cluster headaches. Suggestions for patient selection]
    A May
    Neurologische Universitätsklinik Hamburg Eppendorf UKE
    Schmerz 19:544-8. 2005
    ....
  19. ncbi request reprint Functional anatomy of headache
    A May
    Department of Systems Neuroscience, University of Hamburg, Martinistrasse 52, D 20246, Hamburg, Germany
    Neurol Sci 27:S103-6. 2006
    ....
  20. ncbi request reprint [Headache attacks with ipsilateral autonomic symptoms]
    A May
    Neurologische Klinik, Universitatsklinikum Hamburg Eppendorf
    Schmerz 18:370-7. 2004
    ..This review covers the clinical picture and therapeutic options. Allthough studies following the criteria of evidence based medicine (EBM) are rare, most patients can be treated sufficiently...
  21. doi request reprint [Diagnosis and therapy of chronic headaches]
    A May
    Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg Eppendorf UKE, Martinistrasse 52, 20246, Hamburg, Deutschland
    Nervenarzt 81:1007-16; quiz 1017-8. 2010
    ..The group of symptomatic headaches is heterogeneous. Red flags help to judge the necessity of further diagnostic tests...
  22. doi request reprint [Introduction to the topic: the influence of science on aching heads--an update]
    A May
    Institut für Systemische Neurowissenschaften, Universitäts Krankenhaus Eppendorf UKE, Martinistr 52, 20246, Hamburg, Germany
    Schmerz 22:5-6. 2008
  23. doi request reprint Chronic pain may change the structure of the brain
    Arne May
    Department of Systems Neuroscience, University of Hamburg Eppendorf UKE, Martinistrasse 52, D 20246 Hamburg, Germany
    Pain 137:7-15. 2008
    ..The author suggests that the gray matter change observed in chronic pain patients are the consequence of frequent nociceptive input and should thus be reversible when pain is adequately treated...
  24. ncbi request reprint New insights into migraine: application of functional and structural imaging
    Arne May
    Department of Systems Neuroscience, University of Hamburg, Germany
    Curr Opin Neurol 20:306-9. 2007
    ..This review highlights the recent advances made in studying migraine using neuroimaging techniques...
  25. doi request reprint Structural brain imaging: a window into chronic pain
    Arne May
    Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Neuroscientist 17:209-20. 2011
    ..We need to better understand the behavioral consequences and cellular mechanisms underlying these neuroanatomic changes...
  26. doi request reprint Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache
    A May
    Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Cephalalgia 28:799-803. 2008
    ..These data argue against an unspecific antinociceptive effect or pure inhibition of hypothalamic activity as the mode of action of hypothalamic DBS and suggest functional modulation of the pain-processing network...
  27. ncbi request reprint Update on the diagnosis and management of trigemino-autonomic headaches
    Arne May
    Department of Systems Neuroscience, Universitäts Krankenhaus Eppendorf UKE, Martinistr 52, D 20246, Hamburg, Germany
    J Neurol 253:1525-32. 2006
    ..Although TACs are, in comparison with migraine, quite rare, it is nevertheless very important to consider the clinical factor that they are easy to diagnose and the treatment is very effective in most patients...
  28. ncbi request reprint Trigeminal-autonomic headaches in daily clinical practice
    Arne May
    University of Hamburg, Department of Systems Neuroscience, Martinistr 52, Hamburg, Germany
    Expert Rev Neurother 6:1531-43. 2006
    ..This review gives a brief clinical description of the headache disorders and recent pathophysiological findings, as well as an overview of the treatment of cluster headache, paroxysmal hemicranias and SUNCT syndrome...
  29. ncbi request reprint [Headache patients in routine clinical practice. When are additional instrumental examinations indicated?]
    A May
    Institut für Systemische Neurowissenschaften, Universitäts Krankenhaus Eppendorf UKE, Hamburg
    Schmerz 21:43-8. 2007
    ..This article reviews the evidence from the literature and recommendations of European and American task forces regarding the use of instrumental examinations in case of non-acute primary headache...
  30. ncbi request reprint Magnetic resonance-based morphometry: a window into structural plasticity of the brain
    Arne May
    Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Curr Opin Neurol 19:407-11. 2006
    ..Magnetic resonance morphometry has thereby recently emerged as one of the most promising fields in clinical neuroscience. This review covers the last 3 years, which have witnessed remarkable progress in this alluring new field...
  31. ncbi request reprint Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves
    V Busch
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 27:1206-14. 2007
    ....
  32. ncbi request reprint Experimental cranial pain elicited by capsaicin: a PET study
    A May
    Department of Neurology, University of Essen, Germany
    Pain 74:61-6. 1998
    ....
  33. doi request reprint [Therapy of primary chronic headache: chronic migraine, chronic tension type headache and other forms of daily chronic headache]
    A Straube
    Neurologische Klinik, Klinikum Grosshadern der Ludwig Maximilians Universität München, Marchioninistr 15, 81377 Munchen, Deutschland
    Schmerz 22:531-34, 536-40, 542-3. 2008
    ..The current literature was reviewed and a summary is presented. The therapy recommendations do not only include the scientific evidence but also the practical relevance...
  34. ncbi request reprint Decrease of thalamic gray matter following limb amputation
    B Draganski
    Department of Neurology, University of Regensburg, Germany
    Neuroimage 31:951-7. 2006
    ..No gray matter increase was detected. The unilateral thalamic differences may reflect a structural correlate of the loss of afferent input as a secondary change following deafferentation...
  35. ncbi request reprint Gray matter decrease in patients with chronic tension type headache
    T Schmidt-Wilcke
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Neurology 65:1483-6. 2005
    ..The finding implies that the alterations are specific to CTTH rather than a response to chronic head pain or chronification per se...
  36. doi request reprint Low-frequency short-time nociceptive stimulation of the greater occipital nerve does not modulate the trigeminal system
    T P Jürgens
    Department of Neurology, University of Regensburg, Regensburg, and Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Cephalalgia 28:842-6. 2008
    ..One explanation for a missing modulatory effect in our study is the relatively short duration of the stimulation...
  37. ncbi request reprint Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients
    T Schmidt-Wilcke
    Department of Neurology, University of Regensburg, Germany
    Pain 125:89-97. 2006
    ..These data support the hypothesis that ongoing nociception is associated with cortical and subcortical reorganisation on a structural level, which may play an important role in the process of the chronification of pain...
  38. doi request reprint Migraine-like headache in intracranial haemorrhage is alleviated by sumatriptan and almotriptan
    T P Jürgens
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 28:302-4. 2008
  39. doi request reprint [Pain contra pain : the concept of DNIC]
    C Sprenger
    Institut für Systemische Neurowissenschaften, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246, Hamburg Deutschland
    Schmerz 24:569-74. 2010
    ..This review focusses on DNIC and HNCS including similarities, divergences and their potential clinical relevance...
  40. doi request reprint [Cortical dysbalance in the brain in migraineurs--hyperexcitability as the result of sensitisation?]
    A Stankewitz
    Institut für Systemische Neurowissenschaften, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Schmerz 22:17-21. 2008
    ..Cortical hyperexcitability is presumably the result of chronicity and the concomitant central sensitisation process...
  41. ncbi request reprint Functional connectivity between trigeminal and occipital nerves revealed by occipital nerve blockade and nociceptive blink reflexes
    V Busch
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 26:50-5. 2006
    ....
  42. doi request reprint EFNS guideline on the drug treatment of migraine--revised report of an EFNS task force
    S Evers
    Department of Neurology, University of Munster, Munster, Germany
    Eur J Neurol 16:968-81. 2009
    ..Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life...
  43. doi request reprint [Ins and outs of neurologic therapy for chronic pain]
    S Sternberg
    Institut für Systemische Neurowissenschaften, Universitätsklinikum Eppendorf UKE, Martinistrasse 52, 20246, Hamburg, Deutschland
    Nervenarzt 79:1164-72, 1174-9. 2008
    ..This review provides a synopsis of procedures regarding chronic pain treatments, with particular focus on the most frequent pain disorders. The treatment recommendations follow the current guidelines of the German Society of Neurology...
  44. ncbi request reprint Selective activation of ectopic grey matter during motor task
    B Draganski
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, D 93053 Regensburg, Germany
    Neuroreport 15:251-3. 2004
    ..The present findings are consistent with the hypothesis that ectopic neurons may be functionally integrated in motor circuits during repetitive voluntary movements...
  45. doi request reprint Transcranial direct current stimulation does neither modulate results of a quantitative sensory testing protocol nor ratings of suprathreshold heat stimuli in healthy volunteers
    T P Jürgens
    Department of Systems Neuroscience, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Eur J Pain 16:1251-63. 2012
    ..Several studies have suggested clinical efficacy in pain syndromes such as central neuropathic pain or fibromyalgia. However, little is known regarding tDCS effects on nociception in healthy volunteers...
  46. doi request reprint Sensory and sympathetic correlates of heat pain sensitization and habituation in men and women
    M Breimhorst
    Department of Neurology, University Medical Center of Johannes Gutenberg University Mainz, Germany
    Eur J Pain 16:1281-92. 2012
    ....
  47. pmc Occipital nerve block is effective in craniofacial neuralgias but not in idiopathic persistent facial pain
    T P Jürgens
    Department of Systems Neuroscience, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Headache Pain 13:199-213. 2012
    ..They should be considered in facial pain before more invasive approaches, such as thermocoagulation or vascular decompression, are performed, given that side effects are mild and the procedure is minimally invasive...
  48. ncbi request reprint Subtle grey matter changes between migraine patients and healthy controls
    T Schmidt-Wilcke
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 28:1-4. 2008
    ..We suggest that the grey matter change in migraine patients is the consequence of frequent nociceptive input and should thus be reversible when migraine attacks cease...
  49. doi request reprint [Chronic cluster headache : how much does treatment cost?]
    T P Jürgens
    Institut für Systemische Neurowissenschaften und Kopfschmerzambulanz der Neurologischen Klinik, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Deutschland
    Schmerz 24:221-5. 2010
    ..5%). The inhalation of oxygen accounted for the lion's share...
  50. doi request reprint Changes in brain gray matter due to repetitive painful stimulation
    S Teutsch
    Department of Systems Neuroscience, University of Hamburg UKE, D 20246 Hamburg, Germany
    Neuroimage 42:845-9. 2008
    ..e. they recede after the regular nociceptive input is stopped. This data raises some interesting questions regarding structural plasticity of the brain concerning the experience of both acute and chronic pain...
  51. ncbi request reprint Sumatriptan and corneal reflexes in headache-free migraine patients: a randomized and placebo-controlled crossover study
    V Busch
    Department of Neurology, University of Regensburg, Universitätsstr 84, 93053 Regensburg, Germany
    Cephalalgia 27:165-72. 2007
    ..The stable corneal reflexes after the oral administration of 100 mg sumatriptan suggest that there was no inhibition of the trigeminal system, both in patients during their headache-free period and in healthy controls...
  52. ncbi request reprint Specific hypothalamic activation during a spontaneous cluster headache attack
    T Sprenger
    Department of Neurology, Technical University of Munich, Germany
    Neurology 62:516-7. 2004
  53. doi request reprint A new trigemino-nociceptive stimulation model for event-related fMRI
    A Stankewitz
    Department of Systems Neuroscience, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Cephalalgia 30:475-85. 2010
    ..This method will provide an ideal opportunity to study the trigeminal pain system in both health and pathological conditions such as idiopathic headache disorders...
  54. doi request reprint Neuronal correlates of impaired habituation in response to repeated trigemino-nociceptive but not to olfactory input in migraineurs: an fMRI study
    A Stankewitz
    University Medical Center Hamburg Eppendorf, Department of Systems Neuroscience, Germany
    Cephalalgia 33:256-65. 2013
    ..We exclusively focussed on intrasessional behavioural rating patterns and the related blood oxygen level dependent (BOLD) signal changes...
  55. doi request reprint Treatment of miscellaneous idiopathic headache disorders (Group 4 of the IHS classification)--report of an EFNS task force
    S Evers
    Department of Neurology, University of Munster, Munster, Germany
    Eur J Neurol 18:803-12. 2011
    ..Recent epidemiological research suggests that these headache disorders are underdiagnosed...
  56. ncbi request reprint Patient preference in clinical trials for headache medication: the patient's view
    E Leinisch-Dahlke
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 24:347-55. 2004
    ..This was mailed to and completed by 22 experts in Germany. In this article, we discuss the patient preference compared with the expert preference regarding clinic trials and drug therapy...
  57. ncbi request reprint Hypothalamic involvement and activation in cluster headache
    A May
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, Regensburg 93053, Germany
    Curr Pain Headache Rep 5:60-6. 2001
    ..Understanding both the phenotypic expression and the biotype will, respectively, enable better acute attack treatments and better preventative management of this horrible form of headache...
  58. ncbi request reprint [Headache as a warning symptom]
    Ulrike Bingel
    Neurologische Klinik und Poliklinik, Universitäts Krankenhaus Hamburg Eppendorf
    MMW Fortschr Med 148:47, 49-50. 2006
  59. doi request reprint [Consensus paper of the German Migraine and Headache Society on the structure of headache care facilities in Germany]
    M Marziniak
    Neurologische Klinik, Isar Amper Klinikum München Ost, Haar, Deutschland
    Schmerz 28:128-34. 2014
    ..The objective of the publication is to define and establish reliable criteria in the field of headache care in Germany. ..
  60. ncbi request reprint Habituation to painful stimulation involves the antinociceptive system
    U Bingel
    Department of Neurology, University of Hamburg UKE, Germany
    Pain 131:21-30. 2007
    ..Given this area's predominant role in endogenous pain control, this response pattern suggests that habituation to pain is at least in part mediated by increased antinociceptive activity...
  61. doi request reprint "Alice in Wonderland syndrome" associated with topiramate for migraine prevention
    T P Jürgens
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    J Neurol Neurosurg Psychiatry 82:228-9. 2011
    ..Here, the case of a 17-year-old girl with migraine without aura who developed an 'Alice in Wonderland' syndrome repeatedly on topiramate treatment was presented and potential pathophysiological concepts were discussed...
  62. ncbi request reprint Autonomic activation in experimental trigeminal pain
    A Frese
    Department of Neurology, University of Munster, Germany
    Cephalalgia 23:67-8. 2003
  63. ncbi request reprint Pharmacological opportunities and pitfalls in the therapy of migraine
    A May
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Curr Opin Neurol 14:341-5. 2001
    ..However, all of them failed to demonstrate any antimigraine effects. Current clinical and experimental evidence therefore supports the view that isolated peripheral trigeminal nerve inhibition is insufficient to relieve acute migraine...
  64. ncbi request reprint Greater occipital nerve block is ineffective in chronic tension type headache
    E Leinisch-Dahlke
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 25:704-8. 2005
    ..Our results indicate that block of the greater occipital nerve is not effective in the treatment of chronic tension type headache. If at all, rather a 'pro-nociceptive' effect was observed...
  65. ncbi request reprint Efficacy of 1,000 mg effervescent acetylsalicylic acid and sumatriptan in treating associated migraine symptoms
    H C Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, DE 45147 Essen, Germany
    Eur Neurol 52:50-6. 2004
    ..The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan...
  66. doi request reprint Treatment of cluster headache in pregnancy and lactation
    T P Jürgens
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 29:391-400. 2009
    ..As the individual pharmacokinetics differ substantially, adverse drug effects should be considered if unexplained symptoms occur in the newborn...
  67. doi request reprint Neuronal mechanisms during repetitive trigemino-nociceptive stimulation in migraine patients
    David Aderjan
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Germany
    Pain 151:97-103. 2010
    ..The alteration of pain inhibitory circuits may be the underlying mechanism responsible for the dys-functional neuronal filters of sensory input...
  68. doi request reprint Use of complementary and alternative medicine in patients suffering from primary headache disorders
    C Gaul
    Department of Neurology, Martin Luther University Halle Wittenberg, Halle, Germany
    Cephalalgia 29:1069-78. 2009
    ..This study confirms that CAM is widely used among primary headache patients, mostly in combination with standard care...
  69. ncbi request reprint Improvement of dialysis headache after treatment with ACE-inhibitors but not angiotensin II receptor blocker: a case report with pathophysiological considerations
    E Leinisch-Dahlke
    Department of Neurology, Nephrology, University of Regensburg, Regensburg, Germany
    Cephalalgia 25:71-4. 2005
  70. ncbi request reprint Substance P receptor antagonists in the therapy of migraine
    A May
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    Expert Opin Investig Drugs 10:673-8. 2001
    ..Current clinical and experimental evidence therefore supports the view that NK(1) receptor antagonists may have no significant antimigraine properties...
  71. doi request reprint Hypothalamic deep-brain stimulation modulates thermal sensitivity and pain thresholds in cluster headache
    Tim P Jurgens
    Department of Systems Neuroscience, University of Hamburg, Germany
    Pain 146:84-90. 2009
    ..These results support the notion that neurostimulation of the posterior hypothalamus is specific for cluster headache and only affects certain aspects of pain sensation...
  72. doi request reprint Insular cortex activity is associated with effects of negative expectation on nociceptive long-term habituation
    Rea Rodriguez-Raecke
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Neurosci 30:11363-8. 2010
    ..Neuronally, this process is mediated by the right opercular region...
  73. ncbi request reprint Update on cluster headache
    Arne May
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Curr Opin Neurol 16:333-40. 2003
    ..This review covers the past 3 years, which have seen remarkable progress in understanding the pathophysiology of circadian headache syndromes and have brought exciting news...
  74. doi request reprint Brain gray matter decrease in chronic pain is the consequence and not the cause of pain
    Rea Rodriguez-Raecke
    Department of Systems Neuroscience and Orthopaedics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Neurosci 29:13746-50. 2009
    ....
  75. ncbi request reprint Cortical excitability and migraine
    A Stankewitz
    Department of Systems Neuroscience, University of Hamburg, Germany
    Cephalalgia 27:1454-6. 2007
  76. ncbi request reprint "Motor circuit" gray matter changes in idiopathic cervical dystonia
    B Draganski
    Department of Neurology, University of Regensburg, Germany
    Neurology 61:1228-31. 2003
    ..One crucial criterion for the diagnosis of ICD is normal results on MRI of the brain...
  77. doi request reprint Training-induced brain structure changes in the elderly
    Janina Boyke
    Department of Systems Neuroscience, University of Hamburg, D 22046 Hamburg, Germany
    J Neurosci 28:7031-5. 2008
    ..In addition, elderly volunteers who learned to juggle showed transient increases in gray matter in the hippocampus on the left side and in the nucleus accumbens bilaterally...
  78. ncbi request reprint Botulinum toxin A and the cutaneous nociception in humans: a prospective, double-blind, placebo-controlled, randomized study
    Wendelin Blersch
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, 93053 Regensburg, Germany
    J Neurol Sci 205:59-63. 2002
    ..The study shows that there is no direct peripheral antinociceptive effect of BoNT/A in humans. The efficacy of BoNT/A in various pain syndromes must be explained by other pathways such as chemodenervation or anti-inflammatory effects...
  79. ncbi request reprint Headache: lessons learned from functional imaging
    Arne May
    Department of Neurology, University of Regensburg, Germany
    Br Med Bull 65:223-34. 2003
    ....
  80. ncbi request reprint Botulinum toxin A does not alter capsaicin-induced pain perception in human skin
    Wilhelm J Schulte-Mattler
    Department of Neurology, University of Regensburg, Universitätsstr 84, 93053 Regensburg, Germany
    J Neurol Sci 260:38-42. 2007
    ..No BoNT/A related differences in pain perception were found at any quality. There is neither a direct peripheral antinociceptive effect nor a significant effect against neurogenic inflammation of BoNT/A in humans...
  81. ncbi request reprint Intractable eye pain: indication for triptans
    A May
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 22:195-6. 2002
    ..Further controlled studies are needed to investigate the usefulness of 5-HT1B/1D agonists in painful eye conditions...
  82. doi request reprint Increased limbic and brainstem activity during migraine attacks following olfactory stimulation
    Anne Stankewitz
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neurology 77:476-82. 2011
    ..However, imaging data of how the brain processes associate migraine symptoms, such as photophobia, phonophobia, or osmophobia, are rare...
  83. doi request reprint Ten years of chronic cluster--attacks still cluster
    Tim P Jurgens
    Department of Systems Neuroscience, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Cephalalgia 30:1123-6. 2010
    ....
  84. pmc The effect of opioid receptor blockade on the neural processing of thermal stimuli
    Eszter D Schoell
    NeuroImage Nord, Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 5:e12344. 2010
    ..On the neural level, painful thermal stimulation was associated with a negative BOLD signal within the pregenual anterior cingulate cortex, and this deactivation was abolished by naloxone...
  85. ncbi request reprint Temporal and spatial dynamics of brain structure changes during extensive learning
    Bogdan Draganski
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Neurosci 26:6314-7. 2006
    ..These results indicate that the acquisition of a great amount of highly abstract information may be related to a particular pattern of structural gray matter changes in particular brain areas...
  86. ncbi request reprint Neuroplasticity: changes in grey matter induced by training
    Bogdan Draganski
    Department of Neurology, University of Regensburg, Regensburg 93053, Germany
    Nature 427:311-2. 2004
  87. pmc Changes in gray matter induced by learning--revisited
    Joenna Driemeyer
    Department of Systems Neuroscience, University of Hamburg UKE, Hamburg, Germany
    PLoS ONE 3:e2669. 2008
    ..A better understanding of the temporal parameters may help to elucidate to what extent this type of cortical plasticity contributes to fast adapting cortical processes that may be relevant to learning...
  88. ncbi request reprint Cluster headache: a prospective clinical study with diagnostic implications
    Anish Bahra
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Neurology 58:354-61. 2002
  89. pmc Prevalence of cluster headache in Germany: results of the epidemiological DMKG study
    Stefan Evers
    J Neurol Neurosurg Psychiatry 78:1289-90. 2007
  90. ncbi request reprint Functional and structural neuroimaging in trigeminal autonomic cephalalgias
    Manjit Matharu
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Curr Pain Headache Rep 12:132-7. 2008
    ..These studies suggest that the hypothalamus plays a crucial role in the pathophysiology of TACs, thereby supporting the notion that these disorders are primarily due to central rather than peripheral mechanisms...
  91. ncbi request reprint Headaches with (ipsilateral) autonomic symptoms
    Arne May
    Dept of Neurology, University of Regensburg, 93053, Regensburg, Germany
    J Neurol 250:1273-8. 2003
    ..Some types of trigemino-autonomic headaches, such as paroxysmal hemicrania and hemicrania continua have, unlike cluster headaches, a very robust response to indomethacin, leading to a consideration of indomethacin-sensitive headaches...
  92. ncbi request reprint Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study
    Elizabeth Cittadini
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, England
    Arch Neurol 63:1537-42. 2006
    ..Cluster headache is a form of primary headache in which attacks are rapid in onset with very severe pain. The mainstays of acute therapy are inhaled oxygen and sumatriptan succinate injection...
  93. ncbi request reprint Role of functional imaging in neurological disorders
    Cornelius Weiller
    Neurologische Universitatsklinik Freiburg, Freiburg, Germany
    J Magn Reson Imaging 23:840-50. 2006
    ..Understanding the mechanisms and sites of pathology, such as has been achieved in cluster headaches, facilitates the development of new therapeutic strategies...
  94. pmc Treatment satisfaction with zolmitriptan nasal spray for migraine in a real life setting: results from phase two of the REALIZE study
    Marek Gawel
    Department of Medicine Neurology, Sunnybrook and Women s Health Sciences Centre, Suite 515, 60 Grosvenor Street, Toronto, Ontario M5S 1B6, Canada
    J Headache Pain 6:405-11. 2005
    ..8%). Zolmitriptan nasal spray was well tolerated. Most patients were satisfied with zolmitriptan nasal spray, were willing to continue using it and preferred it to previous therapies...
  95. ncbi request reprint Evaluation of the efficacy of intravenous acetaminophen in the treatment of acute migraine attacks: a double-blind, placebo-controlled parallel group multicenter study
    Elke Leinisch
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Pain 117:396-400. 2005
    ..The results indicate, that 1000mg intravenous acetaminophen is not superior to placebo in treating severe acute migraine attacks...
  96. ncbi request reprint Zolmitriptan 5 mg nasal spray: efficacy and onset of action in the acute treatment of migraine--results from phase 1 of the REALIZE Study
    Marek Gawel
    Department of Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Headache 45:7-16. 2005
    ....
  97. ncbi request reprint Therapeutic stimulation of the hypothalamus: pathophysiological insights and prerequisites for management
    Massimo Leone
    Brain 128:E35. 2005